Intensity-Modulated Radiation Therapy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Disease control and late toxicity in Adaptive Dose Painting by Numbers vs. non-adaptive radiotherapy for head and neck cancer: a randomized controlled phase II trial
Local recurrence remains the main cause of death in stage III-IV non-metastatic head-and-neck cancer (HNC) with relapse-prone regions within high 18F-FDG-PET-signal gross tumor volume. We investigated if dose-escalation within this subvolume combined with a 3-phase treatment-adaptation could increase local (LC) and regional (RC) control at equal or minimized radiation-induced toxicity, by comparing adaptive 18F-FDG-PET-voxel-intensity-based dose-painting-by-numbers (A-DPBN) with non-adaptive standard intensity-modulated radiotherapy (S-IMRT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 20, 2024 Category: Radiology Authors: Aur élie De Bruycker, Wilfried De Neve, Jean-François Daisne, Tom Vercauteren, Werner De Gersem, Luiza Olteanu, Dieter Berwouts, Stéphanie Deheneffe, Indira Madani, Ingeborg Goethals, Fréderic Duprez Source Type: research

Disease Control and Late Toxicity in Adaptive Dose Painting by Numbers Versus Nonadaptive Radiation Therapy for Head and Neck Cancer: A Randomized Controlled Phase 2 Trial
Local recurrence remains the main cause of death in stage III-IV nonmetastatic head and neck cancer (HNC), with relapse-prone regions within high 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET)-signal gross tumor volume. We investigated if dose escalation within this subvolume combined with a 3-phase treatment adaptation could increase local (LC) and regional (RC) control at equal or minimized radiation-induced toxicity, by comparing adaptive 18F-FDG-PET voxel intensity –based dose painting by numbers (A-DPBN) with nonadaptive standard intensity modulated radiation therapy (S-IMRT). (Source: Internation...
Source: International Journal of Radiation Oncology * Biology * Physics - February 20, 2024 Category: Radiology Authors: Aur élie De Bruycker, Wilfried De Neve, Jean-François Daisne, Tom Vercauteren, Werner De Gersem, Luiza Olteanu, Dieter Berwouts, Stéphanie Deheneffe, Indira Madani, Ingeborg Goethals, Fréderic Duprez Tags: CLINICAL INVESTIGATION Source Type: research

Are We Missing Acute Toxicities Associated with Hypofractionated Breast Irradiation? A Report from a Large Multi-Center Cohort Study
CONCLUSION: An earlier post-treatment follow-up for HF-WBI patients did not reveal a significant increased incidence of acute toxicities at 2 weeks compared to 4 weeks. This study provides physicians and patients with additional data on the safety and tolerability of HF-WBI for early stage breast cancer.PMID:38364950 | DOI:10.1016/j.ijrobp.2024.01.225 (Source: Health Physics)
Source: Health Physics - February 16, 2024 Category: Physics Authors: H Beydoun K A Griffith R Jagsi J W Burmeister J M Moran F A Vicini J A Hayman P Paximadis T P Boike E M Walker L J Pierce M M Dominello Michigan Radiation Oncology Quality Consortium (MROQC) Source Type: research

Are We Missing Acute Toxicities Associated with Hypofractionated Breast Irradiation? A Report from a Large Multi-Center Cohort Study
CONCLUSION: An earlier post-treatment follow-up for HF-WBI patients did not reveal a significant increased incidence of acute toxicities at 2 weeks compared to 4 weeks. This study provides physicians and patients with additional data on the safety and tolerability of HF-WBI for early stage breast cancer.PMID:38364950 | DOI:10.1016/j.ijrobp.2024.01.225 (Source: Ann Oncol)
Source: Ann Oncol - February 16, 2024 Category: Cancer & Oncology Authors: H Beydoun K A Griffith R Jagsi J W Burmeister J M Moran F A Vicini J A Hayman P Paximadis T P Boike E M Walker L J Pierce M M Dominello Michigan Radiation Oncology Quality Consortium (MROQC) Source Type: research

Impact of fosaprepitant in the prevention of nausea and emesis in head and neck cancer patients undergoing cisplatin-based chemoradiation: a pilot prospective study and a review of literature
ConclusionsThe use of fosaprepitant in preventing CINV reduced incidence of moderate to severe nausea and vomiting. No correlation has been found between nausea and median dose to DVC and AP. (Source: La Radiologia Medica)
Source: La Radiologia Medica - February 14, 2024 Category: Radiology Source Type: research

The individualized delineation of clinical target volume for primary nasopharyngeal carcinoma based on invasion risk of substructures: a prospective, real-word study with a large population
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in Southeast Asia, exhibiting a significantly uneven geographic distribution [1]. Radiotherapy is the backbone of treatment for NPC due to its inherent radiosensitivity and the intricate anatomic location of the tumor. Intensity modulated radiotherapy (IMRT) can deliver conformal and homogeneous dose distribution to the target area while spare surrounding normal tissue at the same time [2 –4]. A growing body of evidence has demonstrated the efficacy of IMRT in enhancing tumor local control rates and minimizing radiation-induced side effects, making it ...
Source: Radiotherapy and Oncology - February 14, 2024 Category: Radiology Authors: Xiaohui Wang, Nan Huang, Pui Lam Yip, Jing Wang, Runda Huang, Zhuang Sun, Dehua Kang, Qian He, Xiaowu Deng, Chong Zhao, Melvin L.K. Chua, Fei Han Tags: Original Article Source Type: research

Multi-domain neurocognitive impairment following definitive intensity-modulated radiotherapy for nasopharyngeal cancer: a cross-sectional study
CONCLUSIONS: Neurocognitive impairment is prevalent and profound in post-IMRT NPC survivors. Cognitive assessment and rehabilitation should be considered part of survivorship care.PMID:38341098 | DOI:10.1016/j.radonc.2024.110143 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 10, 2024 Category: Radiology Authors: James C H Chow Jack Lee Maria M P Lai Sara Li Adelina M C Lau Beni S Y Ng Gigi G G Leung Sharon T Y Li Jeffrey C F Lui K M Cheung K H Au K H Wong Alexander Y L Lau Benny C Y Zee Source Type: research

An IMRT planning technique for treating whole breast or chest wall with regional lymph nodes on Halcyon and Ethos
CONCLUSION: Institutional plan quality benchmarks were achieved for all eight cases using the IMRT-based planning approach. The IMRT-based planning approach offered superior conformity and OAR sparing than a competing hybrid 3D approach.PMID:38335253 | DOI:10.1002/acm2.14295 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - February 9, 2024 Category: Physics Authors: Kareem Rayn Ryan Clark Klea Hoxha Anthony Magliari Jack Neylon Michael H Xiang Dylan P O'Connell Source Type: research

The effects of mega-voltage CT scan parameters on offline adaptive radiation therapy
AbstractTomoTherapy involves image-guided radiation therapy (IGRT) using Mega-voltage CT (MVCT) for each treatment session. The acquired MVCT images can be utilized for the retrospective assessment of dose distribution. The TomoTherapy provides 18 distinct imaging conditions that can be selected based on a combination of algorithms, acquisition pitch, and slice interval. We investigated the accuracy of dose calculation and deformable image registration (DIR) depending on MVCT scan parameters and their effects on adaptive radiation therapy (ART). We acquired image values for density calibration tables (IVDTs) under 18 diffe...
Source: Radiological Physics and Technology - February 9, 2024 Category: Physics Source Type: research

Validation of complex radiotherapy techniques using polymer gel dosimetry
Phys Med Biol. 2024 Feb 8. doi: 10.1088/1361-6560/ad278f. Online ahead of print.ABSTRACTModern radiotherapy delivers highly conformal dose distributions to irregularly shaped target volumes while sparing the surrounding normal tissue. Due to the complex planning and delivery techniques, dose verification and validation of the whole treatment workflow by end-to-end tests became much more important and polymer gel dosimeters are one of the few possibilities to capture the delivered dose distribution in 3D. The basic principles and formulations of gel dosimetry and its evaluation methods are described and the available studie...
Source: Physics in Medicine and Biology - February 8, 2024 Category: Physics Authors: Christian P Karger Alina Elter Stefan Dorsch Philipp Mann Evangelos Pappas Mark Oldham Source Type: research

Multi-domain neurocognitive impairment following definitive intensity-modulated radiotherapy for nasopharyngeal cancer: a cross-sectional study
Treatment outcomes for nasopharyngeal carcinoma (NPC) have improved significantly over the past few decades. With the advances in radiotherapy techniques and systemic chemotherapy,5-year survival rates as high as 70 – 85% are expected forpatients with loco-regionally advanced diseases.[1] Although the advent of modern intensity-modulated radiotherapy (IMRT) techniques has greatly improved tumor target conformity, radiation that traverses normal tissue continues to bring along late complications that greatly i mpair the quality of life of long-term survivors. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 8, 2024 Category: Radiology Authors: James C.H. Chow, Jack Lee, Maria M.P. Lai, Sara Li, Adelina M.C. Lau, Beni S.Y. Ng, Gigi G.G. Leung, Sharon T.Y. Li, Jeffrey C.F. Lui, K.M. Cheung, K.H. Au, K.H. Wong, Alexander Y.L. Lau, Benny C.Y Zee Tags: Original Article Source Type: research

Inetetamab combined with pyrotinib and chemotherapy in the treatment of breast cancer brain metastasis: A case report
CONCLUSION: Inetetamab combined with small molecule TKI drugs, chemotherapy and radiation may be an effective regimen for maintaining stable disease in patients with BCBM.PMID:38322469 | PMC:PMC10841958 | DOI:10.12998/wjcc.v12.i3.575 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - February 7, 2024 Category: Cancer & Oncology Authors: Qing-Qing Dou Ting-Ting Sun Guo-Qiang Wang Wei-Bing Tong Source Type: research

Inetetamab combined with pyrotinib and chemotherapy in the treatment of breast cancer brain metastasis: A case report
CONCLUSION: Inetetamab combined with small molecule TKI drugs, chemotherapy and radiation may be an effective regimen for maintaining stable disease in patients with BCBM.PMID:38322469 | PMC:PMC10841958 | DOI:10.12998/wjcc.v12.i3.575 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 7, 2024 Category: Cancer & Oncology Authors: Qing-Qing Dou Ting-Ting Sun Guo-Qiang Wang Wei-Bing Tong Source Type: research

Intensity-modulated radiotherapy alone compared with intensity-modulated radiotherapy plus concurrent chemotherapy in intermediate-risk nasopharyngeal carcinoma
ConclusionAdding CC to IMRT provided no survival benefit but increased treatment-associated toxicities in patients with intermediate-risk NPC. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 7, 2024 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 16, Pages 690: Dosimetric Impact of Voluntary Deep Inspiration Breath Hold (DIBH) in Mediastinal Hodgkin Lymphomas: A Comparative Evaluation of Three Different Intensity Modulated Radiation Therapy (IMRT) Delivery Methods Using Voluntary DIBH and Free Breathing Techniques
latpam Jayant S. Goda Hodgkin lymphomas are radiosensitive and curable tumors that often involve the mediastinum. However, the application of radiation therapy to the mediastinum is associated with late effects including cardiac and pulmonary toxicities and secondary cancers. The adoption of conformal IMRT and deep inspiration breath- hold (DIBH) can reduce the dose to healthy normal tissues (lungs, heart and breast). We compared the dosimetry of organs at risk (OARs) using different IMRT techniques for two breathing conditions, i.e., deep inspiration breath hold (DIBH) and free breathing. Twenty-three patients with ...
Source: Cancers - February 6, 2024 Category: Cancer & Oncology Authors: Samarpita Mohanty Divya Patil Kishore Joshi Poonam Gamre Ajay Mishra Sunil Khairnar Sangeeta Kakoti Lingaraj Nayak Sachin Punatar Jeevanshu Jain Reena Phurailatpam Jayant S. Goda Tags: Article Source Type: research