ChatGPT In Healthcare: What Science Says
This study demonstrates that ChatGPT, a large language model, can assist in radiologic decision-making at the point of care, achieving moderate to high accuracy in determining appropriate imaging steps for breast cancer screening and breast pain evaluation, although limitations of the model, such as misalignment and “hallucinations”, must be considered when designing clinically-oriented prompts for use with large language models.Analysis of large-language model versus human performance for genetics questionsMedrxivThe use of language models like ChatGPT in clinical genetics has the potential to provide rapid an...
Source: The Medical Futurist - May 25, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Artificial Intelligence in Medicine ChatGPT digital health large language models ChatGPT in healthcare AI in healthcare AI in medicine Source Type: blogs
Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Optical Biopsy to Spot Tumors Among Healthy Tissue
Researchers at Orel State University in Russia have developed a biopsy system that can distinguish between healthy and cancerous tissue in many clinical cases. The device is designed to address the difficulties that clinicians may experience when trying to obtain a biopsy of a liver tumor, where it can be difficult to know if the needle is in the correct location with small, early-stage tumors. The system uses a combination of lifetime fluorescence measurements and diffuse reflectance spectroscopy to identify a tumor.
Obtaining a tumor biopsy is an important first step in identifying its characteristics, allowing clinic...
Source: Medgadget - January 12, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Pathology Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 5th 2021
In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences.
Heart Failure Correlates with Increased Cancer Risk
https://www.fightaging.org/archives/2021/07/heart-failure-correlates-with-increased-cancer-risk/
Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a...
Source: Fight Aging! - July 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cau...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Mitochondrial Replacement Therapies
A great deal of evidence shows that declining mitochondrial function is important to the aging process. This is directly downstream of various forms of damage, such as to mitochondrial DNA. It is also long way downstream to other forms of age-related disarray that lead to epigenetic changes that impact mitochondrial function - far enough downstream that it is unclear as to how exactly the causes of aging produce this outcome. One common view is that the quality control process of mitophagy suffers as the result of reduced production of necessary proteins, and thus damaged mitochondria accumulate.
Thus we come to mit...
Source: Fight Aging! - May 24, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Stomach Cancer Stage 4 Treatment
Stomach cancer stage 4 is a complex diagnosis. It is the stage of cancer that requires specific treatment options.
Is surgery an option for patients with stomach cancer stage 4?
Stage 4 stomach cancer is characterized by rapid tumor growth, metastasizing to regional lymph nodes and distant organs (liver, bones, pancreas, less often lungs). With the development of metastases in other organs, characteristic symptoms occur such as jaundice and liver failure with liver damage, ascites with metastases in the peritoneum, bowel obstruction with metastases in the small intestine, etc.
Therefore, at the advanced stages, ga...
Source: PickTheBrain | Motivation and Self Improvement - January 22, 2021 Category: Consumer Health News Authors: Booking Health Tags: health and fitness self-improvement cancer stomach cancer treatment Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Hepatitis A in the United States
Few Americans are aware of a major epidemic that has taken hold of large areas of their country in recent years – by a disease that is easily diagnosed and prevented. Sadly, public – and even professional interest in these events have been overshadowed by COVID-19.
AN UPTICK IN CASES
Hepatitis A had been largely under control until three years ago and can be easily prevented through the use of a safe and effective vaccine.
From January 2017 to January 2019, at least 26 separate outbreaks were reported, to a total of 11,628 cases and 99 deaths, nationwide. Homeless individuals and users of illicit dru...
Source: GIDEON blog - October 21, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Outbreaks Source Type: blogs
Non-Alcoholic Fatty Liver Disease as the Marker of a Lifestyle that Shortens Life Span
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest. (Source: Fight Aging!)
Source: Fight Aging! - October 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Renaissance Radiologists: Meet AJ Gunn, MD
AJ Gunn, M.D. graduated magna cum laude from Brigham Young University in Provo, UT, earning a BS in exercise physiology with a minor in sociology. He then returned home to South Dakota to attend medical school at the University of South Dakota. During medical school, he participated in the competitive Howard Hughes Medical Institute – National Institutes of Health Research Scholars Program and was awarded the Donald L. Alcott, M.D. Award for Clinical Promise. He graduated summa cum laude in 2009. He completed his diagnostic radiology residency at the Massachusetts General Hospital of Harvard Medical School in Boston, MA ...
Source: radRounds - February 21, 2020 Category: Radiology Authors: Robin Pine Miles Source Type: blogs
Renaissance Rad Feature: Meet AJ Gunn, MD
AJ Gunn, M.D. graduated magna cum laude from Brigham Young University in Provo, UT, earning a BS in exercise physiology with a minor in sociology. He then returned home to South Dakota to attend medical school at the University of South Dakota. During medical school, he participated in the competitive Howard Hughes Medical Institute – National Institutes of Health Research Scholars Program and was awarded the Donald L. Alcott, M.D. Award for Clinical Promise. He graduated summa cum laude in 2009. He completed his diagnostic radiology residency at the Massachusetts General Hospital of Harvard Medical School in Boston, MA ...
Source: radRounds - February 21, 2020 Category: Radiology Authors: Robin Pine Miles Source Type: blogs
TriNav System Uses Pressure to Push Drugs into Solid Tumors
TriSalus, a Denver, Colorado firm, is launching a new solid tumor infusion system to target hepatocellular carcinoma, liver metastases, and other tumors. The TriNav Infusion System features the company’s SmartValve and Pressure-Enabled Drug Delivery (PEDD) technologies to get more of the tumor killing drug inside the diseased tissue.
The treatment is delivered in a similar manner as many existing intravascular procedures, as the device is compatible with common cath lab tools (0.035-inch and 0.038-inch standard angiographic catheters) and is easy to track through the vasculature because of a single-body design.
...
Source: Medgadget - January 15, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Oncology Radiology Source Type: blogs
Fight Aging! Newsletter, July 29th 2019
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD.
Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - July 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
