Intensity-Modulated Radiation Therapy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Four-dimensional treatment planning strategies for dynamic tumor tracking
CONCLUSIONS: 4D planning strategies are simple to implement and can improve OAR sparing during DTT treatments. The "Boolean OAR Method" improved sparing of OARs but target coverage was reduced. The "Aperture Sorting Method" further improved sparing of OARs and maintained target coverage.PMID:38235952 | DOI:10.1002/acm2.14269 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - January 18, 2024 Category: Physics Authors: Emilie E Carpentier Ronan L McDermott Marie-Laure A Camborde Tania Karan Alanah M Bergman Ante Mestrovic Source Type: research

Comparison of skin dose in IMRT and VMAT with TrueBeam and Halcyon linear accelerator for whole breast irradiation
This study aimed to compare skin doses of treatments using FFF and flattening filter (FF) beams for breast cancer. The study established treatment plans for left breast of an anthropomorphic phantom using Halcyon ’s 6-MV FFF beam and TrueBeam’s 6-MV FF beam. Volumetric modulated arc therapy (VMAT) with varying numbers of arcs and intensity modulated radiation therapy (IMRT) were employed, and skin doses were measured at five points using Gafchromic EBT3 film. Each measurement was repeated three times, an d averaged to reduce uncertainty. All plans were compared in terms of plan quality to ensure homogeneous target cove...
Source: Australasian Physical and Engineering Sciences in Medicine - January 15, 2024 Category: Biomedical Engineering Source Type: research

Ultra-hypofractionated prostate cancer radiotherapy: Dosimetric impact of real-time intrafraction prostate motion and daily anatomical changes
Ultra-hypofractionated (UHF) radiotherapy protocols (from 7 Gy per fraction) have shown effectiveness in treating low and intermediate-risk prostate cancer patients [1,2]. Indeed, the low α/β ratio estimated for prostate cancer (1.4–1.9 Gy compared to 3–5 Gy for rectum and bladder) suggests greater sensitivity to dose escalation. Intensity-modulate d radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT) techniques allow higher dose conformity to the tumor, showing the possibility of a safer dose increment [3]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - January 11, 2024 Category: General Medicine Authors: Francesca di Franco, Thomas Baudier, Pierre Marie Pialat, Alexandre Munoz, Murielle Martinon, Pascal Pommier, David Sarrut, Marie-Claude Biston Source Type: research

A TPS integrated machine learning tool for predicting patient-specific quality assurance outcomes in volumetric-modulated arc therapy
Over the past decade, intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) have increasingly replaced the 3D conformal radiation therapy (3D-CRT) technique. These modulated techniques provide superior dose conformity with greater spatial precision. In VMAT, intensity modulation is accomplished through the variation of many parameters, including the dose rate, position of the multi-leaf collimator (MLC), and the speed of gantry rotation. The greater the variability of these parameters, the higher the complexity attributed to the plan. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - January 10, 2024 Category: General Medicine Authors: Caroline Noblet, Mathis Maunet, Marie Duthy, Fr édéric Coste, Matthieu Moreau Tags: Original paper Source Type: research

Impact of prostate position-based image-guidance in intensity-modulated radiation therapy for localized prostate cancer
CONCLUSIONS: The use of P-IGRT with higher doses and smaller margins was correlated with significantly better biochemical control, and a lower incidence of rectal bleeding in IMRT for intermediate-risk prostate cancer. The enhanced accuracy using P-IGRT has the potential to independently improve disease control and reduce late rectal bleeding.PMID:38191958 | DOI:10.1007/s10147-023-02456-1 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - January 9, 2024 Category: Cancer & Oncology Authors: Rihito Aizawa Haruo Inokuchi Itaru Ikeda Kiyonao Nakamura Takashi Ogata Shusuke Akamatsu Takayuki Goto Kimihiko Masui Takayuki Sumiyoshi Yuki Kita Takashi Kobayashi Takashi Mizowaki Source Type: research

Impact of prostate position-based image-guidance in intensity-modulated radiation therapy for localized prostate cancer
CONCLUSIONS: The use of P-IGRT with higher doses and smaller margins was correlated with significantly better biochemical control, and a lower incidence of rectal bleeding in IMRT for intermediate-risk prostate cancer. The enhanced accuracy using P-IGRT has the potential to independently improve disease control and reduce late rectal bleeding.PMID:38191958 | DOI:10.1007/s10147-023-02456-1 (Source: Cancer Control)
Source: Cancer Control - January 9, 2024 Category: Cancer & Oncology Authors: Rihito Aizawa Haruo Inokuchi Itaru Ikeda Kiyonao Nakamura Takashi Ogata Shusuke Akamatsu Takayuki Goto Kimihiko Masui Takayuki Sumiyoshi Yuki Kita Takashi Kobayashi Takashi Mizowaki Source Type: research

Dosimetric and radiobiological comparison of IMRT, VMAT, and helical tomotherapy planning techniques in hippocampal sparing whole brain radiotherapy with simultaneous integrated boost for multiple brain metastases
Radiat Environ Biophys. 2024 Jan 9. doi: 10.1007/s00411-023-01052-1. Online ahead of print.ABSTRACTTo compare treatment planning and dosimetric outcomes for hippocampal sparing whole brain radiotherapy (WBRT) with the simultaneous integrated boost (SIB) in brain metastasis (BM) patients using tumour control probability (TCP) and normal tissue complication probability (NTCP) formalism between IMRT, VMAT, and HT techniques. In this retrospective study, the treatment data of 20 BM patients who typically received whole brain radiation with SIB treatment were used. Prescription doses of 30 Gy and 36 Gy was delivered in 10 fract...
Source: Radiation and Environmental Biophysics - January 9, 2024 Category: Physics Authors: S Balasubramanian M K Shobana D Anabalagan P Thanasekar S Joel Prekshi Chaudhary Source Type: research

Planning target volume margin in head and neck cancer patients undergoing radiation therapy: Estimations derived from own data and literature
Planning target volume (PTV) to deliver the desired dose to the clinical target volume (CTV) accounts for systematic ( ∑) and random (σ) errors during the planning and execution of intensity modulated radiation therapy (IMRT). As these errors vary at different departments, this study was conducted to determine the 3-dimensional PTV (PTV3D) margins for head and neck cancer (HNC) at our center. The same was also es timated from reported studies for a comparative assessment. A total of 77 patients with HNCs undergoing IMRT were included. (Source: Medical Dosimetry)
Source: Medical Dosimetry - January 8, 2024 Category: Radiology Authors: Pratik Aher, Madhuri Chirkute, Pournima Kale, Rupesh Sonawane, Ashok Singh, Niloy Ranjan Datta Tags: Research Article Source Type: research

Impact of prostate position-based image-guidance in intensity-modulated radiation therapy for localized prostate cancer
ConclusionsThe use of P-IGRT with higher doses and smaller margins was correlated with significantly better biochemical control, and a lower incidence of rectal bleeding in IMRT for intermediate-risk prostate cancer. The enhanced accuracy using P-IGRT has the potential to independently improve disease control and reduce late rectal bleeding. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 8, 2024 Category: Cancer & Oncology Source Type: research

Concurrent chemoradiotherapy versus radiotherapy alone in older patients with stage II Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy: a propensity score-matched cohort study
CONCLUSION: CCRT significantly improved the survival benefits for the older patients with stage II NPC compared with IMRT alone without adding late complications, whereas increased some of the treatment-associated acute toxicities.PMID:38185256 | DOI:10.1016/j.radonc.2024.110081 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2024 Category: Radiology Authors: Fang Wang Lu Zhou Li-Jun Zhang Chang-Bin Xie Zhi-Wei Liao Xiao-Dan Lin Yue-Feng Wen Source Type: research

Concurrent chemoradiotherapy versus radiotherapy alone in older patients with stage II nasopharyngeal carcinoma after intensity-modulated radiotherapy: A propensity score-matched cohort study
CONCLUSION: CCRT significantly improved the survival benefits for the older patients with stage II NPC compared with IMRT alone without adding late complications, whereas increased some of the treatment-associated acute toxicities.PMID:38185256 | DOI:10.1016/j.radonc.2024.110081 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2024 Category: Radiology Authors: Fang Wang Lu Zhou Li-Jun Zhang Chang-Bin Xie Zhi-Wei Liao Xiao-Dan Lin Yue-Feng Wen Source Type: research

Selectively sparing of the supraclavicular area during intensity-modulated radiotherapy in nasopharyngeal carcinoma: A double-center observation study
CONCLUSION: Omitting the supraclavicular area (levels IVb and Vc) during IMRT should be safe and feasible for N1-2 disease (except N1 disease with purely RPN involvement). Well-designed multicenter prospective trials should be conducted to confirm our findings.PMID:38184146 | DOI:10.1016/j.radonc.2024.110086 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2024 Category: Radiology Authors: Qiaojuan Guo Tianzhu Lu Wanfang Huang Hanchuan Xu Quxia Zhang Yun Xiao Jing Zhong Honghui Xie Jihong Chen Jingfeng Zong Xiaochang Gong Jianji Pan Jingao Li Shaojun Lin Source Type: research

Selectively sparing of the supraclavicular area during intensity-modulated radiotherapy in nasopharyngeal carcinoma: A double-center observation study
As a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving IMRT for nasopharyngeal carcinoma (NPC), reducing the toxicity of treatment and improving the patient's quality of life (QoL) is particularly important[1-3]. The lower neck in selective omitting clinical target volume (CTV) is one of the areas being explored[4-7].Published literature have confirmed the feasibility of elective ipsilateral upper-neck irradiation with sparing the lower neck in N0 and the contralateral lower neck in N1 and N3 disease[7-12]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 4, 2024 Category: Radiology Authors: Qiaojuan Guo, Tianzhu Lu, Wanfang Huang, Hanchuan Xu, Quxia Zhang, Yun Xiao, Jing Zhong, Honghui Xie, Jihong Chen, Jingfeng Zong, Xiaochang Gong, Jianji Pan, Jingao Li, Shaojun Lin Tags: Original Article Source Type: research