Intensive management from diagnosis improves HbA1c at 12 months post-diagnosis: results from a prospective cohort study in children with newly diagnosed type 1 diabetes
CONCLUSION: Intensive management when implemented with consistent messaging from the multi-disciplinary team resulted in clinic-wide improvements in HbA1c and the proportion meeting HbA1c targets.PMID:38603784 | DOI:10.26635/6965.6424 (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - April 11, 2024 Category: General Medicine Authors: Caroline Griffin Erin Roxburgh Neil Owens Olivia Sanders Sharon Walsh Chloe Hudson Janet Ferguson Karen MacKenzie Martin de Bock Source Type: research
Nascent shifts in renal cellular metabolism, structure, and function due to chronic empagliflozin in prediabetic mice
Am J Physiol Cell Physiol. 2024 Apr 1;326(4):C1272-C1290. doi: 10.1152/ajpcell.00446.2023. Epub 2024 Mar 4.ABSTRACTSodium-glucose cotransporter, type 2 inhibitors (SGLT2i) are emerging as the gold standard for treatment of type 2 diabetes (T2D) with renal protective benefits independent of glucose lowering. We took a high-level approach to evaluate the effects of the SGLT2i, empagliflozin (EMPA) on renal metabolism and function in a prediabetic model of metabolic syndrome. Male and female 12-wk-old TallyHo (TH) mice, and their closest genetic lean strain (Swiss-Webster, SW) were treated with a high-milk-fat diet (HMFD) plu...
Source: American Journal of Physiology. Cell Physiology - April 11, 2024 Category: Cytology Authors: Blythe D Shepard Jennifer Chau Ryan Kurtz Avi Z Rosenberg Pinaki Sarder Samuel P Border Brandon Ginley Olga Rodriguez Chris Albanese Grace Knoer Aarenee Greene Aline M A De Souza Suman Ranjit Moshe Levi Carolyn M Ecelbarger Source Type: research
Intensive management from diagnosis improves HbA1c at 12 months post-diagnosis: results from a prospective cohort study in children with newly diagnosed type 1 diabetes
CONCLUSION: Intensive management when implemented with consistent messaging from the multi-disciplinary team resulted in clinic-wide improvements in HbA1c and the proportion meeting HbA1c targets.PMID:38603784 | DOI:10.26635/6965.6424 (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - April 11, 2024 Category: General Medicine Authors: Caroline Griffin Erin Roxburgh Neil Owens Olivia Sanders Sharon Walsh Chloe Hudson Janet Ferguson Karen MacKenzie Martin de Bock Source Type: research
Differential susceptibility of BRL cells with/without insulin resistance and the role of endoplasmic reticulum stress signaling pathway in response to acrylamide-exposure toxicity effects in vitro
Toxicology. 2024 Apr 9:153800. doi: 10.1016/j.tox.2024.153800. Online ahead of print.ABSTRACTAcrylamide (ACR) is an endogenous food contaminant, high levels of ACR have been detected in a large number of foods, causing widespread concern. Since different organism states respond differently to the toxic effects of pollutants, this study establishes an insulin-resistant BRL cell model to explore the differential susceptibility of BRL cells with/without insulin resistance in response to acrylamide-exposure (0.0002, 0.02, or 1mM) toxicity effects and its mechanism. The results showed that ACR exposure decreased glucose uptake ...
Source: Toxicology - April 11, 2024 Category: Toxicology Authors: Yuchao Guo Houlin Mao Danni Gong Nuo Zhang Dandan Gu Emmanuel Sunday Okeke Weiwei Feng Yao Chen Guanghua Mao Ting Zhao Liuqing Yang Source Type: research
Yak IGFBP3 promotes hepatocyte proliferation through PI3K-Akt signaling pathway
Gene. 2024 Apr 9;917:148460. doi: 10.1016/j.gene.2024.148460. Online ahead of print.ABSTRACTIGFBP3 (Insulin-like growth factor binding protein 3) constitutes a crucial constituent of the insulin-like growth factor (IGF), which are intimately associated with the organism's growth and development processes. Despite its significance, the precise function of IGFBP3 in yak liver development remains largely unexplored. In the present study, we systematically examined the expression profile of IGFBP3 in the liver tissues of yaks across various growth stages, elucidated its influence on the activity of yak hepatocytes, and probed ...
Source: Gene - April 11, 2024 Category: Genetics & Stem Cells Authors: Nanchi Zhang Ling Zhang Ying Peng Fang Fu Li Wang Qundi Mei Yong Wei Source Type: research
SGLT2 inhibitor monotherapy alleviates hyperglycemia in heredity severe insulin resistance syndrome
Chin Med J (Engl). 2024 Apr 10. doi: 10.1097/CM9.0000000000003108. Online ahead of print.NO ABSTRACTPMID:38602155 | DOI:10.1097/CM9.0000000000003108 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 11, 2024 Category: General Medicine Authors: Huixuan Wu Junaid Iqbal Long Li Hongli Jiang Chen Chao Meibiao Zhang Ou Li Houde Zhou Source Type: research
Nascent shifts in renal cellular metabolism, structure, and function due to chronic empagliflozin in prediabetic mice
Am J Physiol Cell Physiol. 2024 Apr 1;326(4):C1272-C1290. doi: 10.1152/ajpcell.00446.2023. Epub 2024 Mar 4.ABSTRACTSodium-glucose cotransporter, type 2 inhibitors (SGLT2i) are emerging as the gold standard for treatment of type 2 diabetes (T2D) with renal protective benefits independent of glucose lowering. We took a high-level approach to evaluate the effects of the SGLT2i, empagliflozin (EMPA) on renal metabolism and function in a prediabetic model of metabolic syndrome. Male and female 12-wk-old TallyHo (TH) mice, and their closest genetic lean strain (Swiss-Webster, SW) were treated with a high-milk-fat diet (HMFD) plu...
Source: American Journal of Physiology. Cell Physiology - April 11, 2024 Category: Cytology Authors: Blythe D Shepard Jennifer Chau Ryan Kurtz Avi Z Rosenberg Pinaki Sarder Samuel P Border Brandon Ginley Olga Rodriguez Chris Albanese Grace Knoer Aarenee Greene Aline M A De Souza Suman Ranjit Moshe Levi Carolyn M Ecelbarger Source Type: research
Nascent shifts in renal cellular metabolism, structure, and function due to chronic empagliflozin in prediabetic mice
Am J Physiol Cell Physiol. 2024 Apr 1;326(4):C1272-C1290. doi: 10.1152/ajpcell.00446.2023. Epub 2024 Mar 4.ABSTRACTSodium-glucose cotransporter, type 2 inhibitors (SGLT2i) are emerging as the gold standard for treatment of type 2 diabetes (T2D) with renal protective benefits independent of glucose lowering. We took a high-level approach to evaluate the effects of the SGLT2i, empagliflozin (EMPA) on renal metabolism and function in a prediabetic model of metabolic syndrome. Male and female 12-wk-old TallyHo (TH) mice, and their closest genetic lean strain (Swiss-Webster, SW) were treated with a high-milk-fat diet (HMFD) plu...
Source: Am J Physiol Cell Ph... - April 11, 2024 Category: Cytology Authors: Blythe D Shepard Jennifer Chau Ryan Kurtz Avi Z Rosenberg Pinaki Sarder Samuel P Border Brandon Ginley Olga Rodriguez Chris Albanese Grace Knoer Aarenee Greene Aline M A De Souza Suman Ranjit Moshe Levi Carolyn M Ecelbarger Source Type: research
Intensive management from diagnosis improves HbA1c at 12 months post-diagnosis: results from a prospective cohort study in children with newly diagnosed type 1 diabetes
CONCLUSION: Intensive management when implemented with consistent messaging from the multi-disciplinary team resulted in clinic-wide improvements in HbA1c and the proportion meeting HbA1c targets.PMID:38603784 | DOI:10.26635/6965.6424 (Source: Molecular Medicine)
Source: Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Caroline Griffin Erin Roxburgh Neil Owens Olivia Sanders Sharon Walsh Chloe Hudson Janet Ferguson Karen MacKenzie Martin de Bock Source Type: research
Feeding dogs a high-fat diet induces metabolic changes similar to natural aging, including dyslipidemia, hyperinsulinemia, and peripheral insulin resistance
Am J Vet Res. 2024 Apr 15:1-11. doi: 10.2460/ajvr.23.11.0253. Online ahead of print.ABSTRACTOBJECTIVE: The goal of this study was to characterize changes induced by a high-fat diet in body composition, insulin levels and sensitivity, blood lipids, and other key biomarkers also associated with the metabolic dysfunction that occurs with natural aging.ANIMALS: 24 male Beagle dogs, 3 to 7 years of age, of mixed castration status.METHODS: Dogs were randomly assigned to continue twice daily feeding of the commercial adult maintenance diet (n = 12, including 2 intact) that they were previously fed or to a high-fat diet (12, inclu...
Source: American Journal of Veterinary Research - April 11, 2024 Category: Veterinary Research Authors: Brennen McKenzie Matthew Peloquin Ashley Tovar Jessica L Graves Ellen Ratcliff Katya Tucker Kenny Vo Karen Greenwood Celine-Lea Halioua-Haubold Dina Juarez-Salinas Source Type: research
NSQIP 5-factor modified frailty index and complications after ileal anal pouch anastomosis for ulcerative colitis
CONCLUSION: IPAA for CUC is associated with high postoperative morbidity, however, the mFI-5 alone has limited utility in determining which patients are at a higher risk of complications due to frailty. These observations suggest there is a need for more relevant instruments to measure frailty in this patient cohort.PMID:38601734 | PMC:PMC11004715 | DOI:10.1016/j.sopen.2024.03.011 (Source: Anal Sci)
Source: Anal Sci - April 11, 2024 Category: Chemistry Authors: Dakota T Thompson Ethan G Breyfogle Catherine G Tran Mohammed O Suraju Aditi Mishra Hussain A Lanewalla Paolo Goffredo Imran Hassan Source Type: research
Intensive management from diagnosis improves HbA1c at 12 months post-diagnosis: results from a prospective cohort study in children with newly diagnosed type 1 diabetes
CONCLUSION: Intensive management when implemented with consistent messaging from the multi-disciplinary team resulted in clinic-wide improvements in HbA1c and the proportion meeting HbA1c targets.PMID:38603784 | DOI:10.26635/6965.6424 (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - April 11, 2024 Category: General Medicine Authors: Caroline Griffin Erin Roxburgh Neil Owens Olivia Sanders Sharon Walsh Chloe Hudson Janet Ferguson Karen MacKenzie Martin de Bock Source Type: research
Differential susceptibility of BRL cells with/without insulin resistance and the role of endoplasmic reticulum stress signaling pathway in response to acrylamide-exposure toxicity effects in vitro
Toxicology. 2024 Apr 9:153800. doi: 10.1016/j.tox.2024.153800. Online ahead of print.ABSTRACTAcrylamide (ACR) is an endogenous food contaminant, high levels of ACR have been detected in a large number of foods, causing widespread concern. Since different organism states respond differently to the toxic effects of pollutants, this study establishes an insulin-resistant BRL cell model to explore the differential susceptibility of BRL cells with/without insulin resistance in response to acrylamide-exposure (0.0002, 0.02, or 1mM) toxicity effects and its mechanism. The results showed that ACR exposure decreased glucose uptake ...
Source: Toxicology - April 11, 2024 Category: Toxicology Authors: Yuchao Guo Houlin Mao Danni Gong Nuo Zhang Dandan Gu Emmanuel Sunday Okeke Weiwei Feng Yao Chen Guanghua Mao Ting Zhao Liuqing Yang Source Type: research
Yak IGFBP3 promotes hepatocyte proliferation through PI3K-Akt signaling pathway
Gene. 2024 Apr 9:148460. doi: 10.1016/j.gene.2024.148460. Online ahead of print.ABSTRACTIGFBP3 (Insulin-like growth factor binding protein 3) constitutes a crucial constituent of the insulin-like growth factor (IGF), which are intimately associated with the organism's growth and development processes. Despite its significance, the precise function of IGFBP3 in yak liver development remains largely unexplored. In the present study, we systematically examined the expression profile of IGFBP3 in the liver tissues of yaks across various growth stages, elucidated its influence on the activity of yak hepatocytes, and probed its ...
Source: Gene - April 11, 2024 Category: Genetics & Stem Cells Authors: Nanchi Zhang Ling Zhang Ying Peng Fang Fu Li Wang Qundi Mei Yong Wei Source Type: research
Longitudinal association between soft drink consumption and handgrip strength in adults: a prospective analysis from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) cohort study
Br J Nutr. 2024 Apr 11:1-8. doi: 10.1017/S0007114523002817. Online ahead of print.ABSTRACTSoft drink consumption has become a highly controversial public health issue. Given the pattern of consumption in China, sugar-sweetened beverage is the main type of soft drink consumed. Due to containing high levels of fructose, a soft drink may have a deleterious effect on handgrip strength (HGS) due to oxidative stress, inflammation and insulin resistance. However, few studies show an association between soft drink consumption and HGS in adults. We aimed to investigate the association between soft drink consumption and longitudinal...
Source: The British Journal of Nutrition - April 11, 2024 Category: Nutrition Authors: Tongfeng Liu Shengxin Quan Ge Meng Hongmei Wu Yeqing Gu Shunming Zhang Xuena Wang Juanjuan Zhang Qing Zhang Li Liu Shaomei Sun Xing Wang Ming Zhou Qiyu Jia Kun Song Zhongze Fang Kaijun Niu Source Type: research
