GDF-11 and Myostatin Correlate with Heart Disease Outcomes
Here researchers study natural variations in GDF-11 and myostatin levels, finding correlations with health outcomes in heart disease patients. This is one of a number of lines of research emerging from the search for cell signals that differ between old and young tissues, and that might be altered to induce old cell populations to behave more like young cell populations despite the damage they have suffered. In recent years researchers have demonstrated the use of GDF-11 to spur greater levels tissue maintenance in aged mice, for example:
Individuals previously diagnosed with heart disease may be less likely to experience...
Source: Fight Aging! - August 26, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Praluent, the Next Expensive "Game Changer," Blockbuster," "New Hope," - But Not Yet Shown to Benefit Patients
ConclusionsThe NEJM study was accompanied by an editorial by Stone and Lloyd-Jones(2) which documented that drugs previously shown to lower cholesterol were never proved to do any good for patients, and concluded,it would be premature to endorse these drugs for widespread use before the ongoing randomized trials, appropriately powered for primary end-point analysis and safety assessment, are available. After an FDA advisory committee recommended approval of aliromucab and another PCSK9 inhibitor in June, 2015, John Mandrola entitled a Medscape article,Dear FDA: Resist the Urge on PCSK9 DrugsHis reasons included lack o...
Source: Health Care Renewal - August 5, 2015 Category: Health Management Tags: aliromucab evidence-based medicine health care prices manipulating clinical research PCSK9 inhibitor Praluent Regeneron Sanofi-Aventis Source Type: blogs
Ahead of Print: Demystifying the Pediatric ECG
Emergency physicians are able to quickly decode the ciphers of ECGs into meaningful clinical data, at least until they are faced with a pediatric ECG. It breaks their pattern recognition, and they are forced to use the slow part of their brain (recommended reading: Daniel Kahneman’s Thinking, Fast and Slow). Even though the pediatric ECG looks vaguely similar to all of the other ECGs seen during a shift, this one turns into a mystery and confidence drains. It doesn’t look normal based on an adult tracing, but they are unsure if it’s normal for the child. The best ECG readers can resort to folding the tracing under...
Source: Spontaneous Circulation - August 3, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Ahead of Print: Demystifying the Pediatric ECG
Emergency physicians are able to quickly decode the ciphers of ECGs into meaningful clinical data, at least until they are faced with a pediatric ECG. It breaks their pattern recognition, and they are forced to use the slow part of their brain (recommended reading: Daniel Kahneman’s Thinking, Fast and Slow). Even though the pediatric ECG looks vaguely similar to all of the other ECGs seen during a shift, this one turns into a mystery and confidence drains. It doesn’t look normal based on an adult tracing, but they are unsure if it’s normal for the child. The best ECG readers can resort to folding the tracing unde...
Source: Spontaneous Circulation - August 3, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Demystifying the Pediatric ECG
Emergency physicians are able to quickly decode the ciphers of ECGs into meaningful clinical data, at least until they are faced with a pediatric ECG. It breaks their pattern recognition, and they are forced to use the slow part of their brain (recommended reading: Daniel Kahneman’s Thinking, Fast and Slow). Even though the pediatric ECG looks vaguely similar to all of the other ECGs seen during a shift, this one turns into a mystery and confidence drains. It doesn’t look normal based on an adult tracing, but they are unsure if it’s normal for the child. The best ECG readers can resort to folding the tracing under...
Source: Spontaneous Circulation - August 3, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
