Molecular Genealogy of Metabolic-associated Hepatocellular Carcinoma
In conclusion, deciphering the intricate interactions among metabolic processes, genetic predispositions, inflammatory responses, immune regulation, and microbial ecology is imperative for the development of novel therapeutic and preventative measures against metabolic-associated HCC. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - April 18, 2024 Category: Gastroenterology Authors: Kodama, Takahiro Takehara, Tetsuo Tags: Review Article Source Type: research
Effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and cardiovascular disease: A meta-analysis
The impact of the loss-of-function (LOF) genetic variant PCSK9 R46L on glucose homeostasis and cardiovascular disease (CVD) remains uncertain, despite its established correlation with diminished blood cholesterol levels. This meta-analysis aimed at exploring the effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and CVD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 18, 2024 Category: Nutrition Authors: Sen Liu, Jindong Wan, Dan Wang, Yi Yang, Jie Fang, Tao Luo, Dengpan Liang, Jun Hu, Jixin Hou, Peijian Wang Source Type: research
The effects of probiotics supplements on metabolic indices and clinical signs in patients with diabetic retinopathy, a randomized double blind clinical trial
ConclusionsOverall, probiotic supplementation after 12 weeks in DR patients had beneficial effects on few metabolic profiles. This study was registered under the Iranian website for clinical trials ashttp://www.irct.ir: IRCT20130211012438N29. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Leptin and ghrelin dynamics: unraveling their influence on food intake, energy balance, and the pathophysiology of type 2 diabetes mellitus
ConclusionGhrelin, known for its appetite-stimulating effects, and leptin, a hormone involved in the regulation of energy balance, have been implicated in insulin resistance and glucose metabolism. Understanding the complexities of ghrelin and leptin interactions in the context of T2DM may offer insights into novel therapeutic strategies for this prevalent metabolic disorder. Further research is warranted to elucidate the molecular mechanisms underlying these hormone actions and to explore their clinical implications for T2DM prevention and management. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
AMPK pathway: an emerging target to control diabetes mellitus and its related complications
ConclusionAs AMPK activation leads to overall control of diabetes mellitus, designing and developing of small molecules or peptide that can act as AMPK agonist will be highly beneficial for control or manage diabetes mellitus. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Comprehensive data on the relationship between KCNJ11 polymorphisms and gestational diabetes mellitus predisposition: a meta-analysis
ConclusionsPooled data showed a correlation between the KCNJ11 rs5219 polymorphism and GDM susceptibility, but no association was found for the rs5210 polymorphism. Future research with larger sample sizes and more diverse populations is needed to improve result generalizability. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Association of CIITA (rs8048002) and CLEC2D (rs2114870) gene variants and type 1 diabetes mellitus
ConclusionThe rare C allele of CIITA rs8048002 genetic variant was associated with an increased risk of developing T1DM, while the less common A allele of CLEC2D rs2114870 was associated with a reduced risk of T1DM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Association of common single-nucleotide polymorphism of HHEX with type 2 diabetes mellitus
ConclusionOur study revealed that polymorphisms rs7923837 ofHHEX were not associated with T2DM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Inflammation and immunological disarrays are associated with acute exercise in type 2 diabetes
ConclusionFinally; JUN, IL6, IL1B, PTGS2, FOS, ATF3, CXCL8, EGR1, and EGR2 were introduced as the critical targeted genes by exercise. Since the critical genes after exercise are upregulated and mostly are known as the risk factors of T2D, it can be concluded that unsuitable exercise can develop diabetic conditions in patients. Acute exercise-induced inflammation and immune disturbances seem to be associated with the development of T2D in patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
B-Glycine as a marker for β cell imaging and β cell mass evaluation
Conclusion[18F]FBG targeting the endogenous glycine transporter (GLYT), which is highly expressed on islet cells, avoiding extra modification on islet cells. Meanwhile the highly restricted expression pattern of GLYT excluded the background in adjacent tissues. This [18F]FBG-based imaging technique provides a non-invasive method to quantify BCM in vivo, implying a new evaluation index for diabetic assessment. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 18, 2024 Category: Nuclear Medicine Source Type: research
Cancers, Vol. 16, Pages 1538: From Diabetes to Oncology: Glucagon-like Peptide-1 (GLP-1) Receptor Agonist & rsquo;s Dual Role in Prostate Cancer
Cancers, Vol. 16, Pages 1538: From Diabetes to Oncology: Glucagon-like Peptide-1 (GLP-1) Receptor Agonist’s Dual Role in Prostate Cancer
Cancers doi: 10.3390/cancers16081538
Authors:
Abdulrahman Alhajahjeh
Raad Al-Faouri
Hisham F. Bahmad
Taima’ Bader
Ryan W. Dobbs
Ahmed A. Abdulelah
Wassim Abou-Kheir
Elai Davicioni
David I. Lee
Mohammed Shahait
Glucagon-like peptide-1 (GLP-1), an incretin hormone renowned for its role in post-meal blood sugar regulation and glucose-dependent insulin secretion, has gained attention as a novel treatment for diabetes through GLP-1 receptor agonists (GLP-1...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Abdulrahman Alhajahjeh Raad Al-Faouri Hisham F. Bahmad Taima ’ Bader Ryan W. Dobbs Ahmed A. Abdulelah Wassim Abou-Kheir Elai Davicioni David I. Lee Mohammed Shahait Tags: Review Source Type: research
Hyperpigmentation at diabetes technology sites may be indicative of evolving Addisons disease
A 12-year-old boy with type 1 diabetes mellitus and coeliac disease reported 2–3 months of skin darkening at his insulin pump cannula and continuous glucose monitor sites (figure 1). For the preceding 9 months, he had localised itching and redness, which had been managed as allergic contact dermatitis by a dermatologist. He continued to use the dressings and these symptoms had improved. Hyperpigmentation was noted over his knuckles and periorally. He had no symptoms of adrenal insufficiency and was gaining weight (98th centile) and height (50th centile). A synacthen test had a suboptimal peak cortisol (370 nmol/L (&g...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Moon, R. J., Rowland, A. C., Davies, J. H. Tags: Miscellanea Source Type: research
Adipose tissue IL ‐18 production is independent of caspase‐1 and caspase‐11
ConclusionOur findings suggest that IL-18 production in the adipose tissue is independent of Nlrp3 inflammasome and caspase-1 activation, regardless of caloric food intake. In contrast, Nlrp3-mediated IL-1 β production is caspase-1 dependent. These results provide new insights into the mechanisms underlying cytokine production in the adipose tissue during both homeostatic conditions and metabolic stress, highlighting the distinct roles of caspase-1 and the Nlrp inflammasomes in regulating inflammator y responses. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 17, 2024 Category: Allergy & Immunology Authors: Luis Rom án‐Domínguez,
Jonathan Salazar‐León,
Karla F. Meza‐Sosa,
Leonor Pérez‐Martínez,
Gustavo Pedraza‐Alva Tags: ORIGINAL ARTICLE Source Type: research
Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevic Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-Wed Source Type: research
Biomarkers of frailty
Mol Aspects Med. 2024 Apr 16;97:101271. doi: 10.1016/j.mam.2024.101271. Online ahead of print.ABSTRACTSeveral biomarkers have been proposed to identify frailty, a multisystemic age-related syndrome. However, the complex pathophysiology and the absence of a consensus on a comprehensive and universal definition make it challenging to pinpoint a singular biomarker or set of biomarkers that conclusively characterize frailty. This review delves into the main laboratory biomarkers, placing special emphasis on those associated with various pathways closely tied to the frailty condition, such as inflammation, oxidative stress, mit...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Mariam El Assar Isabel Rodr íguez-Sánchez Alejandro Álvarez-Bustos Leocadio Rodr íguez-Mañas Source Type: research
