Last Month in Oncology with Dr. Bishal Gyawali: April 2019
By BISHAL GYAWALI, MD
Keynote speech on the JAVELIN not going far enough to improve survival
The treatment landscape for metastatic renal-cell carcinoma has changed dramatically with the introduction of immunotherapies. Unfortunately though, we are promoting combinations over single agents without having much idea of added benefit of each drug. This is an important issue because when we combine two drugs, the only thing we are certain of are the added toxicities. PD-1 inhibitor nivolumab had improved OS when given in second line, however nivolumab was tested in combination with ipilimumab (not as a nivolumab monother...
Source: The Health Care Blog - May 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Bishal Gyawali Clinical Trials Oncology PD-1 inhibitor Source Type: blogs
Hepatocellular Carcinoma : Triple Phase CT
Presenting brief teaching video under the DAMS Unplugged series on HCC and imaging features.Famous Radiology Blog http://www.sumerdoc.blogspot.com
TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - December 27, 2018 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Hepatocellular carcinoma risk, cirrhosis and hepatitis C
High profile public health strategy needed Related items fromOnMedica Overweight teens more likely to have severe liver disease later Scotland reveals target of halving child obesity by 2030 JCVI recommends universal HPV vaccination Lower cancer risk in people with higher vitamin D levels Public drastically underestimates cannabis risks (Source: OnMedica Blogs)
Source: OnMedica Blogs - December 3, 2018 Category: General Medicine Source Type: blogs
Fight Aging! Newsletter, August 13th 2018
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response.
In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - August 12, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Will Increased Understanding of Cellular Senescence Lead to an End to Cancer?
Selective destruction of senescent cells in old tissues offers the promise of some degree of rejuvenation, coupled with effective therapies for a range of age-related diseases that currently cannot be controlled. In the past few years, a number of companies have raised venture funding for the development of senolytic therapies, those capable of removing some portion of senescent cells with an acceptable side-effect profile. The potential market is enormous, and thus despite the many potential competitors, any new mechanism by which senescent cells can be destroyed might be the pathway to success and revenue for the individ...
Source: Fight Aging! - August 6, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Insurance denials: the law of the land
It all started out with Malaysian methimazole, and didn’t end until two highly trained medical professionals sat on opposite ends of a telephone call, scratching their heads and wondering how two digits being transposed could lead to so many problems.
Those two transposed digits caused a thyroid uptake scan to become a bone marrow scan (whatever that is). But look at all it took to get there.
Mystery illness, mystery medicine
It started when a new patient came to see one of my colleagues with a mystery illness, and a medication in a pill bottle with a label in another language.
After figuring out what this medicine w...
Source: Kevin, M.D. - Medical Weblog - May 7, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/fred-n-pelzman" rel="tag" > Fred N. Pelzman, MD < /a > Tags: Physician Primary Care Source Type: blogs
Eponymythology: Atraumatic Abdominal Ecchymosis
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Overview
We review the original descriptions of 5 eponymous signs (n=6) associated with non-traumatic abdominal ecchymosis.
These commonly cited eponyms involving the abdominal wall and flanks (Grey Turner, Cullen and Stabler); scrotum (Bryant) and upper thigh (Fox) may be useful clues directing the examiner to consider potentially serious causes of abdominal pathology.
Cullen sign
Thomas Stephen Cullen (1869–1953) was a Canadian gynecologist
Non-traumatic peri-um...
Source: Life in the Fast Lane - April 18, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Eponymythology Abdominal Ecchymosis Bryant sign Cullen sign fox sign Francis Edward Stabler George Grey Turner Grey Turner sign John Adrian Fox John Henry Bryant Stabler sign Thomas Stephen Cullen Source Type: blogs
MKSAP: 57-year-old man with chronic hepatitis C infection
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 57-year-old man is evaluated during a routine examination. His medical history is notable for chronic hepatitis C infection with cirrhosis, which was diagnosed 3 years ago. He undergoes surveillance ultrasound for hepatocellular carcinoma every 6 months.
On physical examination, temperature is 36.8 °C (98.2 °F), blood pressure is 110/82 mm Hg, pulse rate is 65/min, and respiration rate is 18/min; BMI is 22. Muscle wasting and scleral icterus are noted. There is no flank dullness and no asterixis.
Ultrasound ...
Source: Kevin, M.D. - Medical Weblog - March 31, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Tropical Travel Trouble 005 RUQ Pain and Jaundice
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 005
Guest Post: Dr Branden Skarpiak – Global Health Fellow, Department of Emergency Medicine. UT Health San Antonio
A 35 year old male presents to your emergency room for right upper quadrant pain that has gotten worse over the last 2-3 days. He also describes associated nausea, vomiting, and fevers. He denies other abdominal pain, or change in his bowel or bladder habits. His wife notes that he has started to “look more yellow” recent...
Source: Life in the Fast Lane - March 19, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine amebic amoeba amoebiasis amoebic dysentery amoebic liver abscess bloody diarrhoea e.dispar e.histolytica entamoeba histolytica Source Type: blogs
Medmastery: Detecting malignant focal lesions.
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
The team at Medmastery are providing LITFL readers with a series of FOAMed courses from across their website.
In this video, from the Abdominal Ultrasound Essentials course, Dr. Nikolaus Mayr discusses the basic principles of liver ultrasound including the differentiation of malignant pathologies such as hepatocellular carcinoma (HCC), cholangiocarcinoma and metastases.
Further reading:
LITFL Medmastery Courses
Medmastery on Facebook and Twitter
Guest post: Nikola...
Source: Life in the Fast Lane - February 20, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Medmastery liver malignant Ultrasound Source Type: blogs
Medmastery: Detecting malignant focal lesions
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
The team at Medmastery are providing LITFL readers with a series of FOAMed courses from across their website.
In this video, from the Abdominal Ultrasound Essentials course, Dr. Nikolaus Mayr discusses the basic principles of liver ultrasound including the differentiation of malignant pathologies such as hepatocellular carcinoma (HCC), cholangiocarcinoma and metastases.
Further reading:
LITFL Medmastery Courses
Medmastery on Facebook and Twitter
G...
Source: Life in the Fast Lane - February 20, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Medmastery liver malignant Ultrasound Source Type: blogs
Precision Medicine and Public Health (from Precision Medicine and the Reinvention of Human Disease)
Excerpted fromPrecision Medicine and the Reinvention of Human DiseaseDespite having the most advanced healthcare technology on the planet, life expectancy in the United States is not particularly high. Citizens from most of the European countries and the highly industrialized Asian countries enjoy longer life expectancies than the United States. According to the World Health Organization, the United States ranks 31st among nations, trailing behind Greece, Chile, and Costa Rica, and barely edging out Cuba [42]. Similar rankings are reported by the US Central Intelligence Agency [43]. These findings lead us to infer that acc...
Source: Specified Life - February 6, 2018 Category: Information Technology Tags: cancer cancer vaccines precision medicine prevention public health Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Hepatocellular carcinoma (HCC) with a focus on diagnosis and screening
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - January 22, 2018 Category: Internal Medicine Tags: gastroenterology oncology Source Type: blogs
