Cancers, Vol. 16, Pages 1582: Hepatocellular Carcinoma: Current Drug Therapeutic Status, Advances and Challenges
Wanjin Hong
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for ~90% of liver neoplasms. It is the second leading cause of cancer-related deaths and the seventh most common cancer worldwide. Although there have been rapid developments in the treatment of HCC over the past decade, the incidence and mortality rates of HCC remain a challenge. With the widespread use of the hepatitis B vaccine and antiviral therapy, the etiology of HCC is shifting more toward metabolic-associated steatohepatitis (MASH). Early-stage HCC can be treated with potentially curative strategies such as surgical...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Shunzhen Zheng Siew Wee Chan Fei Liu Jun Liu Pierce Kah Hoe Chow Han Chong Toh Wanjin Hong Tags: Review Source Type: research
Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy
CONCLUSION: Metformin for DM and statins for HLP have chemopreventive effects on HCC risk in CHC patients who failed antiviral therapy. These findings emphasize the importance of personalized preventive strategies for managing patients with these clinical profiles.PMID:38637957 | DOI:10.3350/cmh.2024.0038 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Pei-Chien Tsai Chung-Feng Huang Ming-Lun Yeh Meng-Hsuan Hsieh Hsing-Tao Kuo Chao-Hung Hung Kuo-Chih Tseng Hsueh-Chou Lai Cheng-Yuan Peng Jing-Houng Wang Jyh-Jou Chen Pei-Lun Lee Rong-Nan Chien Chi-Chieh Yang Gin-Ho Lo Jia-Horng Kao Chun-Jen Liu Chen-Hua L Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Synthesis and preclinical evaluation of a novel probe [ < sup > 18 < /sup > F]AlF-NOTA-IPB-GPC3P for PET imaging of GPC3 positive tumor
In this study, a novel peptide PET imaging agent ([18F]AlF-NOTA-IPB-GPC3P) was developed to target GPC3 expressed in tumors. The overall radiochemical yield of [18F]AlF-NOTA-IPB-GPC3P was 10-15 %, and its lipophilicity, expressed as the logD value at a pH of 7.4, was -1.18 ± 0.06 (n = 3). Compared to the previously reported tracer [18F]AlF-GP2633, [18F]AlF-NOTA-IPB-GPC3P exhibited higher cellular uptake (15.13 vs 5.96) and internalized rate (80.63 % vs 35.93 %) in Huh7 cells at 120 min. Micro-PET/CT and biodistribution studies further demonstrated that [18F]AlF-NOTA-IPB-GPC3P exhibited significantly increased tumor uptake...
Source: Bioorganic Chemistry - April 19, 2024 Category: Chemistry Authors: Chunwei Mo Penghui Sun Haoran Liang Zihao Chen Meng Wang Lilan Fu Shun Huang Ganghua Tang Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy
CONCLUSION: Metformin for DM and statins for HLP have chemopreventive effects on HCC risk in CHC patients who failed antiviral therapy. These findings emphasize the importance of personalized preventive strategies for managing patients with these clinical profiles.PMID:38637957 | DOI:10.3350/cmh.2024.0038 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Pei-Chien Tsai Chung-Feng Huang Ming-Lun Yeh Meng-Hsuan Hsieh Hsing-Tao Kuo Chao-Hung Hung Kuo-Chih Tseng Hsueh-Chou Lai Cheng-Yuan Peng Jing-Houng Wang Jyh-Jou Chen Pei-Lun Lee Rong-Nan Chien Chi-Chieh Yang Gin-Ho Lo Jia-Horng Kao Chun-Jen Liu Chen-Hua L Source Type: research
RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells
Int J Oncol. 2024 Jun;64(6):58. doi: 10.3892/ijo.2024.5646. Epub 2024 Apr 19.ABSTRACTThe exosomal pathway is an essential mechanism that regulates the abnormal content of microRNAs (miRNAs) in hepatocellular carcinoma (HCC). The directional transport of miRNAs requires the assistance of RNA‑binding proteins (RBPs). The present study found that RBPs participate in the regulation of miRNA content through the exosomal pathway in HCC cells. First, differential protein expression profiles in the serum exosomes of patients with HCC and benign liver disease were detected using mass spectrometry. The results revealed that riboso...
Source: International Journal of Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Ang Li Jiyan Xie Lihong Lv Zhihua Zheng Weibang Yang Wenfeng Zhuo Sijia Yang Diankui Cai Jinxin Duan Peiqing Liu Jun Min Jinxing Wei Source Type: research
A Machine Learning Algorithm Facilitates Prognosis Prediction and Treatment Selection for Barcelona Clinic Liver Cancer Stage C Hepatocellular Carcinoma
CONCLUSIONS: ML modeling effectively subclassified patients with BCLC-C HCC, potentially aiding treatment allocation. Our study underscores the potential utilization of ML modeling in terms of prognostication and treatment allocation in patients with BCLC-C HCC.PMID:38639918 | DOI:10.1158/1078-0432.CCR-23-3978 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 19, 2024 Category: Cancer & Oncology Authors: Ji Won Han Soon Kyu Lee Jung Hyun Kwon Soon Woo Nam Hyun Yang Si Hyun Bae Ji Hoon Kim Heechul Nam Chang Wook Kim Hae Lim Lee Hee Yeon Kim Sung Won Lee Ahlim Lee U Im Chang Do Seon Song Seok-Hwan Kim Myeong Jun Song Pil Soo Sung Jong Young Choi Seung Kew Y Source Type: research
CREB3 facilitates Donafenib resistance in hepatocellular carcinoma cells via the LSD1/CoREST/p65 axis by transcriptionally activating long noncoding RNA ZFAS1
CONCLUSION: CREB3 overexpression contributed to Donafenib resistance in HCC cells by activating the ZFAS1/p65 axis.PMID:38641372 | DOI:10.1016/j.tranon.2023.101684 (Source: Translational Oncology)
Source: Translational Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Xunbo Hou Qiannan Xu Ruibao Liu Source Type: research
Facilitators and Barriers of Palliative Care Receipt from the Perspective of People with Advanced Liver Cancer
1. Participants will be able to identify unique aspects of hepatocellular carcinoma (HCC) that necessitate tailored models of palliative care delivery.2. Participants will be able to identify facilitators and barriers of palliative care delivery to people with HCC based on their needs and preferences. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Christopher D. Woodrell, Deborah Watman, Yingtong Chen, Sasha Perez, Lissi Hansen, Nathan Goldstein Source Type: research
Facilitators and Barriers of Palliative Care Receipt from the Perspective of People with Advanced Liver Cancer (GP125)
1. Identify factors that serve as either facilitators of or barriers to palliative care referral from the perspective of patients receiving systemic treatment for hepatocellular carcinoma, the most common type of liver cancer.2. Name specific ways that future scientific inquiry might advance our u nderstanding of these facilitators and barriers, including the development of tailored, embedded care models within liver cancer treatment programs. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Christopher D. Woodrell, Deborah Watman, Yingtong Chen, Sasha Perez, Lissi Hansen, Nathan Goldstein Source Type: research
GSE263962 HDGFR2 regulates osteogenic differentiation by balancing histone crotonoylation and acetylation modifications [RNA-Seq]
Contributors : Meilin Hu ; Yixuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpigenetics regulates the expression of osteogenic genes and mediates the osteogenic differentiation of MSCs. It was found that hepatoma-derived growth factor (HDGFR2) is a histone methylated reader protein, which can recognize histone methylation modification and play an important "switch" role in gene transcriptional regulation. It is unclear whether HDGFR2 is involved in bone formation studies. Our study aims to investigate the effect of HDGFR2 on osteogenic differentiation and provide evidence ...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE263961 HDGFR2 regulates osteogenic differentiation by balancing histone crotonoylation and acetylation modifications [Cut & Tag]
Contributors : Meilin Hu ; Yixuan WangSeries Type : OtherOrganism : Mus musculusEpigenetics regulates the expression of osteogenic genes and mediates the osteogenic differentiation of MSCs. It was found that hepatoma-derived growth factor (HDGFR2) is a histone methylated reader protein, which can recognize histone methylation modification and play an important "switch" role in gene transcriptional regulation. It is unclear whether HDGFR2 is involved in bone formation studies. Our study aims to investigate the effect of HDGFR2 on osteogenic differentiation and provide evidence for BMSCs as seed cells for tissue regenerati...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
Race/ethnicity and socioeconomic position in emergency department utilization in patients with hepatocellular carcinoma
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Daniel Lin Ruoding Tan Christie Teigland Sairy Hernandez Seung Kim Karl M Kilgore Source Type: research
Molecules, Vol. 29, Pages 1859: A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action
Bing Liu
Nonalcoholic fatty liver disease (NAFLD) is the liver component of a cluster of conditions, while its subtype, nonalcoholic steatohepatitis (NASH), emerges as a potentially progressive liver disorder that harbors the risk of evolving into cirrhosis and culminating in hepatocellular carcinoma (HCC). NASH and cardiovascular disease (CVD) have common risk factors, but compared to liver-related causes, the most common cause of death in NASH patients is CVD. Within the pharmacological armamentarium, statins, celebrated for their lipid-modulating prowess, have now garnered attention for their expansive therapeutic ...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Shiqin Zhang Xiaoling Ren Bingzheng Zhang Tian Lan Bing Liu Tags: Review Source Type: research
