A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract
This study first reported cognitive deficits in a spontaneous hyperglycaemia NHPs, which might provide evidence to use macaque as a promising model for translational research in diabetes and neurological complications.PMID:38650114 | DOI:10.1111/1440-1681.13863 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 23, 2024 Category: Drugs & Pharmacology Authors: Hongdi Huang Jianglin Pu Yufang Zhou Yang Fan Yali Zhang Yanling Li Yangzhuo Chen Yun Wang Xiaomei Yu Bulgin Dmitry Zhu Zhou Jianhong Wang Source Type: research
Efficacy and Safety of Alogliptin-Pioglitazone Combination for Type 2 Diabetes Mellitus Poorly Controlled with Metformin: A Multicenter, Double-Blind Randomized Trial
CONCLUSION: Early combination triple therapy showed better efficacy and durability than the single add-on (dual) therapy. Therefore, combination therapy with metformin, alogliptin, and pioglitazone is a valuable early treatment option for T2DM poorly controlled with metformin monotherapy.PMID:38650099 | DOI:10.4093/dmj.2023.0259 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Ji-Yeon Park Joonyub Lee Yoon-Hee Choi Kyung Wan Min Kyung Ah Han Kyu Jeung Ahn Soo Lim Young-Hyun Kim Chul Woo Ahn Kyung Mook Choi Kun-Ho Yoon Practical Evidence of Antidiabetic Combination Therapy in Korea (PEAK) study investigators Source Type: research
Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer ’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
This study aimed to clarify the mechanisms of LBP in the treatment of ICV-STZ mice model of AD from the perspectives of insulin resistance, IRS1/PI3K/AKT signaling pathway, and synaptic protein expression. We used male C57BL/6J mice injected with STZ (3 mg/kg) in the lateral ventricle as an AD model. After treatment with LBP, the learning and memory abilities of ICV-STZ mice were enhanced, and the pathological changes in brain tissue were alleviated. LBP can regulate the expression of proteins related to the IRS1/PI3K/AKT signaling pathway and th ereby reducing Aβ deposition and tau protein phosphorylation in the brain ...
Source: NeuroMolecular Medicine - April 23, 2024 Category: Neurology Source Type: research
The Triglyceride-Glucose Index is Superior to Homeostasis Model Assessment of Insulin Resistance in predicting Metabolic Syndrome in an Adult Population in the United States
Metabolic syndrome (MetS) defined by a set of cardio-metabolic features is associated with an increased risk for atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus (T2DM)[1-3]. Its individual components include an elevated waist circumference [WC], increased triglycerides [TG], low levels of high density lipoprotein cholesterol [HDL-C], elevated fasting glucose and high blood pressure [1 –3]. It is a major global problem with no optimum treatment. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - April 23, 2024 Category: Lipidology Authors: Beverley Adams-Huet, Rafael Zubir án, Alan T Remaley, Ishwarlal Jialal Tags: Original Research Source Type: research
Evaluating the efficacy and safety of weekly Insulin Icodec vs. Daily Insulin Glargine in type 2 Diabetes Mellitus: a systematic review and meta-analysis
ConclusionOnce-weekly Insulin Icodec demonstrates superior glycemic control with a reduced HbA1c compared to Once-Daily Insulin Glargine U100 while maintaining similar safety profiles. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes
The increasing prevalence of childhood overweight and obesity is a severe health problem worldwide that contributes to the development of various comorbidities [1]. Type 1 diabetes (T1D) patients are especially vulnerable to such complications since the intensive insulin therapy is associated with weight gain, abdominal obesity, dyslipidaemia, hypertension, and the presence of atherosclerosis development features in imaging [2]. Although clinical factors associated with the disease and its treatment as well as lifestyle elements have been widely studied, various genetic loci are also known to play important role in the obe...
Source: Diabetes Research and Clinical Practice - April 23, 2024 Category: Endocrinology Authors: Bartosz S łomiński, Maria Skrzypkowska, Małgorzata Myśliwiec, Piotr Trzonkowski Source Type: research
Redox Status as a Key Driver of Healthy Pancreatic Beta-Cells
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTRedox status plays a multifaceted role in the intricate physiology and pathology of pancreatic beta-cells, the pivotal regulators of glucose homeostasis through insulin secretion. They are highly responsive to changes in metabolic cues where reactive oxygen species are part of it, all arising from nutritional intake. These molecules not only serve as crucial signaling intermediates for insulin secretion but also participate in the nuanced heterogeneity observed within the beta-cell population. A central aspect of beta-cell redox biology revolves around the localized p...
Source: Physiological Research - April 22, 2024 Category: Physiology Authors: B Holendov á Š Benáková M K řivonosková L Plecit á-Hlavatá Source Type: research
Mitochondrial Physiology of Cellular Redox Regulations
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTMitochondria (mt) represent the vital hub of the molecular physiology of the cell, being decision-makers in cell life/death and information signaling, including major redox regulations and redox signaling. Now we review recent advances in understanding mitochondrial redox homeostasis, including superoxide sources and H2O2 consumers, i.e., antioxidant mechanisms, as well as exemplar situations of physiological redox signaling, including the intramitochondrial one and mt-to-cytosol redox signals, which may be classified as acute and long-term signals. This review exempl...
Source: Physiological Research - April 22, 2024 Category: Physiology Authors: P Je žek A Dlaskov á H Engstov á J Špačková J Tauber P Pr ůchová E Kloppel O Mozheitova M Jab ůrek Source Type: research
1,3,4-Oxadiazole Scaffold in Antidiabetic Drug Discovery: An Overview
Mini Rev Med Chem. 2024 Apr 19. doi: 10.2174/0113895575298181240410041029. Online ahead of print.ABSTRACTDiabetes mellitus is one of the biggest challenges for the scientific community in the 21st century. With the increasing number of cases of diabetes and drug-resistant diabetes, there is an urgent need to develop new potent molecules capable of combating this cruel disease. Medicinal chemistry concerns the discovery, development, identification, and interpretation of the mode of action of biologically active compounds at the molecular level. Oxadiazole-based derivatives have come up as a potential option for antidiabeti...
Source: Mini Reviews in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Ojasvi Gupta Gita Chawla Tathagata Pradhan Source Type: research
Indications of younger age at menarche in Greek adolescents but with no relation to body mass index
CONCLUSION: The timing of pubertal stages in the Greek female sample studied followed the recent international downward trends. Younger age at menarche was not related to BMI.PMID:38647964 | DOI:10.1007/s42000-024-00557-8 (Source: Hormones)
Source: Hormones - April 22, 2024 Category: Endocrinology Authors: Anastasia Papageorgiou Evangelia Charmandari Vasiliki Efthymiou Dimitrios Vlachakis Flora Bacopoulou Source Type: research
Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters
CONCLUSIONS: Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.PMID:38646985 | DOI:10.5603/ep.99111 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Katarzyna Paczkowska Joachim Sobczuk Katarzyna Zawadzka Diana J ędrzejuk Agnieszka Zembska Jacek Konieczny Dorota Kaszubkiewicz-Ward ęga Marek Bolanowski Jacek Daroszewski Source Type: research
Glycaemic control among adults with type 2 diabetes mellitus in the Gulf Cooperation Council countries: an updated review
Endokrynol Pol. 2024 Apr 22. doi: 10.5603/ep.99519. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) has become a major public health concern, causing significant disability and death worldwide. Fuelled by a modern sedentary lifestyle and poor dietary practices, T2DM affects at least 10.5% of the world's population. This paper seeks to review the progress made by the Gulf Cooperation Council (GCC) countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates) in addressing T2DM, focusing on glycaemic control proportions and comparing it with the 2015 review. The results indicate no signif...
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Ahmad Ali Alrasheedi Source Type: research
The role of genetic risk factors, diet, and gut microbiota in type 1 diabetes mellitus, pancreas and pancreatic islet transplantation
Endokrynol Pol. 2024 Apr 22. doi: 10.5603/ep.98903. Online ahead of print.ABSTRACTDespite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas transplantation can restore long-term normoglycaemia with sustained periods of insulin independence among T1DM patients. However, the same genetic, behavioural, or gut microbiota-related factors that promoted autoimmunity and primary islet destruction may also affect the function of transplante...
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Agnieszka Zawada Marzena Skrzypczak-Zieli ńska Sarah Gondek Piotr Witkowski Anna M Rychter Alicja E Ratajczak-Paw łowska Marek Karczewski Agnieszka Dobrowolska Iwona Krela-Ka źmierczak Source Type: research
Redox Status as a Key Driver of Healthy Pancreatic Beta-Cells
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTRedox status plays a multifaceted role in the intricate physiology and pathology of pancreatic beta-cells, the pivotal regulators of glucose homeostasis through insulin secretion. They are highly responsive to changes in metabolic cues where reactive oxygen species are part of it, all arising from nutritional intake. These molecules not only serve as crucial signaling intermediates for insulin secretion but also participate in the nuanced heterogeneity observed within the beta-cell population. A central aspect of beta-cell redox biology revolves around the localized p...
Source: Physiological Research - April 22, 2024 Category: Physiology Authors: B Holendov á Š Benáková M K řivonosková L Plecit á-Hlavatá Source Type: research
Mitochondrial Physiology of Cellular Redox Regulations
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTMitochondria (mt) represent the vital hub of the molecular physiology of the cell, being decision-makers in cell life/death and information signaling, including major redox regulations and redox signaling. Now we review recent advances in understanding mitochondrial redox homeostasis, including superoxide sources and H2O2 consumers, i.e., antioxidant mechanisms, as well as exemplar situations of physiological redox signaling, including the intramitochondrial one and mt-to-cytosol redox signals, which may be classified as acute and long-term signals. This review exempl...
Source: Physiological Research - April 22, 2024 Category: Physiology Authors: P Je žek A Dlaskov á H Engstov á J Špačková J Tauber P Pr ůchová E Kloppel O Mozheitova M Jab ůrek Source Type: research
