Telerobotic System Uses Magnets to Perform Endovascular Procedures
Researchers at MIT have developed a telerobotic surgical system that allows a surgeon to remotely treat patients who are suffering a stroke or aneurysm. The system could be very useful, as achieving treatment as soon as possible after a stroke is crucial, but the endovascular surgeons who specialize in treating such patients may not be present at smaller clinics or remote hospitals. This system would allow them to provide treatment even if they are located in a different hospital. The robot uses a magnet to guide a wire through the blood vessels to the clot or aneurysm.
When someone suffers an ischemic stroke, time is o...
Source: Medgadget - April 20, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Neurosurgery Radiology Telemedicine Vascular Surgery mit Source Type: blogs
Zoom POD for Sterile Field Clot Capture: Interview with Daniel Davis of Imperative Care
Imperative Care, a medtech company based in California, created the Zoom Stroke Solution, a complete system for the mechanical removal of clots in patients with ischemic stroke. The system includes an access catheter, aspiration catheters, a powerful pump, and the latest addition, the Zoom Pod, a clot filter that is positioned within the sterile field.
As the filter is located within the sterile field, it allows the clinician to immediately identify when the clot has been aspirated, and avoids the need to try to find the clot after the procedure has been completed by opening a sealed aspiration canister. If clinicians w...
Source: Medgadget - March 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Neurosurgery imperative_care Source Type: blogs
Fight Aging! Newsletter, March 21st 2022
This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions.
"This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise."
Variations in Biological Age Across Organs in Younger Individuals
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Source: Fight Aging! - March 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Polarization of Microglia to M2 as a Basis for Treating Neurodegenerative Conditions
A good deal of evidence points to increased inflammatory activation of microglia in the brain, and consequent chronic inflammation of brain tissue, as an important component of neurodegenerative conditions. Some of these inflammatory microglia are senescent, and their clearance has been shown to be helpful in animal models, but the broader problem is an imbalance between pro-inflammatory M1 microglia and anti-inflammatory M2 microglia. A number of options exist if the goal is to shift the balance, from clearance and regeneration of all microglia via CSFR1 inhibition to various mechanisms that might encourage microglia to p...
Source: Fight Aging! - March 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Aging Kidney Harms the Brain
A good deal of evidence points to declining kidney function as a cause of declining cognitive function in aging. There are strong correlations between loss of kidney function and risk of dementia, for example. Correlation isn't a smoking gun in matters of aging, however: it is possible for any one of the underlying forms of molecular damage that cause aging, or for intermediate consequences of that damage, to give rise to otherwise unrelated pathologies in different parts of the body. Those pathologies appear more often in people with greater amounts of that form of damage, and thus appear correlated.
Nonetheless, t...
Source: Fight Aging! - December 22, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 15th 2021
This article will review the relationship between diabetes mellitus and AD as it relates to tau pathology. More understanding of the link between diabetes mellitus and AD could change the approach researchers and clinicians take toward both diseases, potentially leading to new treatments and preventative strategies in the future.
Signaling from White Fat Tissue Contributes to Age-Related Hair Follicle Dysfunction
https://www.fightaging.org/archives/2021/11/signaling-from-white-fat-tissue-contributes-to-age-related-hair-follicle-dysfunction/
Changes in fat tissue behavior in the skin take place with age,...
Source: Fight Aging! - November 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Extremely high HDL – beneficial or harmful?
This study showed extremely high HDL was associated with lower risks for all-cause mortality and cardiovascular events compared to low HDL. But they had higher risks compared to very high HDL.
Paradoxically high all-cause mortality in those with extremely high HDL has also been reported in another study of 52 268 men and 64 240 women [5].
Though most of these studies showed a negative role for extremely high HDL, there is recent study from Korea which showed that extremely high HDL was not associated with increased risk of mortality, myocardial infarction and stroke [6]. That study with 343,687 subjects also defined extrem...
Source: Cardiophile MD - October 20, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Wristband to Detect Strokes: Interview with Sandra Saldana, CEO of Alva Health
Alva Health, a medtech startup based in Connecticut, is developing a wristband that can detect the signs of stroke and promptly alert the wearer and/or healthcare staff. The technology is intended for those at high risk of stroke, such as stroke survivors and those diagnosed with transient ischemic attack.
Strokes cause a huge level of patient morbidity every year, with many suffering debilitating symptoms that are life changing. Early diagnosis and prompt treatment are very important, but in many cases the early symptoms of a stroke are subtle and are easily missed. These issues have inspired this startup to develop a ...
Source: Medgadget - October 18, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Neurosurgery alvahealth stroke Source Type: blogs
P2-CHA2DS2-VASc Score
P2-CHA2DS2-VASc score adds additional two points to the CHA2DS2-VASc score for an abnormal P wave axis to predict risk of stroke in atrial fibrillation (AF) [1]. The seminal study was an attempt to identify utility of P wave indices in sinus rhythm to predict the risk of stroke over and above the existing CHA2DS2-VASc score. P wave indices evaluated were prolonged P wave duration, abnormal P wave axis, advanced interatrial block and abnormal P wave terminal force in lead V1. They found that abnormal P wave axis which is an ECG correlate of left atrial abnormality improves the prediction of ischemic stroke. They concluded ...
Source: Cardiophile MD - July 21, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
University of Freiburg – Research Assistant position
We are seeking a full-time or part time research assistant to support and manage researchprojects at the Department of Neurology. We study how the brain works and how it recoversfrom damage. Clinical and neuropsychological behavioural tests (eg: language, spatialprocessing, praxis, spatial perception, memory) are correlated with brain anatomy andfunction (eg: fMRI, rsfMRI, DTI, sMRT, PET, TMS) in group studies of patients (mainlystroke, Parkinson ’s disease and migraine). In a large scale project carefully selected strokepatients (first ever stroke, single ischemic lesion) are prospectively tested during acute stageand f...
Source: Talking Brains - July 19, 2021 Category: Neuroscience Authors: Greg Hickok Source Type: blogs
University of Freiburg – Research Assistant position
We are seeking a full-time or part time research assistant to support and manage research projects at the Department of Neurology. We study how the brain works and how it recovers from damage. Clinical and neuropsychological behavioural tests (eg: language, spatial processing, praxis, spatial perception, memory) are correlated with brain anatomy and function (eg: fMRI, rsfMRI, DTI, sMRT, PET, TMS) in group studies of patients (mainly stroke, Parkinson ’s disease and migraine). In a large scale project carefully selected stroke patients (first ever stroke, single ischemic lesion) are prospectively tested during acute stag...
Source: Talking Brains - July 19, 2021 Category: Neuroscience Authors: Greg Hickok Source Type: blogs
Alcohol, Smoking, Drugs: How Technology Can Help
The global statistics on substance use are disquieting. Globally, about 3 million people die every year from alcohol abuse. Tobacco kills up to half of its users – over 8 million people annually. And the UN’s 2021 World Drug Report estimated that around 275 million people used drugs worldwide in 2020, while over 36 million people suffered from drug use disorders.
Disruptive technologies could act only as additional tools for managing preventive or reactive treatment for both victims and physicians next to therapy. Alcohol content-measuring wristbands, smart lighters, nicotine tracking wearables, stop smoking apps, virt...
Source: The Medical Futurist - July 15, 2021 Category: Information Technology Authors: berci.mesko Tags: E-Patients Future of Medicine Future of Pharma Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy Telemedicine & Smartphones Virtual Reality alcohol digital health Innovation smoking technology VR health Source Type: blogs
Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future.
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Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in the Context of Aging, Metabolism, and Epigenetics
The accumulation of senescent cells is clearly an important contribution to the progression of degenerative aging. This was firmly established to be the case not by the careful examination of mechanisms, because it is very challenging to assign relative significance to the many different processes involved in aging, but rather by the selective removal of senescent cells in mice. The best way, and possibly the only practical way at the present time, to establish the relevance of a mechanism to aging and disease is to very selectively block just that mechanism and then observe the results.
In the case of senescent cel...
Source: Fight Aging! - July 7, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
