A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma
AbstractHepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt-related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases. Cox regression a...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission
This study uncovered a novel circ_0098823 with tumor-promoting effect, and the mechanism by which circ_0098823 participates in HCC progression through IGF2BP3-guided DNM1L. Our study broadens molecular understanding of HCC progression. (Source: Apoptosis)
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
First-in-Human Safety, Imaging, and Dosimetry of a Carbonic Anhydrase IX-Targeting Peptide, [68Ga]Ga-DPI-4452, in Patients with Clear Cell Renal Cell Carcinoma
Conclusion: [68Ga]Ga-DPI-4452 showed exceptional tumor uptake in patients with clear cell renal cell carcinoma, with very high tumor-to-background ratios and no significant adverse events, suggesting potential diagnostic and patient selection applications. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Hofman, M. S., Tran, B., Feldman, D. R., Pokorska-Bocci, A., Pichereau, S., Wessen, J., Haskali, M. B., Sparks, R. B., Vlasyuk, O., Galetic, I. Tags: FEATURED ARTICLE OF THE MONTH Source Type: research
Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
This study offers new understanding of stress’s role in cancer progression and potential targets for HCC treatment. The scientists concluded that more research is required to fully comprehend these results for future cancer therapies.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Chen Wang Jiaping Ni Dongqing Zhai Yanchao Xu Zijie Wu Yuyuan Chen Ning Liu Juan Du Yumeng Shen Guilai Liu Yong Yang Linjun You Weiwei Hu Source Type: research
Cholangiocarcinoma and Occupational Exposure to Asbestos: Insights From the Italian Pooled Cohort Study
CONCLUSION: Further studies are needed to explore the association between occupational exposure to asbestos and CC. Record linkage was hampered due to incomplete coverage of the study areas and periods by Cancer Registries. The identification of CC among unspecific histology cases is fundamental to establish more effective and targeted liver cancer screening strategies.PMID:38686579 | DOI:10.23749/mdl.v115i2.14649 (Source: Medicina del Lavoro)
Source: Medicina del Lavoro - April 30, 2024 Category: Occupational Health Authors: Stefania Curti Mena Gallo Daniela Ferrante Francesca Bella Lorenza Boschetti Veronica Casotto Marcello Ceppi Daniela Cervino Lucia Fazzo Ugo Fedeli Paolo Giorgi Rossi Lucia Giovannetti Paolo Girardi Cecilia Lando Enrica Migliore Lucia Miligi Enrico Oddone Source Type: research
No-Touch Radiofrequency Ablation Using Twin Cooled Wet Electrodes for Recurrent Hepatocellular Carcinoma Following Locoregional Treatments
CONCLUSION: NT-RFA using TCW electrodes is a safe and effective treatment for recurrent HCC, with 6.0% (ITT analysis) and 1.3% (PP analysis) cumulative incidence of LTP at 2 and 3-year follow-ups.PMID:38685734 | DOI:10.3348/kjr.2023.1225 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Seong Jun Hong Jae Hyun Kim Jeong Hee Yoon Jeong Hoan Park Jung-Hwan Yoon Yoon Jun Kim Su Jong Yu Eun Ju Cho Jeong Min Lee Source Type: research
Toripalimab Plus Bevacizumab as First-line Treatment for Advanced Hepatocellular Carcinoma: A Prospective, Multicenter, Single-Arm, Phase II Trial
CONCLUSIONS: Toripalimab plus bevacizumab showed a favorable efficacy and safety profile, supporting further studies of this combination regimen as a first-line treatment of advanced HCC.PMID:38687583 | DOI:10.1158/1078-0432.CCR-24-0006 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 30, 2024 Category: Cancer & Oncology Authors: Yajin Chen Cheng-You Du Shunli Shen Wu Zhang Yunfeng Shan Ang Lyu Jianhui Wu Changzhen Shang Xuan Luo Jinxing Wei Heng Xiao Jianguo Qiu Yunpeng Hua Shutong Wang Ting Wang Shengjie Dai Shuhao Zhang Bingying Xie Yinghao Wu Chunyi Hao Source Type: research
Efficacy of microwave ablation with parallel acupuncture guided by ultrasound in treating single hepatocellular carcinoma in high-risk areas: A retrospective analysis of 155 patients
CONCLUSION: Microwave ablation with parallel acupuncture guided by ultrasound is a safe and effective treatment for single hepatocellular carcinoma in high-risk areas.PMID:38687924 | DOI:10.4103/jcrt.jcrt_1246_23 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Sheng Liu Pingsheng Zhou Qiang Shen Guojun Qian Source Type: research
Hepatic arterial infusion chemotherapy, lenvatinib plus programmed cell death protein-1 inhibitors: A promising treatment approach for high-burden hepatocellular carcinoma
CONCLUSION: The combination of HAIC-FOLFOX with lenvatinib and PD-1 inhibitors as a first-line therapy has exhibited notable therapeutic efficacy and well-tolerated adverse events among patients with high-burden HCC.PMID:38686567 | DOI:10.1002/cam4.7105 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Shumin Fu Yongkang Xu Ye Mao Mengting He Zhimeng Chen Shenglan Huang Dan Li Yaqin Lv Jianbing Wu Source Type: research
Protective effect of higher free thyroxine levels within the reference range on biliary tract cancer risk: a multivariable mendelian randomization and mediation analysis
CONCLUSION: The findings suggest that higher FT4-RR may have a protective effect against BTC, which is partially mediated by decreased risk of MetS and a reduction in WC. This study highlights the potential role of FT4 in the pathogenesis of BTC and underscores that MetS and WC may play mediation effects as two mediators in this process.PMID:38686204 | PMC:PMC11056546 | DOI:10.3389/fendo.2024.1379607 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Yuxian Chen Hao Dong Baozhen Qu Xuezhen Ma LinLin Lu Source Type: research
Improving Tamoxifen Performance in Inducing Apoptosis and Hepatoprotection by Loading on a Dual Nanomagnetic Targeting System
CONCLUSION: All the results showed that MNPs-DPN-HA-FA-TMX can show good affinity to cancer cells using targeting agents and induce apoptosis in metastatic breast ductal carcinoma T-47D cell lines. Also, the protective effects of MNPs on hepatocytes are quite evident, and they can reduce the side effects of TMX.PMID:38685808 | DOI:10.2174/0118715206289666240423091244 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Yanfang Zhao Wanbao Ding Peixian Zhang Lei Deng Yi Long Jiuqin Lu Fereshteh Shiri Mostafa Heidari Majd Source Type: research
Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation
In conclusion, these findings declare that VV polyphenolic fractions, particularly VVF1, could be promising safe anti-HCC agents.PMID:38688169 | DOI:10.1016/j.biopha.2024.116638 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Nadia Z Shaban Walaa A Hegazy Marwa M Abu-Serie Iman M Talaat Olfat M Awad Noha H Habashy Source Type: research
Effect of stability of PTEN on hepatocellular carcinoma
CONCLUSIONS: On the one hand, our study revealed that CRISPR-Cas12a might play an important role in the screening and prognosis of HCC as a new clinical method to detect PTEN mutation.PMID:38687946 | DOI:10.4103/jcrt.jcrt_349_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yilin Hu Hongliang Mei Tianji Luan Huiling Sun Qiping Lu Rong Liu Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
