Anti-tumor necrosis factor α: originators < em > versus < /em > biosimilars, comparison in clinical response assessment in a multicenter cohort of patients with inflammatory arthropathies
CONCLUSIONS: Real-life data demonstrated a similar safety profile between biosimilars and originators, but a reduced biosimilar retention rate at 24 months. Biosimilars could be considered a valid, safe, and less expensive alternative to originators, allowing access to treatments for a wider patient population.PMID:38115772 | DOI:10.4081/reumatismo.2023.1602 (Source: Reumatismo)
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: C Gioia A Picchianti Diamanti R Perricone M S Chimenti A Afeltra L Navarini A Migliore U Massafra V Bruzzese P Scolieri C Meschini M Paroli R Caccavale P Scapato R Scrivo F Conti B Lagan à M Di Franco Source Type: research
Anti-N-methyl-d-aspartate receptor encephalitis: mimicker of lupus and multiple sclerosis
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1598.ABSTRACTAnti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is a B-cell-mediated autoimmune encephalitis with wide non-specific symptoms like acute-onset psychiatric or neurological ones mimicking various other conditions. A careful history and appropriate workup, including cerebrospinal fluid analysis for anti-NMDAR antibodies, imaging, and electroencephalogram, should be conducted, considering all differential diagnoses that can mimic its presentation. Combination therapy with high-dose steroids, plasma exchange, or immunoglobulin therapy has been show...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: N Sanghavi B Ayesha Source Type: research
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis recurrence temporally associated with allergen-specific immunotherapy in a female adolescent: a case report
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1594.ABSTRACTPeriodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in pediatric patients. It is clinically characterized by fever flares lasting 3-7 days, reappearing every 2-8 weeks with a distinctive clockwork regularity. PFAPA generally begins before 5 years of age and usually ceases 3-5 years after onset. Recurrences may be observed in adolescence and adulthood in up to 20% of cases. The authors aim to describe a case of PFAPA recurrence in adolescence temporally associated with alle...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: C Granjo Morais A Martins S Ganh ão F Aguiar M Rodrigues I Brito Source Type: research
Emergence of acute promyelocytic leukemia in a patient with granulomatosis with polyangiitis during treatment with cyclophosphamide: a rare case report
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1593.ABSTRACTGranulomatosis with polyangiitis (GPA) is a rare autoimmune disease that affects multiple organs and causes inflammation, necrosis, and vasculitis in small blood vessels. Treatment for GPA involves achieving and maintaining remission. In recent studies, cyclophosphamide-based regimens have been linked to comorbidity hazards, including an increased risk of malignancies, especially hematological ones. Acute myeloid leukemia is the main hematologic malignancy that can complicate GPA. In this context, we report the case of a middle-aged woman with GPA who...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: F I Gorial N I Awadh N W Shaheen A Dheyaa Z H Ali N Wajdi Source Type: research
Eosinophilic granulomatosis with polyangiitis: sequential use of mepolizumab following rituximab for inadequate asthma control despite vasculitis remission
This report reinforces the use of rituximab for induction and maintenance of remission in patients with eosinophilic granulomatosis with polyangiitis and predominant vasculitic manifestations, whereas mepolizumab demonstrated better control of the persistent eosinophilic manifestations, ensuing sustained remission and improved quality of life.PMID:38115776 | DOI:10.4081/reumatismo.2023.1588 (Source: Reumatismo)
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: B Cremonezi Lammoglia L De Aguiar Trevise T Paslar Leal M Pereira Lopes Vieira Pinto G Hasselmann N Salles Rosa Neto Source Type: research
