Fight Aging! Newsletter, May 31st 2021

In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD. Cell Signaling via Exosomes in the Development of Vascular Calcification https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/ Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cause harm via their signaling, a good fraction of which is carried via forms of extracellular vesicle, such as exosomes. Here, researchers review what is known of the signaling that may be involved in changing the behavior of cells towards calcification processes. Whether or not it is necessary to understand all of this in order to find a way to block calcification is an interesting question: how much benefit will be produced by reducing inflammation and clearing senescent cells? If a sizable fraction of the problem remains, then a greater understanding will likely be required for further progress. Vascular calcification (VC) is the abnormal deposition of calcium, phosphorus, and other minerals in the vessel wall in the form of hydroxyapatite. Over 60% of elderly people have calcium salt deposits in the vascular walls, and VC is closely associated with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Discussion The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations. Due to their important interactions in ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
lzania Marialuisa Zedde Patent Foramen Ovale (PFO) is a common postnatal defect of cardiac atrial septation. A certain degree of familial aggregation has been reported. Animal studies suggest the involvement of the Notch pathway and other cardiac transcription factors (GATA4, TBX20, NKX2-5) in Foramen Ovale closure. This review evaluates the contribution of genetic alterations in PFO development. We systematically reviewed studies that assessed rare and common variants in subjects with PFO. The protocol was registered with PROSPERO and followed MOOSE guidelines. We systematically searched English studies reporting ra...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
European Journal of Human Genetics, Published online: 06 December 2021; doi:10.1038/s41431-021-01011-830 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
Source: European Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
STATINS are a commonly prescribed medication for people at risk of heart attacks or who have had heart attacks previously. Serious side effects are exceedingly rare.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
NEW BRUNSWICK, N.J., DECEMBER 5, 2021 – Johnson &Johnson (NYSE: JNJ) (the Company) today announced preliminary results from an independent study, including a subset of participants from the Janssen-sponsored COV2008 study, conducted by Dan Barouch, M.D., Ph.D., et al. of Beth Israel Deaconess Medical Center (BIDMC), which showed that a booster shot of the Johnson &Johnson COVID-19 vaccine (Ad26.COV2.S), administered at six months after a two-dose primary regimen of BNT162b2, increased both antibody and T-cell responses. These results demonstrate the potential benefits of heterologous boosting (mix-and-match)....
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
A STROKE is a medical emergency and urgent treatment is essential. There are fortunately several ways to reduce your risk.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Classified American intelligence reports suggest China intends to establish a military installation in Equatorial Guinea, a move that would give Beijing its first permanent naval presence on the... #equatorialguinea #atlanticcoast #atlanticocean
Source: Reuters: Health - Category: Consumer Health News Source Type: news
STOMACH cancer can often go undetected. Early symptoms of stomach cancer can be like symptoms of common stomach conditions.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
STATINS are one of the most commonly prescribed drugs in the UK by around 8 million adults. They became available in the late 1980s, and there have been several reported side effects.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Russian President Vladimir Putin has voiced hope for a quick approval of the country’s Sputnik V coronavirus vaccine by the World Health Organization, saying the move is essential for expanding its global supplies
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
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