3 AC & R Study Summaries: Frailty & Prefrailty in RA, Premature Mortality in Gout & Using Recruitment & Multidisciplinary Care Incentives to Improve Access
Frailty & Prefrailty in Patients with RA TNF-α inhibitors associated with higher infection risk By Namrata Singh, MD, MSCI, Katherine D. Wysham, MD, James S. Andrews, MD, & Una E. Makris, MD Why was this study done? Frailty and prefrailty are more common and occur at a younger age in patients with rheumatoid arthritis (RA)... (Source: The Rheumatologist)
Source: The Rheumatologist - May 5, 2024 Category: Rheumatology Authors: Arthritis Care & Research Tags: Conditions Gout and Crystalline Arthritis Research Reviews Research Rheum Rheumatoid Arthritis Arthritis Care & Research frailty Gout Resource Center multidisciplinary care patient access physician recruitment RA Resource Center Source Type: research
Uric acid-lowering effect of harpagoside and its protective effect against hyperuricemia-induced renal injury in mice
Biochem Biophys Res Commun. 2024 Apr 30;716:150038. doi: 10.1016/j.bbrc.2024.150038. Online ahead of print.ABSTRACTHyperuricemia (HUA) is caused by increased synthesis and/or insufficient excretion of uric acid (UA). Long-lasting HUA may lead to a number of diseases including gout and kidney injury. Harpagoside (Harp) is a bioactive compound with potent anti-inflammatory activity from the roots of Scrophularia ningpoensis. Nevertheless, its potential effect on HUA was not reported. The anti-HUA and nephroprotective effects of Harp on HUA mice were assessed by biochemical and histological analysis. The proteins responsible ...
Source: Biochemical and Biophysical Research communications - May 5, 2024 Category: Biochemistry Authors: Qiong Fu Jin-Juan Zhang Qin-Feng Zhu Ling-Ling Yu Fang Wang Jing Li Xun He Jun-Li Ao Guo-Bo Xu Mao-Chen Wei Xing-Jiang Liao Shang-Gao Liao Source Type: research
Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase
Eur J Med Chem. 2024 Apr 20;271:116437. doi: 10.1016/j.ejmech.2024.116437. Online ahead of print.ABSTRACTAs a cytosolic enzyme involved in the purine salvage pathway metabolism, purine nucleoside phosphorylase (PNP) plays an important role in a variety of cellular functions but also in immune system, including cell growth, apoptosis and cancer development and progression. Based on its T-cell targeting profile, PNP is a potential target for the treatment of some malignant T-cell proliferative cancers including lymphoma and leukemia, and some specific immunological diseases. Numerous small-molecule PNP inhibitors have been d...
Source: European Journal of Medicinal Chemistry - May 3, 2024 Category: Chemistry Authors: Yangyang Chen Yang Li Jing Gao Quanwei Yu Yiwen Zhang Jifa Zhang Source Type: research
Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase
Eur J Med Chem. 2024 Apr 20;271:116437. doi: 10.1016/j.ejmech.2024.116437. Online ahead of print.ABSTRACTAs a cytosolic enzyme involved in the purine salvage pathway metabolism, purine nucleoside phosphorylase (PNP) plays an important role in a variety of cellular functions but also in immune system, including cell growth, apoptosis and cancer development and progression. Based on its T-cell targeting profile, PNP is a potential target for the treatment of some malignant T-cell proliferative cancers including lymphoma and leukemia, and some specific immunological diseases. Numerous small-molecule PNP inhibitors have been d...
Source: European Journal of Medicinal Chemistry - May 3, 2024 Category: Chemistry Authors: Yangyang Chen Yang Li Jing Gao Quanwei Yu Yiwen Zhang Jifa Zhang Source Type: research
Rationalization design, soluble expression and PEG modification of highly active recombinant human-porcine uricase mutant protein
Int J Biol Macromol. 2024 Apr 30:131989. doi: 10.1016/j.ijbiomac.2024.131989. Online ahead of print.ABSTRACTUric acid is the end product of purine metabolism in humans due to inactivation of the uricase determined by the mutated uricase gene. Uricase catalyzes the conversion of uric acid into water-soluble allantoin that is easily excreted by the kidneys. Hyperuricemia occurs when the serum concentration of uric acid exceeds its solubility (7 mg/dl). However, modifications to improve the uricase activity is under development for treating the hyperuricemia. Here we designed 7 types of human-porcine chimeric uricase by multi...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Mingjie Tong Shengli Wang Junxi Luan Qiuling Xie Luquan Wang Xiaoyang Shen Sheng Xiong Source Type: research
Rationalization design, soluble expression and PEG modification of highly active recombinant human-porcine uricase mutant protein
Int J Biol Macromol. 2024 Apr 30:131989. doi: 10.1016/j.ijbiomac.2024.131989. Online ahead of print.ABSTRACTUric acid is the end product of purine metabolism in humans due to inactivation of the uricase determined by the mutated uricase gene. Uricase catalyzes the conversion of uric acid into water-soluble allantoin that is easily excreted by the kidneys. Hyperuricemia occurs when the serum concentration of uric acid exceeds its solubility (7 mg/dl). However, modifications to improve the uricase activity is under development for treating the hyperuricemia. Here we designed 7 types of human-porcine chimeric uricase by multi...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Mingjie Tong Shengli Wang Junxi Luan Qiuling Xie Luquan Wang Xiaoyang Shen Sheng Xiong Source Type: research
Burton's line and scar hyperpigmentation in a patient with severe lead poisoning and saturnine gout
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 2, 2024 Category: Rheumatology Authors: Gisela Garcia ‐Arellano,
Maria Fernanda Ortiz‐Nuño,
Griselda Serna‐Peña,
Juan Pablo Toledo‐Motta,
Ana Victoria Vasquez‐Gallegos,
Dionicio Angel Galarza‐Delgado,
Jesus Alberto Cardenas‐de la Garza Tags: Clinical Image Source Type: research
Nurses ’ roles, interventions, and implications for management of rheumatic diseases
This article provides a comprehensive review of nurses ’ roles, interventions, and impacts in several rheumatic diseases, including rheumatoid arthritis, osteoarthritis, spondyloarthritis, gout, systemic lupus erythematosus, and polymyalgia rheumatica. It has been demonstrated that care under nursing supervision is effective and safe, with benefits in cluding disease management, quality of life, and treatment adherence. In addition, nurses play a crucial role in promoting health, educating patients, and administering biological disease-modifying anti-rheumatic drugs. The COVID-19 pandemic has highlighted the significance...
Source: Rheumatology International - May 2, 2024 Category: Rheumatology Source Type: research
Recurrent Gout and Serum Urate
To the Editor A recent study found that serum urate levels were associated with the risk of subsequent gout flares and hospitalizations for recurrent gout. However, urate-lowering therapy did not significantly alter the association between serum urate levels and the risk of acute gout flares. These findings diverge from management guidelines recommending urate-lowering therapy and maintenance of serum urate levels less than 6 mg/dL to prevent recurrent gout flares. We are concerned that the diverse treatment adherence rates in this study might have influenced the outcomes of recurrent gout flares. At baseline, 43% of the g...
Source: JAMA - Journal of the American Medical Association - May 2, 2024 Category: General Medicine Source Type: research
Recurrent Gout and Serum Urate
To the Editor A recent Review supported use of baseline serum urate level to assess the risk of recurrent gout. A concern raised by the accompanying Editorial pertained to the reliability of a single serum urate measurement. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 2, 2024 Category: General Medicine Source Type: research
Recurrent Gout and Serum Urate —Reply
In Reply Our recent article quantified the role of serum urate, the central causal biomarker for gout, and found graded associations with recurrent gout flares, including those resulting in hospitalizations (with 100% of these cases associated with serum urate ≥5 mg/dL). Regarding the comments from Drs Chang and Hung, our study did not directly evaluate whether urate-lowering therapy affects gout flares, but rather one of our subgroup analyses tested whether the degree of association of serum urate with flares differed between those treated with urate-l owering therapy vs those not treated with urate-lowering therapy and...
Source: JAMA - Journal of the American Medical Association - May 2, 2024 Category: General Medicine Source Type: research
SGLT-2 inhibitors May Decrease Recurrent Gout Flares in Patients with Type 2 diabetes
Dr. Bernal
Clinical question: Do SGLT-2 inhibitors decrease gout flares in patients with type 2 diabetes and a known history of gout?
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) are known to decrease serum urate levels and the risk of incident gout. However, their role in secondary prevention of gout flares is unknown.
Study design: Propensity score–matched, new-user cohort study
Setting: British Columbia, Canada
Synopsis: Using a group of population-based, linked, administrative databases, the population of British Columbia was studied. 15,067 patients with gout and type 2 diabetes had f...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Autoimmune Diseases In the Literature Pharmacology Rheumatology Source Type: research
Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors
Eur J Med Chem. 2024 Apr 26;271:116443. doi: 10.1016/j.ejmech.2024.116443. Online ahead of print.ABSTRACTXanthine oxidase (XO) is a key enzyme for the production of uric acid in the human body. XO inhibitors (XOIs) are clinically used for the treatment of hyperuricemia and gout, as they can effectively inhibit the production of uric acid. Previous studies indicated that both indole and isoxazole derivatives have good inhibitory effects against XO. Here, we designed and synthesized a novel series of N-5-(1H-indol-5-yl)isoxazole-3-carboxylic acids according to bioisosteric replacement and hybridization strategies. Among the ...
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Dongqian Huang Wenye Li Yilan Zhao Cheng Xie Xiaogang Luo Fengshou Wu Zhiqiang Xu Qi Sun Genyan Liu Source Type: research
Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors
Eur J Med Chem. 2024 Apr 26;271:116443. doi: 10.1016/j.ejmech.2024.116443. Online ahead of print.ABSTRACTXanthine oxidase (XO) is a key enzyme for the production of uric acid in the human body. XO inhibitors (XOIs) are clinically used for the treatment of hyperuricemia and gout, as they can effectively inhibit the production of uric acid. Previous studies indicated that both indole and isoxazole derivatives have good inhibitory effects against XO. Here, we designed and synthesized a novel series of N-5-(1H-indol-5-yl)isoxazole-3-carboxylic acids according to bioisosteric replacement and hybridization strategies. Among the ...
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Dongqian Huang Wenye Li Yilan Zhao Cheng Xie Xiaogang Luo Fengshou Wu Zhiqiang Xu Qi Sun Genyan Liu Source Type: research
Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities
ConclusionsWe clustered people with gout into five groups with varying comorbidities. People with CVD, CKD, and cancer had the highest risk of gout flares and should receive comprehensive care. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
