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Treatment of node-positive endometrial cancer: chemotherapy, radiation, immunotherapy, and targeted therapy
Opinion StatementThe standard of treatment for node-positive endometrial cancer (FIGO Stage IIIC) in North America has been systemic therapy with or without additional external beam radiation therapy (RT) given as pelvic or extended field RT. However, this treatment paradigm is rapidly evolving with improvements in systemic chemotherapy, the emergence of targeted therapies, and improved molecular characterization of these tumors. The biggest question facing providers regarding management of stage IIIC endometrial cancer at this time is: what is the best management strategy to use with regard to combinations of cytotoxic ch...
Source: Current Treatment Options in Oncology - January 4, 2024 Category: Cancer & Oncology Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Setup error of electronic portal image device in IMRT for thoracic tumors and its influence
CONCLUSIONS: In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.PMID:38164863 | DOI:10.26355/eurrev_202312_34799 (Sou...
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: Q-S Chen Y-H Zhao X Chen J-K Xu Q Gao J-Y Zhu Source Type: research

Is a  total dose of 54 Gy with radiochemotherapy sufficient for treatment of intermediate-risk volumes in nasopharyngeal cancer?
CONCLUSION: These retrospective data suggest that a dose reduction may be possible for intermediate-risk volumes, especially for the primary site.PMID:38153435 | DOI:10.1007/s00066-023-02186-3 (Source: Cancer Control)
Source: Cancer Control - December 28, 2023 Category: Cancer & Oncology Authors: Meltem Da ğdelen Tuba Kurt Çatal Song ül Çavdar Karaçam Emine Sedef Akoval ı Sevda Kanat Halil Cumhur Y ıldırım Ömer Erol Uzel Source Type: research

Radiological imaging protection: a study on imaging dose used while planning computed tomography for external radiotherapy in Japan
J Radiat Res. 2023 Dec 26:rrad098. doi: 10.1093/jrr/rrad098. Online ahead of print.ABSTRACTPrevious studies have primarily focused on quality of imaging in radiotherapy planning computed tomography (RTCT), with few investigations on imaging doses. To our knowledge, this is the first study aimed to investigate the imaging dose in RTCT to determine baseline data for establishing national diagnostic reference levels (DRLs) in Japanese institutions. A survey questionnaire was sent to domestic RT institutions between 10 October and 16 December 2021. The questionnaire items were volume computed tomography dose index (CTDIvol), d...
Source: Cancer Control - December 28, 2023 Category: Cancer & Oncology Authors: Satoshi Kito Yuhi Suda Satoshi Tanabe Takeshi Takizawa Tomomasa Nagahata Naoki Tohyama Hiroyuki Okamoto Takumi Kodama Yukio Fujita Hisayuki Miyashita Kazuya Shinoda Masahiko Kurooka Hidetoshi Shimizu Takeshi Ohno Masataka Sakamoto Source Type: research

Is a  total dose of 54 Gy with radiochemotherapy sufficient for treatment of intermediate-risk volumes in nasopharyngeal cancer?
CONCLUSION: These retrospective data suggest that a dose reduction may be possible for intermediate-risk volumes, especially for the primary site.PMID:38153435 | DOI:10.1007/s00066-023-02186-3 (Source: Cancer Control)
Source: Cancer Control - December 28, 2023 Category: Cancer & Oncology Authors: Meltem Da ğdelen Tuba Kurt Çatal Song ül Çavdar Karaçam Emine Sedef Akoval ı Sevda Kanat Halil Cumhur Y ıldırım Ömer Erol Uzel Source Type: research