Correction: Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)
Chem Commun (Camb). 2024 Apr 11. doi: 10.1039/d4cc90123a. Online ahead of print.ABSTRACTCorrection for 'Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)' by Alice Kennett et al., Chem. Commun., 2024, 60, 436-439, https://doi.org/10.1039/D3CC02565A.PMID:38602132 | DOI:10.1039/d4cc90123a (Source: Chemical Communications)
Source: Chemical Communications - April 11, 2024 Category: Chemistry Authors: Alice Kennett Sven Epple Gabriella van der Valk Irene Georgiou Evelyne Gout Romain R Viv ès Angela J Russell Source Type: research
Correction: Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)
Chem Commun (Camb). 2024 Apr 11. doi: 10.1039/d4cc90123a. Online ahead of print.ABSTRACTCorrection for 'Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)' by Alice Kennett et al., Chem. Commun., 2024, 60, 436-439, https://doi.org/10.1039/D3CC02565A.PMID:38602132 | DOI:10.1039/d4cc90123a (Source: Chemical Communications)
Source: Chemical Communications - April 11, 2024 Category: Chemistry Authors: Alice Kennett Sven Epple Gabriella van der Valk Irene Georgiou Evelyne Gout Romain R Viv ès Angela J Russell Source Type: research
Site-Specific Conjugation of Bottlebrush Polymers to Therapeutic Protein via Bioorthogonal Chemistry
In this study, we exploited tetrazine bioorthogonal chemistry to achieve the site-specific conjugation of bottlebrush polymers to urate oxidase (UOX), a therapeutic protein for gout treatment. An azido-functionalized zwitterionic bottlebrush polymer (N3-ZBP) using a "grafting-from" strategy involving RAFT and ATRP methods was synthesized, and a trans-cyclooctene (TCO) moiety was introduced at the polymer end through the strain-promoted azide-alkyne click (SPAAC) reaction. The subsequent coupling between TCO-incorporated bottlebrush polymer and tetrazine-labeled UOX using a fast and safe bioorthogonal reaction, inverse elec...
Source: Biomacromolecules - April 9, 2024 Category: Biochemistry Authors: Biswajit Saha Jae Hun Lee Inchan Kwon Hoyong Chung Source Type: research
Higher oxidative balance score is associated with lower kidney stone disease in US adults: a population-based cross-sectional study
ConclusionOur study revealed that OBS was negative associated with KSD, and high OBS might be a protective factor in KSD. Targeting one of the components of OBS might be beneficial. (Source: World Journal of Urology)
Source: World Journal of Urology - April 8, 2024 Category: Urology & Nephrology Source Type: research
Green manufacturing of a hypoxanthine enzyme sensor for fish freshness based on modified nitrocellulose surface with chito-oligosaccharide
Talanta. 2024 Mar 30;274:126007. doi: 10.1016/j.talanta.2024.126007. Online ahead of print.ABSTRACTHypoxanthine (Hx), produced by adenosine triphosphate (ATP) metabolism, is a valuable indicator that determines the quality and degradation status of meat products and is also an important biochemical marker to certain diseases such as gout. The rapid emergence of paper-based enzyme biosensors has already revolutionized its on-site determination. But it is still limited by the complex patterning and fabrication, unstable enzyme and uneven coloration. This work aims to develop an eco-friendly method to construct engineered pap...
Source: Talanta - April 7, 2024 Category: Chemistry Authors: Yilin Wang Xiaoyun Zhang Maole Wei Huigang Kang Zhenqiang Zhang Xiudan Wang Cuiping Ma Source Type: research
Green manufacturing of a hypoxanthine enzyme sensor for fish freshness based on modified nitrocellulose surface with chito-oligosaccharide
Talanta. 2024 Mar 30;274:126007. doi: 10.1016/j.talanta.2024.126007. Online ahead of print.ABSTRACTHypoxanthine (Hx), produced by adenosine triphosphate (ATP) metabolism, is a valuable indicator that determines the quality and degradation status of meat products and is also an important biochemical marker to certain diseases such as gout. The rapid emergence of paper-based enzyme biosensors has already revolutionized its on-site determination. But it is still limited by the complex patterning and fabrication, unstable enzyme and uneven coloration. This work aims to develop an eco-friendly method to construct engineered pap...
Source: Talanta - April 7, 2024 Category: Chemistry Authors: Yilin Wang Xiaoyun Zhang Maole Wei Huigang Kang Zhenqiang Zhang Xiudan Wang Cuiping Ma Source Type: research
Get on top of gout with a fresh look at treatment options
AbstractManaging increasingly prevalent gout, which stems from hyperuricaemia, is not easy. Flare management and long-term serum urate-lowering (ULT) therapy, largely with xanthine oxidase inhibitors (XOIs) or uric acid transporter 1 inhibitors (URAT1Is), are core strategies, but robust comparative trials in these agents are limited. Several are associated, sometimes undeservedly, with adverse drug events. Pipeline URAT1Is report 60 –70% decreases in serum urate, to< 5 mg/dL in most patients. These URAT1Is, plus new XOIs, combination regimens, immunosuppressant adjuncts for intravenous uricases and uricosuric comorb...
Source: Drugs and Therapy Perspectives - April 4, 2024 Category: Drugs & Pharmacology Source Type: research
Association Between Family History in Patients with Primary Gout and Left Ventricular Diastolic Function: A Cross-Sectional Study
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - April 3, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Prednisolone Versus Colchicine for Acute Gout in Primary Care: statistical analysis plan for the pragmatic, multicenter, randomized, and double-blinded COPAGO non-inferiority trial
To date, colchicine and prednisolone are two effective therapies for the treatment of acute gout but have never been compared directly in a randomized clinical trial. In addition, in previous trials of treatin... (Source: Trials)
Source: Trials - April 3, 2024 Category: General Medicine Authors: Adrian Richter, Julia Truthmann, Eva Hummers, Julia Freyer Martins Pereira, Ildik ó Gágyor, Franziska Schuster, Amelie Witte, Susanne Böhm, Alexandra Greser, Petra Kamin, Sylvia Stracke, Marcus Dörr, Robin Bülow, Stefan Engeli, Jean François Chenot Tags: Update Source Type: research
Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions
Int Immunopharmacol. 2024 Mar 31;132:111932. doi: 10.1016/j.intimp.2024.111932. Online ahead of print.ABSTRACTUric acid is a product of purine degradation, and uric acid may have multiple physiologic roles, including the beneficial effects as an antioxidant and neuroprotector, maintenance of blood pressure during low salt ingestion, and modulation of immunity. However, overproduction of metabolic uric acid, and/or imbalance of renal uric acid secretion and reabsorption, and/or underexcretion of extrarenal uric acid, e.g. gut, will contribute to hyperuricemia, which is a common metabolic disease. Long-lasting hyperuricemia ...
Source: International Immunopharmacology - April 1, 2024 Category: Allergy & Immunology Authors: Shuangling Yang Haimei Liu Xian-Ming Fang Fuman Yan Yaxing Zhang Source Type: research
Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions
Int Immunopharmacol. 2024 Mar 31;132:111932. doi: 10.1016/j.intimp.2024.111932. Online ahead of print.ABSTRACTUric acid is a product of purine degradation, and uric acid may have multiple physiologic roles, including the beneficial effects as an antioxidant and neuroprotector, maintenance of blood pressure during low salt ingestion, and modulation of immunity. However, overproduction of metabolic uric acid, and/or imbalance of renal uric acid secretion and reabsorption, and/or underexcretion of extrarenal uric acid, e.g. gut, will contribute to hyperuricemia, which is a common metabolic disease. Long-lasting hyperuricemia ...
Source: International Immunopharmacology - April 1, 2024 Category: Allergy & Immunology Authors: Shuangling Yang Haimei Liu Xian-Ming Fang Fuman Yan Yaxing Zhang Source Type: research
Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice
This study aimed to investigate anti-gout and anti-inflammatory properties of curcumin nanoparticles (CNPs). For this purpose, CNPs were prepared by dissolving curcumin into dichloromethane. Then, gout was induced by injecting monosodium urate crystals (MSU) in the ankle joint and in the intra-per itoneal cavity which caused ankle swelling and increased blood uric acid levels. CNPs in different concentrations (5, 10, and 20 ppm) and allopurinol were orally administered. The MSU crystals increased the xanthine oxidase levels both in serum and the liver. Moreover, MSU crystals increased the se rum levels of interleukin 1β,...
Source: Inflammopharmacology - March 31, 2024 Category: Drugs & Pharmacology Source Type: research
Viruses, Vol. 16, Pages 541: Isolation, Identification, and Pathogenicity of a Goose Astrovirus Genotype 1 Strain in Goslings in China
Yi Tang
Goose astrovirus genotype 1 (GAstV-1) has emerged in goose farms in some provinces of China in recent years and is considered to be one of the pathogens of gout in goslings in China. However, few studies have been conducted on the dynamic distribution, tissue tropism, and pathogenesis of GAstV-1 in goslings. In 2022, an epidemiological investigation of goose astrovirus (GAstV) in goslings was conducted in seven provinces of China. During the investigation, a GAstV-1 designated as GAstV-JSXZ was identified in the kidney of an 8-day-old gosling and was successfully isolated from a goose embryo. The full genome ...
Source: Viruses - March 30, 2024 Category: Virology Authors: Feng Wei Dalin He Bingrong Wu Youxiang Diao Yi Tang Tags: Article Source Type: research
Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice
Biochem Biophys Res Commun. 2024 Mar 20;709:149809. doi: 10.1016/j.bbrc.2024.149809. Online ahead of print.ABSTRACTHyperuricemia is a chronic metabolic disease caused by purine metabolism disorder. And several gene loci and transporter proteins that associated with uric acid transport functions have been identified. Retinol Dehydrogenase 12 (RDH12), recognized for its role in safeguarding photoreceptors, and our study investigated the potential impact of Rdh12 mutations on other organs and diseases, particularly hyperuricemia. We assessed Rdh12 mRNA expression levels in various tissues and conducted serum biochemical analy...
Source: Biochemical and Biophysical Research communications - March 29, 2024 Category: Biochemistry Authors: Jiaxin Bian Hongyu Chen Junhui Sun Shuai Han Ming Qi Qing Pan Source Type: research
Proline-derived quinoline formamide compounds as human urate transporter 1 inhibitors with potent uric acid-lowering activities
We report the design and synthesis of a series of proline-derived quinoline formamide compounds as human urate transporter 1 (URAT1) inhibitors via a ligand-based pharmacophore approach. Structure-activity relationship studies reveal that the replacement of the carboxyl group on the polar fragment with trifluoromethanesulfonamide and substituent modification at the 6-position of the quinoline ring greatly improve URAT1 inhibitory activity compared with lesinurad. Compounds 21c, 21e, 24b, 24c, and 23a exhibit potent activities against URAT1 with IC50 values ranging from 0.052 to 0.56 μM. Furthermore, compound 23a displays ...
Source: European Journal of Medicinal Chemistry - March 28, 2024 Category: Chemistry Authors: Shengnan Li Hui Liao Lijun Luo Bingxu Meng Fengxin Zheng Li Sheng Hongyi Zhao Yi Huan Lei Lei Jiayu Zhai Kunlu Zhao Jinhong Tian Ting Wu Gang Li Jianxin Pang Haihong Huang Source Type: research
