Age-Related Neuroinflammation and the Development of Neurodegenerative Conditions

The research community now considers chronic inflammation in brain tissue to be an important aspect of the development of neurodegenerative conditions. Unresolved inflammatory signaling is disruptive of tissue structure and function. With age, a state of chronic inflammation arises due to the presence of senescent cells, the reaction of the innate immune system to debris from stressed cells and metabolic waste such as protein aggregates, persistent viral infection, and a range of other contributing mechanisms. Therapies - such as senolytic treatments to clear senescent cells - that can suppress excess inflammation without affecting the useful, normal inflammatory reaction to injury and infection should slow down many of the manifestations of aging, including the onset of neurodegenerative conditions such as Alzheimer's disease. Neuroinflammation exists in variety of aging-related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), major depressive disorder (MDD), ischemic stroke, spinal cord injury, and schizophrenia. Among the many critical molecules that regulate neuroinflammation, the NLRP3 inflammasome complex was found to play important roles in cellular immune response such as during stress and infection. Recent evidence demonstrates that NLRP3-medicated neuroinflammation is involved in the pathology of neurodegenerative diseases. Misfolded protein aggre...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs