What is allopurinol "failure" and what should we do about it?
J Rheumatol. 2024 Mar 15:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication world-wide. However, allopurinol "failure" is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol "failure", which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol "failure" underpins the approach required to turn "failure" into "succ...
Source: Journal of Rheumatology - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What is allopurinol "failure" and what should we do about it?
J Rheumatol. 2024 Mar 15:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication world-wide. However, allopurinol "failure" is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol "failure", which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol "failure" underpins the approach required to turn "failure" into "succ...
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What is allopurinol "failure" and what should we do about it?
J Rheumatol. 2024 Mar 15:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication world-wide. However, allopurinol "failure" is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol "failure", which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol "failure" underpins the approach required to turn "failure" into "succ...
Source: Journal of Rheumatology - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What is allopurinol "failure" and what should we do about it?
J Rheumatol. 2024 Mar 15:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication world-wide. However, allopurinol "failure" is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol "failure", which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol "failure" underpins the approach required to turn "failure" into "succ...
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What is allopurinol "failure" and what should we do about it?
J Rheumatol. 2024 Mar 15:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication world-wide. However, allopurinol "failure" is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol "failure", which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol "failure" underpins the approach required to turn "failure" into "succ...
Source: Journal of Rheumatology - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What is allopurinol "failure" and what should we do about it?
J Rheumatol. 2024 Mar 15:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication world-wide. However, allopurinol "failure" is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol "failure", which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol "failure" underpins the approach required to turn "failure" into "succ...
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What is allopurinol "failure" and what should we do about it?
J Rheumatol. 2024 Mar 15:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication world-wide. However, allopurinol "failure" is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol "failure", which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol "failure" underpins the approach required to turn "failure" into "succ...
Source: Journal of Rheumatology - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What is allopurinol "failure" and what should we do about it?
J Rheumatol. 2024 Mar 15:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication world-wide. However, allopurinol "failure" is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol "failure", which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol "failure" underpins the approach required to turn "failure" into "succ...
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What Is Allopurinol Failure and What Should We Do About It?
J Rheumatol. 2024 Apr 1:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication worldwide. However, allopurinol failure is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol failure, which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol failure underpins the approach required to turn failure into success in gout...
Source: Journal of Rheumatology - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
What Is Allopurinol Failure and What Should We Do About It?
J Rheumatol. 2024 Apr 1:jrheum.2024-0144. doi: 10.3899/jrheum.2024-0144. Online ahead of print.ABSTRACTAllopurinol is the most widely used urate-lowering medication worldwide. However, allopurinol failure is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol failure, which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol failure underpins the approach required to turn failure into success in gout...
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Lisa K Stamp Nicola Dalbeth Source Type: research
The clinical benefits of sodium–glucose cotransporter type 2 inhibitors in people with gout
Nature Reviews Rheumatology, Published online: 12 March 2024; doi:10.1038/s41584-024-01092-xGout is associated with various cardiometabolic–renal comorbidities that increase the risk of mortality. Sodium–glucose cotransporter type 2 (SGLT2) inhibitors show promise in both addressing the symptoms of gout and managing relevant comorbidities to help prevent premature mortality. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 12, 2024 Category: Rheumatology Authors: Chio Yokose Natalie McCormick Abhishek Abhishek Nicola Dalbeth Tristan Pascart Fr édéric Lioté Angelo Gaffo John FitzGerald Robert Terkeltaub Meghan E. Sise James L. Januzzi Deborah J. Wexler Hyon K. Choi Source Type: research
Epidemiological investigation and pathogenicity analysis of waterfowl astroviruses in some areas of China
In this study, we collected 1546 waterfowl samples from 13 provinces in China for epidemiological investigation. The results showed that 260 samples (16.8%) were positive. Four species of astrovirus were detected in 13 provinces except Fujian province. Among the four sites tested, the highest positive rates were found in farms and slaughterhouses. Cross-host and mixed infection were observed in four species of waterfowl astroviruses. The whole genome of 17 isolates was sequenced and compared with published sequences. Genetic evolution and homology analysis showed that the isolated strains had high similarity to their refer...
Source: Frontiers in Microbiology - March 11, 2024 Category: Microbiology Source Type: research
Efficacy and safety of orlistat in male patients with overweight/obesity and hyperuricemia: results of a randomized, double-blind, placebo-controlled trial
Obesity is associated with elevated serum uric acid (SUA) levels and frequent gout flares. Losing weight can reduce the SUA level and gout flares. The effect of orlistat on SUA levels and gout flares in patien... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 11, 2024 Category: Lipidology Authors: Shuang Liu, Xiaojing Lin, Minghao Tao, Qi Chen, Hang Sun, Yali Han, Shaoling Yang, Yining Gao, Shen Qu and Haibing Chen Tags: Research Source Type: research
Machine learning models for screening clinically significant nephrolithiasis in overweight and obese populations
ConclusionThis ML-based model was found able to effectively distinguish the overweight and obese subjects with clinically significant nephrolithiasis from those without. We believe that such a model can serve as an easily accessible and reliable screening tool for nephrolithiasis in overweight and obesity populations and make possible early intervention such as lifestyle modifications and medication for prevention stone complications. (Source: World Journal of Urology)
Source: World Journal of Urology - March 9, 2024 Category: Urology & Nephrology Source Type: research
Social Listening in Gout: Impact of Proactive vs. Reactive Management on Self-Reported Emotional States
ConclusionsA unique aspect of examining gout-related social media conversations is the ability to better understand the intersection of clinical management and emotional impacts in the gout community. The effect of social media statements was significantly stratified by management type for gout community members, where proactive management statements were characterized by more positive language than reactive management statements. These results suggest that proactive disease management may result in more positive mental and emotional experiences in patients with gout. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - March 8, 2024 Category: Rheumatology Source Type: research
