Correlation between acne and insulin resistance; experience from central India
CONCLUSION: Our study suggests the prevalence of insulin resistance in 42.67% of patients with acne, thereby providing the possibility of use of insulin modifiers as an adjunct acne treatment and stratifying the possible risk of metabolic syndrome in patients with acne. Also recommended is the control of dietary factors and lifestyle modification for the management of acne with insulin resistance.PMID:38605790 | PMC:PMC11006054 | DOI:10.4103/jfmpc.jfmpc_1232_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Prachi R Srivastava Jaideep Khare Animesh Saxena Sushil Jindal Source Type: research
Substituting carbohydrate at lunch for added protein increases fat oxidation during subsequent exercise in healthy males
CONCLUSION: Substituting carbohydrate for protein in a pre-exercise lunch increased fat oxidation, suppressed subjective and hormonal appetite, and reduced post-exercise energy intake.PMID:38609167 | DOI:10.1210/clinem/dgae237 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Tommy Slater William J A Mode Louise C Bonnard Cian Sweeney Mark P Funnell Harry A Smith John Hough Ruth M James Ian Varley Craig Sale James A Betts Lewis J James David J Clayton Source Type: research
The effect of tamoxifen on estradiol, SHBG, IGF-1, and CRP in women with breast cancer or at risk of developing breast cancer: a meta-analysis of randomized controlled trials
CONCLUSION: Tamoxifen administration seems to increase estradiol and SHBG levels and reduce CRP and IGF-1 levels in women with breast cancer or at risk of developing breast cancer. Further studies are needed to determine whether these changes have any clinical relevance.PMID:38608792 | DOI:10.1016/j.exger.2024.112431 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: XingDa Li XueJiao Hou Benjamin Hern ández-Wolters Kousalya Prabahar Hamed Kord-Varkaneh Bo Mei Source Type: research
Triglyceride - glucose index, remnant cholesterol and common carotid artery intima-media thickness as an atherosclerotic marker in ischemic stroke patients
Georgian Med News. 2024 Feb;(347):59-65.ABSTRACTIschemic stroke (IS) is a major global health concern, often resulting from atherosclerosis and insulin resistance (IR). The triglyceride-glucose index (TyG index), remnant cholesterol (RC), and common artery intima-media thickness (CIMT) are potential markers for assessing atherosclerosis and cardiovascular risk in IS patients. A cross-sectional study was conducted to investigate the association between TyG index, RC, CIMT, and IS in adult patients recruited from a hospital. Demographic, clinical, and laboratory data were collected, and statistical analysis was performed. Th...
Source: Atherosclerosis - April 12, 2024 Category: Cardiology Authors: A Rangan D Balaji U Chand E Raghunathan N Deepthi P Karthik Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Long-term exposure to dietary emulsifier Tween 80 promotes liver lipid accumulation and induces different-grade inflammation in young and aged mice
In conclusion, our study provides compelling evidence that Tween 80 could contribute to a low-grade inflammation and liver lipid accumulation. These findings underscore the need for increasing attention regarding the consumption of UPFs with Tween 80 as the emulsifier, particularly in the elderly consumers.PMID:38609253 | DOI:10.1016/j.foodres.2024.114205 (Source: Cell Research)
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Enjun Xie Yunmei Chen Wanbao Yang Quan Pan James Zheng Shen Fenghua Zhou Jie Shen Tao Li Qili Li Xiaopeng Li Source Type: research
Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis
This study aimed to identify drivers of PGE2 and its role in the inadvertent MSC misdifferentiation into hypertrophic chondrocytes. PGE2 release, which rose in the first three weeks of MSC chondrogenesis, was jointly stimulated by endogenous BMP, WNT, and hedgehog activity that supported the exogenous stimulation by TGF-β1 and insulin to overcome the PGE2 inhibition by dexamethasone. Experiments with PGE2 treatment or the inhibitor celecoxib or specific receptor antagonists demonstrated that PGE2, although driven by prohypertrophic signals, exerted broad autocrine antihypertrophic effects. This chondroprotective effect ma...
Source: European Journal of Cell Biology - April 12, 2024 Category: Cytology Authors: Sven Schmidt Felicia A M Klampfleuthner Tobias Renkawitz Solvig Diederichs Source Type: research
Regulation of host metabolic health by parasitic helminths
Trends Parasitol. 2024 Apr 11:S1471-4922(24)00073-4. doi: 10.1016/j.pt.2024.03.006. Online ahead of print.ABSTRACTObesity is a worldwide pandemic and major risk factor for the development of metabolic syndrome (MetS) and type 2 diabetes (T2D). T2D requires lifelong medical support to limit complications and is defined by impaired glucose tolerance, insulin resistance (IR), and chronic low-level systemic inflammation initiating from adipose tissue. The current preventative strategies include a healthy diet, controlled physical activity, and medication targeting hyperglycemia, with underexplored underlying inflammation. Stud...
Source: Trends in Parasitology - April 12, 2024 Category: Parasitology Authors: Suchandan Sikder Doris Pierce Eti R Sarkar Connor McHugh Kate G R Quinlan Paul Giacomin Alex Loukas Source Type: research
Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers
Expert Rev Mol Med. 2024 Apr 12;26:e8. doi: 10.1017/erm.2024.7.ABSTRACTOsteoarthritis (OA) commonly affects the knee and hip joints and accounts for 19.3% of disability-adjusted life years and years lived with disability worldwide (Refs , ). Early management is important in order to avoid disability uphold quality of life (Ref. ). However, a lack of awareness of subclinical and early symptomatic stages of OA often hampers early management (Ref. ). Moreover, late diagnosis of OA among those with severe disease, at a stage when OA management becomes more complicated is common (Refs , , , ). Established risk factors for the d...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Shi Rui Seow Sumaiyah Mat Amalina Ahmad Azam Nor Fadilah Rajab Intan Safinar Ismail Devinder Kaur Ajit Singh Suzana Shahar Maw Pin Tan Francis Berenbaum Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Independent effect of the triglyceride-glucose index on all-cause mortality in critically ill patients with chronic obstructive pulmonary disease and asthma: A retrospective cohort study
CONCLUSIONS: In summary, our results extend the utility of the TyG index to critically ill patients with COPD and asthma. Our study shows that the TyG index is a potential predictor of all-cause mortality in critically ill patients with COPD and asthma. In addition, in patients with a TyG index exceeding 4.8, there was a heightened risk of mortality. Measuring the TyG index may help with risk stratification and prognosis prediction in critically ill patients with COPD and asthma. Further prospective studies are needed to confirm our findings.PMID:38607315 | DOI:10.1177/14799731241245424 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - April 12, 2024 Category: Respiratory Medicine Authors: Wen-Qiang Zhou Xin Song Wei-Hua Dong Zhi Chen Source Type: research
Independent effect of the triglyceride-glucose index on all-cause mortality in critically ill patients with chronic obstructive pulmonary disease and asthma: A retrospective cohort study
CONCLUSIONS: In summary, our results extend the utility of the TyG index to critically ill patients with COPD and asthma. Our study shows that the TyG index is a potential predictor of all-cause mortality in critically ill patients with COPD and asthma. In addition, in patients with a TyG index exceeding 4.8, there was a heightened risk of mortality. Measuring the TyG index may help with risk stratification and prognosis prediction in critically ill patients with COPD and asthma. Further prospective studies are needed to confirm our findings.PMID:38607315 | DOI:10.1177/14799731241245424 (Source: Respiratory Care)
Source: Respiratory Care - April 12, 2024 Category: Respiratory Medicine Authors: Wen-Qiang Zhou Xin Song Wei-Hua Dong Zhi Chen Source Type: research
Effect of a two-only-meals-a-day and exercise lifestyle on HbA1c and anti-diabetic medication in a follow-up study of subjects with type 2 diabetes attending a free clinic in a north Maharashtra city
CONCLUSIONS: The 2-OMEX lifestyle showed a sizeable, favorable, and significant change in HbA1c, body weight, ADMC use in five months, and subjective benefits. Studies are necessary for remission impact and pathways.PMID:38605789 | PMC:PMC11006040 | DOI:10.4103/jfmpc.jfmpc_795_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Shyam V Ashtekar Ratna S Ashtekar Pradeep R Deshmukh Jagdish D Powar Source Type: research
Correlation between acne and insulin resistance; experience from central India
CONCLUSION: Our study suggests the prevalence of insulin resistance in 42.67% of patients with acne, thereby providing the possibility of use of insulin modifiers as an adjunct acne treatment and stratifying the possible risk of metabolic syndrome in patients with acne. Also recommended is the control of dietary factors and lifestyle modification for the management of acne with insulin resistance.PMID:38605790 | PMC:PMC11006054 | DOI:10.4103/jfmpc.jfmpc_1232_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Prachi R Srivastava Jaideep Khare Animesh Saxena Sushil Jindal Source Type: research
Effect of dietary chitosan on the growth performance, intestinal histology and growth ‐related gene expression in stellate sturgeon (Acipenser stellatus) juveniles
This study aimed to determine the impact of dietary chitosan on growth performance, whole-body proximate composition, growth-related gene expression, and intestinal histology in juvenileAcipenser stellatus. A total of 180 A. stellatus juveniles with an average weight of 31.90 ± 0.73 g were fed with diets containing 0 (control), 1.5, 3.0, 4.5, and 6.0 g chitosan.kg−1 basic diet for eight weeks. The findings revealed a significant enhancement in growth performance with rising chitosan concentrations. Furthermore, chitosan supplementation upregulated the expression of the growth hormone gene in both brain and l...
Source: Journal of Animal Physiology and Animal Nutrition - April 12, 2024 Category: Zoology Authors: Donya Zakeri,
Jamileh Pazooki,
Mahmoud Mohseni,
Shirin Jamshidi Tags: ORIGINAL ARTICLE Source Type: research
