A Novel lncRNA lncRNA-4045 Promotes the Progression of Hepatocellular Carcinoma by Affecting the Expression of AKR1B10
ConclusionLncRNA-4045 may promote HCC via enhancement of the expression of AKR1B10 protein. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 25, 2024 Category: Gastroenterology Source Type: research
Development and validation of a nomogram for assessing hepatocellular carcinoma risk after SVR in hepatitis C patients with advanced fibrosis and cirrhosis
Hepatitis C patients with advanced fibrosis or cirrhosis are at high risk of developing hepatocellular carcinoma (HCC), even after sustained virological response (SVR). Clinical recommendations impose a signif... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Shanshan Xu, Lixia Qiu, Liang Xu, Yali Liu and Jing Zhang Tags: Research Source Type: research
Anesthetic management during laparoscopic liver resection in a patient with Fontan physiology and high central venous pressure
The Fontan procedure was developed in 1971 for the surgical palliation of patients with single ventricle physiology [1]. In patients with Fontan physiology, pulmonary perfusion depends on pulmonary vascular resistance and systemic venous pressure. Long-term survival after the Fontan procedure has improved [2]. However, chronically high venous pressure may cause liver congestion and lead to the development of hepatocellular carcinoma (HCC) [3]. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 25, 2024 Category: Anesthesiology Authors: Kousuke Kikuchi, Akira Iura, Naohiro Hara, Takeshi Iritakenishi, Daisuke Hiramatsu, Yuji Fujino Tags: Case Report Source Type: research
Cancers, Vol. 16, Pages 1665: Stereotactic Radiosurgery for Patients with Brain Metastases from Hepatopancreaticobiliary Cancers
Conclusions: Metastatic spread to the brain from HPB cancers occurs late in the course of the primary disease. In this study, all deceased patients ultimately died from primary disease progression. SRS is a non-invasive strategy that maximally preserves quality of life, and our results reported favorable outcomes compared to the existing literature. SRS should be considered as one of the primary management strategies for patients with brain metastatic spread from HPB cancer. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Wei Srinivasan Patel Bednarz Flickinger Hadjipanayis Niranjan Lunsford Tags: Article Source Type: research
The survival benefit of metastasectomy for metastatic non-clear cell renal cell carcinoma: a retrospective cohort study
ConclusionMetastasectomy in patients with metastatic non-ccRCC may provide clinical benefits in terms of improved PFS and OS, especially in patients without liver metastasis and those with metachronous metastasis. (Source: World Journal of Urology)
Source: World Journal of Urology - April 25, 2024 Category: Urology & Nephrology Source Type: research
A rationally designed nuclei-targeting FAPI 04-based molecular probe with enhanced tumor uptake for PET/CT and fluorescence imaging
ConclusionsThe NOTA-FAPI-MB was successfully synthesized, in which FAPI and MB simultaneously contributed to the targeting effect. Notably, the nuclear delivery mechanism of the probes improved intracellular retention time and targeting efficacy, broadening the imaging time window for fluorescence imaging. In vivo PET/CT demonstrated favorable performance of NOTA-FAPI-MB compared to [18F]F-FDG. This study highlights the significance of fluorescence imaging as an adjunct technique to PET/CT. Furthermore, the encouraging results obtained from the imaging of human HCC tissues hold promise for the potential application of NOTA...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Negative Impact of Intra-Operative Blood Transfusion on Survival Outcomes of Hepatocellular Carcinoma Patients
(Source: Cancer Management and Research)
Source: Cancer Management and Research - April 24, 2024 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Correction to “The adverse characteristics of hepatocellular carcinoma in the non‐cirrhotic liver disproportionately disadvantage black patients”
(Source: Cancer Medicine)
Source: Cancer Medicine - April 24, 2024 Category: Cancer & Oncology Tags: CORRECTION Source Type: research
Assessment of Portuguese fitness centers: bridging the knowledge gap on harmful microbial contamination with focus on fungi
This study intends to characterize microbial contamination in Portuguese FC by passive sampling methods: electrostatic dust collectors (EDC) (N=39), settled dust (N=8), vacuum filters (N=8), and used cleaning mops (N=12). The obtained extracts were plated in selective culture media for fungi and bacteria. Filters, EDC, and mop samples' extracts were also screened for antifungal resistance and used for the molecular detection of the selected Aspergillus sections. The detection of mycotoxins was conducted using a high-performance liquid chromatograph (HPLC) system and to determine the cytotoxicity of microbial contaminants r...
Source: Environmental Pollution - April 24, 2024 Category: Environmental Health Authors: Carla Viegas C átia Peixoto Bianca Gomes Marta Dias Renata Cervantes Pedro Pena Klara Slezakova Maria do Carmo Pereira Simone Morais Elisabete Carolino Magdalena Twaru żek Susana Viegas Liliana Aranha Caetano Source Type: research
Comprehensive study of the interplay between immunological and metabolic factors in hepatic steatosis
Int Immunopharmacol. 2024 Apr 23;133:112091. doi: 10.1016/j.intimp.2024.112091. Online ahead of print.ABSTRACTThe pathophysiology of hepatic steatosis is thoroughly reviewed in this comprehensive report, with particular attention to the complex interactions between inflammatory pathways, insulin resistance, lipid metabolism, metabolic dysregulation, and immunological responses in the liver including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). The study highlights the role of immune cell regulation in disease progression and explores the potential of i...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Arnab Banerjee Debasmita Das Sandip Mukherjee Bithin Kumar Maji Source Type: research
Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma
This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms. At the same time, the prospect of targeted therapy for HCC based on the related mechanisms of glycolysis regulation is put forward.PMID:38658380 (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Xiao-Feng Hu Qing Zhang Mei-Lv Liang Qing-Niao Zhou Rui-Qiang Zhao Zu-Kang Gong Wen-Zhen Lin Source Type: research
GSE261938 Potential utility of L-carnitine for preventing liver tumors derived from metabolic dysfunction-associated steatohepatitis
We examined the potential utility of L-carnitine for alleviating metabolic dysfunction-associated steatohepatitis (MASH) and preventing the development of hepatocellular carcinoma.Short-term L-carnitine administration ameliorated MASH through its anti-inflammatory effects. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Incidentally found parotid gland lesion in 18F-FDG PET/CT for staging evaluation of patients with hepatocellular carcinoma: remote possibility of metastatic tumor or second primary salivary gland malignancy
We primarily aimed to evaluate whether parotid incidental lesion (PIL) in 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging evaluation of patients with hepatocel... (Source: BMC Surgery)
Source: BMC Surgery - April 24, 2024 Category: Surgery Authors: Jin Hyung Jung, Yoon Se Lee, Young Ho Jung, Seung-Ho Choi, Soon Yuhl Nam, Hyo Jung Cho and Minsu Kwon Tags: Research Source Type: research
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1
Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC).... (Source: Biology Direct)
Source: Biology Direct - April 24, 2024 Category: Biology Authors: Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo and Qiuran Xu Tags: Research Source Type: research
Identification of drug responsible glycogene signature in liver carcinoma from meta-analysis using RNA-seq data
In this study, we search public databases for Sequence Read Archive data on drug-treated liver cancer cells, with the aim to comprehensively analyze the drug responses of glycogenes via bioinformatic meta-analysis. The study comprised 86 datasets, encompassing eight distinct liver cancer cell lines and 13 different drugs. Differentially expressed genes were quantified, and 399 glycogenes were identified. The glycogenes signature was then analyzed using bioinformatics methodologies. In the Protein-protein interaction network analysis, we identified drug-responsive glycogenes such as Beta-1,4-Galactosyltransferase 1, GDP-Man...
Source: Glycoconjugate Journal - April 24, 2024 Category: Biochemistry Source Type: research
