Reducing residual cardiovascular risk

Reducing residual cardiovascular risk Reducing residual cardiovascular risk in patients treated with statins and having hypertriglyceridemia was addressed by Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial (REDUCE-IT) [1]. REDUCE-IT was a double blind placebo controlled multicenter randomized trial. Patients with established cardiovascular disease or diabetes mellitus with other risk factors treated with statins were evaluated. At study inclusion they needed to have fasting triglyceride levels between 135 and 499 mg/dL and LDL cholesterol level 41 to 100 mg/dL. They were randomized to either 2 g of icosapent ethyl twice daily or placebo. Icosapent ethyl is a highly purified eicosapentaenoic acid ethyl ester which lowers serum triglyceride levels. Primary endpoint: Composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization or unstable angina. Secondary end point: Composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. Eight thousand one hundred and seventy nine patients were enrolled in REDUCE-IT, of which 70.7% were for secondary prevention of cardiovascular events. Median follow up period was 4.9 years. Primary end-point event occurred in 17.2% of the patients in the study group, while it occurred in 22.0% of the placebo group (P
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs

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Publication date: Available online 16 October 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Ssu-Han Chen, Aron Michael, Chee Yee KwokAbstractThis paper presents the fabrication and characterization of a high performance piezoelectrically driven micro-lens actuator. The fabrication method involves controlling the residual stresses in the structure to predefine the initial deflection of the actuator, resulting in a larger actuation stroke. The residual stress control exploits the unique properties of ultra-high vacuum e-beam evaporated film to form thick tensile polysilicon as the actuator structural layer. This is...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
Publication date: Available online 16 October 2019Source: Molecular and Cellular ProbesAuthor(s): Fengwei Nan, Guibo Sun, Weijie Xie, Tianyuan Ye, Xiao Sun, Ping Zhou, Xi Dong, Jiafu Sun, Mengren Zhang, Xiaobo SunAbstractDiabetic encephalopathy is a severe diabetic complication characterized by cognitive dysfunction and neuropsychiatric disability. Methylglyoxal (MGO), a highly reactive metabolite of hyperglycemia, serves as a major precursor of advanced glycation end products that play key roles in diabetic complications. Ginsenoside Rb1 (abbreviated as Rb1) has received extensive attention due to its potential therapeuti...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: Available online 14 October 2019Source: Microchemical JournalAuthor(s): A. Parsa, H. HeliAbstractWrinkled nanostructure of nickel was electrodeposited from a deep eutectic solvent comprising choline chloride and urea (reline) under golvanostatic conditions. Field emission scanning electron microscopic images were taken to evaluate the shape and size of the nickel nanostructure. The nickel nanostructure was then converted into the corresponding oxides, and the kinetics of charge transfer across the interface of the nanostructured oxides/an alkaline electrolyte was then studied. The electron transfer coeffi...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Conclusions: It appears that further studies are necessary to explain this problem, perhaps to include an evaluation of TF levels in psoriatic skin. PMID: 31616219 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
n BA, Shore-Lesserson L, Abernathy J, Schwann N, Lau WT Abstract Bleeding after cardiac surgery is a common and serious complication leading to transfusion of multiple blood products and resulting in increased morbidity and mortality. Despite the publication of numerous guidelines and consensus statements for patient blood management in cardiac surgery, research has revealed that adherence to these guidelines is poor, and as a result, a significant variability in patient transfusion practices among practitioners still remains. In addition, although utilization of point-of-care (POC) coagulation monitors and the us...
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Publication date: Available online 16 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): SiddiqueAkber Ansari, Ahmed Bari, Riaz Ullah, Maghimaa Mathanmohun, Vishnu Priya Veeraraghavan, Zhongwei SunAbstractDiabetes is a major emerging health consequence across the world which directly associated with the obesity. Contemporary anti-diabetic drugs have numeral limitations, and investigation of herbal remedies for diabetes give novel guide for the expansion of new drugs that can be used as harmonizing to present anti-diabetic allopathic medications. Gold nanoparticles (AuNPs) of 21 nm have be...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
ConclusionsCombining Gini coefficient and GIS network analysis in accessibility can be useful in quantifying and monitoring variation by region. We propose this combination as a new method for helping the government to make evidence-based healthcare planning.
Source: Health Policy and Technology - Category: Health Management Source Type: research
Publication date: Available online 16 October 2019Source: Genes &DiseasesAuthor(s): Prasanna K. SanthekadurAbstractFructose, an essential biomolecule is a major ingredient of the modern diet across the globe. Excess consumption of fructose may be a key driver of many serious diseases such as obesity, heart diseases, type 2 diabetes and cancer. Understanding the metabolism of fructose, molecular mechanisms of its toxic nature will aid in the treatment of various diseases including cancer.
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 16 October 2019Source: American Journal of Kidney DiseasesAuthor(s): Youbao Li, J. David Spence, Xiaobin Wang, Yong Huo, Xiping Xu, Xianhui QinRationale &ObjectiveIn populations with folic acid fortification or supplementation, the main nutritional determinant of total homocysteine levels is vitamin B12 (B12) status. We aimed to evaluate the modifying effect of B12 levels on the association between folic acid treatment and chronic kidney disease (CKD) progression.Study DesignA post hoc analysis of an interventional trial.Setting &ParticipantsThis is a post hoc analysis of 1,374 hy...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
This study describes a 7-year-old boy who presented with duodenal perforation caused by ingestion of a lollipop stick and who was successfully managed by surgery.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
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