Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis in Mice
CONCLUSIONS: Our study provides a novel mechanism with which GLP-1(32-36) acts in modulating metabolic reprogramming toward glycolytic flux in partnership with GLP-1R for improved angiogenesis in high glucose-exposed EPCs and T1DM murine models. We propose that GLP-1(32-36) could be used as a monotherapy or add-on therapy with existing treatments for peripheral artery disease.REGISTRATION: URL: www.ebi.ac.uk/metabolights/; Unique identifier: MTBLS9543.PMID:38511325 | DOI:10.1161/ATVBAHA.124.320714 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Yikai Zhang Shengyao Wang Qiao Zhou Yi Xie Yepeng Hu Weihuan Fang Changxin Yang Zhe Wang Shu Ye Xinyi Wang Chao Zheng Source Type: research

Liraglutide improved the reproductive function of obese mice by upregulating the testicular AC3/cAMP/PKA pathway
CONCLUSIONS: Liraglutide can improve the sex hormone levels and semen quality of obese male mice. In addition to its weight loss effect, liraglutide can improve the reproductive function of obese male mice, which may also be related to the upregulation of AC3/cAMP/PKA pathway in the testis. This work lays the groundwork for future clinical studies.PMID:38509558 | DOI:10.1186/s12958-024-01202-0 (Source: Reproductive Biology)
Source: Reproductive Biology - March 21, 2024 Category: Reproduction Medicine Authors: Ruibing Qi Yuzhen Liang Jinming Yu Bing Chen Jiaqin Jiang Xingye Wu Wensheng Lu Zhengming Li Source Type: research

Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data
This study included 462 patients in the RIF group and 4750 patients in the control group. The patients' basic characteristics, clinical treatment data, and laboratory test indices were compared. Logistic regression was used to analyse RIF-related risk factors, and the prediction model was evaluated by receiver operating characteristic (ROC) curves and the corresponding areas under the curve (AUCs). Further analysis of the influencing factors of live births in the first cycle of subsequent assisted reproduction treatment in RIF patients was performed, including the live birth subgroup (n = 116) and the no live birth subgrou...
Source: Reproductive Biology - March 21, 2024 Category: Reproduction Medicine Authors: Qunying Fang Zonghui Qiao Lei Luo Shun Bai Min Chen Xiangjun Zhang Lu Zong Xian-Hong Tong Li-Min Wu Source Type: research

GSE255540 Activation of GFRAL+ Neurons Induces Hypothermia and Glucoregulatory Responses Associated with Nausea and Torpor
Contributors : Linda Engstr öm Ruud ; Ferran Font-Gironès ; Joanna Zajdel ; Johan RuudSeries Type : Expression profiling by high throughput sequencingOrganism :GFRAL-expressing neurons actuate aversion and nausea, are targets for obesity treatment and may mediate metformin effects by long-term GDF15-GFRAL agonism. If GFRAL+ neurons acutely regulate glucose and energy homeostasis is however underexplored. Here, we report that cell-specific activation of GFRAL+ neurons using a variety of techniques causes a torpor-like state, including hypothermia, the release of stress hormones, a shift from glucose to lipid oxidation...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

Association between triglyceride-glucose index and endothelial dysfunction
ConclusionsSubjects with an elevated TyG index are more likely to have endothelial dysfunction, particularly in populations without DM. (Source: Endocrine)
Source: Endocrine - March 21, 2024 Category: Endocrinology Source Type: research

Combination Therapy of Endoscopic Gastric Remodeling with GLP-1RA for the Treatment of MASLD
ConclusionsIn patients with MASLD and cACLD, combination of EGR with GLP-1RA is associated with greater improvements in hepatic fibrosis, weight profile, and insulin resistance compared to EGR alone.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - March 21, 2024 Category: Surgery Source Type: research

Corrigendum to “Efficacy and safety of basal insulin degludec 100 IU/mL versus glargine 300 IU/mL for type 1 diabetes: The single-center INEOX randomized controlled trial” [Diabetes Res. Clin. Pract. 196 (2023) 110238]
The authors regret that the above-mentioned article did not mention that the INEOX project received funding from the European Union. The funding statement should be corrected as follows: (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 21, 2024 Category: Endocrinology Authors: Mar ía-Soledad Ruiz-de-Adana, Marta-Elena Domínguez, Virginia Morillas, Natalia Colomo, Rosario Vallejo-Mora, Mercedes Guerrero, Eva García-Escobar, Mónica Carreira, Yanina Romero-Zerbo, Francisca Linares, Isabel González-Mariscal, Francisco-Javier B Tags: Corrigendum Source Type: research

FGF19 Promotes the Proliferation and Insulin Secretion from Human Pancreatic β Cells Via the IRS1/GLUT4 Pathway
Conclusion In conclusion, FGF19 partly promoted the proliferation and insulin secretion of human pancreatic β cells and inhibited apoptosis by upregulating the IRS1/GLUT4 pathway. These findings establish a theoretical framework for the clinical utilization of FGF19 in the treatment of obesity-associated T2DM. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 21, 2024 Category: Endocrinology Authors: Zeng, Ting Tang, Xi Bai, Xiaosu Xiong, Haiyan Tags: Article Source Type: research

Real-World Outcomes of Individualized Targeted Therapy with Insulin Glargine 300  Units/mL in Insulin-Naïve Korean People with Type 2 Diabetes: TOBE Study
ConclusionsThis study showed that initiation of insulin therapy with Gla-300 in people with T2DM using an individualized approach is more effective in achieving an HbA1c target. Moreover, earlier initiation of insulin therapy in people with suboptimally controlled T2DM may increase the success rate of glycemic control.A graphical abstract is available with this article.Graphical Abstract (Source: Advances in Therapy)
Source: Advances in Therapy - March 21, 2024 Category: Drugs & Pharmacology Source Type: research

Decision architecture randomisation: extremely efficient clinical trials that preserve clinician and patient choice?
Introduction Healthcare is full of choices between standard-of-care approaches where one might be better but we do not know which. Examples include ‘at what threshold should magnesium be supplemented for critically ill patients?’ and ‘which insulin formulation should be started in a hospitalised patient with diabetes?’1–3 Observational studies of such questions can be conducted relatively easily but are prone to biases, especially selection bias, that prevent them from reliably showing causal relationships between treatments and outcomes.4 Randomised controlled trials (RCTs) allow stronger cau...
Source: Evidence-Based Medicine - March 21, 2024 Category: Internal Medicine Authors: Flory, J., Ancker, J. S., Kim, S. Y. H., Kuperman, G., Vickers, A. Tags: Analysis Source Type: research

Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
Nature Reviews Endocrinology, Published online: 21 March 2024; doi:10.1038/s41574-024-00970-4The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein complex regulates the endocrine transport and bioavailability of IGF-1 and IGF-2 and therefore influences postnatal growth and metabolism. This Review addresses the endocrine physiology and pathology of ALS, discusses the emerging cellular roles for ALS and outlines its involvement in disease states. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2024 Category: Endocrinology Authors: Robert C. Baxter Source Type: research

Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2
Nature Reviews Endocrinology, Published online: 21 March 2024; doi:10.1038/s41574-024-00975-zSlowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2 (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2024 Category: Endocrinology Authors: Tetsuro Kobayashi Takashi Kadowaki Source Type: research

Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’
Nature Reviews Endocrinology, Published online: 21 March 2024; doi:10.1038/s41574-024-00977-xReply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’ (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2024 Category: Endocrinology Authors: Maria J. Redondo Noel G. Morgan Source Type: research

Efficacy and safety of basal insulins in people with type 2 diabetes mellitus: a systematic review and network meta-analysis of randomized clinical trials
ConclusionThe efficacy of various basal insulin regimens is comparable. However, they have different safety profiles. IGlar-300 may be the best choice when weight gain is a concern. In contrast, IDeg-100, IDeg-200, IDet, and IGlar-300 may be preferred when hypoglycemia is the primary concern. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research