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Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro
Toxicol In Vitro. 2024 Apr 24:105833. doi: 10.1016/j.tiv.2024.105833. Online ahead of print.ABSTRACTGout is an immune-metabolic disease that frequently coexists with multiple comorbidities such as chronic kidney disease, cardiovascular disease and metabolic syndrome, therefore, it is often treated in combination with these complications. The present study aimed to evaluate the inhibitory effect of antigout drugs (allopurinol, febuxostat, topiroxostat, benzbromarone, lesinurad and probenecid) on the activity of the crucial phase I drug-metabolizing enzymes, carboxylesterases (CESs). 2-(2-benzoyl-3-methoxyphenyl) benzothiazo...
Source: Toxicology in Vitro - April 26, 2024 Category: Toxicology Authors: Jia-Hong Liang Xiao-Lei Yi Jia-Min Gong Zuo Du Source Type: research

Treat-to-target or treat-to-dissolve strategy to improve gout treatment
Nature Reviews Rheumatology, Published online: 26 April 2024; doi:10.1038/s41584-024-01117-5Medication adherence in gout is low, and discontinuation of urate-lowering therapy puts patients at risk of flares and cardiovascular events. A strategy to regularly monitor serum urate levels and the dissolution of urate deposits (particularly if visualized by patients) might encourage adherence in the long term. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 26, 2024 Category: Rheumatology Authors: Pascal Richette Nicola Dalbeth Source Type: research

Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities
This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments. Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and total antioxidant capacity assays. Antimicrobial activity was evaluated by disc diffusion, MIC, MBC, and MFC determination against bacterial (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa) and fungal (Candida glabrata, Rhodotorula glutinis, Aspergillus nige...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Mounir Haddou Amine Elbouzidi Mohamed Taibi Abdellah Baraich El Hassania Loukili Reda Bellaouchi Ennouaamane Saalaoui Abdeslam Asehraou Ahmad Mohammad Salamatullah Mohammed Bourhia Hiba-Allah Nafidi Mohamed Addi Bouchra El Guerrouj Khalid Chaabane Source Type: research

Molecules, Vol. 29, Pages 1936: The Simultaneous Detection of Dopamine and Uric Acid In Vivo Based on a 3D Reduced Graphene Oxide & ndash;MXene Composite Electrode
Molecules, Vol. 29, Pages 1936: The Simultaneous Detection of Dopamine and Uric Acid In Vivo Based on a 3D Reduced Graphene Oxide–MXene Composite Electrode Molecules doi: 10.3390/molecules29091936 Authors: Lingjun Shang Ruijiao Li Haojie Li Shuaiqun Yu Xuming Sun Yi Yu Qiongqiong Ren Dopamine (DA) and uric acid (UA) are essential for many physiological processes in the human body. Abnormal levels of DA and UA can lead to multiple diseases, such as Parkinson&rsquo;s disease and gout. In this work, a three-dimensional reduced graphene oxide&ndash;MXene (3D rGO-Ti3C2) composite el...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Lingjun Shang Ruijiao Li Haojie Li Shuaiqun Yu Xuming Sun Yi Yu Qiongqiong Ren Tags: Article Source Type: research

Giant gout stone with bone destruction in a Chinese man: A case report
Asian J Surg. 2024 Apr 22:S1015-9584(24)00695-X. doi: 10.1016/j.asjsur.2024.04.035. Online ahead of print.NO ABSTRACTPMID:38653704 | DOI:10.1016/j.asjsur.2024.04.035 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 23, 2024 Category: Surgery Authors: Yuxi Liu Rilei Jiang Source Type: research

A potential therapeutic agent for the treatment of hyperuricemia and gout: 3,4-Dihydroxy-5-nitrobenzaldehyde phenylthiosemicarbazide
Eur J Pharm Sci. 2024 Apr 21:106778. doi: 10.1016/j.ejps.2024.106778. Online ahead of print.ABSTRACTUric acid, the metabolic product of purines, relies on xanthine oxidase (XOD) for production. XOD is a target for the development of drugs for hyperuricemia (HUA) and gout. Currently, treatment options remain limited for gout patients. 3, 4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a derivative of the natural product protocatechualdehyde with good biological activity. In this work, we identify a DHNB thiosemicarbazide class of compounds that targets XOD. 3,4-Dihydroxy-5-nitrobenzaldehyde phenylthiosemicarbazone can effectively...
Source: European Journal of Pharmaceutical Sciences - April 23, 2024 Category: Drugs & Pharmacology Authors: Xiongying Yu Shuaiwei Ren Jun Zhou Yongcui Liao Yousheng Huang Dong Huanhuan Source Type: research

Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients
by Lu Liu, Shuang He, Lin Jia, Hua Yao, Dan Zhou, Xiaobin Guo, Lei Miao ObjectiveThe Toll-like receptor (TLR) 4-mediated nuclear factor kappa B (NF- κB) signaling pathway regulates the production of inflammatory factors and plays a key role in the pathogenesis of gouty arthritis. The aim of the present study was to investigate the link amongTLR4 gene polymorphisms at various loci, protein expression, and gouty arthritis susceptibility. MethodsBetween 2016 and 2021, a case-control study was used to collect a total of 1207 study subjects, including 317 male patients with gouty arthritis (gout group) and 890 healthy males (c...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Lu Liu Source Type: research

Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities
ConclusionsWe clustered people with gout into five groups with varying comorbidities. People with CVD, CKD, and cancer had the highest risk of gout flares and should receive comprehensive care. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 22, 2024 Category: Endocrinology Source Type: research

Pathogenesis of gout: Exploring more therapeutic target
AbstractGout is a chronic metabolic and immune disease, and its specific pathogenesis is still unclear. When the serum uric acid exceeds its saturation in the blood or tissue fluid, it is converted to monosodium urate crystals, which lead to acute arthritis of varying degrees, urinary stones, or irreversible peripheral joint damage, and in severe cases, impairment of vital organ function. Gout flare is a clinically significant state of acute inflammation in gout. The current treatment is mostly anti-inflammatory analgesics, which have numerous side effects with limited treatment methods. Gout pathogenesis involves many asp...
Source: International Journal of Rheumatic Diseases - April 22, 2024 Category: Rheumatology Authors: Niqin Xiao, Zhaohu Xie, Zhiyan He, Yundong Xu, Shuyu Zhen, Yuanyuan Wei, Xiaoyu Zhang, Jiayan Shen, Jian Wang, Yadan Tian, Jinlian Zuo, Jiangyun Peng, Zhaofu Li Tags: REVIEW Source Type: research

The Clinical Significance of Serum Interleukin-36 α Levels in Patients with Gout
CONCLUSION: In conclusion, serum IL-36α levels were elevated in patients with gout and correlated with the clinical markers of inflammation. Our findings suggest that IL-36α may be a novel inflammatory indicator for gout.PMID:38638029 | DOI:10.1080/08820139.2024.2341233 (Source: Immunological Investigations)
Source: Immunological Investigations - April 19, 2024 Category: Allergy & Immunology Authors: Sicen Meng Wubing Lu Zhi Li Yinxin Zhou Shanjun Shi Hui Zhao Mingcai Li Yan Li Source Type: research

Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00372.2023. Online ahead of print.ABSTRACTHumans are predisposed to gout because they lack uricase that converts uric acid to allantoin. Rodents have uricase, resulting in low basal serum uric acid. A uricase inhibitor raises serum uric acid in rodents. There were 2 aims of the study in polycystic kidney disease (PKD): 1) to determine whether increasing serum uric acid with the uricase inhibitor, oxonic acid, resulted in faster cyst growth and 2) to determine whether treatment with the xanthine oxidase inhibitor, oxypurinol, reduced the cyst growth caused by ox...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Anjana Chaudhary Zhibin He Daniel J Atwood Makoto Miyazaki Ozgur A Oto Allen Davidoff Charles L Edelstein Source Type: research

Xanthine oxidase inhibitory constituents from the roots of Ampelopsis japonica 
Nat Prod Res. 2024 Apr 18:1-10. doi: 10.1080/14786419.2024.2341308. Online ahead of print.ABSTRACTBioassay-guided purification of the xanthine oxidase (XOD) inhibitory extract of the roots of Ampelopsis japonica resulted in the isolation of two new triterpenoids (1-2), designated Ampejaponoside A and B, along with sixteen known compounds (3-18). The structures of Ampejaposide A and B were elucidated by comprehensive analysis of spectroscopic data with the structures of the known compounds 3-18 confirmed by comparison the spectral data with corresponding values reported in literatures. All the isolates were evaluated for th...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Yu-Lin Li Fen Liu Li-Yun Zhao Han-Xiang Li Aikebaier Jumai Zhi-Fang Xu Sheng-Xiang Qiu Source Type: research

Correlation between the bacterial community succession and purine compound changes during Huangjiu fermentation
This study is helpful to scientifically understand the formation mechanism of purines, providing a basis for screening functional strains of purine degrading to accurately regulate purine level in Huangjiu.PMID:38637084 | DOI:10.1016/j.fm.2024.104522 (Source: Food Microbiology)
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Xianglin Wang Guolin Cai Dianhui Wu Jian Lu Source Type: research