Adverse drug reaction reporting in Canada: consumer versus reports
This study compares consumer-reported ADRs with physician-reported ADRs based on seriousness, system organ class (SOC), and anatomical therapeutic chemical (ATC) classification.MethodsThis retrospective observational study evaluated ADR reports received by the Canadian Vigilance ADR Reporting Database from January 2000 to December 2014. A total of 198,781 spontaneous ADR reports were analyzed in terms of who reported the ADR, the seriousness of the ADR, and category of ADR by SOC and ATC group. Chi-square tests for independence and odds ratios were used to detect statistically significant differences between reporters (con...
Source: Drugs and Therapy Perspectives - August 4, 2020 Category: Drugs & Pharmacology Source Type: research

Preparedness of pharmacists to respond to the emergency of the COVID-19 pandemic in Brazil: a comprehensive overview
AbstractThe outbreak of COVID-19 in low- and middle-income countries is worrisome due to the social inequalities in these countries, their limited health budgets and the significant burden of other acute and chronic diseases. The leap in the number of cases in Brazil has imposed a huge strain on the healthcare system. We sought to provide a comprehensive overview of the challenges encountered by pharmacy services in responding to the COVID-19 pandemic emergency in Brazil and discuss the role of clinical pharmacists in this context. Pharmaceutical services play a key role in the emergency response to the pandemic. The pharm...
Source: Drugs and Therapy Perspectives - July 31, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of management and factors associated with hypertension control in hemodialysis patients at a tertiary-care hospital in Pakistan
AbstractBackgroundHypertension is highly prevalent and poorly controlled among hemodialysis patients. However, published information regarding the management and control of hypertension among Pakistani hemodialysis patients is scarce.ObjectiveOur objective was to evaluate the pharmacotherapeutic management and control of hypertension and associated factors in hemodialysis patients at a tertiary-care hospital.Materials and methodsEligible hypertensive hemodialysis patients enrolled at the Balochistan Institute of Nephrology-Urology Quetta, Pakistan, between 1 July 2017 and 30 November 2019 were retrospectively followed for ...
Source: Drugs and Therapy Perspectives - July 28, 2020 Category: Drugs & Pharmacology Source Type: research

Strategies to conserve salbutamol pressurized metered-dose inhaler stock levels amid COVID-19 drug shortage
AbstractEssential inhaler medications for patients with respiratory diseases are backordered due to the coronavirus disease of 2019 (COVID-19). In hospitals, there has been a drastic increase in the use of salbutamol pressurized metered-dose inhalers (pMDIs), as well as salbutamol Diskus, leading to a decline in availability and causing interruptions in the supply chain. Patients with asthma are at higher risk of respiratory complications if they are infected with COVID-19. Salbutamol, a short-acting β-agonist (SABA), could be a life-saving medication during critical conditions. Other short-acting muscarinic antagonis...
Source: Drugs and Therapy Perspectives - July 25, 2020 Category: Drugs & Pharmacology Source Type: research

Hospitalized elderly: investigating newly prescribed atypical antipsychotics during the hospital stay and their continuation on discharge
ConclusionsDespite the risks of atypical antipsychotics in the elderly, a large proportion of patients who were newly prescribed atypical antipsychotics in hospital were prescribed these medications on discharge. While the majority of these patients did have an indication for starting an atypical antipsychotic documented in the discharge summary, a plan to follow-up with this medication as an outpatient was commonly absent. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - July 23, 2020 Category: Drugs & Pharmacology Source Type: research

Paradigm shift of drug information centers during the COVID-19 pandemic
This article explores the possible additional roles DICs can play, besides providing drug information within the hospital or in the community. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - July 20, 2020 Category: Drugs & Pharmacology Source Type: research

Prevent postoperative recurrence of paediatric Crohn ’s disease by risk-based treatment and early monitoring
AbstractThe course of Crohn ’s disease (CD) is especially aggressive in paediatric CD, with surgical resection of intestinal macroscopic lesions often being necessary, Unfortunately, surgery is not curative, and most patients experience postoperative disease recurrence within years of undergoing the initial surgery. Paediatr ic CD patients have a higher lifelong risk of repeated surgical interventions than adults, and preventing disease recurrence is of utmost importance to ensure growth and quality of life. Prevention generally involves prophylactic drugs (e.g. anti-TNFα, thiopurines, metronidazole), as well a...
Source: Drugs and Therapy Perspectives - July 20, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Aprotinin in adults at high risk of major blood loss during isolated CABG with cardiopulmonary bypass: a profile of its use in the EU
Page 10, Compliance with ethical standards, Conflict of interest, line 4: the following text, which previously read. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - July 16, 2020 Category: Drugs & Pharmacology Source Type: research

Cenobamate in focal seizures: a profile of its use
AbstractCenobamate (XCOPRI®), a novel tetrazole alkyl carbamate derivative, is approved in the USA for use as monotherapy and adjunctive therapy in adults with focal seizures (also known as partial-onset seizures). Its use (within the recommended dosage of  ≤ 400 mg/day) significantly reduced focal seizure frequency relative to the use of placebo in short-term (≤ 18 weeks) multinational, phase 2 studies in adults with focal seizures, with antiepileptic benefits appearing to be sustained over the longer-term (30 months). Cenobamate appears to have low abuse potential and to be g...
Source: Drugs and Therapy Perspectives - July 14, 2020 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of intra-articular injection with triamcinolone acetonide for patients with rheumatoid arthritis
AbstractBackgroundIntra-articular injection (IAI) with a glucocorticoid (GC) is often used in clinical practice, despite its controversial effectiveness. We performed a retrospective study that evaluated the efficacy and safety of IAI with the GC triamcinolone acetonide (TA) in patients with rheumatoid arthritis (RA) over the period of April 2014 –March 2019.MethodsClinical indices 1  month and 1 year after the initial TA IAI were compared statistically. Changes in disease activity scores (DAS) and correlation between DAS and background factors were evaluated for each time period. Clinical indices, pain ind...
Source: Drugs and Therapy Perspectives - July 8, 2020 Category: Drugs & Pharmacology Source Type: research

Knowledge and beliefs towards universal safety precautions during the coronavirus disease (COVID-19) pandemic among the Indian public: a web-based cross-sectional survey
AbstractBackgroundThe novel coronavirus disease 2019 (COVID-19) is considered the most serious global health threat in recent times. As there is a current lack of approved treatments and vaccines, universal safety precautions (USPs) must be taken to deal with this emergency.ObjectiveThe aim of this study was to assess the knowledge and beliefs of the Indian public with regard to USPs during the COVID-19 pandemic.MethodsA cross-sectional, web-based survey was conducted during March 2020. A 20-item self-administered questionnaire was developed, validated and distributed using Google Forms through social media networks. Binar...
Source: Drugs and Therapy Perspectives - July 4, 2020 Category: Drugs & Pharmacology Source Type: research

Manage acute pain in opioid-tolerant patients with simple analgesics and adjuvants, along with increased doses of opioids if necessary
AbstractOpioid tolerance complicates post-surgical analgesia in many patients, with an increased incidence of psychiatric comorbidity often adding complexity. For the management of acute pain in opioid-tolerant patients, a multimodal approach using simple analgesics, adjuvant agents and short-term increased doses of opioids is recommended, with early involvement of specialist pain services. Paradoxical opioid-induced hyperalgesia, as opposed to acute opioid tolerance, requires compensated dose reduction of the precipitating opioid. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - July 4, 2020 Category: Drugs & Pharmacology Source Type: research

Adverse drug reactions and interactions: first reports and special situations
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - June 24, 2020 Category: Drugs & Pharmacology Source Type: research

Review of evidence on using ACEi and ARBs in patients with hypertension and COVID-19
AbstractCOVID-19 has recently become a major pandemic with associated socioeconomic dimensions. Mortality statistics suggest that COVID-19 is more lethal in aged patients with comorbid conditions including hypertension. There is ongoing debate about whether the use of angiotensin converting enzyme (ACE) inhibitors (ACEi) and angiotensin receptor blockers (ARBs) are useful or hazardous in patients with COVID-19, with both narratives supported by researchers with different hypotheses. The researchers supporting the use of these medications believe ACE2 functional blockers may block cellular entry of the SARS-CoV-2 virus and ...
Source: Drugs and Therapy Perspectives - June 9, 2020 Category: Drugs & Pharmacology Source Type: research

Consider clinically relevant pharmacokinetic drug interactions when co-prescribing drugs in attention-deficit/hyperactivity disorder
AbstractPolypharmacy is common in the treatment of attention-deficit hyperactivity disorder (ADHD). However, the use of multiple drugs increases the risk of pharmacokinetic drug –drug interactions (DDIs) and subsequent adverse safety outcomes. Clinically relevant pharmacokinetic DDIs can be prevented by adjusting the dose of the ADHD drug or, if possible, by using an alternative drug that would not have a pharmacokinetic effect on the ADHD drug. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 30, 2020 Category: Drugs & Pharmacology Source Type: research

Prevalence of potentially inappropriate medications use and associated risk factors among elderly cardiac patients using the 2015 American Geriatrics Society beers criteria
ConclusionThe use of PIMs is common in elderly cardiac patients and significantly associated with dependence in performing ADL. Strict compliance to guideline recommendations is necessary to improve the quality of medication use. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 29, 2020 Category: Drugs & Pharmacology Source Type: research

Be alert for macrophage activation syndrome in seriously sick children with underlying pro-inflammatory disorders
AbstractMacrophage activation syndrome (MAS) is a serious complication of pro-inflammatory conditions, such as systemic juvenile idiopathic arthritis. MAS results from over-stimulated immune-related cytokines. Now considered a form of acquired haemophagocytic lymphohistiocytosis, MAS is fatal in up to 20% of children. Fast diagnosis and immediate treatment with broad immunosuppressants and biological drugs targeting inflammatory cytokines are required. High ferritin levels and a high ferritin to erythrocyte sedimentation rate ratio are quick indicators of potential MAS. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 29, 2020 Category: Drugs & Pharmacology Source Type: research

Pretomanid in drug-resistant tuberculosis: a profile of its use
AbstractPretomanid, a nitroimidazoxazine antimycobacterial agent, presents a valuable option for the treatment of adults with pulmonary extensively drug-resistant (XDR) tuberculosis (TB) or treatment-intolerant or nonresponsive multidrug-resistant (MDR)-TB when used as part of an all-oral combination regimen with bedaquiline and linezolid. In the pivotal phase  III Nix-TB trial, a combination regimen of pretomanid, bedaquiline, and linezolid for 6 months had a high treatment success rate. Besides the demonstrated effectiveness, the pretomanid, bedaquiline, and linezolid combination has other benefits, including t...
Source: Drugs and Therapy Perspectives - May 29, 2020 Category: Drugs & Pharmacology Source Type: research

The challenging times and opportunities for pharmacovigilance in Africa during the COVID-19 pandemic
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 26, 2020 Category: Drugs & Pharmacology Source Type: research

Beliefs about medicine and medication adherence among hypertensive patients in the community setting
ConclusionsThe medication adherence level was considered low among hypertensive patients at the community level and the low adherence level was significantly associated with higher mean BP level. This study demonstrated the importance of patients ’ beliefs regarding the necessity of and concerns about medication and their association with medication adherence, with sharing medication being strongly associated with poor medication adherence. The findings from this study could be useful for planning strategies to improve adherence among comm unity dwelling hypertensive patients in Malaysia. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 25, 2020 Category: Drugs & Pharmacology Source Type: research

Effectiveness of duloxetine for remnant pain relief in patients with rheumatoid arthritis despite remission
ConclusionDuloxetine treatment in patients with RA in clinical remission appears to have comparable effectiveness on relieving remnant pain, improving activities of daily living and maintaining QOL. Duloxetine is not expected to have any effects on disease activity control. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 25, 2020 Category: Drugs & Pharmacology Source Type: research

Dosage adjustment in obese children, even for common drugs, is largely unclear and a treat-to-effect approach may work best
AbstractObesity in children, often accompanied by comorbidities, is increasingly common. For many frequently used paediatric drugs, information on dosage adjustment in obese children is lacking or absent. Scalars, such as total body weight, are not always helpful as obese children may weigh more than adults, but differ with regard to aspects of their anatomy and physiology, especially hepatic function. Further pharmacokinetic studies in obese children are urgently needed and, in the interim, close monitoring for therapeutic effect and toxicity is recommended. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 25, 2020 Category: Drugs & Pharmacology Source Type: research

Current pharmacy practices in low- and middle-income countries; recommendations in response to the COVID-19 pandemic
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 24, 2020 Category: Drugs & Pharmacology Source Type: research

Amid COVID-19 drug shortages: proposed plan for reprocessing and reusing salbutamol pressurized metered dose inhalers (pMDIs) for shared use
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 20, 2020 Category: Drugs & Pharmacology Source Type: research

Within a large healthcare system, the incidence of positive COVID-19 results and mortality are lower in patients on chronic hydroxychloroquine therapy
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 20, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: First reports of adverse drug reactions
The adverse drug reaction‘CB-1158: immune thrombocytopenia (serious) ’ and its associated reference should be deleted. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 20, 2020 Category: Drugs & Pharmacology Source Type: research

Knowledge, attitude and preventive practices related to COVID-19: a cross-sectional study in two Pakistani university populations
ConclusionPakistani university students and employees have good knowledge and attitudes regarding COVID-19, but unsatisfactory preventive practices. Therefore, health regulators should use multiple communication approaches, such as electronic, print and social media, phone messages, etc., to increase awareness and improve practices related to COVID-19. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 9, 2020 Category: Drugs & Pharmacology Source Type: research

Adverse drug reactions and interactions: first and special-situation reports
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 9, 2020 Category: Drugs & Pharmacology Source Type: research

Disability and self-reported adverse drug events among patients with chronic diseases
ConclusionsDisabilities, such as vision problems, chewing problems, and activity limitation, were significantly related to self-reported ADEs in chronic-disease patients in the community setting. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - May 5, 2020 Category: Drugs & Pharmacology Source Type: research

Manage urinary incontinence in COPD depending on whether it is stress, urge or mixed
AbstractUrinary incontinence is a seemingly common, but largely unexplored, comorbidity associated with chronic obstructive pulmonary disease (COPD). It is not only related to older age or the leakage of urine from increased abdominal pressure while coughing (i.e. stress incontinence), but is also possibly an adverse effect of respiratory or non-respiratory drugs. Physicians should actively and routinely screen COPD patients for urinary incontinence and choose the course of management depending on whether it is stress, urge or mixed. Management options include discontinuing or replacing offending agents, prompt referral to...
Source: Drugs and Therapy Perspectives - April 29, 2020 Category: Drugs & Pharmacology Source Type: research

Insulin degludec/liraglutide in type 2 diabetes: a profile of its use
AbstractSubcutaneous insulin degludec/liraglutide (Xultophy ™) is a titratable, fixed-ratio combination of a long-acting insulin analogue and a glucagon-like peptide-1 receptor agonist (GLP-1RA) that is approved in several countries, including the USA and those in the EU for the treatment of type 2 diabetes (T2D) as add-on therapy. In clinical and real-wor ld studies in insulin-naïve or -experienced adults with inadequately controlled T2D, once-daily insulin degludec/liraglutide as add-on therapy to oral antidiabetic drugs consistently provided effective and durable glycaemic control, and delayed the time to tre...
Source: Drugs and Therapy Perspectives - April 25, 2020 Category: Drugs & Pharmacology Source Type: research

Assessment of the utilization pattern of chemotherapy agents in patients with head and neck cancer in an oncology hospital
ConclusionPlatinum analogs and taxanes were highly prescribed chemotherapy agents as they are highly effective in HNSCC. To prevent chemotherapy-induced cytotoxicity, supportive care agents, such as anti-emetics, proton pump inhibitors, anti-infective agents, and colony-stimulating factors, were used along with miscellaneous supplements. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - April 21, 2020 Category: Drugs & Pharmacology Source Type: research

Amiodarone-induced sudden onset of polymorphic ventricular tachycardia following dislodgement of a temporary pacemaker: a case report
AbstractAmiodarone is commonly used to instantly reverse potentially fatal myocardial arrhythmias, but may also potentiate arrhythmic adverse effects, such as QT prolongation and torsades de pointes. This case describes a 56-year-old male patient who, after experiencing a myocardial infarction, had undergone temporary pacemaker (TPM) insertion for bradycardia-induced ventricular tachycardia (VT); however, his VT persisted post-insertion and intravenous amiodarone was administered. Within a few minutes, monomorphic VT occurred, which progressed to polymorphic VT arrest (i.e. torsades de pointes). The polymorphic VT induced ...
Source: Drugs and Therapy Perspectives - April 16, 2020 Category: Drugs & Pharmacology Source Type: research

Is Pakistan on track to have COVID-19 transmission and mortality rates similar to those of Italy, Iran or the USA?
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - April 15, 2020 Category: Drugs & Pharmacology Source Type: research

Preventing COVID-19 in low- and middle-income countries
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - April 13, 2020 Category: Drugs & Pharmacology Source Type: research

Online pharmacies: desirable characteristics and regulations
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - April 11, 2020 Category: Drugs & Pharmacology Source Type: research

Knowledge and attitude regarding insulin self-administration among diabetic patients: a cross-sectional study in a teaching hospital of Khyber-Pakhtunkhwa, Pakistan
ConclusionOverall, participants had poor knowledge and unfavorable attitudes regarding DM and ISA therapy. The positive linear correlation between knowledge and attitude score suggests that if patients are knowledgeable about DM, their attitude regarding DM and ISA will also be favorable. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - April 11, 2020 Category: Drugs & Pharmacology Source Type: research

Development and implementation of a paediatric dosing calculator integrated in the Dutch Paediatric Formulary
AbstractCalculation errors are the most common dosing errors in paediatrics. While health information technology has been advocated to improve patient safety, the broad implementation of computer-calculated dosing in the paediatric setting is delayed for the lack of computable, explicit and unambiguous paediatric dosing guidelines. The structured digital dosing guidelines of the Dutch Paediatric Formulary permitted the   development of a paediatric dosing calculator that combines drug dosing recommendations of the formulary with patient variables. We took into account the European Union Medical Devices Directive ...
Source: Drugs and Therapy Perspectives - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Preventive measures and management of COVID-19 in pregnancy
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Clinical tools for successful treatment of onychomycosis: a narrative review
AbstractOnychomycosis is a difficult-to-treat fungal infection of the human nail plate or bed that primarily affects the natural anatomy of human toe and finger nails, leading to a hard, brittle, and uneven nail surface. The severe structural mutilation of nails restricts the application of conventional formulations and makes onychomycosis therapy a challenging clinical premise. Oral therapy with drugs such as terbinafine hydrochloride and itraconazole may lead to drug interactions and systemic adverse effects, whereas topical treatment with drugs such as ciclopirox olamine and amorolfine are often associated with poor dru...
Source: Drugs and Therapy Perspectives - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Analysis of iatrogenic and in-hospital medication errors reported to United States poison centers: a retrospective observational study
ConclusionThis study provides a more detailed evaluation of iatrogenic and in-hospital errors reported to poison centers and their related scenarios. Prevention efforts should continue to focus on reducing the incidence of errors with an emphasis on reducing the most frequent errors. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - March 26, 2020 Category: Drugs & Pharmacology Source Type: research

Solriamfetol in excessive daytime sleepiness: a profile of its use
AbstractOral solriamfetol (Sunosi ™), a selective dopamine and norepinephrine reuptake inhibitor, is approved to improve wakefulness in adults with excessive daytime sleepiness (EDS) associated with narcolepsy or obstructive sleep apnoea (OSA) in the USA and EU. In phase 3 trials in patients with narcolepsy or OSA, relative to pla cebo, solriamfetol within the recommended dosage for narcolepsy (75–150 mg/day) or OSA (37.5–150 mg/day) improved wakefulness and reduced sleepiness, together with patient- and clinician-rated global improvements. The clinical benefits of solriamfetol were maintained w...
Source: Drugs and Therapy Perspectives - March 20, 2020 Category: Drugs & Pharmacology Source Type: research

Is Pakistan prepared to tackle the coronavirus epidemic?
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - March 20, 2020 Category: Drugs & Pharmacology Source Type: research

Istradefylline: a novel drug for ‘off’ episodes in Parkinson’s disease
AbstractIstradefylline, a selective adenosine A2A receptor antagonist, has recently been approved for the treatment of ‘off’ episodes in patients with Parkinson’s disease (PD) who are already receiving treatment with levodopa/carbidopa. The aim of the article is to review the efficacy, safety and tolerability of istradefylline in the management of ‘off’ episodes of PD, based on English language articles on this topic indexed in PubMed or in the National Institute of Health clinical trials registry during 2003–2019. Based on the beneficial outcomes of phase 2 or 3 clinical trials and...
Source: Drugs and Therapy Perspectives - March 19, 2020 Category: Drugs & Pharmacology Source Type: research

Influence of TPMT polymorphisms on azathioprine-induced myelosuppression in Bangladeshi patients with systemic lupus erythematosus
The objectives of this study were to investigate the prevalence of TPMT mutation in Bangladeshi patients with systemic lupus erythematosus (SLE) requiring azathioprine therapy and its relation to the development of myelosuppression.Methods250 patients with SLE were enrolled, then monitored for myelosuppression adverse events for 4  months.TPMT*3C (rs1142345),TPMT*3B (rs1800460), andTPMT*2 (rs1800462) polymorphisms were analyzed using polymerase chain reaction –restriction fragment length polymorphism. The risk of myelosuppression (i.e., leukopenia, thrombocytopenia, and anemia) was estimated as the odds ratio (O...
Source: Drugs and Therapy Perspectives - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

Coronavirus outbreaks: prevention and management recommendations
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - March 7, 2020 Category: Drugs & Pharmacology Source Type: research

Adverse drug reactions and interactions: first reports and special situations
(Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - February 28, 2020 Category: Drugs & Pharmacology Source Type: research

Frequency and nature of potential drug –drug interaction in medical wards: a cross-sectional study in a teaching hospital
ConclusionThe overall prevalence of pDDIs is very high in medical wards, and the incidence of pDDIs is primarily associated with polypharmacy and patient age. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - February 25, 2020 Category: Drugs & Pharmacology Source Type: research

Modify treatment for atopic dermatitis when patient response to dupilumab is partial or non-durable
AbstractPatients with moderate-to-severe atopic dermatitis may have partial or non-durable responses to subcutaneous dupilumab, the first targeted systemic agent approved for this indication. Subsequent management approaches in such patients include optimising topical therapy, considering alternative diagnoses, adjusting the dosage of dupilumab dosage and/or using dupilumab in combination with traditional systemic immunosuppressive agents. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - February 25, 2020 Category: Drugs & Pharmacology Source Type: research

Manage cardiovascular risk in patients with type 2 diabetes by using agents with proven cardiovascular benefits
AbstractAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). Not only is T2D a risk factor for ASCVD, common comorbid conditions, such as dyslipidaemia and hypertension, are also risk factors for ASCVD. Controlling these risk factors with agents with proven cardiovascular benefits (e.g. metformin, glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 receptor inhibitors, statins, ACE inhibitors and angiotensin receptor blockers) provides considerable clinical benefits. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - February 24, 2020 Category: Drugs & Pharmacology Source Type: research