Autophagy enhances the differentiation of insulin-producing cells from Wharton's jelly-derived mesenchymal stem cells
Tissue Cell. 2024 Apr 15;88:102384. doi: 10.1016/j.tice.2024.102384. Online ahead of print.ABSTRACTAutophagy disruption suppresses insulin production and induces diabetes. The role of autophagy in the differentiation of Wharton's jelly (WJ)-derived mesenchymal stem cells (WJSCs) into insulin-producing cells (IPCs) was investigated in this experimental study. The WJSCs were incubated in a differentiation medium (DM) with or without an autophagy inhibitor (3-methyladenine: 3MA). The differentiation of IPCs was confirmed by flow cytometry analysis of PDX-1 and insulin-positive cells, insulin secretion, and the high expression...
Source: Tissue and Cell - April 16, 2024 Category: Cytology Authors: Nastaran Azarbarz Fereshteh Nejaddehbashi Layasadat Khorsandi Dariuosh Bijan Nejad Ali Sayyahi Source Type: research
Moringa isothiocyanate-1 mitigates the damage of oxidative stress and apoptosis in diabetic nephropathy mice
CONCLUSIONS: MIC-1 ameliorated the kidney injury in DN mice, and its mechanism may be associated with the suppression of renal cell apoptosis, oxidative stress, and inflammatory responses.PMID:38623789 | DOI:10.14670/HH-18-741 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 16, 2024 Category: Cytology Authors: Zhou Hua Jiuhong Deng Guiying Wang Source Type: research
The effect of serum triglyceride levels and different lipid-lowering methods on the prognosis of hypertriglyceridemic acute pancreatitis: a single-center 12-year retrospective study by propensity score matching
CONCLUSION: The severity of HTG-AP is not associated with the triglyceride levels at admission. However, rapid reduction of triglyceride levels can lower the incidence of local complications and respiratory failure. Compared with conservative treatment, insulin and LMWH + bezafibrate can both reduce the incidence of IPN in patients with HTG-AP.PMID:38625376 | DOI:10.1080/00365521.2024.2342406 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2024 Category: Gastroenterology Authors: Yang Liu Jian-Ping Cheng Xiao-Lin Zhao Source Type: research
Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance
Environ Int. 2024 Apr 10;186:108626. doi: 10.1016/j.envint.2024.108626. Online ahead of print.ABSTRACTThe relationship of fine particulate matter (PM2.5) exposure and insulin resistance remains inclusive. Our study aimed to investigate this association in the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). Specifically, we examined the associations between long-term PM2.5 exposure and three surrogate indicators of insulin resistance: the triglyceride-glucose index (TyG), TyG with waist circumference (TyG-WC) and metabolic score for insulin resistance (METS-IR). Additionally, we e...
Source: Environment International - April 16, 2024 Category: Environmental Health Authors: Yanhui Jia Zhi He Fangchao Liu Jianxin Li Fengchao Liang Keyong Huang Jichun Chen Jie Cao Hongfan Li Chong Shen Ling Yu Xiaoqing Liu Dongsheng Hu Jianfeng Huang Yingxin Zhao Yang Liu Xiangfeng Lu Dongfeng Gu Shufeng Chen Source Type: research
Autophagy-dependent lysosomal calcium overload and the ATP5B-regulated lysosomes-mitochondria calcium transmission induce liver insulin resistance under perfluorooctane sulfonate exposure
In this study, we found that PFOS exposure noticeably raised lysosomal calcium in L-02 hepatocytes from 0.5 h. In the PFOS-cultured L-02 cells, inhibiting autophagy alleviated lysosomal calcium overload. Inhibition of mitochondrial calcium uptake aggravated the accumulation of lysosomal calcium, while inhibition of lysosomal calcium outflowing reversed PFOS-induced mitochondrial calcium overload and IR. Transient receptor potential mucolipin 1 (TRPML1), the calcium output channel of lysosomes, interacted with voltage-dependent anion channel 1 (VDAC1), the calcium intake channel of mitochondria, in the PFOS-cultured cells. ...
Source: Ecotoxicology and Environmental Safety - April 16, 2024 Category: Environmental Health Authors: Jixun Li Yu Ma Tianming Qiu Jianyu Wang Jingyuan Zhang Xiance Sun Liping Jiang Qiujuan Li Xiaofeng Yao Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
The spectrum of growth hormone excess in Carney complex and genotype-phenotype correlations
CONCLUSION: Dysregulation of GH secretion is a common finding in CNC. The clinical spectrum of this disorder and its association with genetic and imaging characteristics of the patient make prompt diagnosis and management more successful.PMID:38626285 | DOI:10.1210/clinem/dgae253 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Christina Tatsi Georgia Pitsava Fabio R Faucz Meg Keil Constantine A Stratakis Source Type: research
Impact of ghrelin on islet size in non-pregnant and pregnant female mice
Endocrinology. 2024 Apr 16:bqae048. doi: 10.1210/endocr/bqae048. Online ahead of print.ABSTRACTReducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here, we determined if reducing ghrelin also enlarges islets in females, and if pregnancy-associated changes in islet size are related to reduced ghrelin. Islet size and β-cell mass were larger (P=0.057 for β-cell mass) in female GKO mice. Pregnancy was associated with reduced ghrelin and increased LEAP2 [a ghrelin receptor (GHSR) antagonist] in WT mice. Ghrelin deletion and pregna...
Source: Endocrinology - April 16, 2024 Category: Endocrinology Authors: Deepali Gupta Avi W Burstein Kripa Shankar Salil Varshney Omprakash Singh Sherri Osborne-Lawrence Corine P Richard Jeffrey M Zigman Source Type: research
Inositol supplementation for the prevention and treatment of gestational diabetes mellitus: a meta-analysis of randomized controlled trials
ConclusionsInositol supplementation during pregnancy has the potential to prevent GDM, improve glycemic control, and reduce preterm birth rates. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 16, 2024 Category: OBGYN Source Type: research
GSE263852 Linc-ADAIN, A Human Adipose LincRNA Regulates Adipogenesis by Modulating KLF5 and IL-8 mRNA stability
Contributors : Marcella E O'Reilly ; Chenyi Xue ; Eunyoung KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdipose tissue remodeling and dysfunction, characterized by increased inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2DM) and cardiovascular diseases. Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular functions. Here we describe the functions of linc-ADAIN (ADipose Anti-INflammatory), an adipose lincRNA that is downregulated in white adipose tissue of obese humans. We demonstrate that...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Barriers to the Use of Insulin Therapy and Potential Solutions: A Narrative Review of Perspectives from the Asia –Pacific Region
AbstractThe rising prevalence of type 2 diabetes (T2D) is posing major challenges for the healthcare systems of many countries, particularly in the Asia–Pacific Region, in which T2D can present at younger ages and lower body mass index when compared with Western nations. There is an important role for insulin therapy in the manageme nt of T2D in these nations, but available evidence suggests that insulin is under-utilized and often delayed, to the detriment of patient prognosis. The authors of this article gathered as an advisory panel (representative of some of the larger Asia–Pacific nations) to identify their loca...
Source: Diabetes Therapy - April 16, 2024 Category: Endocrinology Source Type: research
Modification of lipoprotein metabolism and function driving atherogenesis in diabetes
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, characterized by raised blood glucose levels and impaired lipid metabolism resulting from insulin resistance and relative insulin deficiency. In diabetes, the peculiar plasma lipoprotein phenotype, consisting in higher levels of apolipoprotein B-containing lipoproteins, hypertriglyceridemia, low levels of HDL cholesterol, elevated number of small, dense LDL, and increased non-HDL cholesterol, results from an increased synthesis and impaired clearance of triglyceride rich lipoproteins. (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Lorenzo Luciani, Matteo Pedrelli, Paolo Parini Source Type: research
Effects of Prevotella copri on insulin, gut microbiota and bile acids
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - April 16, 2024 Category: Microbiology Authors: Jiatai GongQianjin ZhangRuizhi HuXizi YangChengkun FangLiping YaoJing LvLong WangMingkun ShiWentao ZhangSiqi MaHongkun XiangHongfu ZhangDe-Xing HouYulong YinJianhua HeLijun PengShusong Wua Hunan Collaborative Innovation Center for Utilization of Botanical Source Type: research
It ’s About Timing: Contrasting the Metabolic Effects of Early vs. Late Time-Restricted Eating in Humans
AbstractPurpose of ReviewTime-restricted eating (TRE), a form of intermittent fasting, restricts feeding time across the day, imposing a daily ‘eating window’. Thetime of day when the eating window occurs could result in differential metabolic effects. Here, we describe recent intervention studies in humans assessing the metabolic consequences of an early- (i.e., eating window starting in the early morning) vs. late (i.e., eating window starting after midday)-TRE protocol.Recent FindingsWell-controlled studies indicate that both TRE protocols effectively reduce body weight and improve altered glucose metabolism, lipid ...
Source: Current Nutrition Reports - April 16, 2024 Category: Nutrition Source Type: research
