Toward a holistic tophus assessment in gout clinical trials: What lies beyond tophus count and size?
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 7, 2024 Category: Rheumatology Authors: Kanon Jatuworapruk Tags: EDITORIAL Source Type: research
Hyperuricemia research progress in model construction and traditional Chinese medicine interventions
This article reports on the use of TCM components for uric acid (UA)-lowering activity with excellent efficacy and low side effects based on established HUA models. This work summarizes the advantages and limitations of various HUA disease models for efficacy evaluation. Applications of TCM in HUA treatment have also been discussed in detail. This paper reveals recent research progress on HUA in constructing evaluation models and systematic TCM interventions. It will provide a scientific reference for establishing the HUA model and suggest future TCM-related HUA studies. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 7, 2024 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 29, Pages 1195: Research Progress of Bioactive Components in Sanghuangporus spp.
In conclusion, we substantiate Sanghuang as a functional food by comprehensively presenting information on extraction and purification methods, component medical and structural properties, and nontoxicity, hoping to benefit the development of Sanghuang species as a group of functional food. (Source: Molecules)
Source: Molecules - March 7, 2024 Category: Chemistry Authors: Jungu Lu Manman Su Xuan Zhou Deming Li Xinhui Niu Yi Wang Tags: Review Source Type: research
Exploring the Causal Associations of Micronutrients on Urate Levels and the Risk of Gout: A Mendelian Randomization Study
Growing evidence has indicated a potential association between micronutrient levels, urate levels, and the risk of gout. However, the causal association underlying these associations still remains uncertain. Previous observational studies and randomized controlled trials investigating the association between micronutrients, urate levels, and the risk of gout have been limited in their scope and depth. The aim of this study was to utilize Mendelian randomization (MR) to investigate the causal associations between genetically predicted micronutrient levels, urate levels, and the risk of gout. (Source: Clinical Nutrition)
Source: Clinical Nutrition - March 7, 2024 Category: Nutrition Authors: Yu Qiu, Cantao Li, Yan Huang, Chenxi Wu, Fenfen Li, Xiaoxi Zhang, Daozong Xia Tags: Original article Source Type: research
Coffee intake reduced gout risk by decreasing urate and urea while increasing SHBG levels in plasma: a mediation Mendelian randomization study
ConclusionCoffee intake reduced gout risk by decreasing urate and urea while increasing SHBG levels in plasma. These findings accentuate the benefits of coffee intake for gout management. The mediators may provide a novel insight into potential therapeutic targets for gout prevention.Key Points• This study determines the causally protective effect of coffee intake on gout.• We reveal that coffee intake reduced the risk of gout by decreasing urate and urea while increasing SHBG levels in plasma.• Identifying specific mediators in the causal pathway from coffee intake to gout provides valuable information for clinical ...
Source: Clinical Rheumatology - March 6, 2024 Category: Rheumatology Source Type: research
Epidemiology of gout - Global burden of disease research from 1990 to 2019 and future trend predictions
CONCLUSION: With the development of society, the disease burden of gout will become increasingly severe. It is very important to study the accurate epidemiological data on gout for clinical diagnosis and treatment and health policy.PMID:38439915 | PMC:PMC10910883 | DOI:10.1177/20420188241227295 (Source: Adv Data)
Source: Adv Data - March 5, 2024 Category: Epidemiology Authors: Tingfen Han Wenli Chen Xiasang Qiu Weijie Wang Source Type: research
Epidemiology of gout - Global burden of disease research from 1990 to 2019 and future trend predictions
CONCLUSION: With the development of society, the disease burden of gout will become increasingly severe. It is very important to study the accurate epidemiological data on gout for clinical diagnosis and treatment and health policy.PMID:38439915 | PMC:PMC10910883 | DOI:10.1177/20420188241227295 (Source: Adv Data)
Source: Adv Data - March 5, 2024 Category: Epidemiology Authors: Tingfen Han Wenli Chen Xiasang Qiu Weijie Wang Source Type: research
Elucidating the Mechanism of the Tibetan Medicine Sanguotang in Treating Gouty Arthritis through Network Pharmacology and in vivo Experiments
CONCLUSION: SGT comprehensively contributes to the treatment of GA by regulating UA metabolism, reducing the release of inflammatory factors, and modulating immune and inflammatory pathways.PMID:38431192 | DOI:10.1016/j.amjms.2024.02.008 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 2, 2024 Category: General Medicine Authors: Cairang Nima Ladan Wanma Xianghong Jing Caidan Duojie Duojie Gazang Zengjia Ren Source Type: research
Elucidating the Mechanism of the Tibetan Medicine Sanguotang in Treating Gouty Arthritis through Network Pharmacology and in vivo Experiments
CONCLUSION: SGT comprehensively contributes to the treatment of GA by regulating UA metabolism, reducing the release of inflammatory factors, and modulating immune and inflammatory pathways.PMID:38431192 | DOI:10.1016/j.amjms.2024.02.008 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 2, 2024 Category: General Medicine Authors: Cairang Nima Ladan Wanma Xianghong Jing Caidan Duojie Duojie Gazang Zengjia Ren Source Type: research
Clinical Images: Erosive tophaceous gout and uric acid nephrolithiasis: microscopic and three ‐dimensional high‐resolution peripheral quantitative computed tomography findings
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 29, 2024 Category: Rheumatology Authors: Giovanni Adami,
Francesca Ruzzon,
Angelo Fassio,
Davide Gatti,
Matteo Gatti,
Maurizio Rossini Tags: Clinical Image Source Type: research
Global burden and epidemic trends of gout attributable to high body mass index from 1990 to 2019
CONCLUSIONS: Our findings provide evidence for the burden of gout caused by high BMI. Developing a weight management plan and lifestyle habits for groups severely affected by gout will effectively reduce the global disease and economic burden.PMID:38414454 | PMC:PMC10895944 | DOI:10.5114/aoms/175469 (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 28, 2024 Category: General Medicine Authors: Zhaokai Jin Zhengming Wang Rui Wang Sicheng Xiang Weiqing Zhang Yi Tang Peijian Tong Yong Gu Shuaijie Lv Source Type: research
