Fight Aging! Newsletter, February 4th 2019

In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokines and chemokines, was potently mitigated by lifelong AET, including master regulators of the cytokine cascade and cancer progression (IL-1β, TNF-α, and IL-6). In addition, circulating SPARC, previously known to be upregulated in metabolic disease, was elevated in old, sedentary mice, but was normalized to young control levels in lifelong runners. Remarkably, malignant tumours were also completely absent in the O-AET group, whereas they were present in the brain (pituitary), liver, spleen, and intestines of sedentary mice. Collectively, our results indicate that early-onset, lifelong running dampens inflammaging, protects against multiple cancer types, and extends healthspan of naturally-aged mice. Reduced Blood Pressure Lowers Risk of Mild Cognitive Impairment, but Not Dementia? https://www.fightaging.org/archives/2019/02/redu...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

A growing link—what is the role of height in cancer risk?A growing link—what is the role of height in cancer risk?, Published online: 19 February 2019; doi:10.1038/s41416-018-0370-9A growing link—what is the role of height in cancer risk?
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults, Published online: 19 February 2019; doi:10.1038/s41416-018-0371-8Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: Available online 18 February 2019Source: Journal of Psychiatric ResearchAuthor(s): John W. Rutland, Stephanie Brown, Gaurav Verma, Rebecca E. Feldman, Himanshu Sharma, Matthew Markowitz, Molly Schneider, Bradley N. Delman, James Murrough, Priti BalchandaniAbstractObjectiveDiffusion magnetic resonance imaging (dMRI) enables non-invasive characterization of white matter (WM) structures in vivo. Prior studies suggest that certain WM tracts may be affected in major depressive disorder (MDD), however, hippocampal subfield-specific dMRI measures have not yet been explored in MDD. We use 7 Tesla dMRI to investig...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Finding out you have a chronic illness — one that will, by definition, never go away — changes things, both for you and those you love.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Crohn's Disease Digestive Tract Depression (Mental) Source Type: news
Publication date: Available online 17 February 2019Source: Progress in NeurobiologyAuthor(s): Carlos Silva, Neil McNaughtonAbstractMany see the periaqueductal grey (PAG) as a region responsible for the downstream control of defensive reactions. Here we provide a detailed review of anatomical and functional data on the different parts of the PAG together with the dorsal raphe, which completes the circle of periaqueductal nuclei. Based on anatomical features, we propose a new subdivision of the periaqueductal grey that accounts for the distinct characteristics of the area. We provide a comprehensive functional view of the pe...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
Being transgender carries all manner of social and health risks. Transitioning can drastically improve quality of life, but the necessary hormones raise heart risks, a University of Amsterdam study found.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
An editorial in The BMJ last year warned that even modern stoves carrying government-approved ‘eco-friendly’ labels emit pollution at the same rate as 25 ten-year-old diesel lorries.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Doctors Christopher Kelly and Marc Eisenberg, from New York, go through the most common symptoms and give guidance on the next steps — relaxing, making a GP appointment or rushing to A&E.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The sports personality, 38, from Bedfordshire, walks her dogs ever day and enjoys a healthy vegan diet - but, last summer, had filler in her lips and cheeks.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We report a rheumatic heart disease case presented the exemplary imaging manifestation of massive LA thrombus with calcification. The precise anatomic information of massive LA thrombus with calcification was demonstrated by enhanced multi-detector computed tomography.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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