Fight Aging! Newsletter, July 29th 2019

In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Healthy Longevity https://www.fightaging.org/archives/2019/07/commentary-on-the-developing-uk-government-position-on-healthy-longevity/ One option for patient advocacy for the treatment of aging as a medical condition is to petition governments and large international organizations such as the World Health Organization to adjust their positions on research funding and goals in medicine. This a fairly popular path, for all that I think it not terribly effective at speeding up the cutting edge of research and development. Large organizations of any sort are inherently conservative, and tend to get meaningfully involved in new fields of human endeavor only long after their support would have been truly influential. Nonetheless, numerous examples of government focused initiatives have emerged from our community over the past decade. They include the...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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CONCLUSION: Costoclavicular brachial plexus block is a good alternative for upper limb anesthesia distal to the elbow, being a safe and effective option for patients who are obese or have other limitations to the use of other upper limb blocking techniques. PMID: 31519300 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
PMID: 31519227 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
CONCLUSIONS: The combination of memantine with escitalopram was well tolerated and as effective as escitalopram and placebo in improving depression using HAM-D. Combination memantine and escitalopram was significantly more effective than escitalopram and placebo in improving cognitive outcomes at 12 months. Future reports will address the role of biomarkers of aging in treatment response. PMID: 31519517 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
DISCUSSION: We propose the "AD exposome" to comprehensively assess the modifiable environmental factors relevant to genetic underpinnings of cognitive aging and AD. Analysis of endogenous and exogenous environmental factors requires multi-generational consideration of these interactions over age and time (GxExT). New computational approaches to the multi-level complexities may identify accessible interventions for individual brain aging. International collaborations on diverse populations are needed to identify the most relevant exposures over the life course for GxE interactions. PMID: 31519494 [PubMed - as ...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 14 September 2019Source: Journal of Organometallic ChemistryAuthor(s): Dilek Unluer, Ayse Aktas Kamiloglu, Sahin Direkel, Ersan Bektas, Halit Kantekin, Kemal SancakAbstractIn this work, novel metallophthalocyanine compounds (M = Zn, Cu, Co) bearing four 2-methoxy-4-{(Z)-[(4-morpholin-4-ylphenyl)imino]methyl}phenol at the peripheral positions were sythesized starting from the new phthalonitrile derivative (2). These new compounds (2–5) have been characterized by a combination of FT-IR, 1H NMR (for compounds 2 and 3), 13C NMR (for compound 2), UV–Vis (for compounds 3,4 and 5...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
CONCLUSIONS: Epidemiological figures emerging from this study confirm that trends in Lebanon are in line with a global pattern of decreasing age at menarche. Urban-rural differences suggest that higher caloric content of diet and consequent early overweight, more evident in urban areas, are likely determinants of younger menarche. Evidence from this study calls for an urgent implementation of comprehensive multisectoral obesity prevention in children in Lebanon. PMID: 31519350 [PubMed - as supplied by publisher]
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Publication date: Available online 15 September 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Saira Shams, Arif Ullah Khan, Qipeng Yuan, Waqas Ahmad, Yun Wei, Zia Ul Haq Khan, Sumaira Shams, Aftab Ahmad, Aziz Ur Rahman, Sadeeq UllahAbstractThe development of eco-benign experimental procedures for the synthesis of nanomaterials is a fundamental developing branch of green nanotechnology. In this paper, green synthetic route was followed to synthesize novel Au@Fe2O3nanocomposite using Citrus sinensis fruit extract as a reducing and stabilizing agent. The as synthesized Au@Fe2O3nanocomposite was s...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Publication date: Available online 14 September 2019Source: Genes &DiseasesAuthor(s): Wei Liu, Zhongliang Deng, Zongyue Zeng, Jiaming Fan, Yixiao Feng, Xi Wang, Daigui Cao, Bo Zhang, Lijuan Yang, Bin Liu, Mikhail Pakvasa, William Wagstaff, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Fang He, Yukun Mao, Huiming Ding, Yongtao ZhangAbstractBone morphogenetic protein 9 (BMP9) (or GDF2) was originally identified from fetal mouse liver cDNA libraries. Emerging evidence indicates BMP9 exerts diverse and pleotropic functions during postnatal development and in maintaining tissue homeostasis. However, the expression landsc...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
ConclusionsEndovascular coil fiducial placement for lung SBRT is associated with high procedural success rates and lower rates of clinically relevant complications than transthoracic marker placement.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
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