Cancers, Vol. 16, Pages 1785: Programmed Death Ligand 1 Expression in Circulating Tumor Cells as a Predictor and Monitor of Response to Atezolizumab plus Bevacizumab Treatment in Patients with Hepatocellular Carcinoma
Yasunari Nakamoto
There remains no reliable biomarker of therapeutic efficacy in hepatocellular carcinoma (HCC) for the PD-L1 inhibitor atezolizumab and bevacizumab (Atezo/Bev). Circulating tumor cells (CTCs) enable the serial collection of living tumor cells. Pre-treatment and serial CTC gene expression changes and tumor histology were evaluated to identify predictors of response to Atezo/Bev. Peripheral blood from 22 patients with HCC treated with Atezo/Bev and 24 patients treated with lenvatinib was serially collected. The RNA expression in CTCs was analyzed using qRT-PCR. Higher PD-L1 expression in pre-treatment ...
Source: Cancers - May 6, 2024 Category: Cancer & Oncology Authors: Takuto Nosaka Yosuke Murata Yu Akazawa Tomoko Tanaka Kazuto Takahashi Tatsushi Naito Hidetaka Matsuda Masahiro Ohtani Yoshiaki Imamura Yasunari Nakamoto Tags: Article Source Type: research
Preoperative prediction power of radiomics and non-radiomics methods based on MRI for early recurrence in hepatocellular carcinoma: a systemic review and meta-analysis
ConclusionThe radiomics from preoperative MRI effectively predicts ER of HCC and has higher diagnostic accuracy than non-radiomics. Due to potential publication bias and suboptimal RQS scores in radiomics, these results should be interpreted cautiously.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - May 5, 2024 Category: Radiology Source Type: research
Regulatory effect of Yinchenhao decoction on bile acid metabolism to improve the inflammatory microenvironment of hepatocellular carcinoma in mice
AbstractHepatocellular carcinoma (HCC) is a malignant tumor with extremely high mortality. The tumor microenvironment is the “soil” of its occurrence and development, and the inflammatory microenvironment is an important part of the “soil”. Bile acid is closely related to the occurrence of HCC. Bile acid metabolism disorder is not only directly involved in the occurrence and development of HCC but also affects the inflammatory microenvironment of HCC. Yinchenhao decoction, a traditional Chinese medicine formula, can regulate bile acid metabolism and may affect the inflammatory microenvironment of HCC. To determine ...
Source: Journal of Natural Medicines - May 5, 2024 Category: Drugs & Pharmacology Source Type: research
Role of FXR in the development of NAFLD and intervention strategies of small molecules
Arch Biochem Biophys. 2024 May 2:110024. doi: 10.1016/j.abb.2024.110024. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) remains a prevailing etiological agent behind hepatocyte diseases like chronic liver disease. The spectrum of processes involved in NAFLD stages includes hepatic steatosis, non-alcoholic fatty liver, and non-alcoholic steatohepatitis (NASH). Without intervention, the progression of NASH can further deteriorate into cirrhosis and ultimately, hepatocellular carcinoma. The cardinal features that characterize NAFLD are insulin resistance, lipogenesis, oxidative stress and inflammation...
Source: Archives of Biochemistry and Biophysics - May 4, 2024 Category: Biochemistry Authors: Jiachan Long Yuanhang Xu Xuerong Zhang Bingxing Wu Caiyan Wang Source Type: research
G6PC expression is downregulated in hepatocellular carcinoma and associated with malignant progression
Asian J Surg. 2024 May 3:S1015-9584(24)00761-9. doi: 10.1016/j.asjsur.2024.04.099. Online ahead of print.NO ABSTRACTPMID:38704270 | DOI:10.1016/j.asjsur.2024.04.099 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - May 4, 2024 Category: Surgery Authors: Qiulan Wang Wenbin Gao Wenxia Pu Ruozhu Dong Source Type: research
IL-12 improves the anti-HCC efficacy of dendritic cells loaded with exosomes from overexpressing Rab27a tumor cells
In this study, we transfected hepatocellular carcinoma cells with Rab27a to enhance the yield of exosomes, which were characterized using transmission electron microscopy and Western blot analysis. We found that Tex secreted by overexpressing Rab27a Hepatocellular carcinoma cell lines pulsed DC is beneficial for the differentiation and maturation of DCs but inhibits the secretion of the IL-12 cytokine. Consequently, we developed a complementary immunotherapy approach by using Tex as an antigen loaded onto DCs, in combination with the cytokine IL-12 to induce antigen-specific cytotoxic T lymphocytes （CTLs）. The results ...
Source: Experimental Cell Research - May 4, 2024 Category: Cytology Authors: JieYu Li WanSong Lin TianYing Huang MingShui Chen QiaoYan Lin Source Type: research
Role of FXR in the development of NAFLD and intervention strategies of small molecules
Arch Biochem Biophys. 2024 May 2:110024. doi: 10.1016/j.abb.2024.110024. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) remains a prevailing etiological agent behind hepatocyte diseases like chronic liver disease. The spectrum of processes involved in NAFLD stages includes hepatic steatosis, non-alcoholic fatty liver, and non-alcoholic steatohepatitis (NASH). Without intervention, the progression of NASH can further deteriorate into cirrhosis and ultimately, hepatocellular carcinoma. The cardinal features that characterize NAFLD are insulin resistance, lipogenesis, oxidative stress and inflammation...
Source: Archives of Biochemistry and Biophysics - May 4, 2024 Category: Biochemistry Authors: Jiachan Long Yuanhang Xu Xuerong Zhang Bingxing Wu Caiyan Wang Source Type: research
G6PC expression is downregulated in hepatocellular carcinoma and associated with malignant progression
Asian J Surg. 2024 May 3:S1015-9584(24)00761-9. doi: 10.1016/j.asjsur.2024.04.099. Online ahead of print.NO ABSTRACTPMID:38704270 | DOI:10.1016/j.asjsur.2024.04.099 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - May 4, 2024 Category: Surgery Authors: Qiulan Wang Wenbin Gao Wenxia Pu Ruozhu Dong Source Type: research
A comprehensive review of phytoconstituents in liver cancer prevention and treatment: targeting insights into molecular signaling pathways
This study reviews natural compounds, such as curcumin, resveratrol, green tea catechins, grape seed extracts, vitamin D, and selenium. Preclinical and clinical studies have shown that these medications reduce the risk of liver cancer through their antiviral, anti-inflammatory, antioxidant, anti-angiogenic, and antimetastatic properties. This article discusses the therapeutic properties of natural products, nutraceuticals, and Chinese compounds for the prevention and treatment of liver cancer.PMID:38703282 | DOI:10.1007/s12032-024-02333-5 (Source: Cancer Control)
Source: Cancer Control - May 4, 2024 Category: Cancer & Oncology Authors: Md Rezaul Islam Abdur Rauf Shopnil Alash Md Naeem Hossain Fakir Gazi Kaifeara Thufa Mahbuba Sharmin Sowa Dattatreya Mukherjee Harendra Kumar Md Sadique Hussain Abdullah S M Aljohani Muhammad Imran Waleed Al Abdulmonem Rekha Thiruvengadam Muthu Thiruvengad Source Type: research
Interpretable machine learning based on CT-derived extracellular volume fraction to predict pathological grading of hepatocellular carcinoma
ConclusionThis study successfully developed and validated a non-invasive auxiliary assessment method based on CT-derived ECV to predict the HCC PG, providing important supplementary information for clinical decision-making. (Source: Abdominal Imaging)
Source: Abdominal Imaging - May 4, 2024 Category: Radiology Source Type: research
Current role and perspectives of living donor liver transplantation for hepatocellular carcinoma: systematic review of the past 20 years
AbstractHepatocellular carcinoma (HCC) poses a significant global health challenge, and liver transplantation (LT) remains the best curative option. Living donor liver transplantation (LDLT) emerged as a potential solution to organ scarcity, reducing waitlist times. This comprehensive review explores LDLT practices, focusing on patient selection criteria and oncologic outcomes. A systematic review following PRISMA guidelines included 50 studies (2004 –2023) with 8062 patients. Data encompassed baseline characteristics, HCC features, and oncologic outcomes. Further analysis categorized results by geography and publication...
Source: Updates in Surgery - May 4, 2024 Category: Surgery Source Type: research
The cuproptosis-related gene UBE2D2 functions as an immunotherapeutic and prognostic biomarker in pan-cancer
ConclusionsWe comprehensively investigated the potential value of UBE2D2 as a prognostic and immunotherapeutic predictor for pan-cancer, providing a novel insight for cancer immunotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 4, 2024 Category: Cancer & Oncology Source Type: research
A comprehensive review of phytoconstituents in liver cancer prevention and treatment: targeting insights into molecular signaling pathways
This study reviews natural compounds, such as curcumin, resveratrol, green tea catechins, grape seed extracts, vitamin D, and selenium. Preclinical and clinical studies have shown that these medications reduce the risk of liver cancer through their antiviral, anti-inflammatory, antioxidant, anti-angiogenic, and antimetastatic properties. This article discusses the therapeutic properties of natural products, nutraceuticals, and Chinese compounds for the prevention and treatment of liver cancer. (Source: Medical Oncology)
Source: Medical Oncology - May 4, 2024 Category: Cancer & Oncology Source Type: research
A Nomogram for Preoperative Prediction of Vessels Encapsulating Tumor Clusters (VETC) Pattern and Prognosis of Hepatocellular Carcinoma
This study aimed to establish a nomogram model to predict VETC patterns based on preoperative CT imaging features. (Source: American Journal of Surgery)
Source: American Journal of Surgery - May 4, 2024 Category: Surgery Authors: Yinzhong Wang, Miaomiao Wang, Liang Cao, Hongliang Huang, Shi Cao, Xiaoxue Tian, Junqiang Lei Source Type: research
Cancers, Vol. 16, Pages 1772: Macrophages Orchestrate the Liver Tumor Microenvironment
elli
Liver cancer is one of the leading causes of cancer-related mortality. Hepatocellular carcinoma and cholangiocarcinoma are the most common types, and despite numerous advances, therapeutic options still remain poor for these cancer patients. Tumor development and progression strictly depend on a supportive tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the most abundant immune cells population within a tumorigenic liver; they sustain cancer cells’ growth and invasiveness, and their presence is correlated with a poor prognosis. Furthermore, TAM cross-talk with cells and componen...
Source: Cancers - May 4, 2024 Category: Cancer & Oncology Authors: Valeria Quaranta Costanza Ballar ò Gianluigi Giannelli Tags: Review Source Type: research
