GSE263852 Linc-ADAIN, A Human Adipose LincRNA Regulates Adipogenesis by Modulating KLF5 and IL-8 mRNA stability
Contributors : Marcella E O'Reilly ; Chenyi Xue ; Eunyoung KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdipose tissue remodeling and dysfunction, characterized by increased inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2DM) and cardiovascular diseases. Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular functions. Here we describe the functions of linc-ADAIN (ADipose Anti-INflammatory), an adipose lincRNA that is downregulated in white adipose tissue of obese humans. We demonstrate that...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Barriers to the Use of Insulin Therapy and Potential Solutions: A Narrative Review of Perspectives from the Asia –Pacific Region
AbstractThe rising prevalence of type 2 diabetes (T2D) is posing major challenges for the healthcare systems of many countries, particularly in the Asia–Pacific Region, in which T2D can present at younger ages and lower body mass index when compared with Western nations. There is an important role for insulin therapy in the manageme nt of T2D in these nations, but available evidence suggests that insulin is under-utilized and often delayed, to the detriment of patient prognosis. The authors of this article gathered as an advisory panel (representative of some of the larger Asia–Pacific nations) to identify their loca...
Source: Diabetes Therapy - April 16, 2024 Category: Endocrinology Source Type: research
Modification of lipoprotein metabolism and function driving atherogenesis in diabetes
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, characterized by raised blood glucose levels and impaired lipid metabolism resulting from insulin resistance and relative insulin deficiency. In diabetes, the peculiar plasma lipoprotein phenotype, consisting in higher levels of apolipoprotein B-containing lipoproteins, hypertriglyceridemia, low levels of HDL cholesterol, elevated number of small, dense LDL, and increased non-HDL cholesterol, results from an increased synthesis and impaired clearance of triglyceride rich lipoproteins. (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Lorenzo Luciani, Matteo Pedrelli, Paolo Parini Source Type: research
Effects of Prevotella copri on insulin, gut microbiota and bile acids
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - April 16, 2024 Category: Microbiology Authors: Jiatai GongQianjin ZhangRuizhi HuXizi YangChengkun FangLiping YaoJing LvLong WangMingkun ShiWentao ZhangSiqi MaHongkun XiangHongfu ZhangDe-Xing HouYulong YinJianhua HeLijun PengShusong Wua Hunan Collaborative Innovation Center for Utilization of Botanical Source Type: research
It ’s About Timing: Contrasting the Metabolic Effects of Early vs. Late Time-Restricted Eating in Humans
AbstractPurpose of ReviewTime-restricted eating (TRE), a form of intermittent fasting, restricts feeding time across the day, imposing a daily ‘eating window’. Thetime of day when the eating window occurs could result in differential metabolic effects. Here, we describe recent intervention studies in humans assessing the metabolic consequences of an early- (i.e., eating window starting in the early morning) vs. late (i.e., eating window starting after midday)-TRE protocol.Recent FindingsWell-controlled studies indicate that both TRE protocols effectively reduce body weight and improve altered glucose metabolism, lipid ...
Source: Current Nutrition Reports - April 16, 2024 Category: Nutrition Source Type: research
A case of congenital hyperinsulinism presenting with diabetes after long-term diazoxide therapy
AbstractCongenital hyperinsulinism (CHI) is the most common form of persistent hypoglycemia in infants, and diazoxide is the most widely used drug for its treatment. Diazoxide suppresses insulin secretion and attenuates hypoglycemia by binding to sulfonylurea receptor 1 and activating KATP channels. While the short-term side effects of this drug, such as edema and blood cell abnormalities, are well known, the clinical course after its long-term oral administration remains unclear. Furthermore, there are currently no case reports clearly demonstrating a causal relationship between diazoxide and impaired glucose tolerance. W...
Source: Diabetology International - April 16, 2024 Category: Endocrinology Source Type: research
Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton ’s jelly-derived mesenchymal stem cells: a novel therapeutic approach
Type 2 diabetes mellitus (T2DM), characterized by β-cell dysfunction and insulin resistance (IR), presents considerable treatment challenges. Apelin is an adipocyte-derived factor that shows promise in improvi... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - April 16, 2024 Category: Endocrinology Authors: Jing Cui, Mingkun Wang, Wenhong Zhang, Jiachen Sun, Yan Zhang, Li Zhao, Zhibo Hong, Dongtao Li, Yi Xiong Huang, Ningkun Zhang and Yu Chen Tags: Research Source Type: research
Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients
Volume 40, Issue 1, December 2024 . (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - April 16, 2024 Category: Endocrinology Authors: Alessandro D. GenazzaniChristian BattipagliaLaura RusceGreta PrampoliniClaudia AioFrancesco RicciardielloMartina FoschiAlessandra SponzilliElisa SempriniTabatha PetrilloGynecological Endocrinology Center, Department of Obstetrics and Gynecology, Universit Source Type: research
Barriers to the Use of Insulin Therapy and Potential Solutions: A Narrative Review of Perspectives from the Asia –Pacific Region
AbstractThe rising prevalence of type 2 diabetes (T2D) is posing major challenges for the healthcare systems of many countries, particularly in the Asia–Pacific Region, in which T2D can present at younger ages and lower body mass index when compared with Western nations. There is an important role for insulin therapy in the manageme nt of T2D in these nations, but available evidence suggests that insulin is under-utilized and often delayed, to the detriment of patient prognosis. The authors of this article gathered as an advisory panel (representative of some of the larger Asia–Pacific nations) to identify their loca...
Source: Diabetes Therapy - April 16, 2024 Category: Endocrinology Source Type: research
Association between DASH and novel atherogenic risk factors, anthropometric indices and foot ulcer indicators in type 2 diabetic patients with foot ulcer: a cross-sectional study
ConclusionDASH adherence did not change neuropathy score and cholindex and cardiovascular risk factors significantly and has no significant effect on foot ulcer size. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 16, 2024 Category: Endocrinology Source Type: research
Cancers, Vol. 16, Pages 1513: Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice
In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Manasi Das Deepak Kumar Consuelo Sauceda Alexis Oberg Lesley G. Ellies Liping Zeng Lily J. Jih Isabel G. Newton Nicholas J. G. Webster Tags: Article Source Type: research
People with complicated pregnancies may suffer health problems, die early
Preterm births are a well-known hazard for babies—who can require months and sometimes years of extra care—but far less attention is paid to the people who deliver them. Now, a new analysis of more than 2 million pregnancies over 4 decades finds those parents need consideration, too: Even years later, people who experienced some common pregnancy complications had a higher risk of death.
“We are starting to understand that pregnancy complications … are windows into longer term complications,” says Cynthia Gyamfi-Bannerman, a maternal fetal medicine specialist at the University of California San Diego who was...
Source: Science of Aging Knowledge Environment - April 15, 2024 Category: Geriatrics Source Type: research
Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio predict the prognosis in patients with type B aortic dissection receiving thoracic endovascular aortic repair
CONCLUSIONS: Elevated baseline TG/HDL-c ratio and TG/HDL-c ≥4.11 were significantly related to a higher risk of 1-year all-cause mortality among TBAD patients undergoing TEVAR. At the same time, the low TG/HDL-c ratio was also independently associated with 1-year all-cause mortality. Special attention should be paid to TBAD patients with a higher or an overly low TG/HDL-c ratio.PMID:38617790 | PMC:PMC11009597 | DOI:10.21037/jtd-23-1411 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Kaiwen Zhao Jinzhu Niu Hongqiao Zhu Rong Zhao Yudong Sun Shuangshuang Li Zaiping Jing Jian Zhou Source Type: research
Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types
We report the synthesis of a novel, Zn2+-chelating derivative of the pan-BETi (+)-JQ1, (+)-JQ1-DPA, in which (+)-JQ1 was conjugated to dipicolyl amine (DPA). As controls, we synthesized (+)-JQ1-DBA, a non-Zn2+-chelating derivative, and (-)-JQ1-DPA, an inactive enantiomer that chelates Zn2+. Molecular modeling and biophysical assays showed that (+)-JQ1-DPA and (+)-JQ1-DBA retain potent binding to BET bromodomains in vitro. Cellular assays demonstrated (+)-JQ1-DPA attenuated NF-ĸB target gene expression in β-cells stimulated with the pro-inflammatory cytokine interleukin 1β. To assess β-cell selectivity, we isolated isle...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 15, 2024 Category: Physiology Authors: Rachel A Jones Lipinski Jennifer S Stancill Raymundo Nu ñez Sarah L Wynia-Smith Daniel J Sprague Joshua A Nord Amir Bird John A Corbett Brian C Smith Source Type: research
