Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study
Reumatismo. 2020 Nov 19;72(3):125-130. doi: 10.4081/reumatismo.2020.1272.ABSTRACTThe aim of this study was to evaluate the effect of an oral preparation containing a naturally occurring matrix of hydrolyzed collagen type II, chondroitin sulfate (CS), and hyaluronic acid (HA), and bioactive oligopeptides of natural hydrolyzed keratin (K) in patients affected by knee OA through the evaluation of synovial fluid (SF) and clinical changes before and after treatment. Thirty patients with knee OA and swollen joint were included in the study and submitted to arthrocentesis. Patients were randomized in two groups: 1) the treatment ...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: F Oliviero R Ramonda A Hoxha A Scanu P Galozzi M Favero P Frallonardo L Punzi Source Type: research

Hand dominance in early and established rheumatoid arthritis: evaluation by dynamometer, Ritchie index and musculoskeletal ultrasound: a cross sectional study
Reumatismo. 2020 Nov 19;72(3):131-144. doi: 10.4081/reumatismo.2020.1273.ABSTRACTRheumatoid arthritis (RA) usually occurs as a symmetrical disease, which mainly affects the small joints of the hands and feet. The correlation of handedness with radiological changes shows significantly greater radiological changes in the dominant hand than in the non-dominant one. Additionally, the dominant hand is more severely affected in terms of strength, function and deformity. Our objective is to evaluate the influence of handedness on musculoskeletal ultrasound (US), Ritchie articular index (RAI) and digital dynamometer findings in pa...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: A M Elsaman A Sayed A R Radwan Source Type: research

Measurement of serum interferon alpha in Egyptian patients with systemic lupus erythematosus and evaluation of its effect on disease activity: a case-control study
Reumatismo. 2020 Nov 19;72(3):145-153. doi: 10.4081/reumatismo.2020.1308.ABSTRACTMuch evidence highlighted the role of interferon alpha (IFN-α) in systemic lupus erythematosus (SLE) and suggested its possible role in assessing disease activity. We measured serum IFN-α in Egyptian SLE patients in order to determine a cutoff value that can be used to distinguish patients from healthy controls and explored its clinical value in monitoring disease activity and different aspects of the disease, in particular lupus nephritis. This cross-sectional, case-control study was conducted on 59 SLE patients and 30 healthy con...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: A Fayed M M El Menyawi M Ghanema O Shaker R Elgohary Source Type: research

Systemic lupus erythematosus and infections
Reumatismo. 2020 Nov 19;72(3):154-169. doi: 10.4081/reumatismo.2020.1303.ABSTRACTSystemic lupus erythematosus (SLE) is an inflammatory and multi-systemic autoimmune disorder, characterized by an uncontrolled auto-reactivity of B and T lymphocytes, leading to the production of autoantibodies against self-directed antigens and tissue damage. The life expectancy in patients with SLE has improved tremendously in the last two decades, but the mortality rates still remain three times greater compared to those of the general population. Despite increased awareness and improved management, infections remain a major source of morbi...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: B K Singh S Singh Source Type: research

Psoriatic spondyloarthritis and Sj ögren syndrome: a casual association?
Reumatismo. 2020 Nov 19;72(3):170-172. doi: 10.4081/reumatismo.2020.1287.ABSTRACTThe association between Sjögren syndrome (SS) and psoriatic arthritis (PsA) is rare. Herein, we report a case of SS in a PsA patient with the mutilans variant. A 67-year old woman developed PsA with progressive articular destruction up to the typical deformation of 'telescoping fingers' in the distal phalanges. Psoriatic onychopathy presented ten years after the osteolytic damage in the hands. This late appearance led to delayed diagnosis and therapy, and, consequently, worsened the articular destruction. Thereafter, the patient developed...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: V Bruzzese C Marrese P Scolieri J Pepe Source Type: research

COVID-19 pandemic and biological therapy in rheumatologic disorders: how to deal with?
In conclusion, during the COVID-19 pandemic, due to the key roles of cytokines in the promotion of the disease, the rheumatic patients may benefit from continuing their previous treatment, which may have protective effects.PMID:33213130 | DOI:10.4081/reumatismo.2020.1289 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: Z Ahmadinejad R Assari N Ayoobi Yazdi S-H Mazloomi P Javanshayani H Khalili Afousi V Ziaee Source Type: research

Case report of polymyalgia rheumatica in a male patient with three different neoplasms treated with pembrolizumab
Reumatismo. 2020 Nov 19;72(3):178-181. doi: 10.4081/reumatismo.2020.1297.ABSTRACTIn this manuscript we aim to describe a particular case of a 63 years-old man who developed three different malignancies (one was a rare case of breast cancer) among nearly five years. In particular, for the diagnosis of melanoma, he was treated with pembrolizumab, a PD-1 inhibitor. After few months of treatment with pembrolizumab, the patient reported the onset of musculoskeletal symptoms such as inflammatory pain at the shoulders and morning stiffness, with raised CRP and ESR and imaging evidence of bursitis and tenosynovitis. A polymyalgia-...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: F M Perrotta S Scriffignano M Fatica M Specchia E Lubrano Source Type: research

Observations about subcalcaneal adventitial bursitis (heel fat pad inflammatory lesion) in rheumatoid arthritis. Comment on the article of Suzuki and Shirai
Reumatismo. 2020 Nov 19;72(3):182-183. doi: 10.4081/reumatismo.2020.1282.ABSTRACTNot available.PMID:33213132 | DOI:10.4081/reumatismo.2020.1282 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: P Falsetti E Conticini C Baldi C Acciai R D'Alessandro M Bardelli L Cantarini B Frediani Source Type: research

Reply to the comments by Falsetti et al
Reumatismo. 2020 Nov 19;72(3):184-185. doi: 10.4081/reumatismo.2020.1307.ABSTRACTNot available.PMID:33213133 | DOI:10.4081/reumatismo.2020.1307 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: T Suzuki H Shirai Source Type: research

Transcranial direct current stimulation improves myofascial pain syndrome and chronic fatigue
Reumatismo. 2020 Nov 19;72(3):186-188. doi: 10.4081/reumatismo.2020.1317.ABSTRACTNot available.PMID:33213134 | DOI:10.4081/reumatismo.2020.1317 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: R G Misse A M Dos Santos J M De Souza S K Shinjo Source Type: research

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study
Reumatismo. 2020 Nov 19;72(3):125-130. doi: 10.4081/reumatismo.2020.1272.ABSTRACTThe aim of this study was to evaluate the effect of an oral preparation containing a naturally occurring matrix of hydrolyzed collagen type II, chondroitin sulfate (CS), and hyaluronic acid (HA), and bioactive oligopeptides of natural hydrolyzed keratin (K) in patients affected by knee OA through the evaluation of synovial fluid (SF) and clinical changes before and after treatment. Thirty patients with knee OA and swollen joint were included in the study and submitted to arthrocentesis. Patients were randomized in two groups: 1) the treatment ...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: F Oliviero R Ramonda A Hoxha A Scanu P Galozzi M Favero P Frallonardo L Punzi Source Type: research

Hand dominance in early and established rheumatoid arthritis: evaluation by dynamometer, Ritchie index and musculoskeletal ultrasound: a cross sectional study
Reumatismo. 2020 Nov 19;72(3):131-144. doi: 10.4081/reumatismo.2020.1273.ABSTRACTRheumatoid arthritis (RA) usually occurs as a symmetrical disease, which mainly affects the small joints of the hands and feet. The correlation of handedness with radiological changes shows significantly greater radiological changes in the dominant hand than in the non-dominant one. Additionally, the dominant hand is more severely affected in terms of strength, function and deformity. Our objective is to evaluate the influence of handedness on musculoskeletal ultrasound (US), Ritchie articular index (RAI) and digital dynamometer findings in pa...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: A M Elsaman A Sayed A R Radwan Source Type: research

Measurement of serum interferon alpha in Egyptian patients with systemic lupus erythematosus and evaluation of its effect on disease activity: a case-control study
Reumatismo. 2020 Nov 19;72(3):145-153. doi: 10.4081/reumatismo.2020.1308.ABSTRACTMuch evidence highlighted the role of interferon alpha (IFN-α) in systemic lupus erythematosus (SLE) and suggested its possible role in assessing disease activity. We measured serum IFN-α in Egyptian SLE patients in order to determine a cutoff value that can be used to distinguish patients from healthy controls and explored its clinical value in monitoring disease activity and different aspects of the disease, in particular lupus nephritis. This cross-sectional, case-control study was conducted on 59 SLE patients and 30 healthy con...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: A Fayed M M El Menyawi M Ghanema O Shaker R Elgohary Source Type: research

Systemic lupus erythematosus and infections
Reumatismo. 2020 Nov 19;72(3):154-169. doi: 10.4081/reumatismo.2020.1303.ABSTRACTSystemic lupus erythematosus (SLE) is an inflammatory and multi-systemic autoimmune disorder, characterized by an uncontrolled auto-reactivity of B and T lymphocytes, leading to the production of autoantibodies against self-directed antigens and tissue damage. The life expectancy in patients with SLE has improved tremendously in the last two decades, but the mortality rates still remain three times greater compared to those of the general population. Despite increased awareness and improved management, infections remain a major source of morbi...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: B K Singh S Singh Source Type: research

Psoriatic spondyloarthritis and Sj ögren syndrome: a casual association?
Reumatismo. 2020 Nov 19;72(3):170-172. doi: 10.4081/reumatismo.2020.1287.ABSTRACTThe association between Sjögren syndrome (SS) and psoriatic arthritis (PsA) is rare. Herein, we report a case of SS in a PsA patient with the mutilans variant. A 67-year old woman developed PsA with progressive articular destruction up to the typical deformation of 'telescoping fingers' in the distal phalanges. Psoriatic onychopathy presented ten years after the osteolytic damage in the hands. This late appearance led to delayed diagnosis and therapy, and, consequently, worsened the articular destruction. Thereafter, the patient developed...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: V Bruzzese C Marrese P Scolieri J Pepe Source Type: research

COVID-19 pandemic and biological therapy in rheumatologic disorders: how to deal with?
In conclusion, during the COVID-19 pandemic, due to the key roles of cytokines in the promotion of the disease, the rheumatic patients may benefit from continuing their previous treatment, which may have protective effects.PMID:33213130 | DOI:10.4081/reumatismo.2020.1289 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: Z Ahmadinejad R Assari N Ayoobi Yazdi S-H Mazloomi P Javanshayani H Khalili Afousi V Ziaee Source Type: research

Case report of polymyalgia rheumatica in a male patient with three different neoplasms treated with pembrolizumab
Reumatismo. 2020 Nov 19;72(3):178-181. doi: 10.4081/reumatismo.2020.1297.ABSTRACTIn this manuscript we aim to describe a particular case of a 63 years-old man who developed three different malignancies (one was a rare case of breast cancer) among nearly five years. In particular, for the diagnosis of melanoma, he was treated with pembrolizumab, a PD-1 inhibitor. After few months of treatment with pembrolizumab, the patient reported the onset of musculoskeletal symptoms such as inflammatory pain at the shoulders and morning stiffness, with raised CRP and ESR and imaging evidence of bursitis and tenosynovitis. A polymyalgia-...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: F M Perrotta S Scriffignano M Fatica M Specchia E Lubrano Source Type: research

Observations about subcalcaneal adventitial bursitis (heel fat pad inflammatory lesion) in rheumatoid arthritis. Comment on the article of Suzuki and Shirai
Reumatismo. 2020 Nov 19;72(3):182-183. doi: 10.4081/reumatismo.2020.1282.ABSTRACTNot available.PMID:33213132 | DOI:10.4081/reumatismo.2020.1282 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: P Falsetti E Conticini C Baldi C Acciai R D'Alessandro M Bardelli L Cantarini B Frediani Source Type: research

Reply to the comments by Falsetti et al
Reumatismo. 2020 Nov 19;72(3):184-185. doi: 10.4081/reumatismo.2020.1307.ABSTRACTNot available.PMID:33213133 | DOI:10.4081/reumatismo.2020.1307 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: T Suzuki H Shirai Source Type: research

Transcranial direct current stimulation improves myofascial pain syndrome and chronic fatigue
Reumatismo. 2020 Nov 19;72(3):186-188. doi: 10.4081/reumatismo.2020.1317.ABSTRACTNot available.PMID:33213134 | DOI:10.4081/reumatismo.2020.1317 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: R G Misse A M Dos Santos J M De Souza S K Shinjo Source Type: research

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study
Reumatismo. 2020 Nov 19;72(3):125-130. doi: 10.4081/reumatismo.2020.1272.ABSTRACTThe aim of this study was to evaluate the effect of an oral preparation containing a naturally occurring matrix of hydrolyzed collagen type II, chondroitin sulfate (CS), and hyaluronic acid (HA), and bioactive oligopeptides of natural hydrolyzed keratin (K) in patients affected by knee OA through the evaluation of synovial fluid (SF) and clinical changes before and after treatment. Thirty patients with knee OA and swollen joint were included in the study and submitted to arthrocentesis. Patients were randomized in two groups: 1) the treatment ...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: F Oliviero R Ramonda A Hoxha A Scanu P Galozzi M Favero P Frallonardo L Punzi Source Type: research

Hand dominance in early and established rheumatoid arthritis: evaluation by dynamometer, Ritchie index and musculoskeletal ultrasound: a cross sectional study
Reumatismo. 2020 Nov 19;72(3):131-144. doi: 10.4081/reumatismo.2020.1273.ABSTRACTRheumatoid arthritis (RA) usually occurs as a symmetrical disease, which mainly affects the small joints of the hands and feet. The correlation of handedness with radiological changes shows significantly greater radiological changes in the dominant hand than in the non-dominant one. Additionally, the dominant hand is more severely affected in terms of strength, function and deformity. Our objective is to evaluate the influence of handedness on musculoskeletal ultrasound (US), Ritchie articular index (RAI) and digital dynamometer findings in pa...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: A M Elsaman A Sayed A R Radwan Source Type: research

Measurement of serum interferon alpha in Egyptian patients with systemic lupus erythematosus and evaluation of its effect on disease activity: a case-control study
Reumatismo. 2020 Nov 19;72(3):145-153. doi: 10.4081/reumatismo.2020.1308.ABSTRACTMuch evidence highlighted the role of interferon alpha (IFN-α) in systemic lupus erythematosus (SLE) and suggested its possible role in assessing disease activity. We measured serum IFN-α in Egyptian SLE patients in order to determine a cutoff value that can be used to distinguish patients from healthy controls and explored its clinical value in monitoring disease activity and different aspects of the disease, in particular lupus nephritis. This cross-sectional, case-control study was conducted on 59 SLE patients and 30 healthy con...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: A Fayed M M El Menyawi M Ghanema O Shaker R Elgohary Source Type: research

Systemic lupus erythematosus and infections
Reumatismo. 2020 Nov 19;72(3):154-169. doi: 10.4081/reumatismo.2020.1303.ABSTRACTSystemic lupus erythematosus (SLE) is an inflammatory and multi-systemic autoimmune disorder, characterized by an uncontrolled auto-reactivity of B and T lymphocytes, leading to the production of autoantibodies against self-directed antigens and tissue damage. The life expectancy in patients with SLE has improved tremendously in the last two decades, but the mortality rates still remain three times greater compared to those of the general population. Despite increased awareness and improved management, infections remain a major source of morbi...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: B K Singh S Singh Source Type: research

Psoriatic spondyloarthritis and Sj ögren syndrome: a casual association?
Reumatismo. 2020 Nov 19;72(3):170-172. doi: 10.4081/reumatismo.2020.1287.ABSTRACTThe association between Sjögren syndrome (SS) and psoriatic arthritis (PsA) is rare. Herein, we report a case of SS in a PsA patient with the mutilans variant. A 67-year old woman developed PsA with progressive articular destruction up to the typical deformation of 'telescoping fingers' in the distal phalanges. Psoriatic onychopathy presented ten years after the osteolytic damage in the hands. This late appearance led to delayed diagnosis and therapy, and, consequently, worsened the articular destruction. Thereafter, the patient developed...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: V Bruzzese C Marrese P Scolieri J Pepe Source Type: research

COVID-19 pandemic and biological therapy in rheumatologic disorders: how to deal with?
In conclusion, during the COVID-19 pandemic, due to the key roles of cytokines in the promotion of the disease, the rheumatic patients may benefit from continuing their previous treatment, which may have protective effects.PMID:33213130 | DOI:10.4081/reumatismo.2020.1289 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: Z Ahmadinejad R Assari N Ayoobi Yazdi S-H Mazloomi P Javanshayani H Khalili Afousi V Ziaee Source Type: research

Case report of polymyalgia rheumatica in a male patient with three different neoplasms treated with pembrolizumab
Reumatismo. 2020 Nov 19;72(3):178-181. doi: 10.4081/reumatismo.2020.1297.ABSTRACTIn this manuscript we aim to describe a particular case of a 63 years-old man who developed three different malignancies (one was a rare case of breast cancer) among nearly five years. In particular, for the diagnosis of melanoma, he was treated with pembrolizumab, a PD-1 inhibitor. After few months of treatment with pembrolizumab, the patient reported the onset of musculoskeletal symptoms such as inflammatory pain at the shoulders and morning stiffness, with raised CRP and ESR and imaging evidence of bursitis and tenosynovitis. A polymyalgia-...
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: F M Perrotta S Scriffignano M Fatica M Specchia E Lubrano Source Type: research

Observations about subcalcaneal adventitial bursitis (heel fat pad inflammatory lesion) in rheumatoid arthritis. Comment on the article of Suzuki and Shirai
Reumatismo. 2020 Nov 19;72(3):182-183. doi: 10.4081/reumatismo.2020.1282.ABSTRACTNot available.PMID:33213132 | DOI:10.4081/reumatismo.2020.1282 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: P Falsetti E Conticini C Baldi C Acciai R D'Alessandro M Bardelli L Cantarini B Frediani Source Type: research

Reply to the comments by Falsetti et al
Reumatismo. 2020 Nov 19;72(3):184-185. doi: 10.4081/reumatismo.2020.1307.ABSTRACTNot available.PMID:33213133 | DOI:10.4081/reumatismo.2020.1307 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: T Suzuki H Shirai Source Type: research

Transcranial direct current stimulation improves myofascial pain syndrome and chronic fatigue
Reumatismo. 2020 Nov 19;72(3):186-188. doi: 10.4081/reumatismo.2020.1317.ABSTRACTNot available.PMID:33213134 | DOI:10.4081/reumatismo.2020.1317 (Source: Reumatismo)
Source: Reumatismo - November 20, 2020 Category: Rheumatology Authors: R G Misse A M Dos Santos J M De Souza S K Shinjo Source Type: research

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study.
Abstract The aim of this study was to evaluate the effect of an oral preparation containing a naturally occurring matrix of hydrolyzed collagen type II, chondroitin sulfate (CS), and hyaluronic acid (HA), and bioactive oligopeptides of natural hydrolyzed keratin (K) in patients affected by knee OA through the evaluation of synovial fluid (SF) and clinical changes before and after treatment. Thirty patients with knee OA and swollen joint were included in the study and submitted to arthrocentesis. Patients were randomized in two groups: 1) the treatment group (N.15) took a dietary supplement containing 120 mg HA, 24...
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Oliviero F, Ramonda R, Hoxha A, Scanu A, Galozzi P, Favero M, Frallonardo P, Punzi L Tags: Reumatismo Source Type: research

Hand dominance in early and established rheumatoid arthritis: evaluation by dynamometer, Ritchie index and musculoskeletal ultrasound: a cross sectional study.
Abstract Rheumatoid arthritis (RA) usually occurs as a symmetrical disease, which mainly affects the small joints of the hands and feet. The correlation of handedness with radiological changes shows significantly greater radiological changes in the dominant hand than in the non-dominant one. Additionally, the dominant hand is more severely affected in terms of strength, function and deformity. Our objective is to evaluate the influence of handedness on musculoskeletal ultrasound (US), Ritchie articular index (RAI) and digital dynamometer findings in patients with active RA (early, group B, vs. established, group A...
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Elsaman AM, Sayed A, Radwan AR Tags: Reumatismo Source Type: research

Measurement of serum interferon alpha in Egyptian patients with systemic lupus erythematosus and evaluation of its effect on disease activity: a case-control study.
Abstract Much evidence highlighted the role of interferon alpha (IFN-α) in systemic lupus erythematosus (SLE) and suggested its possible role in assessing disease activity. We measured serum IFN-α in Egyptian SLE patients in order to determine a cutoff value that can be used to distinguish patients from healthy controls and explored its clinical value in monitoring disease activity and different aspects of the disease, in particular lupus nephritis. This cross-sectional, case-control study was conducted on 59 SLE patients and 30 healthy controls. Serum IFN-α was measured in all participants using...
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Fayed A, El Menyawi MM, Ghanema M, Shaker O, Elgohary R Tags: Reumatismo Source Type: research

Systemic lupus erythematosus and infections.
Abstract Systemic lupus erythematosus (SLE) is an inflammatory and multi-systemic autoimmune disorder, characterized by an uncontrolled auto-reactivity of B and T lymphocytes, leading to the production of autoantibodies against self-directed antigens and tissue damage. The life expectancy in patients with SLE has improved tremendously in the last two decades, but the mortality rates still remain three times greater compared to those of the general population. Despite increased awareness and improved management, infections remain a major source of morbidity, mortality, hospitalization, and death in patients with SL...
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Singh BK, Singh S Tags: Reumatismo Source Type: research

Psoriatic spondyloarthritis and Sj ögren syndrome: a casual association?
Psoriatic spondyloarthritis and Sjögren syndrome: a casual association? Reumatismo. 2020 Nov 19;72(3):170-172 Authors: Bruzzese V, Marrese C, Scolieri P, Pepe J Abstract The association between Sjögren syndrome (SS) and psoriatic arthritis (PsA) is rare. Herein, we report a case of SS in a PsA patient with the mutilans variant. A 67-year old woman developed PsA with progressive articular destruction up to the typical deformation of 'telescoping fingers' in the distal phalanges. Psoriatic onychopathy presented ten years after the osteolytic damage in the hands. This late appearance led to del...
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Bruzzese V, Marrese C, Scolieri P, Pepe J Tags: Reumatismo Source Type: research

COVID-19 pandemic and biological therapy in rheumatologic disorders: how to deal with?
In conclusion, during the COVID-19 pandemic, due to the key roles of cytokines in the promotion of the disease, the rheumatic patients may benefit from continuing their previous treatment, which may have protective effects. PMID: 33213130 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Ahmadinejad Z, Assari R, Ayoobi Yazdi N, Mazloomi SH, Javanshayani P, Khalili Afousi H, Ziaee V Tags: Reumatismo Source Type: research

Case report of polymyalgia rheumatica in a male patient with three different neoplasms treated with pembrolizumab.
Abstract In this manuscript we aim to describe a particular case of a 63 years-old man who developed three different malignancies (one was a rare case of breast cancer) among nearly five years. In particular, for the diagnosis of melanoma, he was treated with pembrolizumab, a PD-1 inhibitor. After few months of treatment with pembrolizumab, the patient reported the onset of musculoskeletal symptoms such as inflammatory pain at the shoulders and morning stiffness, with raised CRP and ESR and imaging evidence of bursitis and tenosynovitis. A polymyalgia-like syndrome was diagnosed. Understanding if these manifestati...
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Perrotta FM, Scriffignano S, Fatica M, Specchia M, Lubrano E Tags: Reumatismo Source Type: research

Observations about subcalcaneal adventitial bursitis (heel fat pad inflammatory lesion) in rheumatoid arthritis. Comment on the article of Suzuki and Shirai.
Abstract Not available. PMID: 33213132 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Falsetti P, Conticini E, Baldi C, Acciai C, D'Alessandro R, Bardelli M, Cantarini L, Frediani B Tags: Reumatismo Source Type: research

Reply to the comments by Falsetti et al.
Abstract Not available. PMID: 33213133 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Suzuki T, Shirai H Tags: Reumatismo Source Type: research

Transcranial direct current stimulation improves myofascial pain syndrome and chronic fatigue.
Abstract Not available. PMID: 33213134 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - November 19, 2020 Category: Rheumatology Authors: Misse RG, Dos Santos AM, De Souza JM, Shinjo SK Tags: Reumatismo Source Type: research

Rheumatologists in the COVID-19 era: will there be a new role for the rheumatologist in the care of rheumatic patients?
la FJ PMID: 32889590 [PubMed - as supplied by publisher] (Source: Reumatismo)
Source: Reumatismo - September 4, 2020 Category: Rheumatology Authors: Morales-Torres J, Aceves-Ávila FJ Tags: Clin Rheumatol Source Type: research

Different fracture risk profile in patients treated with anti-osteoporotic drugs in real-life.
Abstract In this retrospective study, we intended to investigate the baseline fracture risk profile in patients who started treatment with different anti-osteoporotic medications. We analyzed retrospectively the fracture risk calculated with DeFRA, a validated FRAX derived tool, in women who started an anti-osteoporotic treatment from 2010 to 2017. We analyzed baseline data of 12,024 post-menopausal women aged over 50 years. Teriparatide initiators had a baseline 10-year risk of major osteoporotic fracture of 82.1% with a Standard Deviation (SD) of 66.5%. Denosumab initiators and zoledronic acid initiators had a g...
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Adami G, Giollo A, Rossini M, Orsolini G, Benini C, Viapiana O, Gatti D, Fassio A Tags: Reumatismo Source Type: research

Multidisciplinary model for hospital-territory integrated management of patient with bone fragility: primary and secondary prevention of fractures according to severity and complexity.
ait M Abstract The aim of this study was to promote the construction of a real network and a shared diagnostic and therapeutic management model between hospitals and out-of-hospital healthcare services to capture as many patients with bone fragility as possible. Starting from the analysis of the clinical competences present in the province of Pavia, the bone specialists (BSs) organized some educational events involving both general practitioners (GPs) and hospital specialists. The Fracture Liaison Service (FLS) model, the revision of Note 79, the national plan for chronicity and the health reform of the Lombardy R...
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Caffetti C, Bogliolo L, Giuffrè G, Sozzi A, Degli Esposti L, Bellis E, Montecucco C, Reitano F, Triarico A, Silva S, Bejor M, Muzzi A, Mirabile P, Ramaioli N, Brait M Tags: Reumatismo Source Type: research

The clinical manifestations at the onset of antisynthetase syndrome: A chameleon with multiple faces.
Abstract The antisynthetase syndrome (ASS) is clinically characterized by fever, myositis, interstitial lung disease, joint involvement, mechanic's hands, or Raynaud's phenomenon, and the presence of antisynthetase autoantibodies. These clinical manifestations may not occur simultaneously. Therefore, the aim of this study was to analyze the sequence in which these clinical manifestations can develop at the onset of ASS. This retrospective, single-center cohort study enrolled 55 ASS patients. Their mean age at the onset of ASS symptoms was 42.3±11.8 years. There was a predominance of female patients (75.9%) ...
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Baccaro ACCD, Behrens Pinto GL, Carboni RCS, Shinjo SK Tags: Reumatismo Source Type: research

Effects of mannuronic acid (M2000) on gene expression profile of signal transducer and activator of transcription proteins (STATs) in rheumatoid arthritis patients.
Abstract Rheumatoid arthritis (RA), a form of inflammatory arthritis, is a chronic joint disease characterized by pain and inflammation that affects 0.5% to 1% of the population worldwide. The safety, efficacy, tolerability, and potency of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property has been reported by several in vitro studies, experimental models and clinical trials phase I/II and III in ankylosing spondylitis and rheumatoid arthritis (RA) patients This research is designed to study the therapeutic efficacy of oral administration of mannuronic acid in RA patients who had ina...
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Gaafar NAG, Aslani M, Aghazadeh Z, Mortazavi-Jahromi SS, Razavi A, Mirshafiey A Tags: Reumatismo Source Type: research

Is there a reliable association between patient-reported limb claudication and vascular imaging methods in Takayasu arteritis?
Abstract Vessel imaging in Takayasu arteritis (TAK) is often performed in clinical practice following laboratory test abnormalities or clinical symptoms, such as limb claudication. Conversely, the association between limb claudication and vessel imaging manifestations has not been assessed. This observational, cross-sectional study analyzed 139 adult TAK patients from 2000 to 2018. Their arterial vessel imaging information (especially significant stenosis and occlusion data) was registered and crosschecked with clinical and laboratory data. When vessel imaging was performed, the median age and disease duration of ...
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Araujo CSR, Dos Santos AM, Olivo Pallo PA, Pereira RMR, Shinjo SK Tags: Reumatismo Source Type: research

Pronounced dys-autonomic symptoms announcing a primary Sj ögren's syndrome.
Pronounced dys-autonomic symptoms announcing a primary Sjögren's syndrome. Reumatismo. 2020 Jul 23;72(2):111-114 Authors: Masini F, Monaco L, Gjeloshi K, Pinotti E, Ferrrara R, Pafundi PC, Santini M, Salvatore T, Cuomo G Abstract Sjögren's syndrome (SS) is an autoimmune disease that involves the nervous system in about 20% of cases. In 25-92% of patients affected by Sjögren's syndrome, neurological symptoms may precede the sicca syndrome. A 65-year-old male presented with a seven-month history of episodes of near-syncope, constipation, anhidrosis, disabling fatigue and asthenia. Physica...
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Masini F, Monaco L, Gjeloshi K, Pinotti E, Ferrrara R, Pafundi PC, Santini M, Salvatore T, Cuomo G Tags: Reumatismo Source Type: research

Severe bullous systemic lupus erythematosus successfully treated with low dose rituximab: a case report from sub-Saharan Africa.
Abstract Bullous systemic lupus erythematosus (BSLE) is a blistering skin condition occurring in lupus patients. Although cutaneous manifestations are common in lupus (59-85%), BSLE is rare, affecting
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Akpabio AA, Otike-Odibi BI Tags: Reumatismo Source Type: research

Clinical practice guidelines for patients with polymyalgia rheumatica: the need for an active involvement of all stakeholder is still unmet.
Abstract Not available. PMID: 32700879 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Manzo C Tags: Reumatismo Source Type: research

Reply to the Letter to the Editor: The Italian Society of Rheumatology clinical practice guidelines for the management of polymyalgia rheumatica.
zzi A Abstract Not available. PMID: 32700880 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - July 22, 2020 Category: Rheumatology Authors: Ughi N, Sebastiani GD, Gerli R, Salvarani C, Parisi S, Ariani A, Prevete I, Manara M, Rumi F, Scirè CA, Bortoluzzi A Tags: Reumatismo Source Type: research