From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
Endocrinology. 2024 Apr 5:bqae044. doi: 10.1210/endocr/bqae044. Online ahead of print.ABSTRACTIn the classical insulin target tissues liver, muscle and adipose tissue, chronically elevated levels of free fatty acids (FFA) impair insulin signaling. Insulin signaling molecules are also present in β-cells where they play a role in β-cell function. Therefore, inhibition of the insulin/IGF-1 pathway may be involved in fat-induced β-cell dysfunction. To address the role of β-cell insulin resistance in FFA-induced β-cell dysfunction we co-infused bisperoxovanadate (BPV) with oleate or olive oil for 48 h in rats. BPV, a tyros...
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Aleksandar Ivovic Justin Hou Ming Yung Andrei I Oprescu Filip Vlavcheski Yusaku Mori S M Niazur Rahman Wenyue Ye Judith A Eversley Michael B Wheeler Minna Woo Evangelia Tsiani Adria Giacca Source Type: research
Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females
CONCLUSIONS: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.PMID:38578949 | DOI:10.1210/endocr/bqae045 (Source: Endocrinology)
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Anke Vermehren-Schmaedick Sonali Joshi Wendy Wagoner Mason A Norgard William Packwood Parham Diba Heike Mendez Lev M Fedorov Shauna Rakshe Byung Park Daniel L Marks Aaron Grossberg Shiuh-Wen Luoh Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems - a real-world analysis at a Swiss tertiary centre
CONCLUSIONS: Glucose levels significantly improved when transitioning from a (P)LGS to a hybrid-closed loop. Glucose levels improved further when switching from a hybrid-closed loop to an advanced hybrid-closed loop. However, the added benefit of an advanced hybrid-closed loop was comparably smaller. This pattern was also reflected in the subgroup analysis.PMID:38579305 | DOI:10.57187/s.3501 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Vera Lehmann Franco Noti Markus Laimer Christoph Stettler Thomas Z üger Source Type: research
Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females
CONCLUSIONS: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.PMID:38578949 | DOI:10.1210/endocr/bqae045 (Source: Endocrinology)
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Anke Vermehren-Schmaedick Sonali Joshi Wendy Wagoner Mason A Norgard William Packwood Parham Diba Heike Mendez Lev M Fedorov Shauna Rakshe Byung Park Daniel L Marks Aaron Grossberg Shiuh-Wen Luoh Source Type: research
β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
Endocrinology. 2024 Apr 5:bqae044. doi: 10.1210/endocr/bqae044. Online ahead of print.ABSTRACTIn the classical insulin target tissues liver, muscle and adipose tissue, chronically elevated levels of free fatty acids (FFA) impair insulin signaling. Insulin signaling molecules are also present in β-cells where they play a role in β-cell function. Therefore, inhibition of the insulin/IGF-1 pathway may be involved in fat-induced β-cell dysfunction. To address the role of β-cell insulin resistance in FFA-induced β-cell dysfunction we co-infused bisperoxovanadate (BPV) with oleate or olive oil for 48 h in rats. BPV, a tyros...
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Aleksandar Ivovic Justin Hou Ming Yung Andrei I Oprescu Filip Vlavcheski Yusaku Mori S M Niazur Rahman Wenyue Ye Judith A Eversley Michael B Wheeler Minna Woo Evangelia Tsiani Adria Giacca Source Type: research
Common and divergent molecular mechanisms of fasting and ketogenic diets
Trends Endocrinol Metab. 2024 Feb;35(2):125-141. doi: 10.1016/j.tem.2023.10.001. Epub 2023 Oct 28.ABSTRACTIntermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not identical effects on cell metabolism, function, and resilience. Whereas health benefits of KD are largely mediated by the ketone bodies (KBs), ISTF engages additional adaptive physiological responses. KDs act mainly through inhibition of histone deacetylases (HDACs), reduction of oxidative stress, improvement of mitochondria efficiency, and control of inflammation. Mechanisms of action of ISTF include stimulation of autophagy, in...
Source: Trends in Endocrinology and Metabolism: TEM - April 5, 2024 Category: Endocrinology Authors: Antonio Paoli Grant M Tinsley Mark P Mattson Immaculata De Vivo Ravi Dhawan Tatiana Moro Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems - a real-world analysis at a Swiss tertiary centre
CONCLUSIONS: Glucose levels significantly improved when transitioning from a (P)LGS to a hybrid-closed loop. Glucose levels improved further when switching from a hybrid-closed loop to an advanced hybrid-closed loop. However, the added benefit of an advanced hybrid-closed loop was comparably smaller. This pattern was also reflected in the subgroup analysis.PMID:38579305 | DOI:10.57187/s.3501 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Vera Lehmann Franco Noti Markus Laimer Christoph Stettler Thomas Z üger Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
Common and divergent molecular mechanisms of fasting and ketogenic diets
Trends Endocrinol Metab. 2024 Feb;35(2):125-141. doi: 10.1016/j.tem.2023.10.001. Epub 2023 Oct 28.ABSTRACTIntermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not identical effects on cell metabolism, function, and resilience. Whereas health benefits of KD are largely mediated by the ketone bodies (KBs), ISTF engages additional adaptive physiological responses. KDs act mainly through inhibition of histone deacetylases (HDACs), reduction of oxidative stress, improvement of mitochondria efficiency, and control of inflammation. Mechanisms of action of ISTF include stimulation of autophagy, in...
Source: Trends in Endocrinology and Metabolism: TEM - April 5, 2024 Category: Endocrinology Authors: Antonio Paoli Grant M Tinsley Mark P Mattson Immaculata De Vivo Ravi Dhawan Tatiana Moro Source Type: research
RNA expression changes driven by altered epigenetics status related to NASH etiology
In conclusion, the chromatin landscape is altered in NASH patients compared to patients without this liver condition. This alteration might cause mRNA changes explaining, at least partially, the etiology and pathophysiology of the disease.PMID:38579398 | DOI:10.1016/j.biopha.2024.116508 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 5, 2024 Category: Drugs & Pharmacology Authors: Daniel Castellano-Castillo Bruno Ramos-Molina Mar ía Dolores Frutos Isabel Arranz-Salas Armando Reyes-Engel Mar ía Isabel Queipo-Ortuño Fernando Cardona Source Type: research
Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females
CONCLUSIONS: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.PMID:38578949 | DOI:10.1210/endocr/bqae045 (Source: Endocrinology)
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Anke Vermehren-Schmaedick Sonali Joshi Wendy Wagoner Mason A Norgard William Packwood Parham Diba Heike Mendez Lev M Fedorov Shauna Rakshe Byung Park Daniel L Marks Aaron Grossberg Shiuh-Wen Luoh Source Type: research
