Bilateral ICA block: MRI
Case Report 76 yrs old female pt. presets for MR brain angio with c/o giddiness of long duration.MRA shows– marked narrowing& grossly reduced flow signal of both ICA in carotid canal with complete absence of cavernous ICA with source images suggesting right PCOM feeding ipsilateral MCA& left MCA possibly filling from right side. Both MCA are grossly reduced in caliber with origins not identified along with poorly visualized both ACA& ACOM.Dominant grossly tortuous& atheromatous vertebral system with basilar artery suggesting tortuosity/atheromatous looping / redundancy with both PCA normal ...
Source: Sumer's Radiology Site - February 23, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Computer often fails to diagnose atrial fibrillation in ventricular paced rhythm, and that can be catastrophic
Conclusion: Incorrect computerized interpretation of atrial fibrillation, combined with the failure of the ordering physician to correct the erroneous interpretation, can result in the initiation of unnecessary, potentially harmful medical treatment as well as inappropriate use of medical resources. Greater efforts should be directed toward educating physicians about the electrocardiographic appearance of atrial dysrhythmias and in the recognition of confounding artifacts. (Source: Dr. Smith's ECG Blog)
Source: Dr. Smith's ECG Blog - February 21, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Calcification of Arteries is an Independent Cardiovascular Risk, Distinct from Atherosclerosis and Inflammation
The same underlying molecular and cellular damage of aging contributes to both calcification of blood vessel walls and the development of atherosclerosis, but researchers here argue that calcification can be considered on its own, an independent risk factor for cardiovascular dysfunction and mortality in later life. The presence of senescent cells is one of the common underlying factors that accelerates the progression of both atherosclerosis and calcification of blood vessels. This is due to the inflammatory signaling produced by these cells. That signaling distorts the behavior of macrophages trying to clear up deposits ...
Source: Fight Aging! - February 20, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How much time are you willing to wait for OMI to become STEMI (if it ever does)?
Written by Pendell Meyers, few edits by SmithA man in his 60s with history of stroke and hypertension but no known heart disease presented with chest pain that started on the morning of presentation at around 8am.Here is his triage ECG when he presented at 1657:What do you think?There is sinus rhythm with normal QRS complex and ST depression in V2-V5, maximal in V3-V4. There is no ST depression in V6, II, III, or aVF, and no significant ST elevation in aVR, all confirming that the ST vector is not consistent with diffuse subendocardial ischemia, but rather a focal ST vector pointed at the posterior wall. It is posterior OM...
Source: Dr. Smith's ECG Blog - February 16, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, February 4th 2019
In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model.
Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokin...
Source: Fight Aging! - February 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Apple Collaborates with Janssen on Apple Watch AFib/Stroke Clinical Trial
Apple has been in the news recently regarding innovations with iPhones in partnership with hospitals (see:Apple Has Plans to Copy EHR Records to iPhones and Apple Watches) and with health insurance about the Apple Watch (see:Apple Watch"Gifted" to Insurance Policy Holders; Any Gotcha's with the Deal?). Continuing to expand the functionality of the Apple Watch, the company is now partnering withJanssen Pharmaceuticals, a division of J&J, on a clinical trial (see:Johnson& Johnson partners with Apple to see if Watch can prevent strokes). Below are some of the details, copied from the article:...
Source: Lab Soft News - February 1, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Food and Drug Administration Healthcare Information Technology Healthcare Innovations Lab Industry Trends Medical Consumerism Medical Research Preventive Medicine Test Kits and Home Testing Source Type: blogs
The Goal of Symbiotic Microbes in Tissues, Generating Additional Oxygen as Required
We live in an era of biotechnology, of tremendous year by year increases in the capacity to engineer the fundamental mechanisms of life and disease. The research community and funding institutions should aim high, aim at the new and the amazing, rather than slouching forward in the service of crafting yet more marginal, incremental improvements to existing forms of therapy. Sadly, mediocrity rules when it comes to all too much of the research community. Vision is lacking, and far too few people are willing to tread the roads yet untraveled.
Why is it necessary to spend so much time and effort to convince people to f...
Source: Fight Aging! - January 31, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The VERDICT Trial
This study is unable to comment on whether patients with STEMI(-) Occlusion MI have benefit from emergent cath, because that is not the population studied and this subgroup is not commented on.This study is just the most recent in a long long line of similar literature. Context is everything for understanding this study. See below for an excerpt from theOMI Manifesto which summarizes the existing literature and provides details on each study:-------------------------------------------------------------------------------------------------------------- Counter-argument:“Haven’t there been RCTs showing no benefit for earl...
Source: Dr. Smith's ECG Blog - January 4, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, December 24th 2018
In conclusion, we found a gradient of increasing blood pressure with higher levels of BMI. The fact that this gradient is present even in the fully adjusted analyses suggests that BMI may cause a direct effect on blood pressure, independent of other clinical risk factors.
PRRX1 as a Possible Point of Control for Remyelination
https://www.fightaging.org/archives/2018/12/prrx1-as-a-possible-point-of-control-for-remyelination/
Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operati...
Source: Fight Aging! - December 23, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Upregulation of Slit Improves Functional Recovery After Stroke in Mice
Researchers here report on a mechanism that increase the regenerative capacity of brain cells following the damage of a stroke, at least in mice. There are now a few similar approaches demonstrated in the laboratory, but it remains to be seen whether any of them will lead to therapies in the near future. It is certainly the case that mammalian cells do not respond to structural damage and loss of blood supply in the most optimal way; many of their reactions make matters worse, not better. Perhaps that can be adjusted safely and soon, though it would be far preferable to focus on potential ways to prevent that sort of event...
Source: Fight Aging! - December 18, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Alcohol, Smoking, Drugs: Can Digital Solutions Give A Helping Hand To The Addicted?
Alcohol content measuring wristbands, smart lighters, nicotine tracking wearables, stop smoking apps, virtual reality therapies, automated messaging platforms are the newest elements in the arsenal of digital health technologies supporting everyone in the fight against addiction to cigarettes, alcohol or drugs.
Addiction and dependency ruins lives
Once you become addicted, it sticks with you for a long time, if not for life. It doesn’t matter whether it’s about cigarettes, alcohol, medication, drugs, gambling, sex, etc., any of these substances or phenomena could cause you strong dependency and might impact your everyd...
Source: The Medical Futurist - December 6, 2018 Category: Information Technology Authors: nora Tags: Future of Medicine Future of Pharma Medical Professionals Patients Researchers alcohol cigarette digital health drugs health technology Innovation medication opioid opioid crisis smartphone smartphone apps smoking virtual Source Type: blogs
Aspirin for primary prevention of cardiovascular disease?
This study did find a significant reduction in adverse cardiovascular outcomes with daily aspirin in people with diabetes, though there was also a similar magnitude of increased major bleeding. Still, many people would rather be hospitalized for bleeding and get a transfusion versus being hospitalized for a heart attack that causes permanent damage to the heart. Others may not see much difference between the two types of events and may prefer not to take an additional medication.
Should you take a daily aspirin?
So, where does this leave the average person who is worried about a heart attack and wants to do everything they...
Source: Harvard Health Blog - September 20, 2018 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Heart Health Source Type: blogs
Daily Low Dose Aspirin Fails to Extend Healthy Life Spans in Older Patients
Aspirin is arguably a calorie restriction mimetic, able to spur some of the same beneficial cellular stress responses that are activated by low nutrient levels. Calorie restriction itself, practiced over the long term, does not have a very large effect on human life span. Given the existing demographic data, a gain of even five years of life would be very surprising. Further, it is well established that the life extension resulting from calorie restriction scales down as species life span scales up. Mice live up to 40% longer on calorie restricted diets, but we humans certainly don't.
Aspirin has other effects besid...
Source: Fight Aging! - September 18, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 3rd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - September 2, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is Medical Imaging a Ricardian Derived Demand?
By SAURABH JHA
Medical Imaging and the Price of Corn
After the Napoleonic wars, the price of corn in England became unaffordable. The landowners were blamed for the high price, which some believed was a result of the unreasonably high rents for farm land. Economist David Ricardo disagreed.
According to Ricardo, detractors had the directionality wrong. It was the scarcity of corn (the high demand relative to its supply) that induced demand for the most fertile land. That is, the rent did not increase the price of corn. The demand for corn raised the rent. Rent was a derived demand.
Directionality is important. Getting dire...
Source: The Health Care Blog - August 30, 2018 Category: Consumer Health News Authors: at RogueRad Tags: OP-ED Tech CT Angiograms derived demand Imaging Medical Imaging Source Type: blogs
