Fight Aging! Newsletter, February 4th 2019

In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokines and chemokines, was potently mitigated by lifelong AET, including master regulators of the cytokine cascade and cancer progression (IL-1β, TNF-α, and IL-6). In addition, circulating SPARC, previously known to be upregulated in metabolic disease, was elevated in old, sedentary mice, but was normalized to young control levels in lifelong runners. Remarkably, malignant tumours were also completely absent in the O-AET group, whereas they were present in the brain (pituitary), liver, spleen, and intestines of sedentary mice. Collectively, our results indicate that early-onset, lifelong running dampens inflammaging, protects against multiple cancer types, and extends healthspan of naturally-aged mice. Reduced Blood Pressure Lowers Risk of Mild Cognitive Impairment, but Not Dementia? https://www.fightaging.org/archives/2019/02/redu...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Fahd M. Abdelkarem, Ezz-Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Maki Nagata, Tomofumi Miyamoto, Kuniyoshi ShimizuAbstractFurther chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structu...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Karolina Nowak, Marcin Zawadzki, Tomasz JurekAbstractPostmortem diagnosis of hyperglycaemia is a challenge in forensic medicine. Glycated haemoglobin (HbA1c) is considered one of the markers providing an alternative to postmortem determinations of glucose concentration. On the other hand, glycated albumin (GA) may be determined in cases of difficulty in determining HbA1c.The aim of this study was to implement and evaluate the usefulness of methods enabling determination of HbA1c an GA in postmortem material (HbA1c–peripheral blood, GA&ndas...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): David S.M. Ribeiro, Rafael C. Castro, José X. Soares, João L.M. SantosAbstractIn this work, the ability of thiomalic acid (TMA)-capped AgInS2 quantum dots to generate reactive oxygen species (ROS) upon irradiation with visible light was investigated, which led to the subsequent development of a luminol-based chemiluminometric method for the monitoring of melatonin (MLT) in commercial dietary supplements. The developed approach was based on the antioxidant properties of melatonin conferred by the electron-rich aromatic indole ring w...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 20 February 2020Source: Journal of Photochemistry and Photobiology A: ChemistryAuthor(s): Abdessalem Omri, Wiem Hamza, Mourad BenzinaAbstractA novel heterogeneous photo-Fenton catalyst, iron coated sand (Fe-sand) was synthesized by impregnation-calcination method. The catalyst Fe-sand was characterized by XRD, BET, SEM, TEM, FTIR, XRF and DRS methods. X-ray diffraction (XRD) analysis showed that the Fe-sand catalyst mainly consists of Fe2O3 and SiO2 crystallites, and the Fe concentration of the prepared catalyst measured by AAS is 135.7 mg/g. BET results revealed that Fe-sand posse...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Journal of Analytical and Applied PyrolysisAuthor(s): Behnam Nejati, Parisa Adami, Ali Bozorg, Ahmad Tavasoli, Alireza Hajiseyed MirzahosseiniAbstractCatalytic and non-catalytic pyrolysis of Chlorella vulgaris microalgae was studied and the temperature, as the primary variable, was assessed to optimize the process. By changing the temperature from 450 to 850 °C, the highest performance of 58.51% was achieved in terms of energy recovery (ER) at the optimal temperature of 650 °C. Although known as a useless pyrolysis by-product, the remaining bi...
Source: Journal of Analytical and Applied Pyrolysis - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Meitong Ou, Chao Pan, Yongkang Yu, Xuan Wang, Yun Zhou, Hanjie Zhang, Qinzhen Cheng, Meiying Wu, Xiaoyuan Ji, Lin MeiAbstractExcessive reactive oxygen species (ROS), as effective cancer therapeutic agents, can promote tumor apoptosis. However, the clinical applications of ROS-mediated cancer therapies still have many limitations, such as self-defects of traditional photosensitizer, adverse tumor microenvironment (TME), and insufficient ROS production. Here, two-dimensional and highly oxidized ilmenite nanosheets (HOIL NSs, for...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Yang Zhang, Yanjun Xu, Di Sun, Zheying Meng, Weiwei Ying, Wei Gao, Rui Hou, Yuanyi Zheng, Xiaojun Cai, Bing Hu, Xianfang LinAbstractAs a promising treatment modality with spatial and temporal control, alternating magnetic field (AMF) triggered magnetic hyperthermal therapy (MHT) shows broad and promising applications to overcome the drawbacks of traditional focal therapies in combating cancer. However, the MHT efficacy is still not satisfactory with the presence of heat shock proteins (HSPs). In addition, sustained tumor hypox...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Alsayed Mostafa, Seongwon Im, Mo-Kwon Lee, Young-Chae Song, Dong-Hoon KimAbstractIn the present work, effects of direct interspecies electron transfer (DIET)-promoting condition on anaerobic treatment of phenol, in up-flow anaerobic sludge blanket reactors (UASB) were investigated. One reactor (C-UASB) was operated as a control, while two reactors (EA-UASBs) were operated with electrical energy input (EEI) at 0.3 V and 0.6 V. The organic loading rate was gradually increased from 0.5 to 14 kg COD/m3/d at a fixed hydraulic ...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 20 February 2020Source: Catalysis TodayAuthor(s): Thi Phuong Thao Nguyen, Ki Hyuck Yang, Moon Hyeon Kim, Yong Seok HongAbstractFe2O3-promoted V2O5-WO3/TiO2 catalysts with high Fe2O3-to-V2O5 ratios (3.4 – 6) have been prepared for the selective reduction of NO with NH3 (NH3-SCR) and extensively characterized using various spectroscopic measurements. No crystalline iron oxides were indicated even for 8% Fe2O3-promoted V2O5-WO3/TiO2 but distorted α-Fe2O3 crystallites were observed in a XRD pattern for 7.04% Fe2O3-promoted WO3/TiO2. Both Raman and XPS measurements suggest the form...
Source: Catalysis Today - Category: Chemistry Source Type: research
Publication date: Available online 20 February 2020Source: Catalysis TodayAuthor(s): Nafeezuddin Mohammad, Richard Y. Abrokwah, Robert G. Stevens-Boyd, Shyam Aravamudhan, Debasish KuilaAbstractFischer-Tropsch (FT) synthesis was carried out using 3D-printed stainless steel (SS) microreactors, containing channels of dimensions 500 μm × 500 μm ×2.7 cm, to study the effect of Fe, Ru, and Ni on Co-MCM-41 catalyst. The mono and bimetallic cobalt-based catalysts: 15% Co-MCM-41, 10%Co5% Ru MCM-41, 10%Co 5%Ni MCM-41, and 10%Co 5%Fe MCM-41 were synthesized using one-pot hydrotherm...
Source: Catalysis Today - Category: Chemistry Source Type: research
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