Spa therapy induces clinical improvement and protein changes in patients with chronic back pain.
This study is primarily aimed at assessing serum changes on a large panel of proteins in patients with chronic back pain following spa therapy, as well as evaluating different spa therapy regimens as a preliminary exploratory clinical study. Sixty-six patients with chronic back pain secondary to osteoarthritis were randomly enrolled and treated with daily mud packs and bicarbonate-alkaline mineral water baths, or a thermal hydrotherapy rehabilitation scheme, the combination of the two regimens or usual medication only (control group), for two weeks. Clinical variables were evaluated at baseline, after 2 and 12 weeks. One t...
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Angioni MM, Denotti A, Pinna S, Sanna C, Montisci F, Dessole G, Loi A, Cauli A Tags: Reumatismo Source Type: research

Don't forget the jumper's knee in the young sportsman: evaluation of patellar tendinopathy with a high frequency ultrasound probe.
Abstract Patellar tendinopathy, or Jumper's knee, is a painful knee condition caused by inflammation of the patella tendon. This condition is most frequently observed in subjects who play sports that require repetitive regular jumping. Jumper's knee is frequently misdiagnosed as a minor injury and many athletes, like our patient, keep on training and competing and either tend to ignore the injury or attempt to treat it themselves. However, jumper's knee is a serious condition that requires a correct and timely diagnosis, which often necessitates ultrasound investigation in order to start the most appropriate treat...
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Ruaro B, Cutolo M, Alessandri E, Zaottini F, Picasso R, Pistoia F, Ferrari G, Martinoli C Tags: Reumatismo Source Type: research

Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus.
Abstract Not available. PMID: 31649378 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Joob B, Wiwanitkit V Tags: Reumatismo Source Type: research

Prevalence of low back pain and its effect on health-related quality of life in 409 scholar adolescents from the Veneto region.
Abstract Low back pain (LBP) is a common condition with profound effects on well-being. We aimed to define the prevalence and the characteristics of LBP and to investigate its impact on the quality of life (QoL) of 409 students (265 females and 144 males), all high-school adolescents from the Veneto region. LBP was measured with a structured, self-report questionnaire, while the SF-36 questionnaire was used to measure physical and mental QoL. 253 students (61.3%) reported one or more episodes of LBP, with female predominance. Adolescents with LBP treated with drugs and rehabilitation cares have significantly poor ...
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Galozzi P, Maghini I, Bakdounes L, Ferlito E, Lazzari V, Ermani M, Chia M, Gatti D, Masiero S, Punzi L Tags: Reumatismo Source Type: research

Infliximab in the treatment of Budd-Chiari syndrome in Beh çet's disease.
We report a case of a 27-yearold man with Behçet's disease who developed Budd-Chiari syndrome while on immunosuppressive therapy. Infliximab resulted in a rapid and total clinical remission. Literature data have shown that antitumor necrosis factor alpha (anti-TNF-α) agents including infliximab can suppress disease activity but there is no long-term experience on tapering and/or discontinuation of treatment under clinical remission. Our case supports the use of infliximab in vasculo-Behçet patients. PMID: 31649380 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Santos LB, Rigueira J, Vilas AP Tags: Reumatismo Source Type: research

Acute effect of strength training on mood of patients with fibromyalgia syndrome.
Abstract Fibromyalgia syndrome (FM) is a musculoskeletal disorder characterized by chronic pain and frequently associated changes in mood states. The aim of this study was to analyze the acute effect of strength training (ST) sessions on the mood states of patients with fibromyalgia. A total of 110 FM patients were eligible for this study. After the inclusion criteria, twenty-eight women with FM (mean age: 51.88±10.22 years) performed three sessions of ST. Each training session worked the main muscle groups and lasted 60 min. Three sets of 12 repetitions were performed with 1-min intervals between them. Out...
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Andrade A, De Azevedo Klumb Steffens R, Mendes Sieczkowska S, Reis Coimbra D, Torres Vilarino G Tags: Reumatismo Source Type: research

Late onset systemic sclerosis with seronegativity: a rare presentation of an uncommon disease.
We report a rare case where the patient was negative for ANA, Anti-topoisomerase I, Anti-centromere and Anti-RNA polymerase III antibodies. PMID: 31649382 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Saxena D, Jain D, Yadav M, Giri K, Yadav T, Jain P Tags: Reumatismo Source Type: research

Validity and reliability study of the Turkish version of SACRAH (Score for Assessment and quantification of Chronic Rheumatic Affections of the Hands).
Abstract Rheumatic diseases cause deformities in the hands and affect daily living activities. Therefore, assessment of hand disabilities is important in rheumatic disease. The aim of this study was to test the validity and reliability of the Turkish version of the A Score For Assessment and Quantification of Chronic Rheumatic Affections of the Hands (SACRAH). A translation and back-translation of the SACRAH were performed, according to the Beaton guidelines. Patients who were between 18-65 years old, who were literate in Turkish, who had rheumatic disease diagnosis and whose hands were affected, were included in ...
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Tore NG, Sari F, Tuna Z, Varan O, Babaoglu H, Goker B, Oskay D Tags: Reumatismo Source Type: research

Treat-to-target (T2T) of serum urate (SUA) in gout: a clinical audit in real-world gout patients.
Abstract Treat-to-target (T2T) for gout has been established recently to improve its management, which has been reported to be sub-optimal with significant gaps between the goals of treatment and day-to-day clinical practice. T2T recommended a goal of serum urate (SUA) target of
Source: Reumatismo - October 24, 2019 Category: Rheumatology Authors: Teh CL, Cheong YK, Wan SA, Ling GR Tags: Reumatismo Source Type: research

A case of inflammatory pseudotumor of the lung presenting as polymyalgia rheumatica.
Abstract A common inflammatory condition, the investigation and diagnosis of polymyalgia rheumatica should be within the scope of a general physician's repertoire. While there is limited evidence to confirm the existence of polymyalgia rheumatica as a distinct paraneoplastic syndrome (Reumatismo. 2018;70(1):23), a broadened differential should be utilized prior to diagnosis of this disease. PMID: 31428379 [PubMed] (Source: Reumatismo)
Source: Reumatismo - August 1, 2019 Category: Rheumatology Authors: Tompkins EL, Middlebrook CE, Tracy CL Tags: Clin Case Rep Source Type: research

Vitamin D: no efficacy without deficiency. What's new?
Abstract Not available. PMID: 31309774 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Fassio A, Rossini M, Gatti D Tags: Reumatismo Source Type: research

Health-related quality of life burden in scleroderma patients treated with two different intravenous iloprost regimens.
Abstract Systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) and digital ulcers (DU) can impair health-related quality of life (HRQoL). The aim of our study was to estimate HRQoL in SSc patients treated with two different intravenous (IV) iloprost (ILO) regimens and in patients not treated with IV ILO. 96 consecutive SSc patients were enrolled in a pragmatic, prospective and non-randomized study, and divided into 3 groups: not requiring therapy with IV ILO (N=52), IV ILO once monthly (N=24) or IV ILO for 5 consecutive days every 3 months (N=20). Patients were followed up for three months. We assessed HRQoL ...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Schioppo T, Scalone L, Cozzolino P, Mantovani L, Cesana G, De Lucia O, Murgo A, Ingegnoli F Tags: Reumatismo Source Type: research

Pain and quality of life in knee osteoarthritis, chronic low back pain and fibromyalgia: a comparative cross-sectional study.
The objective of our study was to compare pain and health-related quality of life among patients with knee osteoarthritis (OA), chronic nonspecific low back pain (CNLBP) and fibromyalgia (FM). This cross-sectional study included 87 subjects, who were divided into three groups according to their diagnosis: knee OA (n=29), CNLBP (n=29) and FM (n=29), between March 2013 and March 2014. Pain intensity was measured using the Numeric Pain Rating Scale (NPRS), quality of pain using the McGill Pain Questionnaire (MPQ) and health-related quality of life using the 36-item Short-Form Health Survey (SF-36). Painful body areas were mar...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: De Oliveira Paes Leme M, Yuan SLK, Oliveira Magalhães M, Ferreira de Meneses SR, Marques AP Tags: Reumatismo Source Type: research

Tophi reduction: ultrasound imaging and correlation with plasma levels of uric acid in patients undergoing treatment for tophaceous gout.
The objective was to determine the reduction of tophi in patients undergoing drug therapy in correlation with urate serum levels through ultrasound examination. A total of 31 male patients, between the ages of 33 to 77 years, with tophaceous gout were evaluated between 2005 and 2009, 11 of which were selected. Ultrasound examinations of visible tophi and evaluations of serum uric acids levels were performed annually on each patient. There was a statistically significant difference between measurements 1, 2, 3 and measurement 4 and between measurements 4 and 5. A strong significant positive association was seen between vari...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Ferrari AJL, Corrêa Fernandes AR, De Almeida Agustinelli R, Seike H, De Ávila Fernandes E Tags: Reumatismo Source Type: research

Radiological features of knee joint synovial chondromatosis.
We report a case of massive primary SC of the knee, properly evaluated with X-rays, ultrasonography and magnetic resonance imaging and successfully treated with an arthroscopic approach. PMID: 31309778 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Boninsegna E, Fassio A, Testoni M, Gatti D, Viapiana O, Mansueto G, Rossini M Tags: Reumatismo Source Type: research

A new MEFV gene mutation in an Iranian patient with familial Mediterranean fever.
We report a 12-year-old boy from Iran, with a clinical history of recurrent fever. Based on the suggestive clinical data, mutational analysis revealed the presence of the novel c.1945C>T heterozygous variant in exon 10, which leads to a leucine to phenylalanine change at position 649 of the protein. The mutation was inherited from the mother. This novel mutation lies in exon 10 of the MEFV gene, which encodes for a domain called B30.2-SPRY, located in the C-terminal region of the pyrin protein and contains the most frequent mutations associated with FMF. The present report expands the spectrum of MEFV gene mutations ass...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Farjadian S, Bonatti F, Soriano A, Reina M, Adorni A, Graziano C, Moghtaderi M, Percesepe A, Romeo G, Martorana D Tags: Reumatismo Source Type: research

Occult axial involvement in patients with psoriatic arthritis mutilans: a case report.
We present the case of a patient with psoriatic arthritis (PsA) mutilans and occult axial involvement. The patient had suffered from PsA mutilans for more than a decade, with severe residual articular damage, but had been in clinical remission for years. Clinical axial involvement was never reported; however, magnetic resonance imaging of the sacroiliac joints, performed for other reasons, documented active inflammation and damage even without clinical symptoms. These findings corroborated the hypothesis that axial involvement could be asymptomatic, subclinical and, furthermore, underdiagnosed or even occult in patients wi...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Perrotta FM, Scriffignano S, De Socio A, Lubrano E Tags: Reumatismo Source Type: research

Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis.
ky AA Abstract A 62-year-old man with a history of systemic sclerosis was admitted with diffuse alveolar hemorrhage and acute kidney injury without clinical data suggestive of glomerulonephritis. Laboratory tests showed anemia, leukocytosis with neutrophilia, thrombocytopenia, elevated serum creatinine and metabolic acidosis. Antinuclear antibodies were positive at a titer of 1/640 (speckled, 1/160; nucleolar, 1/320) while rheumatoid factor, anti Scl-70, anti-centromere, anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibodies were negative and serum complement levels were within norma...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Manzella DJ, Vicente L, Pérez de la Hoz AA, Zamora RJ, De Rosa G, Pisarevsky AA Tags: Reumatismo Source Type: research

Etanercept biosimilar associated with Guillain-Barr é syndrome: insights from a case.
Etanercept biosimilar associated with Guillain-Barré syndrome: insights from a case. Reumatismo. 2019 Jul 09;71(2):99-102 Authors: Shobha V, Desai AM, Matthew T Abstract Anti-tumor necrosis factor drugs are used routinely according to treatment guidelines for several chronic rheumatologic problems. However, a rare and usually unpredictable adverse drug reaction namely peripheral nervous system demyelination is being increasingly recognized. Biosimilars are gaining momentum especially in countries like India. Hence, we report a case of Guillain-Barré syndrome secondary to an etanercept bi...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Shobha V, Desai AM, Matthew T Tags: Reumatismo Source Type: research

Pulmonary multiple cystic lesions in a patient with Beh çet's syndrome.
We describe, for the first time in literature, computerised tomography images of a male BS patient with multiple pulmonary cystic lesions possibly originated from vasculitis or bronchiolar stenosis. PMID: 31309783 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Tezcan ME, Isci B Tags: Reumatismo Source Type: research

Kikuchi-Fujimoto disease with multiple extra-nodal features - A clinical mimic.
Abstract Extranodal involvement in Kikuchi's disease is uncommon. A 31-year-old previously healthy Indian woman was admitted with high grade fever, multiple joint pain and skin rash for 3 weeks. She had negative anti-nuclear antibodies and had features of Kikuchi's disease on lymph node biopsy. She also had multiple extranodal manifestations including erythematous maculopapular rash, symmetric polyarthritis and hepatosplenomegaly. Kikuchi's disease with extranodal involvement can clinically mimic diseases like hematological malignancies, connective tissue disorders and certain infections. A lymph node biopsy plays...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Mansoor CA, Shemin Z Tags: Reumatismo Source Type: research

Pseudo-pseudo Meigs' syndrome: a rare presentation of systemic lupus erythematosus.
Abstract Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease. Ascites when associated with pleural effusion and raised CA-125 levels in SLE patient, is known as pseudo-pseudo Meigs' syndrome (PPMS). This is the case of a 22-year-old lady who presented with complaints of abdominal distension for one month and had a history of spontaneous abortion in the past. Abdominal imaging did not reveal any tumor and after extensive workup a diagnosis of PPMS was made. She was successfully treated with steroids, hydroxychloroquine and cyclophosphamide. PMID: 31309785 [PubMed - in pr...
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Tansir G, Kumar P, Pius A, Sunny SK, Soneja M Tags: Reumatismo Source Type: research

Angioleiomyoma as a rare cause of a painful subcutaneous nodule in the leg: a case report.
Abstract Angioleiomyomas are benign tumors originating in the vascular smooth muscles. The tumor typically presents as a painful, solitary, small subcutaneous nodule. Herein, we have described a case report of chronic leg pain due to angioleiomyoma. We outline the clinical, radiological and histopathological features of this rare diagnosis for a painful nodule of extremity. Although rare, angioleiomyoma should be included in the differential diagnosis of chronic leg pain. PMID: 31309786 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - July 9, 2019 Category: Rheumatology Authors: Younis AA, Hamed RA, Abdulkareem IH Tags: Reumatismo Source Type: research

Is Palindromic Rheumatism a Pre-rheumatoid Arthritis Condition? Low Incidence of Rheumatoid Arthritis in Palindromic Rheumatism Patients Treated with Tight Control Strategy.
CONCLUSIONS: Tight control strategy by using DMARDs may control PR and prevent disease progression to RA. PMID: 30987884 [PubMed - as supplied by publisher] (Source: Reumatismo)
Source: Reumatismo - April 13, 2019 Category: Rheumatology Authors: Khabbazi A, Mirza-Aghazadeh-Attari M, Goli MT, Mahdavi AM, Hajialilo M, Rashtchizadeh N Tags: Reumatol Clin Source Type: research

Novel autoantibodies in rheumatoid arthritis.
Abstract Rheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified. Several proteins can trigger an aberrant autoimmune response in their native form while others acquire this feature after post-translational modifications such as citrullination, carbamylation or acetylation. It is of interest that also the enzymes catalyzing such post-translational modifications (e.g. the protein arginine deiminases) can transform themselves into autoantibodies in RA. The purpose...
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Bonifacio AF, Alunno A, La Paglia GMC, Valentini E, Leone MC, Bartoloni E, Gerli R Tags: Reumatismo Source Type: research

The Italian version of rheumatoid arthritis pain scale (IT-RAPS): psychometric properties on community and clinical samples.
Abstract This paper describes the validation process of the Italian version of the Rheumatoid Arthritis Pain Scale (ITRAPS), describing its translation and adaptation to Italian culture. The cultural adaptation and validation were based on data from a sample of people affected by rheumatoid arthritis (RA). The process required a forward and backward translation of the original language, reviewed by an expert panel. The adapted version of the RAPS was then tested on a community and clinical sample, in order to test its psychometric properties. The IT-RAPS was submitted to 122 people affected by RA. The data was ana...
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Tofani M, Nobilia M, Culicchia G, Esposito G, Savona A, Tashi I, Ventura A, Galeoto G Tags: Reumatismo Source Type: research

Serum klotho concentrations inversely correlate with the severity of nailfold capillaroscopic patterns in patients with systemic sclerosis.
Abstract Klotho is a transmembrane and soluble glycoprotein that governs vascular integrity. Previous studies have demonstrated reduced serum klotho concentrations in patients with systemic sclerosis (SSc), and it is known that klotho deficiency can impair the healing of digital ulcers related to microvessel damage. The aim of this study was to evaluate the association between serum klotho levels and nailfold capillaroscopic abnormalities in SSc patients. We retrospectively enrolled 54 consecutive patients with SSc diagnosed on the basis of the 2013 EULAR/ACR criteria [11 with diffuse SSc; 47 females; median age 6...
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Talotta R, Rigamonti F, Letizia T, Bongiovanni S, Ditto MC, Antivalle M, Santandrea S, Atzeni F, Vago T, Sarzi-Puttini P Tags: Reumatismo Source Type: research

Occult HBV infection may negatively impact on drug survival in patients with rheumatoid arthritis on treatment with a first biologic drug. An appraisal from the Biologic Apulian Registry (BIOPURE).
Abstract We performed a retrospective analysis to evaluate the survival on first line biologic drug of rheumatoid arthritis (RA) patients with potential occult HBV infection (pOBI). We analysed longitudinal data of 486 consecutive RA patients starting a first biological drug in a time frame from 1st January 2008 to 31st December 2014. Demographic and disease related characteristics were collected at baseline and at the last observation visit. Baseline serological markers of HBV infection and causes of treatment discontinuation were also recorded. Primary endpoint was the influence of pOBI on drug survival, estimat...
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Carlino G, Fornaro M, Santo L, Bucci R, Semeraro A, Quarta L, D'Onofrio F, Marsico A, Zuccaro C, Falappone PC, Mazzotta D, Cantatore FP, Muratore M, Iannone F Tags: Reumatismo Source Type: research

A rare disease with a rare presentation: hemi-atrophy caused by fibromuscular dysplasia in a 27 month old girl.
Abstract We discuss the case of a 27-month-old girl afflicted with fibromuscular dysplasia. She presented with hemiatrophy of left upper and lower limbs, nail dystrophy, ulcers on the tips of her toes, cold and painful limbs, foot drop, and hypertension. The initial appearance started at 2 months of age and other diagnoses such as complex regional pain syndrome, reflex sympathetic syndrome, vasculitis and coagulation disorders had been considered. Angiography revealed that all the arterial branches of the left lower and upper limbs, from brachial to ulnar and radial, and from iliac and femoral to tibialis arteries...
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Gharib B, Ghareh Zadeh Shirazi A, Moradi E, Yaghmaei B, Ziaee V Tags: Reumatismo Source Type: research

Acquired Haemophilia A. Which is the best therapeutic choice in older adults? Single center study of 4 cases.
Abstract Acquired haemophilia A (AHA) is a rare bleeding disorder due to autoantibodies directed against coagulation factor VIII. The treatment is based on recombinant activated factor VII and activated prothrombin complex concentrate. However, mainly in older patients, severe thrombotic complications have been reported. Here we report the different therapeutic approaches in 4 cases of elderly patients with AHA and co-morbidities. PMID: 30932442 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Mauro E, Garlatti Costa E, Zanier A, Maset M, Ermacora A, Ghersetti M, Casarin P Tags: Reumatismo Source Type: research

Incidental papillary thyroid cancer diagnosis in patient with adult-onset Still's disease-like manifestations.
Abstract Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized primarily by a triad consisting of daily fever, arthritis and maculopapular exanthema. The pathogenesis and etiology of AOSD are unknown and the diagnosis, which can be very challenging, is often made by exclusion. Here, we report a case of a 61-year-old woman with a history of mild psoriatic arthritis, fever, arthritis and maculopapular exanthema. Her initial laboratory tests showed neutrophilic leukocytosis, hypertransaminasemia, and markedly elevated levels of the erythrocyte sedimentation rate and C-reactive protein. W...
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Tirri R, Capocotta D Tags: Reumatismo Source Type: research

Poncet's disease diagnostic criteria decodes conundrum: Poncet's vs pseudo Poncet's.
Abstract Poncet's disease is very important and yet a challenging diagnosis of importance in countries with high TB endemicity (e.g. India). In this case series, we present 5 patients with diagnosed as Poncet's disease and in our tertiary health care center over 12 months and examine the performance of the diagnostic criteria suggested by Sharma and Pinto. The majority (4/5) of the patients were subsequently diagnosed and responded to anti-tuberculous therapy. In the other patient, a diagnosis of atypical seropositive rheumatoid arthritis or Pseudo Poncet's disease was established on follow up. PMID: 30932444...
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Shobha V, Desai AM Tags: Reumatismo Source Type: research

The hominid thumb and its influence on the employment during evolution.
ano P Abstract Not available. PMID: 30932445 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Villafañe JH, Cantero-Tellez R, Berjano P Tags: Reumatismo Source Type: research

Long-term treatment with anakinra and canakinumab resolves patellar subchondral erosion in neonatal-onset multisystem inflammatory disease.
Abstract Not available. PMID: 30932446 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - April 1, 2019 Category: Rheumatology Authors: Leone A, Manna R, Verrecchia E, Cipullo M, Rigante D Tags: Reumatismo Source Type: research

Paraneoplastic rheumatic disorders: a narrative review.
Abstract Paraneoplastic syndromes (PS) are a heterogeneous group of diseases related to a neoplasm, indirectly dependent on it. Diagnosis and the treatment are often a challenge for clinicians, not least because the pathogenetic mechanisms are highly complex and not entirely known. Nonetheless, in most cases, PS precede the diagnosis of malignancies, thus their identification is particularly important in addressing physicians' diagnostic work-up with regard to early cancer diagnosis. Among paraneoplastic syndromes, those of rheumatologic interest represent a large component. In this paper, we review the main rheum...
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Manzini CU, Colaci M, Ferri C, Manzini E Tags: Reumatismo Source Type: research

Extra-articular rheumatoid arthritis.
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly affects the joints, though a consistent proportion of patients may also display extra articular manifestations (EAMs). From rheumatoid nodules to interstitial lung disease, from cardiovascular events to vasculitis, the spectrum of EAMs encompasses various conditions with different prognoses. EAMs may also occur as first RA manifestation, therefore the coordination with other health professionals, including general practitioners, is needed. The aim of this article is to provide an overview on EAMs in RA with particular focus on the rec...
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Marcucci E, Bartoloni E, Alunno A, Leone MC, Cafaro G, Luccioli F, Valentini V, Valentini E, La Paglia GMC, Bonifacio AF, Gerli R Tags: Reumatismo Source Type: research

Thermal alterations in patients with inflammatory diseases: a comparison between psoriatic and rheumatoid arthritis.
This study aims to evaluate the application of fIRI in rheumatoid arthritis (RA) assessment, evaluating the thermoregulatory alterations due to joint inflammation in RA patients both in basal conditions and after a mild functional (isometric) exercise, using the same protocol we projected in our recent work on psoriatic arthritis (PsA); fIRI outcomes were compared with those provided by power-Doppler ultrasonography. Ten patients with RA and 11 healthy controls were enrolled in the study. The cutaneous temperature dynamics of 20 regions of interest located on the dominant hand were recorded by means of high-resolution ther...
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Capo A, Di Paolo J, Celletti E, Ismail E, Merla A, Amerio P Tags: Reumatismo Source Type: research

Inflammatory markers predict insulin sensitivity in active rheumatoid arthritis but not in psoriatic arthritis.
Abstract Whether the insulin resistance commonly observed in patients with inflammatory arthritis is a disease-specific feature and/or is limited to a disease phase (i.e., it occurs only during phases of high disease activity) is unknown. Fifty-three rheumatoid arthritis (RA) and 44 psoriatic arthritis (PsA) patients were recruited consecutively along with 194 controls matched for age, sex and body mass index for a case-control study. All underwent an oral glucose tolerance test, the results of which were analysed to derive the following indexes: homeostatic model of insulin resistance (HOMA-IR), insulin sensitivi...
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Bellan M, Bor S, Gibbin A, Gualerzi A, Favretto S, Guaschino G, Bonometti R, Rossini A, Sola D, Pedrazzoli R, Carnevale Schianca GP, Pirisi M, Sainaghi PP Tags: Reumatismo Source Type: research

The association between serum prolactin levels and interleukin-6 and systemic lupus erythematosus activity.
This study concurred with the previous findings that stated that hyperprolactinemia is prevalent in SLE patients and correlated with clinical disease activity and UPCI level. The baseline of the fasting serum prolactin level was found to be a sensitive biomarker for the evaluation of lupus nephritis disease activity. PMID: 30570242 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Wan Asyraf WA, Mohd Shahrir MS, Asrul W, Norasyikin AW, Hanita O, Kong WY, Azmi MT Tags: Reumatismo Source Type: research

Spasmophilia and entrapment nerve syndrome comorbidities in fibromyalgic patients: a possible neuromuscular pain generator.
Abstract This paper is aimed at investigating whether peripheral dysfunction at the neuromuscular level may represent a pain generator in fibromyalgia. We studied the prevalence of spasmophilia (SP), carpal tunnel syndrome (CTS) and ulnar neuropathy at the elbow (UNE) in a group of 40 subjects suffering from fibromyalgia. Clinical and electrophysiological data were obtained to ascertain whether comorbid conditions were present. For subjective evaluation of symptoms severity, validated questionnaires for CTS and UNE were completed by patients. Twenty subjects were positive for SP (50%); CTS was diagnosed in 12 subj...
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Ginanneschi F, Filippou G, Adinolfi A, Di Sabatino V, Frediani B, Rossi A Tags: Reumatismo Source Type: research

Nailfold videocapillaroscopy in antisynthetase syndrome.
Abstract A 57-year-old woman with a diagnosis of antisynthetase syndrome (ASSD) underwent a nailfold videocapillaroscopy (NVC) showing a scleroderma pattern. Alterations in capillary morphology have been reported in adults with inflammatory myositis (IM) but only recently have the differences in NVC findings between these two diseases been established. ASSD is currently classified as a subset of IM, for which reason only a few studies in literature evaluate its specific hallmarks, showing nonspecific features of NVC in patients with polymyositis and dermatomyositis (DM) and antisynthetase antibodies. To our knowle...
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Cassone G, Sebastiani M, Cavagna L, Triantafyllias K, Codullo V, Salvarani C, Manfredi A Tags: Reumatismo Source Type: research

Urticarial vasculitis as an initial manifestation of colonic carcinoma: a case report and review of the literature.
Abstract Cutaneous vasculitis may behave as a paraneoplastic syndrome. Paraneoplastic vasculitis as a phenomenon of colonic adenocarcinoma has been described in the literature. To the best of my knowledge, this is the first case report of urticarial vasculitis being an initial presentation of signet-ring cell carcinoma of the colon. I here report a case of 27-year-old woman who had rash, arthritis, and episodic bleeding per rectum. The rash was biopsy-proven to be leukocytoclastic vasculitis. There was only partial response to high-dose steroid, and rectal bleeding continued. Colonoscopy revealed a stenosing growt...
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Younis AA Tags: Reumatismo Source Type: research

Magnetic resonance imaging findings of infectious sacroiliitis associated with iliopsoas abscess: a case report in a young male.
We describe a case of a 16 year-old male with 5 days' history of fever, abdominal pain, constipation, low-back and left hip pain extended to the left knee associated with sudden inability to walk. In the first place, magnetic resonance imaging (MRI) examination of his sacroiliac joint revealed an enlarged corpuscolated fluid collection near the left iliopsoas muscle, extended to homolateral paravertebral muscles and a little fluid at the left sacroiliac joint. Drainage by aspiration of the iliopsoas abscess was applied; Staphylococcus aureus was found in the aspirated fluid and isolated from the blood too. Therefore intrav...
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Diacinti D, Gioia C, Vullo F, Cannavale G, Catalano C, Valesini G Tags: Reumatismo Source Type: research

Hashimoto's encephalopathy in a patient with septal panniculitis: a case report.
We describe a patient with HE and panniculitis, an association reported twice in the literature. PMID: 30570247 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - December 20, 2018 Category: Rheumatology Authors: Cosso C, Ghio M, Cutolo M Tags: Reumatismo Source Type: research

Histopathology of the synovial tissue: perspectives for biomarker development in chronic inflammatory arthritides.
Abstract The histopathological and molecular analysis of the synovial tissue has contributed to fundamental advances in our comprehension of arthritis pathogenesis and of the mechanisms of action of currently available treatments. On the other hand, its exploitation in clinical practice for diagnostic or prognostic purposes as well as for the prediction of treatment response to specific disease-modifying anti-rheumatic drugs is still limited. In this review, we present an overview of recent advances in the field of synovial tissue research with specific reference to the methods for synovial tissue collection, appr...
Source: Reumatismo - October 3, 2018 Category: Rheumatology Authors: Manzo A, Bugatti S, Caporali R, Montecucco C Tags: Reumatismo Source Type: research

Histopathology of the muscle in rheumatic diseases.
Abstract The presence of muscular symptoms is common in rheumatological clinical practice, but often the differential diagnosis between muscular involvement in connective tissue diseases, vasculitis and drug-induced myopathy may be difficult. In addition to clinical assessment, laboratory analysis and instrumental examinations, muscle biopsy may help to clarify the diagnosis in patients with muscular involvement. The purpose of this review is to provide a critical analysis of the current medical literature on muscular histopathology, to help clinicians to identify when to perform muscular biopsy and to provide a p...
Source: Reumatismo - October 3, 2018 Category: Rheumatology Authors: Barsotti S, Tripoli A, Pollina LE, Mosca M, Neri R Tags: Reumatismo Source Type: research

Histopathology of salivary glands.
Abstract Salivary gland (SG) biopsy is a technique broadly applied for the diagnosis of primary Sjögren's syndrome (pSS), lymphoma accompanying SS, sarcoidosis, amyloidosis, and IgG4-related disease The most peculiar feature of pSS on biopsy is focal lymphocytic sialadenitis. In the past, several histological scores have been reported in the literature to describe glandular involvement during pSS. However, the variability among centres in reporting glandular scores is one of the rationales behind the development of standardised consensus guidance. SGs as well as lacrimal glands are involved in up to 50% of pa...
Source: Reumatismo - October 3, 2018 Category: Rheumatology Authors: Carubbi F, Alunno A, Gerli R, Giacomelli R Tags: Reumatismo Source Type: research

Histopathology of vasculitis.
Abstract The range of pathologies that are related to primitive vasculitis is broad, complex and not as typical as we would expect. Clinicians should be aware that several forms of primitive and systemic vasculitis, regardless of the size of the affected vessel, may exhibit identical histological alterations. This observation has important clinical implications as it means that cases of vasculitis do not correspond clinically and histologically. Thus, while histology remains the diagnostic gold standard, it can be used only as part of the most complete clinical assessment possible. Another point worth of the clini...
Source: Reumatismo - October 3, 2018 Category: Rheumatology Authors: Bajocchi G, Cavazza A Tags: Reumatismo Source Type: research

Diagnostic and prognostic role of renal histopathology in rheumatic diseases.
The objective was to evaluate renal involvement in several rheumatic diseases (i.e. rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, systemic sclerosis, systemic vasculitides). The method chosen was to define histopathological profiles reported in renal biopsies performed on patients with renal involvement due to different rheumatic diseases. Renal involvement observed in patients with rheumatic disease can be the direct result of the disease per se and/or a complication of drugs used in the disease treatment. The clinical-pathological correlations derived from the study of renal tissues can be us...
Source: Reumatismo - October 3, 2018 Category: Rheumatology Authors: Saccon F, Gatto M, Larosa M, Ometto F, Felicetti M, Padoan R, Zen M Tags: Reumatismo Source Type: research

Histopathology of the gut in rheumatic diseases.
Abstract The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity to non-self-antigens. Various evidence indicates that intestinal inflammation occurs in patients with rheumatic diseases. In many rheumatic diseases intestinal inflammation appears to be linked to dysbiosis and possibly represents the common denominator in the pathogenesis of different rheumatic diseases. The continuative interaction between dysbiosis and t...
Source: Reumatismo - October 3, 2018 Category: Rheumatology Authors: Macaluso F, Guggino G, Rizzo A, Ferrante A, Ciccia F Tags: Reumatismo Source Type: research