Laparoscopic repair of diaphragmatic hernia after radiofrequency ablation for hepatocellular carcinoma: case report
Publication date: Available online 5 March 2021Source: International Journal of Surgery Case ReportsAuthor(s): Hokuto Ushijima, Jin-ichi Hida, Yoshinori Yane, Hiroaki Kato, Kazuki Ueda, Junichiro Kawamura (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - March 6, 2021 Category: Surgery Source Type: research

Higher Efficiency of Percutaneous Microwave (MWA) Than Radiofrequency Ablation (RFA) in Achieving Complete Response in Cirrhotic Patients with Early Hepatocellular Carcinoma
CONCLUSION: This study showed that MWA is more efficient than RFA in achieving complete response in HCC nodules with 21 to 35 mm diameter.PMID:33669107 | DOI:10.3390/curroncol28020101 (Source: Current Oncology)
Source: Current Oncology - March 6, 2021 Category: Cancer & Oncology Authors: Silvia Gaia Michela Ciruolo Davide Giuseppe Ribaldone Emanuela Rolle Enrica Migliore Elena Mosso Simone Vola Alessandra Risso Sharmila Fagoonee Giorgio Maria Saracco Patrizia Carucci Source Type: research

Neutrophil-to-Apolipoprotein A1 Ratio Predicted Overall Survival in Hepatocellular Carcinoma receiving Transarterial Chemoembolization
Oncologist. 2021 Mar 5. doi: 10.1002/onco.13743. Online ahead of print.ABSTRACTPURPOSE: To investigate the predictive capability of Neutrophil-to-Apolipoprotein A1 ratio (NAR) for predicting overall survival (OS) among hepatocellular carcinoma (HCC) patients receiving transarterial chemoembolization (TACE).PATIENTS AND METHODS: We investigated the clinical features of 554 HCC patients receiving TACE and assessed NAR's predictive value for OS with 222 consisting the discovery cohort and 332 consisting the validation cohort. The association of NAR with circulation LOX-1+ polymorphonuclear myeloid-derived suppressor cells (PM...
Source: The Oncologist - March 6, 2021 Category: Cancer & Oncology Authors: Jie Chen Yong-Jian Chen Nan Jiang Jian-Liang Xu Zi-Ming Liang Ming-Jun Bai Yan-Fang Xing Zhuo Liu Xiang-Yuan Wu Xing Li Source Type: research

Long-term Effectiveness of Population-wide Multifaceted Interventions for Hepatocellular Carcinoma in Taiwan
A series of population-wide interventions on hepatocellular carcinoma related to hepatitis B and C virus infection have been launched in Taiwan since 1984, including universal hepatitis B vaccination program from 1984, universal health care from 1995, and national viral hepatitis therapy program from 2004. Here, we assessed relative contributions to long-term mortality reduction between incidence reduction and the improvement of case-fatality rate attributed to each intervention program focusing on multiple stages of HCC evolution by using mortality rate decomposition method with the Bayesian Poisson regression model. (Sou...
Source: Journal of Hepatology - March 6, 2021 Category: Gastroenterology Authors: Sih-Han Liao, Chi-Ling Chen, Chen-Yang Hsu, Kuo-Liong Chien, Jia-Horng Kao, Pei-Jer Chen, Tony Hsiu-Hsi Chen, Chien-Hung Chen Source Type: research

Efficacy of microwave ablation versus radiofrequency ablation for hepatocellular carcinoma: a propensity score analysis
ConclusionMWA and RFA have similar therapeutic effects and safety, although MWA has advantages over RFA regarding efficacy, including shorter ablation time and fewer sessions required. (Source: Abdominal Imaging)
Source: Abdominal Imaging - March 6, 2021 Category: Radiology Source Type: research

Inter-reader agreement of CEUS LI-RADS among radiologists with different levels of experience
AbstractObjectivesTo investigate the inter-reader agreement of contrast-enhanced ultrasound (CEUS) of Liver Imaging Reporting and Data System version 2017 (LI-RADS v2017) categories among radiologists with different levels of experience.Materials and methodsFrom January 2014 to December 2014, a total of 326 patients at high risk of hepatocellular carcinoma (HCC) who underwent CEUS were included in this retrospective study. All lesions were classified according to LI-RADS v2017 by six radiologists with different levels of experiences: two residents, two fellows, and two specialists. Kappa coefficient was used to assess cons...
Source: European Radiology - March 6, 2021 Category: Radiology Source Type: research

Current updates in machine learning in the prediction of therapeutic outcome of hepatocellular carcinoma: what should we know?
AbstractWith the development of machine learning (ML) algorithms, a growing number of predictive models have been established for predicting the therapeutic outcome of patients with hepatocellular carcinoma (HCC) after various treatment modalities. By using the different combinations of clinical and radiological variables, ML algorithms can simulate human learning to detect hidden patterns within the data and play a critical role in artificial intelligence techniques. Compared to traditional statistical methods, ML methods have greater predictive effects. ML algorithms are widely applied in nearly all steps of model establ...
Source: Insights into Imaging - March 6, 2021 Category: Radiology Source Type: research

Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix
AbstractSmall cell neuroendocrine carcinoma (SCNEC) of the uterine cervix is a rare disease with a poor prognosis. The lack of established disease models has hampered therapy development. We generated a panel of cancer tissue-originated spheroid (CTOS) lines derived from SCNEC of the uterine cervix using a method based upon cell –cell contact throughout the preparation and culturing processes. Using 11 CTOS lines, we assessed the sensitivity of various drugs used in clinical practice. Drug sensitivity assays revealed significant heterogeneous inter-CTOS chemosensitivity. Microarray analyses were then performed to ide...
Source: Human Cell - March 6, 2021 Category: Cytology Source Type: research

Predictors and patterns of recurrence after radiofrequency ablation for hepatocellular carcinoma within up-to-seven criteria: a multicenter retrospective study
Publication date: Available online 4 March 2021Source: European Journal of RadiologyAuthor(s): Yi Yang, Yi Chen, Xinyuan Zhang, Yujing Xin, Yanan Wang, Xiao Li, Qingsheng Fan, Xiang Zhou, Feng Ye (Source: European Journal of Radiology)
Source: European Journal of Radiology - March 5, 2021 Category: Radiology Source Type: research

Corrigendum to "Antitumor effects of polysaccharide from Sargassum fusiforme against human hepatocellular carcinoma HepG2 cells" [Food Chem. Toxicol. 102 (2017), 53-62]
Food Chem Toxicol. 2021 Mar 1:112083. doi: 10.1016/j.fct.2021.112083. Online ahead of print.NO ABSTRACTPMID:33663893 | DOI:10.1016/j.fct.2021.112083 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - March 5, 2021 Category: Food Science Authors: Sairong Fan Junfeng Zhang Wenjian Nie Wenyuan Zhou Liqin Jin Xiaoming Chen Jianxin Lu Source Type: research

ASO Visual Abstract: Laparoscopic R1 Vascular Hepatectomy for Hepatocellular Carcinoma (With Video)
Ann Surg Oncol. 2021 Mar 4. doi: 10.1245/s10434-021-09758-6. Online ahead of print.NO ABSTRACTPMID:33665714 | DOI:10.1245/s10434-021-09758-6 (Source: Ann Oncol)
Source: Ann Oncol - March 5, 2021 Category: Cancer & Oncology Authors: Annarita Libia Valentina Ferraro Michele Tedeschi Nicola de'Angelis Guido Torzilli Luca Aldrighetti Patrick Pessaux Daniel Cherqui Riccardo Memeo Source Type: research

Nivolumab + Ipilimumab for patients with hepatocellular carcinoma previously treated with Sorafenib
This article reviews the pharmacology, efficacy and safety of nivolumab-ipilimumab in advanced HCC with prior sorafenib. Other existing systemic treatment options for advanced HCC will be described and compared to nivolumab-ipilimumab. Impact of different dose regimes, ongoing research and future developments of nivolumab-ipilimumab will be discussed. We focus on the analysis from the aforementioned CheckMate-040 cohort 4 registration trial.EXPERT OPINION: The approval of nivolumab-ipilimumab in the second-line treatment of advanced HCC by the FDA is an important development for treatment of advanced HCC. However, further ...
Source: Expert Review of Gastroenterology and Hepatology - March 5, 2021 Category: Gastroenterology Authors: Josephine Tsang Jeffrey Sum Lung Wong Gerry Gin Wai Kwok Bryan Cho Wing Li Roland Leung Joanne Chiu Tan To Cheung Thomas Yau Source Type: research

Nuclear PTEN and p53 suppress stress-induced liver cancer through distinct mechanisms
Biochem Biophys Res Commun. 2021 Mar 2;549:83-90. doi: 10.1016/j.bbrc.2021.02.093. Online ahead of print.ABSTRACTPTEN and p53 are highly mutated in many cancers. These two tumor suppressors have critical functions in the nucleus, such as DNA repair, cell cycle progression, and genome maintenance. However, the in vivo functional relationship of nuclear PTEN and p53 is unknown. Here, we analyzed the liver of mice in which nuclear PTEN and p53 are individually or simultaneously depleted. We found that nuclear PTEN loss greatly upregulates p53 expression upon oxidative stress, while the loss of p53 potentiates stress-induced a...
Source: Biochemical and Biophysical Research communications - March 5, 2021 Category: Biochemistry Authors: Takashi Kato Daisuke Murata Robert A Anders Hiromi Sesaki Miho Iijima Source Type: research

Dual-modified albumin-polymer nanocomplexes with enhanced in vivo stability for hepatocellular carcinoma therapy
Colloids Surf B Biointerfaces. 2021 Feb 19;201:111642. doi: 10.1016/j.colsurfb.2021.111642. Online ahead of print.ABSTRACTEtoposide (ETO) is a semi-synthetic derivative of podophyllotoxin with a definite antitumour effect, but its use is hampered by poor solubility and numerous side-effects. In this work, we developed a hyaluronic acid and ethylenediamine dual-modified albumin-polymer nanocomplex for tumour targeted delivery of ETO. The ETO loaded dual-modified albumin-polymer nanocomplexes (E-HEAP NCs) was composed of a hyaluronic acid decorated cationic albumin shell and a stable poly (butyl cyanoacrylate) core. E-HEAP N...
Source: Colloids and Surfaces - March 5, 2021 Category: Biotechnology Authors: Ying Xu Lei Tang Yulong Liu Chen Qian Peng Chen Yuanrong Xin Hongfei Liu Yang Qu Source Type: research

Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3 β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma
Biomark Med. 2021 Mar 5. doi: 10.2217/bmm-2021-0039. Online ahead of print.ABSTRACTBackground: Recent studies have shown that cleavage and polyadenylation-specific factor 3 (CPSF3) is a promising antitumor therapeutic target, but its potential role in hepatocellular carcinoma (HCC) has not been reported. Materials & methods: We explored the expression pattern of CPSF3 in HCC through bioinformatics analysis, quantitative polymerase chain reaction (qPCR) and western blot. The potential role of CPSF3 as a biomarker for HCC was evaluated by Kaplan-Meier analysis. Next, changes in HCC cell lines in the CPSF3 knockdown model...
Source: Future Medicine: Biomarkers in Medicine - March 5, 2021 Category: Internal Medicine Authors: Ning Li Shaotao Jiang Rongdang Fu Jin Lv Jiyou Yao Jialuo Mai Xuefeng Hua Huan Chen Jie Liu Minqiang Lu Source Type: research

The diagnostic value of plasma exosomal < em > hsa_circ_0070396 < /em > for hepatocellular carcinoma
Conclusion: Exosomal circ_0070396 may be a potential biomarker for HCC detection and management.PMID:33666515 | DOI:10.2217/bmm-2020-0476 (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 5, 2021 Category: Internal Medicine Authors: Lihua Lyu Wenjing Yang Jiayi Yao Hao Wang Jie Zhu Anli Jin Te Liu Beili Wang Jian Zhou Jia Fan Xinrong Yang Wei Guo Source Type: research

ASO Visual Abstract: Laparoscopic R1 Vascular Hepatectomy for Hepatocellular Carcinoma (With Video)
Ann Surg Oncol. 2021 Mar 4. doi: 10.1245/s10434-021-09758-6. Online ahead of print.NO ABSTRACTPMID:33665714 | DOI:10.1245/s10434-021-09758-6 (Source: Ann Oncol)
Source: Ann Oncol - March 5, 2021 Category: Cancer & Oncology Authors: Annarita Libia Valentina Ferraro Michele Tedeschi Nicola de'Angelis Guido Torzilli Luca Aldrighetti Patrick Pessaux Daniel Cherqui Riccardo Memeo Source Type: research

Comparison of the Clinical Outcome of Ramucirumab for Unresectable Hepatocellular Carcinoma with That of Prior Tyrosine Kinase Inhibitor Therapy
Conclusion: The AFP response to ramucirumab and the treatment response to prior TKI therapy are associated with treatment response to ramucirumab.Oncology (Source: Oncology)
Source: Oncology - March 5, 2021 Category: Cancer & Oncology Source Type: research

Image Guidance in Ablation for Hepatocellular Carcinoma: Contrast-Enhanced Ultrasound and Fusion Imaging
The ultrasound (US) imaging technology, including contrast-enhanced US (CEUS) and fusion imaging, has experienced radical improvement, and advancement in technology thus overcoming the problem of poor conspicuous hepatocellular carcinoma (HCC). On CEUS, the presence or absence of enhancement distinguishes the viable portion from the ablative necrotic portion. Using volume data of computed tomography (CT) or magnetic resonance imaging (MRI), fusion imaging enhances the three-dimensional relationship between the liver vasculature and HCC. Therefore, CT/MR-US fusion imaging provides synchronous images of CT/MRI with real-time...
Source: Frontiers in Oncology - March 5, 2021 Category: Cancer & Oncology Source Type: research

Prognostic Value of S100P Expression in Patients With Digestive System Cancers: A Meta-Analysis
BackgroundDigestive system cancers (DSCs) are associated with high morbidity and mortality. S100P has been reported as a prognostic biomarker in DSCs, but its prognostic value remains controversial. Accordingly, we conducted a meta-analysis to investigate whether S100P is correlated with overall survival (OS) of patients with DSCs. The relationship between S100P and clinicopathological features was also evaluated.MethodsWe systematically searched PubMed, Embase, Web of Science and Cochrane Library for eligible studies up to January 2020. In total, 16 publications with 1,925 patients were included.ResultsS100P overexpressio...
Source: Frontiers in Oncology - March 5, 2021 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 13, Pages 1110: ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity
In conclusion, ARMCX3 is identified as a novel molecular actor in liver physiopathology and carcinogenesis. ARMCX3 downregulation appears to protect against hepatocarcinogenesis, especially under conditions of high dietary lipid-mediated hepatic insult. (Source: Cancers)
Source: Cancers - March 5, 2021 Category: Cancer & Oncology Authors: Serena Mirra Aleix Gavald à-Navarro Yasmina Manso M ónica Higuera Rom án Serrat Mar ía Teresa Salcedo Ferran Burgaya Jos é Maria Balibrea Eva Santamar ía Iker Uriarte Carmen Berasain Matias A. Avila Beatriz M ínguez Eduardo Soriano Francesc Villarr Tags: Article Source Type: research

Model to Predict Overall Survival in Patients With Hepatocellular Carcinoma After Curative Hepatectomy
ConclusionsBased on serum markers and other clinical indicators, a precise model to predict the prognosis of patients with HCC was developed. This novel scoring system can be an effective tool for both surgeons and patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 5, 2021 Category: Cancer & Oncology Source Type: research

CT imaging findings of lenvatinib-induced enteritis
AbstractObjectivesTo evaluate the relationship between abnormal findings on abdomino-pelvic CT and adverse events in oncologic patients treated with lenvatinib, and their relationship with treatment planning.MethodsThis single institutional retrospective study included 58 patients with unresectable hepatocellular carcinoma or unresectable thyroid carcinoma (mean age  ± standard deviation 69.6 ± 10.0 years; range 39–84 years; 48 men) who underwent CT between October 2016 and July 2020. Two radiologists who were blinded to clinical information including the presence o...
Source: Abdominal Imaging - March 5, 2021 Category: Radiology Source Type: research

Value of gadoxetic acid-enhanced MRI for microvascular invasion of small hepatocellular carcinoma: a retrospective study
The objective of this study was to analyze the accuracy of gadolinium –ethoxybenzyl–diethylenetriamine penta–acetic acid enhanced magnetic resonance imaging (Gd–EOB–DTPA–MRI) for predicting microvascular invasi... (Source: BMC Medical Imaging)
Source: BMC Medical Imaging - March 5, 2021 Category: Radiology Authors: Meng Zhou, Dan Shan, Chunhui Zhang, Jianhua Nie, Guangyu Wang, Yanqiao Zhang, Yang Zhou and Tongsen Zheng Tags: Research article Source Type: research

Atezolizumab and bevacizumab for hepatocellular carcinoma: mechanism, pharmacokinetics  and future treatment strategies
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - March 5, 2021 Category: Cancer & Oncology Authors: Xiufeng Liu Yi Lu Shukui Qin Source Type: research

Shedding more light on the role of Midkine in hepatocellular carcinoma: New perspectives on diagnosis and therapy
AbstractOne of the most common malignant tumors is hepatocellular carcinoma (HCC). Progression of HCC mainly results from highly complex molecular and pathological pathways. Midkine (MDK) is a growth factor that impacts viability, migration, and other cell activities. Since MDK has been involved in the inflammatory responses, it has been claimed that MDK has a crucial role in HCC. MDK acts as an anti ‐apoptotic factor, which mediates tumor cell viability. In addition, MDK blocks anoikis to promote metastasis. There is also evidence that MDK is involved in angiogenesis. It has been shown that the application of anti‐MDK...
Source: IUBMB Life - March 4, 2021 Category: Research Authors: Arezoo Gowhari Shabgah, Fatemeh Ezzatifar, Surendar Aravindhan, Angelina Olegovna Zekiy, Majid Ahmadi, Seyed Mohammad Gheibihayat, Jamshid Gholizadeh Navashenaq Tags: CRITICAL REVIEW Source Type: research

Intraindividual Comparison of Hepatocellular Carcinoma Washout between MRIs with Hepatobiliary and Extracellular Contrast Agents
This study included 114 prospectively enrolled patients with chronic liver disease (mean age, 55 ± 9 years; 94 men) who underwent both HBA-MRI and ECA-MRI before surgical resection for HCC between November 2016 and May 2019. For 114 HCCs, the lesion-to-liver visual signal intensity ratio (SIR) using a 5-point scale (-2 to +2) was evaluated in each phase. Washout was defined as negative visual SIR with temporal reduction of visual SIR from the arterial phase. Illusional washout (IW) was defined as a visual SIR of 0 with an enhancing capsule. The frequency of washout and MRI sensitivity for HCC using LR-5 or its modif...
Source: Korean Journal of Radiology - March 4, 2021 Category: Radiology Authors: Yeun Yoon Kim Young Kon Kim Ji Hye Min Dong Ik Cha Jong Man Kim Gyu Seong Choi Soohyun Ahn Source Type: research

Effectiveness of Albumin-bilirubin Score as a Predictor of Post-hepatectomy Liver Failure in Patients with Hepatocellular Carcinoma
CONCLUSIONS: The ALBI score is an effective predictor of PHLF in patients with HCC, and its predictive ability is comparable to that of ICG-R15.PMID:33658474 | DOI:10.4166/kjg.2020.148 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - March 4, 2021 Category: Gastroenterology Authors: Hyun Joon Park Kwang Il Seo Sung Jun Kim Sang Uk Lee Byung Cheol Yun Byung Hoon Han Dong Hoon Shin Young Il Choi Hyung Hwan Moon Source Type: research

Applicability and prognostic value of frailty assessment tools among hospitalized patients with advanced chronic liver disease
Croat Med J. 2021 Feb 28;62(1):8-16.ABSTRACTAIM: To assess and compare the feasibility and prognostic value of various frailty assessment tools among decompensated cirrhosis inpatients.METHODS: Our prospective observational registry included consecutive patients admitted for cirrhosis between June 2017 and July 2018. Exclusion criteria were intensive-care unit admission, hepatocellular carcinoma outside of the Milan criteria, and other malignancies. Frailty at baseline was assessed with the Liver Frailty Index (LFI), Clinical Frailty Scale (CFS), Fried Frailty Score (FFS), and Short Physical Performance Battery test (SPPB)...
Source: Croatian Medical Journal - March 4, 2021 Category: General Medicine Authors: Lubomir Skladany Zuzana Drotarova Janka Vnencakova Daniela Jancekova Pavol Molcan Tomas Koller Source Type: research

Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma
CONCLUSIONS The expression of the UBE2T gene was significantly upregulated in HCC tissue compared to in normal liver tissue. UBE2T may be a new marker for the diagnosis and subsequent therapy of HCC.PMID:33658475 | DOI:10.12659/MSM.929023 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 4, 2021 Category: Research Authors: Xuemiao Zhao Wei Weng Miao Jin Sunjian Li Qingwei Chen Bingrong Li Zhou Zhou Chuanqiang Lan Yunjun Yang Source Type: research

Intraindividual Comparison of Hepatocellular Carcinoma Washout between MRIs with Hepatobiliary and Extracellular Contrast Agents
This study included 114 prospectively enrolled patients with chronic liver disease (mean age, 55 ± 9 years; 94 men) who underwent both HBA-MRI and ECA-MRI before surgical resection for HCC between November 2016 and May 2019. For 114 HCCs, the lesion-to-liver visual signal intensity ratio (SIR) using a 5-point scale (-2 to +2) was evaluated in each phase. Washout was defined as negative visual SIR with temporal reduction of visual SIR from the arterial phase. Illusional washout (IW) was defined as a visual SIR of 0 with an enhancing capsule. The frequency of washout and MRI sensitivity for HCC using LR-5 or its modif...
Source: Korean J Radiol - March 4, 2021 Category: Radiology Authors: Yeun Yoon Kim Young Kon Kim Ji Hye Min Dong Ik Cha Jong Man Kim Gyu Seong Choi Soohyun Ahn Source Type: research

Circular RNA circSOX4 promotes the proliferation, migration and apoptosis of hepatocellular carcinoma cells by down regulating microRNA-432 expression
CONCLUSIONS: CircSOX4, highly expressed in HCC, indicates a poor prognosis. CircSOX4 may mediate the progression of HCC by binding to microRNA-432.PMID:33660794 | DOI:10.26355/eurrev_202102_25079 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: Z Wen Y-X Guo H-D Sun Source Type: research

Three new sesquineolignans from the seeds of < em > Ziziphus jujuba < /em >
Nat Prod Res. 2021 Mar 3:1-5. doi: 10.1080/14786419.2021.1875465. Online ahead of print.ABSTRACTThree undescribed sesquineolignans, Ziziphusmps A-C (1-3) were isolated from the seeds of Ziziphus jujuba. their gross structure was identified by comprehensive spectroscopic analyses. The part relative configurations were determined by the NOESY correlation and coupling constant. All isolates were tested for their cytotoxicity against the hepatocellular carcinoma Hep3B and HepG2 cells. The results indicated that none of them exhibited obvious cytotoxicity against two hepatocellular carcinoma cell lines.PMID:33657910 | DOI:10.10...
Source: Natural Product Research - March 4, 2021 Category: Biochemistry Authors: Wen Mi Yue-Jiao Guo Pei Hu Xin Di Source Type: research

Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris
Int J Biol Macromol. 2021 Mar 1:S0141-8130(21)00489-X. doi: 10.1016/j.ijbiomac.2021.02.191. Online ahead of print.ABSTRACTOne novel alkali-extracted polysaccharide, CM3-SII, was obtained from the fruiting body of C. militaris via column chromatography. Its structural characteristics were investigated via chemical and spectroscopic methods. The backbone of CM3-SII was composed of →4)-β-D-Manp(1→, →6)-β-D-Manp(1→, and →6)-α-D-Manp(1→ glycosyls, and branching at the O-4 positions of →6)-β-D-Manp(1→ glycosyls with β-D-Galp, (1→2) linked-β-D-Galf, and &...
Source: International Journal of Biological Macromolecules - March 4, 2021 Category: Biochemistry Authors: Jin Wang Yunhai Wang Xiaoqian Yang Ping Lin Na Liu Xinjian Li Baihui Zhang Shoudong Guo Source Type: research

DNAJC5 promotes hepatocellular carcinoma cells proliferation though regulating SKP2 mediated p27 degradation
Biochim Biophys Acta Mol Cell Res. 2021 Mar 1:118994. doi: 10.1016/j.bbamcr.2021.118994. Online ahead of print.ABSTRACTDNAJC5 (DnaJ heat shock protein family (Hsp40) member C5), also known as cysteine tandem protein (CSPα), is important for maintaining the normal function of nerve tissues, but its oncogenic function remains unknown. Here, we report a unique mechanism underlying the oncogenic function of DNAJC5. DNAJC5 protein expression is highly detectable in human hepatocellular carcinoma (HCC) tissues and is strongly related to a poor prognosis among HCC patients. DNAJC5 overexpression promotes HCC cell proliferat...
Source: Biochimica et Biophysica Acta - March 4, 2021 Category: Biochemistry Authors: Hailong Wang Jiayu Luo Xuesi Tian Linlin Xu Zhenyu Zhai Minzhang Cheng Limin Chen Shiwen Luo Source Type: research

Extracellular HMGB1 promotes CD44 expression in hepatocellular carcinoma via regulating miR-21
In this study, our results indicated that extracellular HMGB1 promoted the invasion, sphere formation and EMT process of HCC by increasing CD44 expression, which was dependent on miR-21. Moreover, miR-21 upregulated CD44 expression via activating OCT4/TGF-β1 signaling. Finally, we demonstrated the activation of Rage/JNK signaling caused by extracellular HMGB1 was responsible for miR-21 overexpression. Together, these findings reveal an important role of extracellular HMGB1 in HCC progression through upregulating miR-21/CD44.PMID:33661757 | DOI:10.18632/aging.202649 (Source: Aging)
Source: Aging - March 4, 2021 Category: Biomedical Science Authors: Jun Li Haozhen Ren Jinglin Wang Pengfei Zhang Xiaolei Shi Source Type: research

No difference in hepatocellular carcinoma risk in chronic hepatitis B patients treated with tenofovir vs entecavir: evidence from an updated meta-analysis
Aging (Albany NY). 2021 Feb 26;13. doi: 10.18632/aging.202573. Online ahead of print.ABSTRACTWhether tenofovir disoproxil fumarate (TDF) is superior to entecavir in reducing hepatocellular carcinoma (HCC) risk among treatment-naïve chronic hepatitis B (CHB) patients remains controversial. We aimed to clarify this controversy. Several databases, including PubMed and Embase, were retrieved through November 2020. Cohort studies comparing the effectiveness of TDF and entecavir in reducing HCC incidence among treatment-naïve CHB patients were included if they reported multivariable-adjusted or propensity-score-matched...
Source: Aging - March 4, 2021 Category: Biomedical Science Authors: Jie Yuan Yang Peng Fa-Bao Hao Ya-Qin Wang Chun-Rui Wang Guo-Chao Zhong Source Type: research

Intraindividual Comparison of Hepatocellular Carcinoma Washout between MRIs with Hepatobiliary and Extracellular Contrast Agents
This study included 114 prospectively enrolled patients with chronic liver disease (mean age, 55 ± 9 years; 94 men) who underwent both HBA-MRI and ECA-MRI before surgical resection for HCC between November 2016 and May 2019. For 114 HCCs, the lesion-to-liver visual signal intensity ratio (SIR) using a 5-point scale (-2 to +2) was evaluated in each phase. Washout was defined as negative visual SIR with temporal reduction of visual SIR from the arterial phase. Illusional washout (IW) was defined as a visual SIR of 0 with an enhancing capsule. The frequency of washout and MRI sensitivity for HCC using LR-5 or its modif...
Source: Korean Journal of Radiology - March 4, 2021 Category: Radiology Authors: Yeun Yoon Kim Young Kon Kim Ji Hye Min Dong Ik Cha Jong Man Kim Gyu Seong Choi Soohyun Ahn Source Type: research

Effectiveness of Albumin-bilirubin Score as a Predictor of Post-hepatectomy Liver Failure in Patients with Hepatocellular Carcinoma
CONCLUSIONS: The ALBI score is an effective predictor of PHLF in patients with HCC, and its predictive ability is comparable to that of ICG-R15.PMID:33658474 | DOI:10.4166/kjg.2020.148 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - March 4, 2021 Category: Gastroenterology Authors: Hyun Joon Park Kwang Il Seo Sung Jun Kim Sang Uk Lee Byung Cheol Yun Byung Hoon Han Dong Hoon Shin Young Il Choi Hyung Hwan Moon Source Type: research

Applicability and prognostic value of frailty assessment tools among hospitalized patients with advanced chronic liver disease
Croat Med J. 2021 Feb 28;62(1):8-16.ABSTRACTAIM: To assess and compare the feasibility and prognostic value of various frailty assessment tools among decompensated cirrhosis inpatients.METHODS: Our prospective observational registry included consecutive patients admitted for cirrhosis between June 2017 and July 2018. Exclusion criteria were intensive-care unit admission, hepatocellular carcinoma outside of the Milan criteria, and other malignancies. Frailty at baseline was assessed with the Liver Frailty Index (LFI), Clinical Frailty Scale (CFS), Fried Frailty Score (FFS), and Short Physical Performance Battery test (SPPB)...
Source: Croatian Medical Journal - March 4, 2021 Category: General Medicine Authors: Lubomir Skladany Zuzana Drotarova Janka Vnencakova Daniela Jancekova Pavol Molcan Tomas Koller Source Type: research

Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma
CONCLUSIONS The expression of the UBE2T gene was significantly upregulated in HCC tissue compared to in normal liver tissue. UBE2T may be a new marker for the diagnosis and subsequent therapy of HCC.PMID:33658475 | DOI:10.12659/MSM.929023 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 4, 2021 Category: Research Authors: Xuemiao Zhao Wei Weng Miao Jin Sunjian Li Qingwei Chen Bingrong Li Zhou Zhou Chuanqiang Lan Yunjun Yang Source Type: research

Intraindividual Comparison of Hepatocellular Carcinoma Washout between MRIs with Hepatobiliary and Extracellular Contrast Agents
This study included 114 prospectively enrolled patients with chronic liver disease (mean age, 55 ± 9 years; 94 men) who underwent both HBA-MRI and ECA-MRI before surgical resection for HCC between November 2016 and May 2019. For 114 HCCs, the lesion-to-liver visual signal intensity ratio (SIR) using a 5-point scale (-2 to +2) was evaluated in each phase. Washout was defined as negative visual SIR with temporal reduction of visual SIR from the arterial phase. Illusional washout (IW) was defined as a visual SIR of 0 with an enhancing capsule. The frequency of washout and MRI sensitivity for HCC using LR-5 or its modif...
Source: Korean J Radiol - March 4, 2021 Category: Radiology Authors: Yeun Yoon Kim Young Kon Kim Ji Hye Min Dong Ik Cha Jong Man Kim Gyu Seong Choi Soohyun Ahn Source Type: research

Liver Resections Can Be Safely Performed in Cirrhotic Patients after Careful Patient Selection
Zentralbl Chir. 2021 Mar 4. doi: 10.1055/a-1373-6218. Online ahead of print.ABSTRACTBACKGROUND: Hepatocellular Carcinoma (HCC) is the most frequent malignant primary liver tumour in a cirrhotic liver. Liver transplantation and resection are the only curative treatment options in compensated liver cirrhosis, but liver resections are associated with increased perioperative morbidity and mortality.PATIENTS: We identified 108 cirrhotic patients, who underwent liver resections at the University Hospital of Mainz between January 2008 and December 2019. During the same period, 185 liver resections were performed for HCC in non-ci...
Source: Zentralblatt fur Chirurgie - March 4, 2021 Category: Surgery Authors: Lea Penzkofer Tobias Huber Jens Mittler Hauke Lang Stefan Heinrich Source Type: research

Circular RNA circSOX4 promotes the proliferation, migration and apoptosis of hepatocellular carcinoma cells by down regulating microRNA-432 expression
CONCLUSIONS: CircSOX4, highly expressed in HCC, indicates a poor prognosis. CircSOX4 may mediate the progression of HCC by binding to microRNA-432.PMID:33660794 | DOI:10.26355/eurrev_202102_25079 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: Z Wen Y-X Guo H-D Sun Source Type: research

Three new sesquineolignans from the seeds of < em > Ziziphus jujuba < /em >
Nat Prod Res. 2021 Mar 3:1-5. doi: 10.1080/14786419.2021.1875465. Online ahead of print.ABSTRACTThree undescribed sesquineolignans, Ziziphusmps A-C (1-3) were isolated from the seeds of Ziziphus jujuba. their gross structure was identified by comprehensive spectroscopic analyses. The part relative configurations were determined by the NOESY correlation and coupling constant. All isolates were tested for their cytotoxicity against the hepatocellular carcinoma Hep3B and HepG2 cells. The results indicated that none of them exhibited obvious cytotoxicity against two hepatocellular carcinoma cell lines.PMID:33657910 | DOI:10.10...
Source: Natural Product Research - March 4, 2021 Category: Biochemistry Authors: Wen Mi Yue-Jiao Guo Pei Hu Xin Di Source Type: research

Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris
Int J Biol Macromol. 2021 Mar 1:S0141-8130(21)00489-X. doi: 10.1016/j.ijbiomac.2021.02.191. Online ahead of print.ABSTRACTOne novel alkali-extracted polysaccharide, CM3-SII, was obtained from the fruiting body of C. militaris via column chromatography. Its structural characteristics were investigated via chemical and spectroscopic methods. The backbone of CM3-SII was composed of →4)-β-D-Manp(1→, →6)-β-D-Manp(1→, and →6)-α-D-Manp(1→ glycosyls, and branching at the O-4 positions of →6)-β-D-Manp(1→ glycosyls with β-D-Galp, (1→2) linked-β-D-Galf, and &...
Source: International Journal of Biological Macromolecules - March 4, 2021 Category: Biochemistry Authors: Jin Wang Yunhai Wang Xiaoqian Yang Ping Lin Na Liu Xinjian Li Baihui Zhang Shoudong Guo Source Type: research

DNAJC5 promotes hepatocellular carcinoma cells proliferation though regulating SKP2 mediated p27 degradation
Biochim Biophys Acta Mol Cell Res. 2021 Mar 1:118994. doi: 10.1016/j.bbamcr.2021.118994. Online ahead of print.ABSTRACTDNAJC5 (DnaJ heat shock protein family (Hsp40) member C5), also known as cysteine tandem protein (CSPα), is important for maintaining the normal function of nerve tissues, but its oncogenic function remains unknown. Here, we report a unique mechanism underlying the oncogenic function of DNAJC5. DNAJC5 protein expression is highly detectable in human hepatocellular carcinoma (HCC) tissues and is strongly related to a poor prognosis among HCC patients. DNAJC5 overexpression promotes HCC cell proliferat...
Source: Biochimica et Biophysica Acta - March 4, 2021 Category: Biochemistry Authors: Hailong Wang Jiayu Luo Xuesi Tian Linlin Xu Zhenyu Zhai Minzhang Cheng Limin Chen Shiwen Luo Source Type: research

Extracellular HMGB1 promotes CD44 expression in hepatocellular carcinoma via regulating miR-21
In this study, our results indicated that extracellular HMGB1 promoted the invasion, sphere formation and EMT process of HCC by increasing CD44 expression, which was dependent on miR-21. Moreover, miR-21 upregulated CD44 expression via activating OCT4/TGF-β1 signaling. Finally, we demonstrated the activation of Rage/JNK signaling caused by extracellular HMGB1 was responsible for miR-21 overexpression. Together, these findings reveal an important role of extracellular HMGB1 in HCC progression through upregulating miR-21/CD44.PMID:33661757 | DOI:10.18632/aging.202649 (Source: Aging)
Source: Aging - March 4, 2021 Category: Biomedical Science Authors: Jun Li Haozhen Ren Jinglin Wang Pengfei Zhang Xiaolei Shi Source Type: research

No difference in hepatocellular carcinoma risk in chronic hepatitis B patients treated with tenofovir vs entecavir: evidence from an updated meta-analysis
Aging (Albany NY). 2021 Feb 26;13. doi: 10.18632/aging.202573. Online ahead of print.ABSTRACTWhether tenofovir disoproxil fumarate (TDF) is superior to entecavir in reducing hepatocellular carcinoma (HCC) risk among treatment-naïve chronic hepatitis B (CHB) patients remains controversial. We aimed to clarify this controversy. Several databases, including PubMed and Embase, were retrieved through November 2020. Cohort studies comparing the effectiveness of TDF and entecavir in reducing HCC incidence among treatment-naïve CHB patients were included if they reported multivariable-adjusted or propensity-score-matched...
Source: Aging - March 4, 2021 Category: Biomedical Science Authors: Jie Yuan Yang Peng Fa-Bao Hao Ya-Qin Wang Chun-Rui Wang Guo-Chao Zhong Source Type: research

Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2
In conclusion, our studies disclosed the chemopreventive effect of FA supplementation on hepatocarcinogenesis, which partial attributed to the inhibition of LCN2 by regulating histone methylation in promoter. Our results provide a potential mechanism of the chemoprevention of FA supplementation on tumorigenesis of HCC and may be helpful in developing treatment target against HCC.PMID:33659047 | PMC:PMC7899549 | DOI:10.18632/oncotarget.27136 (Source: Oncotarget)
Source: Oncotarget - March 4, 2021 Category: Cancer & Oncology Authors: Yin-Ling Zhang Geng Xue Hui Miao Chuan-Chuan Zhou Shu-Han Sun Yi Zhang Source Type: research