Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system as one is going to find in the body, and only small amounts of a gene therapy vector are required for effective delivery. This very localized, comparatively isolated therapy bypasses or minimizes many of the technical concerns and areas of uncertainty regarding reprogramming, allowing those who are focused on pushing applications to the clinical to forge ahead. The more interesting applications remain those in which reprogramming factors are delivered systemically to muc...
Source: Fight Aging! - May 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A big data COVID train wreck
BY ANISH KOKA
If there was any doubt the academic research enterprise is completely broken, we have an absolute train wreck of a study in one of the many specialty journals of the Journal of the American Medical Association — JAMA Health.
I had no idea the journal even existed until today, but I now know to approach the words printed in this journal to the words printed in supermarket tabloids. You should too!
The paper that was brought to my attention is one that purports to examine the deleterious health effects of Long COVID. A sizable group of intellectuals who are still socially distancing and wearing n95s ...
Source: The Health Care Blog - March 13, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Anish Koka Covid research COVID-19 Long Covid Source Type: blogs
Fight Aging! Newsletter, February 6th 2023
In conclusion, our study reveals that aging enhances atherosclerosis via increased inflammation of visceral fat. Our study suggests that future therapies targeting the visceral fat may reduce atherosclerosis diseaseburden in the expanding older population.
Is the Gut a Significant Source of Amyloid-β in Alzheimer's Disease?
https://www.fightaging.org/archives/2023/02/is-the-gut-a-significant-source-of-amyloid-%ce%b2-in-alzheimers-disease/
The early stages of Alzheimer's disease are characterized by rising levels of amyloid-β in the brain and the formation of misfolded amyloid aggregates. It is present...
Source: Fight Aging! - February 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Innate Immune Signaling and the Inflammation that Drives Cerebrovascular Disease
In the progression of degenerative aging, a process of constant, unresolved inflammatory signaling is one of the most important ways in which low-level molecular damage gives rise to widespread dysfunction of tissue and organs. In today's open access paper, researchers discuss what is known of the way in which the innate immune system reacts to molecular signs of aging, the damage-associated molecular patterns such as DNA debris from dysfunctional mitochondrial and stressed and dying cells. This reaction is amplified by the rest of the immune system into a constant, disruptive state of chronic inflammation that changes cel...
Source: Fight Aging! - February 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age-Related Neuroinflammation and the Development of Neurodegenerative Conditions
The research community now considers chronic inflammation in brain tissue to be an important aspect of the development of neurodegenerative conditions. Unresolved inflammatory signaling is disruptive of tissue structure and function. With age, a state of chronic inflammation arises due to the presence of senescent cells, the reaction of the innate immune system to debris from stressed cells and metabolic waste such as protein aggregates, persistent viral infection, and a range of other contributing mechanisms. Therapies - such as senolytic treatments to clear senescent cells - that can suppress excess inflammation without ...
Source: Fight Aging! - January 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
What are the mechanisms of beneficial action of alcohol in moderate amounts ?
Putative mechanisms
Alcohol dis-engages platelets that are in aggregation mode (Renaud et al Clin Chim Acta. 1996 Mar 15;246(1-2):77-89)
Alcohol has anti-atherogenic properties (BRUNECK study Stroke. 1998;29:900–907 )
Alcohol Increases HDL which we still believe to be good cholesterol ( Elizabeth R. De Oliveira e Silva Circulation. 2000)
Alcohol causes less Ischemic stroke, that is documented ( Hillbom M Alcohol and stroke: pathophysiologic mechanisms. Neuroepidemiology. 1998)
Alcohol promotes energy consumption.
It is a sort of baseline exercise equivalent (ELI* )
Alcohol can make a perso...
Source: Dr.S.Venkatesan MD - December 8, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Alcohol and heart disease ada guidelines alcohol alcohol and cad alcohol and Interheart alcohol is it really beneficial INTERHEART study lancet interheart gbd study moderate alcohol beenfits what is moderate alcohol intake Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What is secondary AF?
Secondary AF has been defined as self limited atrial fibrillation caused by a reversible etiology. Conditions which cause secondary AF are myocardial infarction, myocarditis, pericarditis, acute pulmonary disease, hyperthyroidism, ethanol intoxication, sepsis and postoperative state. It is well known that postoperative AF can increase the morbidity and ICU/hospital stay after cardiac and non cardiac surgery.
Reference
Quon MJ, Behlouli H, Pilote L. Anticoagulant Use and Risk of Ischemic Stroke and Bleeding in Patients With Secondary Atrial Fibrillation Associated With Acute Coronary Syndromes, Acute Pulmonary Disease, or...
Source: Cardiophile MD - December 1, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Advocating for Glutathione Upregulation as a Basis for Therapy
You might recall a recent small clinical trial in which oral supplementation with large amounts of glutathione precursors produced improvements in health in older adults, the size of the outcome surprisingly large for a treatment based on supplements. Here, researchers enthusiastically advocate for glutathione upregulation, reversing the normal age-related decline in glutathione levels, as a basis for improving the health of older people and slowing the onset of age-related degeneration.
Many local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmona...
Source: Fight Aging! - November 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What do you think of this " Ventricular Bigeminy " ?
Written by Bobby Nicholson MD, with edits by MeyersA woman in her 50s with past medical history of heart failure, prior stroke, atrial fibrillation on Eliquis, lung cancer in remission, and CKD, presented to the emergency department for evaluation of cough and shortness of breath. EKG was obtained in triage and read as ventricular bigeminy. What do you think?On my first read of the EKG, I agreed with the initial interpretation. Pendell Meyers then recommended that I take a second look at the morphology of the QRS complexes. I think it was easiest for me to see in the rhythm strip, but there are clearly P waves in front of ...
Source: Dr. Smith's ECG Blog - November 19, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging.
HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People
https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/
An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How are stroke and heart disease related? Cardiology Basics
Ischemic stroke is often due to sudden obstruction to a cerebral artery which usually results in paralysis. Hemorrhage stroke is due a bleed from a cerebral vessel and deemed to be more dangerous than ischemic stroke.
Stroke and heart disease are linked together in various ways. In general, risk factors for stroke and ischemic heart disease are similar. Ischemic strokes can sometimes occur simultaneously with an acute myocardial infarction.
Stroke can occur after a myocardial infarction as well. Myocardial infarction can cause damage to a region of endocardium over the infarct. This region can be a nidus for the formation...
Source: Cardiophile MD - October 21, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
