Profiles of m6A RNA methylation regulators for the prognosis of hepatocellular carcinoma.
Authors: Li W, Chen QF, Huang T, Shen L, Huang ZL, Wu P Abstract N6-methyladenosine (m6A) RNA methylation, which is related to cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators (including 'writers', 'erasers' and 'readers'). However, the prognostic value of m6A RNA methylation regulators involved in hepatocellular carcinoma (HCC) carcinogenesis and progression remains to be elucidated. The aim of the present study was to determine the prognostic score in predicting the prognosis of HCC patients based on these regulators. In The Cancer Genome Atlas, most of the 13 majo...
Source: Oncology Letters - April 8, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Early risk warning system for distant metastasis of hepatitis B virus-associated hepatocellular carcinoma with portal vein tumor thrombus.
Authors: Li M, Zhao Y, Liu X, Zhang S, Jiang Y, Yang Z Abstract Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with PVTT. Data from 346 patients (263 and 83 in the modeling and validation cohorts, respectively) who had received primary diagnoses of HBV-HCC and PVTT between January 2012 and June 2015 at Beijing Ditan Hospital (Beijing, China) were retros...
Source: Oncology Letters - April 8, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Enolase 1 differentially contributes to cell transformation in lung cancer but not in esophageal cancer.
Authors: Chen JM, Chiu SC, Chen KC, Huang YJ, Liao YA, Yu CR Abstract Enolase transforms 2-phospho-D-glycerate into phosphoenolpyruvate during glycolysis. The human enolase (ENO) family comprises three members named ENO3, which is restricted to muscle tissues, ENO2, which is neuron- and neuroendocrine tissue-specific, and ENO1, which is expressed in almost all tissues. ENO1 is involved in various types of human cancer, including retinoblastoma, hepatocellular carcinoma, pancreatic cancer, renal cell carcinoma, cholangiocarcinoma and gastric cancer. Furthermore, ENO1 enhances cell transformation in numerous cancer c...
Source: Oncology Letters - April 8, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

High expression of FOXO3 is associated with poor prognosis in patients with hepatocellular carcinoma.
In conclusion, the high expression of FOXO3 predicts a poor prognosis in patients with HCC, indicating this protein as a potential therapeutic target in HCC. PMID: 32256814 [PubMed - as supplied by publisher] (Source: Oncology Letters)
Source: Oncology Letters - April 8, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The natural history of alcohol-related liver disease
Purpose of review This review will describe the natural history of alcohol-related liver disease (ArLD) in light of recent data that have synthesized existing knowledge on this topic and described new research cohorts to improve our understanding of progression and outcomes in ArLD. Recent findings ArLD occurs after a threshold of alcohol consumption, but this threshold is lowered by the presence of comorbid factors of which obesity is the most common. The most common stage of ArLD is alcohol-related steatosis: this is associated with a low rate of progression to cirrhosis (3%/year) and nonliver-related morbidity is m...
Source: Current Opinion in Gastroenterology - April 8, 2020 Category: Gastroenterology Tags: LIVER: Edited by Don C. Rockey Source Type: research

New systemic agents for hepatocellular carcinoma: an update 2020
Purpose of review Despite major therapeutic improvements in most cancer entities, hepatocellular carcinoma (HCC) has remained a dismal disease. In fact, incidence and mortality are increasing in many parts of the world, including the United States. Given that a number of systemic agents has recently been tested positive in phase 3 clinical trials, the objective of this review is to summarize the current treatment landscape for advanced HCC. Recent findings Following the positive SHARP trial in 2008, sorafenib has been the only systemic agent for advanced HCC for almost a decade. However, in first line, lenvatinib was ...
Source: Current Opinion in Gastroenterology - April 8, 2020 Category: Gastroenterology Tags: LIVER: Edited by Don C. Rockey Source Type: research

CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma
Publication date: Available online 8 April 2020Source: Pharmacological ResearchAuthor(s): Yanan Gao, Xing Fan, Nan Li, Chengzhi Du, Bin Yang, Wenhao Qin, Jing Fu, Geoffrey J. Markowitz, Hongyang Wang, Jianli Ma, Shuqun Cheng, Pengyuan Yang (Source: Pharmacological Research)
Source: Pharmacological Research - April 8, 2020 Category: Drugs & Pharmacology Source Type: research

Outcomes in hepatocellular carcinoma patients undergoing sorafenib treatment: toxicities, cellular oxidative stress, treatment adherence, and quality of life
This study focused on toxicities, cellular oxidative stress, adherence, and quality of life of 11 patients with HCC treated with sorafenib. Dermatotoxicity, myelotoxicity, gastro toxicity, nephrotoxicity, pain, and fatigue were investigated. For oxidative stress analysis, the peripheral blood mononuclear cells were isolated and mitochondrial superoxide anion production was measured using MitoSOX Red test. Medication adherence was evaluated based on Morisky-Green and MedTake tests. Quality of life assessment was performed using EORTC QLQ C-30 and QLQ HCC18 questionnaires. The results showed that hand-foot syndrome (45.5%), ...
Source: Anti-Cancer Drugs - April 8, 2020 Category: Cancer & Oncology Tags: Clinical Reports Source Type: research

Total tumor volume as a prognostic value for survival following liver resection in patients with hepatocellular carcinoma. Retrospective cohort study
Publication date: Available online 7 April 2020Source: Annals of Medicine and SurgeryAuthor(s): Hazem M. Zakaria, Mahmoud Macshut, Nahla K. Gaballa, Ahmed E. Sherif, Mohammed E. Abdel-Samea, Mohamed Abdel-Samiee, Ibrahim Marwan, Taha Yassein (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - April 8, 2020 Category: General Medicine Source Type: research

Covariate-adjusted analysis of the Phase 3 REFLECT study of lenvatinib versus sorafenib in the treatment of unresectable hepatocellular carcinoma
British Journal of Cancer, Published online: 08 April 2020; doi:10.1038/s41416-020-0817-7Covariate-adjusted analysis of the Phase 3 REFLECT study of lenvatinib versus sorafenib in the treatment of unresectable hepatocellular carcinoma (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 8, 2020 Category: Cancer & Oncology Authors: Andrew Briggs Bruno Daniele Katherine Dick Thomas R. Jeffry Evans Peter R. Galle Richard A. Hubner Carlos Lopez Uwe Siebert Gabriel Tremblay Source Type: research

Trillin prevents proliferation and induces apoptosis through inhibiting STAT3 nuclear  translocation in hepatoma carcinoma cells
This study demonstrated that trillin could dramatically inhibit hepatoma carcinoma cell proliferation, induce apoptosis and decrease migration and invasion through suppressing phosphorylated STAT3 translocated to nucleus. Trillin could down-regulate Bcl-2 and Survivin, up-regulate cleaved PRAP, leading to dramatically apoptosis; trillin could also down-regulate MMP1, MMP2, MucI and VEGF, which displayed an inhibition effect on hepatocellular tumor cells invasion and development. The results of this study indicated the potential utility of trillin as a STAT3 inhibitor for the treatment of cancers. (Source: Medical Oncology)
Source: Medical Oncology - April 8, 2020 Category: Cancer & Oncology Source Type: research

Zinc finger protein 703 induces EMT and sorafenib resistance in hepatocellular carcinoma by transactivating CLDN4 expression
Cell Death & Disease, Published online: 08 April 2020; doi:10.1038/s41419-020-2422-3Zinc finger protein 703 induces EMT and sorafenib resistance in hepatocellular carcinoma by transactivating CLDN4 expression (Source: Cell death and disease)
Source: Cell death and disease - April 8, 2020 Category: Internal Medicine Authors: Hao Wang Hongfa Xu Feng Ma Meixiao Zhan Xiangyu Yang Shengni Hua Wei Li Yong Li Ligong Lu Source Type: research

The efficacy and safety of sorafenib in older adults with advanced hepatocellular carcinoma: An analysis of a majority Hispanic cohort
Publication date: Available online 6 April 2020Source: Journal of Geriatric OncologyAuthor(s): Sukeshi Patel Arora, Snegha Ananth, Norma Ketchum, Jonathan Gelfond, Joel Michalek, Devalingam Mahalingam (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 7, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: mLST8 is a Prognostic Biomarker and Involved in Tumor Progression in Hepatocellular Carcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 7, 2020 Category: Cancer & Oncology Source Type: research

Semi-quantitative F-18-FDG PET/computed tomography parameters for prediction of grade in patients with renal cell carcinoma and the incremental value of diuretics
Conclusion Semi-quantitative F-18 FDG PET parameters (SUVmax, MTV and T/L) were found to be significantly correlated with Fuhrman grade in patients with RCC and are important markers for differentiation between low- and high-grade tumors. Furthermore, forced diuresis had no incremental value in characterization of primary RCC lesions. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 7, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Long Noncoding RNA RMRP Suppresses the Tumorigenesis of Hepatocellular Carcinoma Through Targeting microRNA-766
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - April 7, 2020 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Tripterine Restrains the Aggressiveness of Hepatocellular Carcinoma Cell via Regulating miRNA-532-5p/CXCL2 Axis
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - April 7, 2020 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Genome-wide CRISPR knockout screens identify ADAMTSL3 and PTEN genes as suppressors of HCC proliferation and metastasis, respectively
ConclusionsUsing both in vitro and in vivo approaches, we described the profound role of theADAMTSL3 andPTEN genes. This study indicates novel candidate targets for use in HCC treatment and therapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 7, 2020 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 12, Pages 897: Comparison between Y90 Radioembolization Plus Sorafenib and Y90 Radioembolization alone in the Treatment of Hepatocellular Carcinoma: A Propensity Score Analysis
Conclusions: The association of sorafenib does not prolong survival nor delay progression in patients treated with radioembolization. Liver toxicity does not differ among the two therapeutic schemes. (Source: Cancers)
Source: Cancers - April 7, 2020 Category: Cancer & Oncology Authors: Antonio Facciorusso Irene Bargellini Marina Cela Ivan Cincione Rodolfo Sacco Tags: Article Source Type: research

Hepatocellular Carcinoma Cells Upregulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice
Immune checkpoint inhibitors are effective in treatment of some hepatocellular carcinomas (HCCs), but these tumors do not always respond to inhibitors of programmed cell death 1 (PDCD1, also called PD1). We investigated mechanisms of resistance of liver tumors in mice to infiltrating T cells. (Source: Gastroenterology)
Source: Gastroenterology - April 7, 2020 Category: Gastroenterology Authors: David Kung-Chun Chiu, Vincent Wai-Hin Yuen, Jacinth Wing-Sum Cheu, Larry Lai Wei, Vox Ting, Michael Fehlings, Hermi Sumatoh, Alessandra Nardin, Evan W. Newell, Irene Oi-Lin Ng, Thomas Chung-Cheung Yau, Chun-Ming Wong, Carmen Chak-Lui Wong Source Type: research

A comment on the Sun et al trial 'Postoperative adjuvant IMRT for patients with HCC and portal vein tumor thrombus: An open-label randomized controlled trial'
Sun et al published an exciting randomized control trial in the November issue investigating the role of adjuvant intensity-modulated radiotherapy (IMRT) in patients after resected hepatocellular carcinoma(HCC) with portal vein tumor thrombus(PVTT)[1]. It is a relevant study targeting disease with a dismal prognosis especially when it presents with PVTT[2]. The authors did a commendable job summarizing their data and findings. However, after analyzing the trial and the results, we are curious about a few aspects which could clarify the findings of the study. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 7, 2020 Category: Radiology Authors: Kombathula Sri Harsha, Jeewan Ram Vishnoi, Puneet Pareek, Rakesh Kumar Vyas Tags: Letter to the Editor Source Type: research

Recent developments with advancing gene therapy to treat chronic infection with hepatitis B virus
Purpose of review The available vaccine and therapies against hepatitis B virus (HBV) rarely eliminate chronic infection with the virus. High mortality resulting from complicating cirrhosis and hepatocellular carcinoma makes improving anti-HBV therapy an important priority. Recent advances with using gene therapy to counter HBV have potential and are the focus of this review. Recent findings The stable replication-competent HBV intermediate comprising covalently closed circular DNA (cccDNA) is the template for expression of all viral genes. Inactivating cccDNA has thus been a focus of research aimed at achieving cure ...
Source: Current Opinion in HIV and AIDS - April 6, 2020 Category: Infectious Diseases Tags: HIV AND HEPATITIS B CURE: Edited by Sharon R. Lewin and Peter A. Revill Source Type: research

In-vitro and in-vivo models for hepatitis B cure research
Purpose of review Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research and focuses on recent developments since 2017 until today. Recent findings The field has progressed in the development of cell culture and animal models to study HBV. Although early cell culture systems relied on transfection of HBV genomes in hepatoma cell lines, novel models expressing the entry receptor...
Source: Current Opinion in HIV and AIDS - April 6, 2020 Category: Infectious Diseases Tags: HIV AND HEPATITIS B CURE: Edited by Sharon R. Lewin and Peter A. Revill Source Type: research

Population-Based Analysis of Hepatocellular Carcinoma in Children: Identifying Optimal Surgical Treatment
Hepatocellular carcinoma (HCC) constitutes 0.5% of childhood malignancies and exhibits poor prognosis. Complete tumor extirpation either by partial liver resection (LR) or liver transplantation (LT) is the only curative treatment. Due to the poor initial outcomes of LT, LR has remained the mainstay of treatment for all but select children fulfilling the Milan criteria (originally designed for adults). (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - April 6, 2020 Category: Surgery Authors: Ioannis A. Ziogas, Fei Ye, Zhiguo Zhao, Lea K. Matsuoka, Martin I. Montenovo, Manhal Izzy, Daniel J. Benedetti, Harold N. Lovvorn, Lynette A. Gillis, Sophoclis P. Alexopoulos Tags: Original Scientific Article Source Type: research

ASO Author Reflections: Minimally Invasive Surgery for Hepatocellular Carcinoma in the Setting of Portal Vein Hypertension
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

Actual long-term survival in HCC patients with portal vein tumor thrombus after liver resection: a nationwide study
AbstractBackgroundLiver resection for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) offers a chance of cure, although survival is often limited. The actual 3-year survival and its associated prognostic factors have not been reported.MethodsA nationwide database of HCC patients with PVTT who underwent liver resection with ‘curative’ intent was analyzed. The clinicopathologic characteristics, the perioperative, and survival outcomes for the actual long-term survivors were compared with the non-long-term survivors (patients who died within 3 years of surgery). Univariable and ...
Source: Hepatology International - April 6, 2020 Category: Infectious Diseases Source Type: research

Di ‐2‐picolylamine triggers caspase‐independent apoptosis by inducing oxidative stress in human liver hepatocellular carcinoma cells
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - April 6, 2020 Category: Biochemistry Authors: Thobeka Madide, Anou M. Somboro, Daniel G. Amoako, Hezekiel M. Khumalo, Rene B. Khan Tags: Original Article Source Type: research

The mechanistic, diagnostic and therapeutic novel nucleic acids for hepatocellular carcinoma emerging in past score years.
Abstract Despite The Central Dogma states the destiny of gene as 'DNA makes RNA and RNA makes protein', the nucleic acids not only store and transmit genetic information but also, surprisingly, join in intracellular vital movement as a regulator of gene expression. Bioinformatics has contributed to knowledge for a series of emerging novel nucleic acids molecules. For typical cases, microRNA (miRNA), long noncoding RNA (lncRNA) and circular RNA (circRNA) exert crucial role in regulating vital biological processes, especially in malignant diseases. Due to extraordinarily heterogeneity among all malignancies, hepatoc...
Source: Briefings in Bioinformatics - April 6, 2020 Category: Bioinformatics Authors: Zhang S, Zhou Y, Wang Y, Wang Z, Xiao Q, Zhang Y, Lou Y, Qiu Y, Zhu F Tags: Brief Bioinform Source Type: research

Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice.
This study supports that combination of systemic hypoxia and metformin treatment may represent a novel strategy for HCC. PMID: 32250393 [PubMed - as supplied by publisher] (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - April 6, 2020 Category: Biochemistry Authors: Lin H, Zhou W, Huang Y, Ren M, Xu F, Wang H Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

ASO Author Reflections: Minimally Invasive Surgery for Hepatocellular Carcinoma in the Setting of Portal Vein Hypertension.
PMID: 32253676 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - April 6, 2020 Category: Cancer & Oncology Authors: Bagante F, Tsilimigras DI, Pawlik TM Tags: Ann Surg Oncol Source Type: research

Prognostic significance of E-cadherin expression in hepatocellular carcinoma: correlations with clinical features.
Authors: Dobrescu AE, Basa SN, Cornianu M, Lazăr DC, Suciu SC, Tudor A, Viţa OC, Tarţă-Marcu DC, Barna RA, Lazăr OF Abstract BACKGROUND: Hepatocellular carcinoma (HCC) represents a major public health issue, being associated with high morbidity and mortality rates. Previous studies have demonstrated that reduction and∕or absence of E-cadherin expression is correlated with a potential for invasion and low survival rate in patients with HCC. PATIENTS, MATERIALS AND METHODS: We assessed the immunohistochemical expression of E-cadherin in 32 HCCs and peritumoral hepatic tissues using monoclonal anti-E-cadher...
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Reproducibility of LI-RADS treatment response algorithm for hepatocellular carcinoma after locoregional therapy
Publication date: Available online 3 April 2020Source: Diagnostic and Interventional ImagingAuthor(s): A.A.K. Abdel Razek, L.G. El-Serougy, G.A. Saleh, W. Shabana, R. Abd El-Wahab (Source: Diagnostic and Interventional Imaging)
Source: Diagnostic and Interventional Imaging - April 5, 2020 Category: Radiology Source Type: research

Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma
Volume 9, Issue 1, January 2020 . (Source: OncoImmunology)
Source: OncoImmunology - April 5, 2020 Category: Cancer & Oncology Authors: Fangming Liu Weiren Liu David E. Sanin Guangshuai Jia Mengxin Tian Han Wang Bijun Zhu Yan Lu Tiankui Qiao Xiangdong Wang Yinghong Shi Duojiao Wu Source Type: research

Hepatic hemangiomas: the various imaging avatars and its mimickers
AbstractHemangiomas are the most common benign tumors of the liver. These lesions are typically asymptomatic, solitary and almost always discovered incidentally, and in recent years with advances in imaging technology these lesions are being detected more frequently. Although, in majority of the cases, the imaging diagnosis of a liver hemangioma is clearly and confidently established, not all hemangiomas present with their characteristic or typical appearance on imaging. Occasionally, these lesions do present with an atypical pattern, and can be confused with other malignant lesions such as hepatocellular carcinoma, intrah...
Source: La Radiologia Medica - April 5, 2020 Category: Radiology Source Type: research

Cancers, Vol. 12, Pages 883: Biological and Clinical Significance of the CCR5/CCL5 Axis in Hepatocellular Carcinoma
Bae Singh Despite the improvement in survival for patients with liver cancer (LCa) in recent decades, only one in five patients survive for 5 years after diagnosis. Thus, there is an urgent need to find new treatment options to improve patient survival. For various cancers, including LCa, the chemokine CCL5 (RANTES) facilitates tumor progression and metastasis. Since the function of the CCR5/CCL5 interaction in LCa cell proliferation and migration is poorly understood, the present study was undertaken to investigate the role of the CCR5/CCL5 axis in these processes. Flow cytometry, RT-PCR, Western blot, and immunofl...
Source: Cancers - April 5, 2020 Category: Cancer & Oncology Authors: Singh Mishra Rivers Gordetsky Bae Singh Tags: Article Source Type: research

MiR-616 plays oncogenic role in hepatocellular carcinoma progression through suppressing PTEN expression and activating PI3K/AKT pathway.
Authors: Sa R, Song H, Wei M, Su H, Hong Y, Zhou L, Bai Y Abstract Aims: Given their regulatory roles in gene expression, microRNAs play an important role in tumorigenesis. The current study aimed to explore the function and the related mechanisms of miR-616 in hepatocellular carcinoma (HCC).Methods: The expression of miR-616 was detected using quantitative real-time polymerase chain reaction (qRT-PCR). Chi-square test was applied to estimate the association of miR-616 with clinical characteristics of HCC patients. Cell transfection was performed by Lipofectamine® 2000. MTT assay was used to detect cell prolife...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 4, 2020 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

A semi-automated workflow for adverse outcome pathway hypothesis generation: The use case of non-genotoxic induced hepatocellular carcinoma
Publication date: Available online 3 April 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Tatyana Y. Doktorova, Noffisat O. Oki, Tomaž Mohorič, Thomas E. Exner, Barry Hardy (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - April 4, 2020 Category: Toxicology Source Type: research

Uncovering the potential differentially expressed miRNAs as diagnostic biomarkers for hepatocellular carcinoma based on machine learning in The Cancer Genome Atlas database.
In conclusion, the five differentially expressed miRNAs may be considered as diagnostic biomarkers for patients with hepatocellular carcinoma. In addition, the differential expression levels of the targets of these five mRNAs, including SFRP1, EDNRB, NR4A3, FHL2, NKX3‑1, IL6ST and FOXO1, may be involved in hepatocellular carcinoma tumorigenesis. PMID: 32236623 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 4, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibitory effect of therapeutic genes, cytosine deaminase and interferon ‑β, delivered by genetically engineered stem cells against renal cell carcinoma.
Inhibitory effect of therapeutic genes, cytosine deaminase and interferon‑β, delivered by genetically engineered stem cells against renal cell carcinoma. Oncol Rep. 2020 Mar 30;: Authors: Kim GS, Kim SM, Kim SU, Lee G, Choi KC Abstract Although the effects of stem cells expressing anticancer genes on tumor growth have been demonstrated by many researchers in various types of cancer, relatively few studies have investigated their inhibitory effects on cancer metastasis. In the present study, we examined the inhibitory effects of cytosine deaminase (CD)/5‑fluorocytosine (5‑FC) and interferon...
Source: Oncology Reports - April 4, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth.
miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth. Mol Med Rep. 2020 Mar 30;: Authors: Wang J, Li Y, Ma Q, Huang J Abstract Ultrasonic microbubbles in combination with microRNA (miRNAs/miRs) exhibited promising effects on cancer treatments. The aim was to investigate the role of miR‑378 in hepatoma cells and the efficiency of it in combination with ultrasonic irradiation and SonoVue® microbubbles method for cell transfection. HuH‑7, Hep3B and SK‑Hep1 cells were transfected with an miR‑378 mimic using only Lipofectamine&r...
Source: Molecular Medicine Reports - April 4, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mucinous cystic neoplasm of the liver communicated with intrahepatic duct exhibiting peculiar chronological change in MR imaging appearances: a case report
AbstractA 70-year-old woman has been followed up for chronic hepatitis C and hepatocellular carcinoma which had been successfully controlled by several sessions of radiofrequency ablation. A small cystic lesion in segment IV associated with adjacent intrahepatic duct dilatation was firstly noted 4  years before on MR imaging, which showed gradual increase in size and significant interval change in the MRI signal intensity of the cystic content on the follow-up examinations. The mass finally reached 4 cm in its largest dimension, associated with slightly enhancing thickened wall, suggesting its neoplastic nature. ...
Source: Abdominal Imaging - April 4, 2020 Category: Radiology Source Type: research

Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis
AbstractIt has been established that ZFP36 (also known as Tristetraprolin or TTP) promotes mRNA degradation of proteins involved in inflammation, proliferation and tumor invasiveness. In mammary epithelial cellsZFP36 expression is induced by STAT5 activation during lactogenesis, while in breast cancerZFP36 expression is associated with lower grade and better prognosis. Here, we show that the AP-1 transcription factor components, i.e.JUN, JUNB, FOS, FOSB, in addition toDUSP1, EGR1, NR4A1,IER2 andBTG2, behave as a conserved co-regulated group of genes whose expression is associated toZFP36 in cancer cells. In fact, a signifi...
Source: Journal of Mammary Gland Biology and Neoplasia - April 4, 2020 Category: Cancer & Oncology Source Type: research

Prognostic model for identifying candidates for hepatectomy among patients with hepatocellular carcinoma and hepatic vein invasion.
rative Group for Diagnosis and Treatment of Hepatocellular Carcinoma with Tumour Thrombus Abstract BACKGROUND: Hepatic vein tumour thrombus (HVTT) is a major determinant of survival outcomes for patients with hepatocellular carcinoma (HCC). An Eastern Hepatobiliary Surgery Hospital (EHBH)-HVTT model was established to predict the prognosis of patients with HCC and HVTT after liver resection, in order to identify optimal candidates for liver resection. METHODS: Patients with HCC and HVTT from 15 hospitals in China were included. The EHBH-HVTT model with contour plot was developed using a non-linear model in th...
Source: The British Journal of Surgery - April 4, 2020 Category: Surgery Authors: Zhang XP, Wang K, Gao YZ, Wei XB, Lu CD, Chai ZT, Zhen ZJ, Li J, Yang DH, Zhou D, Fan RF, Yan ML, Xia YJ, Liu B, Huang YQ, Zhang F, Hu YR, Zhong CQ, Lin JH, Fang KP, Cheng ZH, Wu MC, Lau WY, Chen SQ,  on behalf of the Chinese National Research Cooperati Tags: Br J Surg Source Type: research

Reactive oxygen species generation and mitochondrial dysfunction for the initiation of apoptotic cell death in human hepatocellular carcinoma HepG2 cells by a cyclic dipeptide Cyclo(-Pro-Tyr).
This study was aimed to investigate the anticancer activity of a dipeptide Cyclo(-Pro-Tyr) (DP) identified from marine sponge Callyspongia fistularis symbiont Bacillus pumilus AMK1 and the underlying apoptotic mechanisms in the liver cancer HepG2 cell lines. MTT assay was done to demonstrate the cytotoxic effect of DP in HepG2 cells and mouse Fibroblast McCoy cells. Initially, apoptosis inducing activity of DP was identified using propidium iodide (PI) and acridine orange/ethidium bromide (AO/EB) dual staining, then it was confirmed by DNA fragmentation assay and western blotting analysis of apoptosis related markers Bax, ...
Source: Molecular Biology Reports - April 4, 2020 Category: Molecular Biology Authors: Karanam G, Arumugam MK Tags: Mol Biol Rep Source Type: research

CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population.
Abstract The cell division cycle 25 (CDC25) gene members, including CDC25A, CDC25B and CDC25C, are reported to be associated with several human cancers. Here, we aim to investigate the association of functional polymorphisms of CDC25 gene family with the risk of hepatocellular carcinoma (HCC) and persistent infection of Hepatitis B virus (HBV) in a Chinese HBV-related population. First, we used bioinformatics tools to systematically screen functional polymorphisms within CDC25 gene family. Second, we evaluated the effects of candidate polymorphisms by recruiting 790 HCC cases, 709 persistent HBV carriers (PHC), an...
Source: Molecular Biology Reports - April 4, 2020 Category: Molecular Biology Authors: Wang P, Peng J, Gong Y, Shen N Tags: Mol Biol Rep Source Type: research

Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2.
Abstract Decreased chemosensitivity among tumor cells is often an obstacle in cisplatin (Cis) chemotherapy. Overexpression of multidrug resistance-associated protein 2 (MRP2) is a key mechanism underlying decreased Cis chemosensitivity and resistance. Astragaloside IV (AS IV) is an important component derived from the well-known traditional Chinese herb Astragalus membranaceus. The aim of this study was to explore the role of AS IV in enhancing the antitumor effect of Cis by suppressing MRP2 expression in HepG2 cells and H22 tumor-bearing mice. After co-treatment of HepG2 cells with Cis and AS IV, we assessed the ...
Source: European Journal of Pharmaceutical Sciences - April 4, 2020 Category: Drugs & Pharmacology Authors: Qu X, Gao H, Zhai J, Sun J, Tao L, Zhang Y, Song Y, Hu T Tags: Eur J Pharm Sci Source Type: research

ALBI versus Child-Pugh in predicting outcome of patients with HCC: A systematic review.
Authors: Peng Y, Wei Q, He Y, Xie Q, Liang Y, Zhang L, Xia Y, Li Y, Chen W, Zhao J, Chai J Abstract Introduction: Hepatocellular carcinoma (HCC) is an aggressive tumor type which results in poor prognosis. ALBI and Child-Pugh score have been widely applied for predicting prognosis in patients with liver diseases. We conducted a systematic review to compare the prognostic ability of ALBI versus Child-Pugh in HCC patients.Areas covered: PubMed, EMBASE and Cochrane Library were explored. The data were extracted from every study. Studies investigating HCC patients and comparing the predicting ability between ALBI and C...
Source: Expert Review of Gastroenterology and Hepatology - April 3, 2020 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Platelet-albumin-bilirubin score - a predictor of outcome of acute variceal bleeding in patients with cirrhosis.
CONCLUSION: PALBI score on admission is a good prognostic indicator for patients with acute variceal bleeding and predicts early mortality and rebleeding. PMID: 32231763 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 3, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells.
Authors: Ghazali R, Mehta KJ, Bligh SA, Tewfik I, Clemens D, Patel VB Abstract BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide and is a growing epidemic. A high ratio of omega-6 fatty acids to omega-3 fatty acids in the diet has been implicated in the development of NAFLD. However, the inflicted cellular pathology remains unknown. A high ratio may promote lipogenic pathways and contribute to reactive oxygen species (ROS)-mediated damage, perhaps leading to mitochondrial dysfunction. Therefore, these parameters were investigated to understand their contribution to N...
Source: World Journal of Hepatology - April 3, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Influence of Interferon-free Direct-acting Antiviral Therapy on Primary Hepatocellular Carcinoma Recurrence: A Landmark Time Analysis and Time-dependent Extended Cox Proportional Hazards Model Analysis.
Conclusion Our results, with a consideration of the time interval between HCC curative treatment and IFN-free DAA induction, showed that IFN-free DAA therapy was not associated with early-stage HCC recurrence after curative treatment. PMID: 32238660 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - April 3, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research