Making Hepatitis C A Rare Disease In The United States

New breakthrough medicines for Hepatitis C present an important choice about setting goals and taking systemic action to achieve public health advances in the United States. Despite appearing to offer cure rates greater than 90 percent, high-priced Hepatitis C drugs have driven treatment rationing since their approval over two years ago. Gaps in the screening, diagnosis, and treatment of Hepatitis C pose significant public health consequences. In May, the Centers for Disease Control and Prevention (CDC) identified Hepatitis C as the leading infectious killer in the United States in 2014—the first year in which new medicines for the disease were available—claiming more lives (nearly 20,000) than 60 other infectious diseases, including HIV/AIDS, pneumococcal disease, and tuberculosis, combined. However, recent steps have improved the prospects for many patients waiting for treatment. In March, the Veterans Affairs department announced access to Hepatitis C medicines for all patients regardless of disease stage. Last month, New York State Medicaid also lifted treatment restrictions. A newly organized Institute of Medicine committee on viral hepatitis proclaimed in its interim April report that the “elimination of hepatitis C as a public health problem in the United States is feasible.” Notably, the committee stopped short of setting a national goal for the elimination of Hepatitis C, as they continue to study the challenge for their final report due in 20...
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Costs and Spending Drugs and Medical Technology Equity and Disparities Featured Global Health Population Health Public Health Gilead hepatitis C Sovaldi Source Type: blogs

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In conclusion, this review reported that IL-37 has a crucial role in reducing infection-associated inflammation and has a good impact on inflammation-induced pathology. However, tight regulation that achieved balance between effector immune responses that required for pathogen elimination and limited tissue damage that resulted from excessive inflammation should be existed in the potential IL-37 therapy to prevent clinical complications of a disease. PMID: 31633447 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
ConclusionRRA must be initiated within 58 days after surgery in patients with high-risk DTCs. Under this approach, risk of SIR and associated mortality risk may be reduced. RRA timing for women in reproductive ages with low/intermediate risk groups may be planned according to their pregnancy/breastfeeding intent. For other low/intermediate risk groups, they can safely proceed according to the capacity of the medical facility and related logistical considerations.ResumenIntroducciónEs difícil adoptar un enfoque científico basado en la evidencia con respecto al intervalo de aplicación de la ablaci...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
ConclusionResults of our study revealed that raw and the standard scores of stereotyped behaviors was notably (p
Source: IRBM - Category: Biomedical Engineering Source Type: research
Publication date: Available online 22 October 2019Source: Journal of Food EngineeringAuthor(s): Jiyoon Yi, Kang Huang, Glenn M. Young, Nitin NitinAbstractCross-contamination of fresh produce during postharvest processing could be a significant risk factor that can lead to foodborne outbreaks. The aim of this study was to simulate cross-contamination from a contaminated lettuce to non-contaminated leaves/abiotic surfaces (glass, polyethylene), quantify the bacterial transfer efficiency to determine the influences of contact time, number of repeated contacts, and applied contact force, and evaluate the influences of surface ...
Source: Journal of Food Engineering - Category: Food Science Source Type: research
Authors: Mostafa WSEM, Al-Dahr MHS, Omran DAH, Abdullah ZF, Elmasry SAH, Ibrahim MN Abstract Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients. This work aimed to elucidate the role of promoter methylation (PM) in response to antiviral therapy, and its contribution to the development of fibrosis through hepatocarcinogenesis-related genes. A total of 159 chronic hepatitis Egyptian patients versus 100 healthy control group were included...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Publication date: Available online 22 October 2019Source: Journal of Theoretical BiologyAuthor(s): María del Valle Rafo, Juan Pablo AparicioAbstractNetwork models for disease transmission and dynamics are popular because they are among the simplest agent-based models. Highly heterogeneous populations (in the number of contacts) may be modeled by networks with long-tailed degree distributions for which the variance is much greater than the mean degree. An example is given by scale-free networks where the degree distribution follows a power law. In these type of networks there is not a typical degree. Some nodes may h...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Conclusion: Composite lymphomas pose a particular diagnostic challenge, and currently there are no agreed standards for treatment (4). PMID: 31633478 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
[Global Fund] Lyon, France -At the opening of the Sixth Replenishment conference, the Global Fund announced a range of private sector partners that will spur innovation to accelerate the end to HIV, tuberculosis and malaria, the world's deadliest infectious diseases.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Global Fund] Geneva -Efforts to find and treat people with tuberculosis are showing remarkable progress, with 7 million people with TB found globally in 2018, including 600,000 more people than in 2017.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
ConclusionHepatitis C presents a high burden of disease in the countries under study, and its management imposes significant costs on health systems.ResumenObjetivoLa infección crónica por el virus de la hepatitis C (VHC) es una de las principales causas de cirrosis y carcinoma hepatocelular (CHC) en el mundo. El objetivo fue describir la epidemiología, el consumo de recursos y los costos relevantes en el manejo de la hepatitis C en cuatro países latinoamericanos: Argentina, Colombia, Uruguay y Venezuela.Diseño del estudioRevisión bibliográfica, estudio de costos y opini&oac...
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
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