Why a case report being circulated by advocates doesn't show that the ketogenic diet combats cancer
In conclusion, this combined metabolic approach appears effective in treating advanced TNBC, given this patient’s complete response with a good quality of life.Now, there is one thing that is interesting here. The doses of chemotherapy used were considerably lower thanwhat is usually used, with doses decreased by at least half or more. Does this mean anything? Who knows? cPR rates for TNBC have been reported to range from 20-35%. It could mean the regimen made the chemotherapy more effective, or it could mean that this woman just happened to have a particularly chemosensitive tumor. Even if we take this case report at fa...
Source: Respectful Insolence - October 4, 2017 Category: Surgery Authors: oracknows Source Type: blogs
Why a case report being circulated by advocates doesn't show that the ketogenic diet combats cancer
In conclusion, this combined metabolic approach appears effective in treating advanced TNBC, given this patient’s complete response with a good quality of life.Now, there is one thing that is interesting here. The doses of chemotherapy used were considerably lower thanwhat is usually used, with doses decreased by at least half or more. Does this mean anything? Who knows? cPR rates for TNBC have been reported to range from 20-35%. It could mean the regimen made the chemotherapy more effective, or it could mean that this woman just happened to have a particularly chemosensitive tumor. Even if we take this case report at fa...
Source: Respectful Insolence - October 4, 2017 Category: Surgery Authors: oracknows Source Type: blogs
One ‐Step Multigram‐Scale Biomimetic Synthesis of Psiguadial B
AngewchemOne ‐Step Multigram‐Scale Biomimetic Synthesis of Psiguadial B: A gram ‐scale synthesis of psiguadial B, a purported inhibitor of human hepatoma cell growth, has been achieved in one step by a biomimetic three‐component coupling of caryophyllene, benzaldehyde, and diformylphloroglucinol.... (Source: Organometallic Current)
Source: Organometallic Current - September 27, 2017 Category: Chemistry Tags: Natural products Total synthesis Source Type: blogs
Fight Aging! Newsletter, August 28th 2017
In conclusion, CAVD is highly prevalent. Long understood as a passive process, it is now known to be complex and one which involves pathophysiological mechanisms similar to those of atherosclerosis. Understanding these mechanisms could help to establish new therapeutic targets that might allow us to halt or at least slow down the progression of the disease.
Early Steps in the Tissue Engineering of Intervertebral Discs
https://www.fightaging.org/archives/2017/08/early-steps-in-the-tissue-engineering-of-intervertebral-discs/
In this paper, researchers report on progress towards the manufacture of interve...
Source: Fight Aging! - August 27, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The 2017 Summer Scholars Working at the SENS Research Foundation
Each year, the SENS Research Foundation accepts a group of young life science academics and puts them to work on projects in aging research, both at the foundation and in allied laboratories, creating ties between research groups that can help to advance the state of the art. This year's batch has worked on a diverse set of projects that spread out beyond core SENS initiatives such as allotopic expression of mitochondrial genes. Reading through their projects is a reminder that a great deal can be accomplished these days given a small team, a little funding, and an equipped laboratory. Progress in medical research is no lo...
Source: Fight Aging! - August 26, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Rapid Hepatocellular Carcinoma Test Can be Administered Anywhere
Researchers at the University of Utah have developed a rapid and highly portable liver cancer screening test, that can be administered anywhere.
One of the biggest challenges in treating liver cancer is that often symptoms don’t appear until the disease is in the later stages, meaning it is important that people are tested rapidly when doctors suspect they might have it. At the moment, testing for liver cancer involves sending a blood sample to a hospital lab, which could take weeks to return the results. The testing also typically requires patients to undergo ultrasound imaging, which is difficult for people living in r...
Source: Medgadget - August 25, 2017 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics GI Oncology Pathology Source Type: blogs
Fight Aging! Newsletter, June 12th 2017
In this study, we focused on two pathways of cardiomyocytes or heart cells: the Hippo pathway, which is involved in stopping renewal of adult cardiomyocytes, and the dystrophin glycoprotein complex (DGC) pathway, essential for cardiomyocyte normal functions."
Previous work had hinted that components of the DGC pathway may somehow interact with members of the Hippo pathway. The researchers genetically engineered mice to lack genes involved in one or both pathways, and then determined the ability of the heart to repair an injury. These studies showed for the first time that dystroglycan 1, a component of the DGC pathw...
Source: Fight Aging! - June 11, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Top Companies in Genomics
From portable genome sequencers until genetic tests revealing distant relations with Thomas Jefferson, genomics represents a fascinatingly innovative area of healthcare. As the price of genome sequencing has been in free fall for years, the start-up scene is bursting from transformative power. Let’s look at some of the most amazing ventures in genomics!
The amazing journey of genome sequencing
Genome sequencing has been on an amazing scientific as well as economic journey for the last three decades. The Human Genome Project began in 1990 with the aim of mapping the whole structure of the human genome and sequencing it. ...
Source: The Medical Futurist - May 30, 2017 Category: Information Technology Authors: nora Tags: Genomics Personalized Medicine AI artificial intelligence bioinformatics cancer DNA dna testing DTC gc3 genetic disorders genetics genome sequencing personal genomics precision medicine Source Type: blogs
A Demonstration in Mice of Whole Mitochondria Delivered as a Therapy
Mitochondria, the swarming power plants of the cell, become damaged and dysfunctional with age. Can this be addressed by delivering complete, whole, new mitochondria as a therapy? There have been signs in past years that cells can ingest and incorporate mitochondria from the surrounding environment, but few useful demonstrations to show whether or not this is common in living tissues. In the research here, researchers achieve that result, delivering mitochondria into tissues as a therapy, and using this approach to treat an animal model of Parkinson's disease. This neurodegenerative condition is associated with degraded mi...
Source: Fight Aging! - March 7, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Suddenly Everyone is Casting their Views of Aging in Terms of Cellular Senescence
I exaggerate in the title of this post, of course, but there is some truth in it. Certainly, a lot more attention is focused on the phenomenon of cellular senescence now that mouse life spans have been extended and aspects of aging have been reversed via clearance of senescent cells. The existence of several startup biotechnology companies aiming to bring senescent cell clearance treatments to the clinic is shining even more of a spotlight on this area. It has been something of a transformation. Five years ago, one of the few groups of researchers interested in this field struggled greatly to raise the funding for the pivo...
Source: Fight Aging! - November 17, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reduced Levels of Myc Regulator Mtbp Modestly Extend Life in Mice
Despite the fact that we stand within reach of human rejuvenation, to be achieved through repair of the known forms of biological damage that cause aging, the majority of research into aging and longevity has next to nothing to do with that goal. It is instead a slow and painstaking process of mapping, an attempt to understand how exactly cellular biology produces aging, at the detailed level of genes and protein interactions. It takes years of work to obtain a useful amount of new information about the role of one specific gene, and there are thousands of genes of interest, formed into networks. There are many ways to inf...
Source: Fight Aging! - November 5, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Making Hepatitis C A Rare Disease In The United States
New breakthrough medicines for Hepatitis C present an important choice about setting goals and taking systemic action to achieve public health advances in the United States. Despite appearing to offer cure rates greater than 90 percent, high-priced Hepatitis C drugs have driven treatment rationing since their approval over two years ago. Gaps in the screening, diagnosis, and treatment of Hepatitis C pose significant public health consequences.
In May, the Centers for Disease Control and Prevention (CDC) identified Hepatitis C as the leading infectious killer in the United States in 2014—the first year in which new me...
Source: Health Affairs Blog - June 15, 2016 Category: Health Management Authors: Victor Roy, Dave Chokshi, Stephen Kissler and Prabhjot Singh Tags: Costs and Spending Drugs and Medical Technology Equity and Disparities Featured Global Health Population Health Public Health Gilead hepatitis C Sovaldi Source Type: blogs
Interview with Thomas London
A major new feature of the fourth edition of Principles of Virology is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology. These in-depth interviews provide the background and thinking that went into the discoveries or observations connected to the concepts being taught in this text. Students will discover the personal stories and twists of fate that led the scientists to work with viruses and make their seminal discoveries.
For the chapter on Infections of Populations, Vincent spoke with Thomas London, MD, of the Fox Chase Cancer Center, about h...
Source: virology blog - April 18, 2016 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information Fox Chase Cancer Center hepadnavirus hepatitis b virus hepatocellular carcinoma Principles of Virology textbook Thomas London video viral viruses Source Type: blogs
Highly effective HCV treatment: once daily oral Sofosbuvir/Velpatasvir
The hepatitis C virus (HCV), a single-stranded RNA virus of the family Flaviviridae with six major genotypes, infects up to 150 million people worldwide. Chronic hepatitis C virus infection causes progressive liver fibrosis, which can lead to cirrhosis and hepatocellular carcinoma. There is now an effective oral regimen. New research findings are summarized in this short video from NEJM: This is a ribavirin-free single-tablet regimen. There 2 medications in the single tablet:- Sofosbuvir is a nucleotide analogue inhibitor of the HCV NS5B polymerase approved for the treatment of HCV in combination with a variety of other ag...
Source: Clinical Cases and Images - Blog - January 1, 2016 Category: Universities & Medical Training Tags: Gastroenterology NEJM Source Type: blogs
Infant Dies Following 5 Vaccine Doses
Life after losing a loved one to vaccines is very painful. With a heavy heart, we share Sebastian Ryan Morley’s story. He was a healthy boy whose life ended after routine vaccinations. Sebastian’s mother and grandmother have worked many years in both the veterinary and human healthcare fields. What they were taught in school led them to believe vaccines were safe, but now they will never vaccinate again. We thank his family for coming forward and sharing very important information the public isn’t usually made aware of.
Sebastian’s grandmother, Valerie Murfin, shared:
“On December 11, 2002, when my grandson Sebas...
Source: vactruth.com - September 5, 2015 Category: Allergy & Immunology Authors: Augustina Ursino Tags: Augustina Ursino Human Top Stories adverse reactions dtap Hepatitis B vaccine Sebastian Ryan Morley truth about vaccines Vaccine Death vaccine injury VAERS Valerie Murfin Source Type: blogs
