Anti-tumor necrosis factor α: originators < em > versus < /em > biosimilars, comparison in clinical response assessment in a multicenter cohort of patients with inflammatory arthropathies
CONCLUSIONS: Real-life data demonstrated a similar safety profile between biosimilars and originators, but a reduced biosimilar retention rate at 24 months. Biosimilars could be considered a valid, safe, and less expensive alternative to originators, allowing access to treatments for a wider patient population.PMID:38115772 | DOI:10.4081/reumatismo.2023.1602 (Source: Reumatismo)
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: C Gioia A Picchianti Diamanti R Perricone M S Chimenti A Afeltra L Navarini A Migliore U Massafra V Bruzzese P Scolieri C Meschini M Paroli R Caccavale P Scapato R Scrivo F Conti B Lagan à M Di Franco Source Type: research
Anti-N-methyl-d-aspartate receptor encephalitis: mimicker of lupus and multiple sclerosis
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1598.ABSTRACTAnti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is a B-cell-mediated autoimmune encephalitis with wide non-specific symptoms like acute-onset psychiatric or neurological ones mimicking various other conditions. A careful history and appropriate workup, including cerebrospinal fluid analysis for anti-NMDAR antibodies, imaging, and electroencephalogram, should be conducted, considering all differential diagnoses that can mimic its presentation. Combination therapy with high-dose steroids, plasma exchange, or immunoglobulin therapy has been show...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: N Sanghavi B Ayesha Source Type: research
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis recurrence temporally associated with allergen-specific immunotherapy in a female adolescent: a case report
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1594.ABSTRACTPeriodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in pediatric patients. It is clinically characterized by fever flares lasting 3-7 days, reappearing every 2-8 weeks with a distinctive clockwork regularity. PFAPA generally begins before 5 years of age and usually ceases 3-5 years after onset. Recurrences may be observed in adolescence and adulthood in up to 20% of cases. The authors aim to describe a case of PFAPA recurrence in adolescence temporally associated with alle...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: C Granjo Morais A Martins S Ganh ão F Aguiar M Rodrigues I Brito Source Type: research
Emergence of acute promyelocytic leukemia in a patient with granulomatosis with polyangiitis during treatment with cyclophosphamide: a rare case report
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1593.ABSTRACTGranulomatosis with polyangiitis (GPA) is a rare autoimmune disease that affects multiple organs and causes inflammation, necrosis, and vasculitis in small blood vessels. Treatment for GPA involves achieving and maintaining remission. In recent studies, cyclophosphamide-based regimens have been linked to comorbidity hazards, including an increased risk of malignancies, especially hematological ones. Acute myeloid leukemia is the main hematologic malignancy that can complicate GPA. In this context, we report the case of a middle-aged woman with GPA who...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: F I Gorial N I Awadh N W Shaheen A Dheyaa Z H Ali N Wajdi Source Type: research
Eosinophilic granulomatosis with polyangiitis: sequential use of mepolizumab following rituximab for inadequate asthma control despite vasculitis remission
This report reinforces the use of rituximab for induction and maintenance of remission in patients with eosinophilic granulomatosis with polyangiitis and predominant vasculitic manifestations, whereas mepolizumab demonstrated better control of the persistent eosinophilic manifestations, ensuing sustained remission and improved quality of life.PMID:38115776 | DOI:10.4081/reumatismo.2023.1588 (Source: Reumatismo)
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: B Cremonezi Lammoglia L De Aguiar Trevise T Paslar Leal M Pereira Lopes Vieira Pinto G Hasselmann N Salles Rosa Neto Source Type: research
Acquired hemophilia A treated with rituximab in a 62-year-old female with rheumatoid arthritis: a case-based review
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1585.ABSTRACTAcquired hemophilia A (AHA) is a rare autoimmune disorder with unpredictable hemostasis that is caused by autoantibody formation against coagulation factor VIII. AHA can occur in the context of autoimmune inflammatory rheumatic disorders. Here we report the case of a 62-year-old female with an 11-year history of rheumatoid arthritis (RA) who presented with cutaneous and mucosal bleeding. Activated partial thromboplastin time was prolonged and not corrected by the mixing test. Factor VIII activity was decreased, and the anti-factor VIII antibody was po...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: D Mohamadzadeh S Assar F Farsad Source Type: research
Ultrasound imaging in crystal arthropathies: a pictorial review
CONCLUSIONS: High-prevalence crystal arthropathies are reliably detectable by ultrasound with current ultrasound equipment. It is necessary to have extensive ultrasound training, know specific sonographic findings, and understand all possible differential diagnoses for disorders affecting the musculoskeletal system.PMID:38115778 | DOI:10.4081/reumatismo.2023.1583 (Source: Reumatismo)
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: G Tamborrini T H ügle V Ricci G Filippou Source Type: research
Lumbosacral pain in a patient with psoriatic arthritis: when the rheumatic disease is innocent
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1565.ABSTRACTLumbar pain is a very common symptom that derives from benign musculoskeletal conditions, rheumatic inflammatory diseases, neoplasms, and referred and/or nociplastic pain. A 70-year-old man with psoriatic arthritis presented with early-onset lumbosacral pain without evident red flags. Symptomatic treatment was unhelpful. Radiographic imaging showed subtle signs of a disease that could easily be missed. Magnetic resonance imaging revealed a massive prostatic malignancy with bone (sacral and iliopubic) metastasis. Awareness must be given not to disregar...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: H Parente M Pontes Ferreira C Soares F Guimar ães S Azevedo D Santos-Faria J Tavares-Costa D Peixoto C Afonso D Roriz F Teixeira Source Type: research
Polymyositis following varicella and mumps infection in adults: report of two cases
The objective of this study is to describe the clinical features and the treatment strategy of 2 cases of polymyositis developing shortly after chickenpox and mumps, respectively, and to review the existing literature on the topic. The clinical records of the 2 patients suspected to have developed inflammatory myositis following a viral infection were reviewed. Their clinical history, main laboratory findings, and treatment outcome are presented here. Moreover, a literature search was performed in the PubMed and MEDLINE databases to identify reports describing the association between viral infections and IIMs in patients a...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: F Masini K Gjeloshi E Pinotti R Ferrara C Romano G Cuomo Source Type: research
Can restless legs be a sign of something else? A case report of spondyloarthritis presenting with restless legs syndrome and a review of the literature
In this report, a case of coexistence of spondyloarthritis and RLS is presented, showing satisfactory improvement with conservative treatment and additionally adding naproxen. Anemia of chronic disease occurring in rheumatic diseases, and associated iron deficiency may contribute to the development of RLS.PMID:38115781 | DOI:10.4081/reumatismo.2023.1557 (Source: Reumatismo)
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: E Y ılmaz Source Type: research
Infliximab as successful treatment option in a case of adenosine deaminase 2 deficiency
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1543.ABSTRACTDeficiency of adenosine deaminase 2 (DADA2) is a recessively inherited autoinflammatory disease characterized by systemic inflammation and immunodeficiency. Infliximab proved to be favorable in the treatment of this condition. This case report is concerned with a DADA2 deficient patient treated with infliximab. This is a rare case of DADA2 in a 32-year-old female patient. The patient was admitted with a clinical presentation of erythema, ulcers, and pruritus on both legs and ankles, accompanied by red ulcerative oral lesions, fatigue, malaise, and diz...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: M B Ates S Karup S Ugurlu Source Type: research
Janus kinase inhibitors: between prescription authorization and reimbursability
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1627.ABSTRACTFollowing the restrictions on the reimbursability of Janus kinase inhibitors introduced by the Italian Medicines Agency, the Italian Society of Rheumatology has drafted this document to shed light on the clinical conditions and reimbursability criteria set out in the prescription forms.PMID:38115771 | DOI:10.4081/reumatismo.2023.1627 (Source: Reumatismo)
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: F R Spinelli F Conti R Caporali F Iannone F Cacciapaglia On Behalf Of The Steering Committee Of The Italian Society Of Rheumatology Source Type: research
Anti-tumor necrosis factor α: originators < em > versus < /em > biosimilars, comparison in clinical response assessment in a multicenter cohort of patients with inflammatory arthropathies
CONCLUSIONS: Real-life data demonstrated a similar safety profile between biosimilars and originators, but a reduced biosimilar retention rate at 24 months. Biosimilars could be considered a valid, safe, and less expensive alternative to originators, allowing access to treatments for a wider patient population.PMID:38115772 | DOI:10.4081/reumatismo.2023.1602 (Source: Reumatismo)
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: C Gioia A Picchianti Diamanti R Perricone M S Chimenti A Afeltra L Navarini A Migliore U Massafra V Bruzzese P Scolieri C Meschini M Paroli R Caccavale P Scapato R Scrivo F Conti B Lagan à M Di Franco Source Type: research
Anti-N-methyl-d-aspartate receptor encephalitis: mimicker of lupus and multiple sclerosis
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1598.ABSTRACTAnti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is a B-cell-mediated autoimmune encephalitis with wide non-specific symptoms like acute-onset psychiatric or neurological ones mimicking various other conditions. A careful history and appropriate workup, including cerebrospinal fluid analysis for anti-NMDAR antibodies, imaging, and electroencephalogram, should be conducted, considering all differential diagnoses that can mimic its presentation. Combination therapy with high-dose steroids, plasma exchange, or immunoglobulin therapy has been show...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: N Sanghavi B Ayesha Source Type: research
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis recurrence temporally associated with allergen-specific immunotherapy in a female adolescent: a case report
Reumatismo. 2023 Dec 19;75(4). doi: 10.4081/reumatismo.2023.1594.ABSTRACTPeriodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in pediatric patients. It is clinically characterized by fever flares lasting 3-7 days, reappearing every 2-8 weeks with a distinctive clockwork regularity. PFAPA generally begins before 5 years of age and usually ceases 3-5 years after onset. Recurrences may be observed in adolescence and adulthood in up to 20% of cases. The authors aim to describe a case of PFAPA recurrence in adolescence temporally associated with alle...
Source: Reumatismo - December 20, 2023 Category: Rheumatology Authors: C Granjo Morais A Martins S Ganh ão F Aguiar M Rodrigues I Brito Source Type: research
