Fight Aging! Newsletter, December 27th 2021

We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases. Suppression of Inflammatory Signaling as a Treatment for Frailty https://www.fightaging.org/archives/2021/12/suppression-of-inflammatory-signaling-as-a-treatment-for-frailty/ Age-related frailty is accompanied by marked chronic inflammation, and indeed much of the physical weakness of frailty is likely caused by long-term inflammation and the ways in which it disrupts muscle tissue maintenance. The tools presently available to suppress inflammation are somewhat blunt, interfering in the necessary signaling needed to maintain a normal immune response, as well as in the unwanted overactivation of the immune system found in older people. Nonetheless, such tools are slowly becoming better and more selective over time, and some are now being tested as treatments for frailty. Earlier this year, MyMD Pharmaceuticals merged with Akers B...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs