Epithelial-Mesenchymal Transformation Promotes the Progression of Hepatocellular Carcinoma through NF- κB/MMP9 Axis
CONCLUSIONS: The NF-κB/MMP9 signaling axis serves as a pivotal regulator that fosters proliferation and impedes apoptosis in Huh7 cells by modulating the process of EMT.PMID:38665016 | DOI:10.24976/Discov.Med.202436183.63 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Jinsen Li Qingbin Cai Ziyue Wang Liangshi Wang Guangrun Yang Zhilong Zhang Na Ge Shunxin Hu Tian Bai Source Type: research
Metabolome Profiling of Malignant Ascites Identifies Candidate Metabolic Biomarkers of Hepatocellular Carcinoma
CONCLUSION: Our results suggest that the key factors associated with pathways, such as arachidonic acid, phenylalanine, and glutamic acid pathways, are potential ascitic fluidbased biomarkers for differentiating hepatocellular carcinoma with cirrhosis ascites; the results also provide a clinical pathophysiological interpretation of biomarkers and metabolic pathways relevant to disease status.PMID:38666505 | DOI:10.2174/0929867330666230324153552 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 26, 2024 Category: Chemistry Authors: Weijia Wang Yue Wu Qinsheng Zhang Peilin Cui Source Type: research
Unmet needs in the post-DAA era: the risk and molecular mechanisms of hepatocellular carcinoma after HCV eradication
Clin Mol Hepatol. 2024 Apr 26. doi: 10.3350/cmh.2024.0155. Online ahead of print.ABSTRACTHepatitis C virus (HCV) is one of the major etiologies of hepatocellular carcinoma with approximately 30% of HCC being due to HCV infection worldwide. HCV eradication by antivirals greatly reduces the risk of HCC; nevertheless, HCC remains to occur in CHC patients who have achieved a sustained virological response (SVR). The proportion of post-SVR HCC among newly diagnosed HCC patients is increasing in the DAA era and might be due to preexisting inflammatory and fibrotic liver background, immune dysregulation between host and virus int...
Source: Clinical and molecular hepatology - April 26, 2024 Category: Gastroenterology Authors: Chung-Feng Huang Manar Hijaze Awad Meital Gal-Tanamy Ming-Lung Yu Source Type: research
Efficacy of metastatic lesion radiotherapy in patients with metastatic nasopharyngeal carcinoma: A multicenter retrospective study
CONCLUSIONS: MLRT offers survival advantages to patients diagnosed with mNPC. Patients with limited metastatic burden derive the most benefit from MLRT, and the recommended regimen for MLRT is a minimum BED of 56 Gy for optimal outcomes.PMID:38670263 | DOI:10.1016/j.radonc.2024.110311 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 26, 2024 Category: Radiology Authors: Yang Liu Jie Ma Xiao-Yi Zeng Zhi-Chao Zuo Rui-Zhong Chen Xiao-Yu Li Zhong-Guo Liang Kai-Hua Chen Xin-Bin Pan Su Pei Bin-Bin Yu Ling Li Song Qu Yun-Li Yang Xiao-Dong Zhu Source Type: research
A Rare Early-Onset Fatal Complication after Transarterial Chemoembolization: A Case Report and Review of the Literature
In conclusion, this case underscores the importance of recognizing the rare complication of HCC rupture post-TACE and the need for personalized risk assessment. While TAE emerges as a primary treatment choice, the lack of consensus necessitates further studies to establish evidence-based approaches for managing this uncommon yet life-threatening complication.PMID:38668050 | PMC:PMC11049493 | DOI:10.3390/curroncol31040147 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Monika P éčová Jakub Benko Martin Jozef P éč Jakub Jurica Simona Horn á Tom áš Bolek Tatiana Hurtov á J án Sýkora Kamil Zele ňák Matej Samo š Juraj Sokol Source Type: research
Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review)
Oncol Rep. 2024 Jun;51(6):84. doi: 10.3892/or.2024.8743. Epub 2024 Apr 26.ABSTRACTEven under aerobic conditions, tumor cells can reprogram their metabolism to preferentially metabolize glucose into lactic acid. This abnormal metabolic pattern, known as the 'Warburg' effect or aerobic glycolysis, promotes cancer progression. Long non‑coding RNAs (lncRNAs) are RNAs that are >200 nucleotides in length and do not have protein‑coding capabilities. However, these RNAs play a key role in tumor development. There is increasing evidence to indicate that lncRNAs regulate glucose metabolism in tumor cells by affecting metaboli...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Qiongqing Huang Zhengui Liang Qiqi Huang Xueyu Li Jingjing Xia Lining Huang Lin Bing Huang Chao Ou Source Type: research
Comparative analysis of sorafenib and lenvatinib on HepG2 cells and human umbilical vein endothelial cells: Involvement of transforming growth factor- β signaling in their molecular effects
CONCLUSIONS: Our findings indicate that both sorafenib and lenvatinib possess anticancer abilities by inducing the cytotoxicity of hepatocellular carcinoma cells. Furthermore, they show opposing effects on TGF-β-induced cell invasion and angiogenesis, thereby enhancing the understanding of the multifaceted functions of molecular targeted drugs in treating hepatocellular carcinoma.PMID:38666637 | DOI:10.1111/hepr.14045 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Ting Wang Yasuhiro Takikawa Kazuyuki Suzuki Hidekatsu Kuroda Keisuke Kakisaka Toshimi Chiba Source Type: research
TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis
EMBO Mol Med. 2024 Apr 26. doi: 10.1038/s44321-024-00068-4. Online ahead of print.ABSTRACTRadiotherapy (RT) has been reported to induce abscopal effect in advanced hepatocellular carcinoma (HCC), but such phenomenon was only observed in sporadic cases. Here, we demonstrated that subcutaneous administration of Toll-like receptor 3 (TLR3) agonist poly(I:C) could strengthen the abscopal effect during RT through activating tumor cell ferroptosis signals in bilateral HCC subcutaneous tumor mouse models, which could be significantly abolished by TLR3 knock-out or ferroptosis inhibitor ferrostatin-1. Moreover, poly(I:C) could pro...
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Liman Qiu Hongbing Ji Kai Wang Wenhan Liu Qizhen Huang Xinting Pan Honghao Ye Zhenli Li Geng Chen Xiaohua Xing Xiuqing Dong Ruijing Tang Haipo Xu Jingfeng Liu Zhixiong Cai Xiaolong Liu Source Type: research
Epithelial-Mesenchymal Transformation Promotes the Progression of Hepatocellular Carcinoma through NF- κB/MMP9 Axis
CONCLUSIONS: The NF-κB/MMP9 signaling axis serves as a pivotal regulator that fosters proliferation and impedes apoptosis in Huh7 cells by modulating the process of EMT.PMID:38665016 | DOI:10.24976/Discov.Med.202436183.63 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Jinsen Li Qingbin Cai Ziyue Wang Liangshi Wang Guangrun Yang Zhilong Zhang Na Ge Shunxin Hu Tian Bai Source Type: research
Metabolome Profiling of Malignant Ascites Identifies Candidate Metabolic Biomarkers of Hepatocellular Carcinoma
CONCLUSION: Our results suggest that the key factors associated with pathways, such as arachidonic acid, phenylalanine, and glutamic acid pathways, are potential ascitic fluidbased biomarkers for differentiating hepatocellular carcinoma with cirrhosis ascites; the results also provide a clinical pathophysiological interpretation of biomarkers and metabolic pathways relevant to disease status.PMID:38666505 | DOI:10.2174/0929867330666230324153552 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 26, 2024 Category: Chemistry Authors: Weijia Wang Yue Wu Qinsheng Zhang Peilin Cui Source Type: research
Unmet needs in the post-DAA era: the risk and molecular mechanisms of hepatocellular carcinoma after HCV eradication
Clin Mol Hepatol. 2024 Apr 26. doi: 10.3350/cmh.2024.0155. Online ahead of print.ABSTRACTHepatitis C virus (HCV) is one of the major etiologies of hepatocellular carcinoma with approximately 30% of HCC being due to HCV infection worldwide. HCV eradication by antivirals greatly reduces the risk of HCC; nevertheless, HCC remains to occur in CHC patients who have achieved a sustained virological response (SVR). The proportion of post-SVR HCC among newly diagnosed HCC patients is increasing in the DAA era and might be due to preexisting inflammatory and fibrotic liver background, immune dysregulation between host and virus int...
Source: Clinical and molecular hepatology - April 26, 2024 Category: Gastroenterology Authors: Chung-Feng Huang Manar Hijaze Awad Meital Gal-Tanamy Ming-Lung Yu Source Type: research
Biomarkers in Detection of Hepatitis C Virus Infection
Pathogens. 2024 Apr 17;13(4):331. doi: 10.3390/pathogens13040331.ABSTRACTThe hepatitis C virus (HCV) infection affects 58 million people worldwide. In the United States, the incidence rate of acute hepatitis C has doubled since 2014; during 2021, this increased to 5% from 2020. Acute hepatitis C is defined by any symptom of acute viral hepatitis plus either jaundice or elevated serum alanine aminotransferase (ALT) activity with the detection of HCV RNA, the anti-HCV antibody, or hepatitis C virus antigen(s). However, most patients with acute infection are asymptomatic. In addition, ALT activity and HCV RNA levels can fluct...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Jungreem Woo Youkyung Choi Source Type: research
Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review)
Oncol Rep. 2024 Jun;51(6):84. doi: 10.3892/or.2024.8743. Epub 2024 Apr 26.ABSTRACTEven under aerobic conditions, tumor cells can reprogram their metabolism to preferentially metabolize glucose into lactic acid. This abnormal metabolic pattern, known as the 'Warburg' effect or aerobic glycolysis, promotes cancer progression. Long non‑coding RNAs (lncRNAs) are RNAs that are >200 nucleotides in length and do not have protein‑coding capabilities. However, these RNAs play a key role in tumor development. There is increasing evidence to indicate that lncRNAs regulate glucose metabolism in tumor cells by affecting metaboli...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Qiongqing Huang Zhengui Liang Qiqi Huang Xueyu Li Jingjing Xia Lining Huang Lin Bing Huang Chao Ou Source Type: research
A Rare Early-Onset Fatal Complication after Transarterial Chemoembolization: A Case Report and Review of the Literature
In conclusion, this case underscores the importance of recognizing the rare complication of HCC rupture post-TACE and the need for personalized risk assessment. While TAE emerges as a primary treatment choice, the lack of consensus necessitates further studies to establish evidence-based approaches for managing this uncommon yet life-threatening complication.PMID:38668050 | DOI:10.3390/curroncol31040147 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Monika P éčová Jakub Benko Martin Jozef P éč Jakub Jurica Simona Horn á Tom áš Bolek Tatiana Hurtov á J án Sýkora Kamil Zele ňák Matej Samo š Juraj Sokol Source Type: research
THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma
Through bioinformatic analysis of transcriptomes in the cancer genome atlas (TCGA), we identified a new role for the transcription factor THAP domain-containing 3 (THAP3) in the expression of oxidative phosphorylation (OXPHOS) genes and mitochondrial respiration. Mechanistically, THAP3 cooperated with the histone methyltransferase SET and MYND domain-containing protein 3 (SMYD3) to upregulate H3K4me3 and promote OXPHOS gene expression. These actions of THAP3 support liver cancer cell proliferation and contribute to tumor development. Mitochondria harbor the oxidative phosphorylation (OXPHOS) system to sustain cellular resp...
Source: FEBS Letters - April 26, 2024 Category: Biochemistry Authors: Zi ‐Hao Wang,
Jingyi Wang,
Fuchen Liu,
Sijun Sun,
Quan Zheng,
Xiaotian Hu,
Zihan Yin,
Chengmei Xie,
Haiyan Wang,
Tianshi Wang,
Shengjie Zhang,
Yi‐Ping Wang Tags: Research Article Source Type: research
