Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00372.2023. Online ahead of print.ABSTRACTHumans are predisposed to gout because they lack uricase that converts uric acid to allantoin. Rodents have uricase, resulting in low basal serum uric acid. A uricase inhibitor raises serum uric acid in rodents. There were 2 aims of the study in polycystic kidney disease (PKD): 1) to determine whether increasing serum uric acid with the uricase inhibitor, oxonic acid, resulted in faster cyst growth and 2) to determine whether treatment with the xanthine oxidase inhibitor, oxypurinol, reduced the cyst growth caused by ox...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Anjana Chaudhary Zhibin He Daniel J Atwood Makoto Miyazaki Ozgur A Oto Allen Davidoff Charles L Edelstein Source Type: research
Correlation between the bacterial community succession and purine compound changes during Huangjiu fermentation
This study is helpful to scientifically understand the formation mechanism of purines, providing a basis for screening functional strains of purine degrading to accurately regulate purine level in Huangjiu.PMID:38637084 | DOI:10.1016/j.fm.2024.104522 (Source: Food Microbiology)
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Xianglin Wang Guolin Cai Dianhui Wu Jian Lu Source Type: research
Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00372.2023. Online ahead of print.ABSTRACTHumans are predisposed to gout because they lack uricase that converts uric acid to allantoin. Rodents have uricase, resulting in low basal serum uric acid. A uricase inhibitor raises serum uric acid in rodents. There were 2 aims of the study in polycystic kidney disease (PKD): 1) to determine whether increasing serum uric acid with the uricase inhibitor, oxonic acid, resulted in faster cyst growth and 2) to determine whether treatment with the xanthine oxidase inhibitor, oxypurinol, reduced the cyst growth caused by ox...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Anjana Chaudhary Zhibin He Daniel J Atwood Makoto Miyazaki Ozgur A Oto Allen Davidoff Charles L Edelstein Source Type: research
The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization
CONCLUSIONS: This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris.PMID:38633818 | PMC:PMC11022507 | DOI:10.1155/2024/4564596 (Source: Pain Research and Management)
Source: Pain Research and Management - April 18, 2024 Category: Anesthesiology Authors: Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang Source Type: research
Correlation between the bacterial community succession and purine compound changes during Huangjiu fermentation
This study is helpful to scientifically understand the formation mechanism of purines, providing a basis for screening functional strains of purine degrading to accurately regulate purine level in Huangjiu.PMID:38637084 | DOI:10.1016/j.fm.2024.104522 (Source: Food Microbiology)
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Xianglin Wang Guolin Cai Dianhui Wu Jian Lu Source Type: research
The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization
CONCLUSIONS: This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris.PMID:38633818 | PMC:PMC11022507 | DOI:10.1155/2024/4564596 (Source: Pain Research and Management)
Source: Pain Research and Management - April 18, 2024 Category: Anesthesiology Authors: Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang Source Type: research
Correlation between the bacterial community succession and purine compound changes during Huangjiu fermentation
This study is helpful to scientifically understand the formation mechanism of purines, providing a basis for screening functional strains of purine degrading to accurately regulate purine level in Huangjiu.PMID:38637084 | DOI:10.1016/j.fm.2024.104522 (Source: Food Microbiology)
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Xianglin Wang Guolin Cai Dianhui Wu Jian Lu Source Type: research
The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization
CONCLUSIONS: This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris.PMID:38633818 | PMC:PMC11022507 | DOI:10.1155/2024/4564596 (Source: Pain Research and Management)
Source: Pain Research and Management - April 18, 2024 Category: Anesthesiology Authors: Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang Source Type: research
Correlation between the bacterial community succession and purine compound changes during Huangjiu fermentation
This study is helpful to scientifically understand the formation mechanism of purines, providing a basis for screening functional strains of purine degrading to accurately regulate purine level in Huangjiu.PMID:38637084 | DOI:10.1016/j.fm.2024.104522 (Source: Food Microbiology)
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Xianglin Wang Guolin Cai Dianhui Wu Jian Lu Source Type: research
The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization
CONCLUSIONS: This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris.PMID:38633818 | PMC:PMC11022507 | DOI:10.1155/2024/4564596 (Source: Pain Research and Management)
Source: Pain Research and Management - April 18, 2024 Category: Anesthesiology Authors: Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang Source Type: research
Correlation between the bacterial community succession and purine compound changes during Huangjiu fermentation
This study is helpful to scientifically understand the formation mechanism of purines, providing a basis for screening functional strains of purine degrading to accurately regulate purine level in Huangjiu.PMID:38637084 | DOI:10.1016/j.fm.2024.104522 (Source: Food Microbiology)
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Xianglin Wang Guolin Cai Dianhui Wu Jian Lu Source Type: research
The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization
CONCLUSIONS: This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris.PMID:38633818 | PMC:PMC11022507 | DOI:10.1155/2024/4564596 (Source: Pain Research and Management)
Source: Pain Research and Management - April 18, 2024 Category: Anesthesiology Authors: Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang Source Type: research
Correlation between the bacterial community succession and purine compound changes during Huangjiu fermentation
This study is helpful to scientifically understand the formation mechanism of purines, providing a basis for screening functional strains of purine degrading to accurately regulate purine level in Huangjiu.PMID:38637084 | DOI:10.1016/j.fm.2024.104522 (Source: Food Microbiology)
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Xianglin Wang Guolin Cai Dianhui Wu Jian Lu Source Type: research
The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization
CONCLUSIONS: This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris.PMID:38633818 | PMC:PMC11022507 | DOI:10.1155/2024/4564596 (Source: Pain Research and Management)
Source: Pain Research and Management - April 18, 2024 Category: Anesthesiology Authors: Jian Xiong Yuxin Sun Hui Huang Yu Liu Fayang Ling Yin Wei Qianhua Zheng Wenchuan Qi Fanrong Liang Source Type: research
Correlation between the bacterial community succession and purine compound changes during Huangjiu fermentation
This study is helpful to scientifically understand the formation mechanism of purines, providing a basis for screening functional strains of purine degrading to accurately regulate purine level in Huangjiu.PMID:38637084 | DOI:10.1016/j.fm.2024.104522 (Source: Food Microbiology)
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Xianglin Wang Guolin Cai Dianhui Wu Jian Lu Source Type: research
