Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Changes in Serum Urate Levels after Bariatric Surgery in Patients with Obesity: An Observational Study
ConclusionBariatric surgery leads to significant reduction in serum urate levels at 12 and 24 months. This could reduce incidence of gout and need for prophylactic medication(s).Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - March 25, 2024 Category: Surgery Source Type: research
Comprehensive review of statin-intolerance and the practical application of Bempedoic Acid
J Cardiol. 2024 Mar 21:S0914-5087(24)00045-5. doi: 10.1016/j.jjcc.2024.03.006. Online ahead of print.ABSTRACTStatin-intolerance (SI) has prevalence between 8.0 % and 10 %, and muscular complaints are the most common reason for discontinuation. Bempedoic acid (BA), an ATP citrate lyase inhibitor, decreases hepatic generation of cholesterol, upregulates low-density lipoprotein (LDL) receptor expression in the liver, and eventually clears circulating LDL-cholesterol from the blood. Multiple randomized clinical trials studying BA demonstrate a reduction in LDL levels by 17-28 % in SI. The CLEAR OUTCOME trial established signif...
Source: Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Siva Naga S Yarrarapu Amandeep Goyal Vikramaditya Samala Venkata Viraj Panchal Barath Prashanth Sivasubramanian Doantrang T Du Roopesh Sai Jakulla Hema Pamulapati Mazhar A Afaq Steven Owens Tarun Dalia Source Type: research
Comprehensive review of statin-intolerance and the practical application of Bempedoic Acid
J Cardiol. 2024 Mar 21:S0914-5087(24)00045-5. doi: 10.1016/j.jjcc.2024.03.006. Online ahead of print.ABSTRACTStatin-intolerance (SI) has prevalence between 8.0 % and 10 %, and muscular complaints are the most common reason for discontinuation. Bempedoic acid (BA), an ATP citrate lyase inhibitor, decreases hepatic generation of cholesterol, upregulates low-density lipoprotein (LDL) receptor expression in the liver, and eventually clears circulating LDL-cholesterol from the blood. Multiple randomized clinical trials studying BA demonstrate a reduction in LDL levels by 17-28 % in SI. The CLEAR OUTCOME trial established signif...
Source: Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Siva Naga S Yarrarapu Amandeep Goyal Vikramaditya Samala Venkata Viraj Panchal Barath Prashanth Sivasubramanian Doantrang T Du Roopesh Sai Jakulla Hema Pamulapati Mazhar A Afaq Steven Owens Tarun Dalia Source Type: research
Comprehensive review of statin-intolerance and the practical application of Bempedoic Acid
J Cardiol. 2024 Mar 21:S0914-5087(24)00045-5. doi: 10.1016/j.jjcc.2024.03.006. Online ahead of print.ABSTRACTStatin-intolerance (SI) has prevalence between 8.0 % and 10 %, and muscular complaints are the most common reason for discontinuation. Bempedoic acid (BA), an ATP citrate lyase inhibitor, decreases hepatic generation of cholesterol, upregulates low-density lipoprotein (LDL) receptor expression in the liver, and eventually clears circulating LDL-cholesterol from the blood. Multiple randomized clinical trials studying BA demonstrate a reduction in LDL levels by 17-28 % in SI. The CLEAR OUTCOME trial established signif...
Source: Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Siva Naga S Yarrarapu Amandeep Goyal Vikramaditya Samala Venkata Viraj Panchal Barath Prashanth Sivasubramanian Doantrang T Du Roopesh Sai Jakulla Hema Pamulapati Mazhar A Afaq Steven Owens Tarun Dalia Source Type: research
Comprehensive review of statin-intolerance and the practical application of Bempedoic Acid
J Cardiol. 2024 Mar 21:S0914-5087(24)00045-5. doi: 10.1016/j.jjcc.2024.03.006. Online ahead of print.ABSTRACTStatin-intolerance (SI) has prevalence between 8.0 % and 10 %, and muscular complaints are the most common reason for discontinuation. Bempedoic acid (BA), an ATP citrate lyase inhibitor, decreases hepatic generation of cholesterol, upregulates low-density lipoprotein (LDL) receptor expression in the liver, and eventually clears circulating LDL-cholesterol from the blood. Multiple randomized clinical trials studying BA demonstrate a reduction in LDL levels by 17-28 % in SI. The CLEAR OUTCOME trial established signif...
Source: Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Siva Naga S Yarrarapu Amandeep Goyal Vikramaditya Samala Venkata Viraj Panchal Barath Prashanth Sivasubramanian Doantrang T Du Roopesh Sai Jakulla Hema Pamulapati Mazhar A Afaq Steven Owens Tarun Dalia Source Type: research
Comprehensive review of statin-intolerance and the practical application of Bempedoic Acid
J Cardiol. 2024 Mar 21:S0914-5087(24)00045-5. doi: 10.1016/j.jjcc.2024.03.006. Online ahead of print.ABSTRACTStatin-intolerance (SI) has prevalence between 8.0 % and 10 %, and muscular complaints are the most common reason for discontinuation. Bempedoic acid (BA), an ATP citrate lyase inhibitor, decreases hepatic generation of cholesterol, upregulates low-density lipoprotein (LDL) receptor expression in the liver, and eventually clears circulating LDL-cholesterol from the blood. Multiple randomized clinical trials studying BA demonstrate a reduction in LDL levels by 17-28 % in SI. The CLEAR OUTCOME trial established signif...
Source: Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Siva Naga S Yarrarapu Amandeep Goyal Vikramaditya Samala Venkata Viraj Panchal Barath Prashanth Sivasubramanian Doantrang T Du Roopesh Sai Jakulla Hema Pamulapati Mazhar A Afaq Steven Owens Tarun Dalia Source Type: research
Causal association between several gender ‐driven factors and gout: A bidirectional Mendelian randomization study
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 23, 2024 Category: Rheumatology Authors: Yanshuang Ren,
Yuqing Jiang,
Huifang Peng,
Hongwei Jiang Tags: LETTER TO THE EDITOR Source Type: research
Dual-Energy Computed Tomography Applications in Rheumatology
Dual-energy computed tomography (DECT) has emerged as a transformative tool in the past decade. Initially employed in gout within the field of rheumatology to distinguish and quantify monosodium urate crystals through its dual-material discrimination capability, DECT has since broadened its clinical applications. It now encompasses various rheumatic diseases, employing advanced techniques such as bone marrow edema assessment, iodine mapping, and collagen-specific imaging. This review article aims to examine the unique characteristics of DECT, discuss its strengths and limitations, illustrate its applications for accurately...
Source: Radiologic Clinics of North America - March 23, 2024 Category: Radiology Authors: Eun Hae Park, Thomas O ’Donnell, Jan Fritz Source Type: research
Role of Colchicine in Cardiovascular Disease Management
Arterioscler Thromb Vasc Biol. 2024 Mar 21. doi: 10.1161/ATVBAHA.124.319851. Online ahead of print.ABSTRACTColchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in extremely high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can even add to secondary prevention of major adverse cardiovascular events. As...
Source: Atherosclerosis - March 21, 2024 Category: Cardiology Authors: Leo F Buckley Peter Libby Source Type: research
Role of Colchicine in Cardiovascular Disease Management
Arterioscler Thromb Vasc Biol. 2024 Mar 21. doi: 10.1161/ATVBAHA.124.319851. Online ahead of print.ABSTRACTColchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in extremely high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can even add to secondary prevention of major adverse cardiovascular events. As...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Leo F Buckley Peter Libby Source Type: research
Role of Colchicine in Cardiovascular Disease Management
Arterioscler Thromb Vasc Biol. 2024 Mar 21. doi: 10.1161/ATVBAHA.124.319851. Online ahead of print.ABSTRACTColchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in extremely high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can even add to secondary prevention of major adverse cardiovascular events. As...
Source: Atherosclerosis - March 21, 2024 Category: Cardiology Authors: Leo F Buckley Peter Libby Source Type: research
Role of Colchicine in Cardiovascular Disease Management
Arterioscler Thromb Vasc Biol. 2024 Mar 21. doi: 10.1161/ATVBAHA.124.319851. Online ahead of print.ABSTRACTColchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in extremely high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can even add to secondary prevention of major adverse cardiovascular events. As...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Leo F Buckley Peter Libby Source Type: research
