Ultra-hypofractionated prostate cancer radiotherapy: Dosimetric impact of real-time intrafraction prostate motion and daily anatomical changes

Ultra-hypofractionated (UHF) radiotherapy protocols (from 7  Gy per fraction) have shown effectiveness in treating low and intermediate-risk prostate cancer patients [1,2]. Indeed, the low α/β ratio estimated for prostate cancer (1.4–1.9 Gy compared to 3–5 Gy for rectum and bladder) suggests greater sensitivity to dose escalation. Intensity-modulate d radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT) techniques allow higher dose conformity to the tumor, showing the possibility of a safer dose increment [3].
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Source Type: research