SGLT-2 inhibitors May Decrease Recurrent Gout Flares in Patients with Type 2 diabetes
Dr. Bernal
Clinical question: Do SGLT-2 inhibitors decrease gout flares in patients with type 2 diabetes and a known history of gout?
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) are known to decrease serum urate levels and the risk of incident gout. However, their role in secondary prevention of gout flares is unknown.
Study design: Propensity score–matched, new-user cohort study
Setting: British Columbia, Canada
Synopsis: Using a group of population-based, linked, administrative databases, the population of British Columbia was studied. 15,067 patients with gout and type 2 diabetes had f...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Autoimmune Diseases In the Literature Pharmacology Rheumatology Source Type: research
Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors
Eur J Med Chem. 2024 Apr 26;271:116443. doi: 10.1016/j.ejmech.2024.116443. Online ahead of print.ABSTRACTXanthine oxidase (XO) is a key enzyme for the production of uric acid in the human body. XO inhibitors (XOIs) are clinically used for the treatment of hyperuricemia and gout, as they can effectively inhibit the production of uric acid. Previous studies indicated that both indole and isoxazole derivatives have good inhibitory effects against XO. Here, we designed and synthesized a novel series of N-5-(1H-indol-5-yl)isoxazole-3-carboxylic acids according to bioisosteric replacement and hybridization strategies. Among the ...
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Dongqian Huang Wenye Li Yilan Zhao Cheng Xie Xiaogang Luo Fengshou Wu Zhiqiang Xu Qi Sun Genyan Liu Source Type: research
Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors
Eur J Med Chem. 2024 Apr 26;271:116443. doi: 10.1016/j.ejmech.2024.116443. Online ahead of print.ABSTRACTXanthine oxidase (XO) is a key enzyme for the production of uric acid in the human body. XO inhibitors (XOIs) are clinically used for the treatment of hyperuricemia and gout, as they can effectively inhibit the production of uric acid. Previous studies indicated that both indole and isoxazole derivatives have good inhibitory effects against XO. Here, we designed and synthesized a novel series of N-5-(1H-indol-5-yl)isoxazole-3-carboxylic acids according to bioisosteric replacement and hybridization strategies. Among the ...
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Dongqian Huang Wenye Li Yilan Zhao Cheng Xie Xiaogang Luo Fengshou Wu Zhiqiang Xu Qi Sun Genyan Liu Source Type: research
Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities
ConclusionsWe clustered people with gout into five groups with varying comorbidities. People with CVD, CKD, and cancer had the highest risk of gout flares and should receive comprehensive care. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Predictors of Inadequate Serum Urate Response to Low-Dose Febuxostat in Male Patients with Gout
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 30, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Prediction and causal inference of hyperuricemia using gut microbiota
This study aimed to determine the relationship between HUA and GM. The microbiome of 224 men and 254 women aged 40 years was analyzed through next-generation sequencing and machine learning. We obtained GM data through 16S rRNA-based sequencing of the fecal samples, finding that alpha-diversity by Shannon index was significantly low in the HUA group. Linear discriminant effect size analysis detected a high abundance of the genera Collinsella and Faecalibacterium in the HUA and non-HUA groups. Based on light gradient boosting machine learning, we propose that HUA can be predicted with high AUC using four clinical characteri...
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Yuna Miyajima Shigehiro Karashima Ren Mizoguchi Masaki Kawakami Kohei Ogura Kazuhiro Ogai Aoi Koshida Yasuo Ikagawa Yuta Ami Qiunan Zhu Hiromasa Tsujiguchi Akinori Hara Shin Kurihara Hiroshi Arakawa Hiroyuki Nakamura Ikumi Tamai Hidetaka Nambo Shigefumi O Source Type: research
The association between Helicobacter pylori infection and the risk for gout in hyperuricemia patients in China – A cross-sectional study
ConclusionH. pylori infection is positively associated with higher risk of gout in hyperuricemia population. The causal relationship and potential mechanism betweenH. pylori infection and gout warrants further investigation. (Source: Gut Pathogens)
Source: Gut Pathogens - April 27, 2024 Category: Microbiology Source Type: research
Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro
Toxicol In Vitro. 2024 Apr 24:105833. doi: 10.1016/j.tiv.2024.105833. Online ahead of print.ABSTRACTGout is an immune-metabolic disease that frequently coexists with multiple comorbidities such as chronic kidney disease, cardiovascular disease and metabolic syndrome, therefore, it is often treated in combination with these complications. The present study aimed to evaluate the inhibitory effect of antigout drugs (allopurinol, febuxostat, topiroxostat, benzbromarone, lesinurad and probenecid) on the activity of the crucial phase I drug-metabolizing enzymes, carboxylesterases (CESs). 2-(2-benzoyl-3-methoxyphenyl) benzothiazo...
Source: Toxicology in Vitro - April 26, 2024 Category: Toxicology Authors: Jia-Hong Liang Xiao-Lei Yi Jia-Min Gong Zuo Du Source Type: research
Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro
Toxicol In Vitro. 2024 Apr 24:105833. doi: 10.1016/j.tiv.2024.105833. Online ahead of print.ABSTRACTGout is an immune-metabolic disease that frequently coexists with multiple comorbidities such as chronic kidney disease, cardiovascular disease and metabolic syndrome, therefore, it is often treated in combination with these complications. The present study aimed to evaluate the inhibitory effect of antigout drugs (allopurinol, febuxostat, topiroxostat, benzbromarone, lesinurad and probenecid) on the activity of the crucial phase I drug-metabolizing enzymes, carboxylesterases (CESs). 2-(2-benzoyl-3-methoxyphenyl) benzothiazo...
Source: Toxicology in Vitro - April 26, 2024 Category: Toxicology Authors: Jia-Hong Liang Xiao-Lei Yi Jia-Min Gong Zuo Du Source Type: research
Treat-to-target or treat-to-dissolve strategy to improve gout treatment
Nature Reviews Rheumatology, Published online: 26 April 2024; doi:10.1038/s41584-024-01117-5Medication adherence in gout is low, and discontinuation of urate-lowering therapy puts patients at risk of flares and cardiovascular events. A strategy to regularly monitor serum urate levels and the dissolution of urate deposits (particularly if visualized by patients) might encourage adherence in the long term. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 26, 2024 Category: Rheumatology Authors: Pascal Richette Nicola Dalbeth Source Type: research
Exploring the multifaceted bioactivities of < em > Lavandula pinnata L. < /em > essential oil: promising pharmacological activities
This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments. Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and total antioxidant capacity assays. Antimicrobial activity was evaluated by disc diffusion, MIC, MBC, and MFC determination against bacterial (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa) and fungal (Candida glabrata, Rhodotorula glutinis, Aspergillus nige...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Mounir Haddou Amine Elbouzidi Mohamed Taibi Abdellah Baraich El Hassania Loukili Reda Bellaouchi Ennouaamane Saalaoui Abdeslam Asehraou Ahmad Mohammad Salamatullah Mohammed Bourhia Hiba-Allah Nafidi Mohamed Addi Bouchra El Guerrouj Khalid Chaabane Source Type: research
Molecules, Vol. 29, Pages 1936: The Simultaneous Detection of Dopamine and Uric Acid In Vivo Based on a 3D Reduced Graphene Oxide & ndash;MXene Composite Electrode
Molecules, Vol. 29, Pages 1936: The Simultaneous Detection of Dopamine and Uric Acid In Vivo Based on a 3D Reduced Graphene Oxide–MXene Composite Electrode
Molecules doi: 10.3390/molecules29091936
Authors:
Lingjun Shang
Ruijiao Li
Haojie Li
Shuaiqun Yu
Xuming Sun
Yi Yu
Qiongqiong Ren
Dopamine (DA) and uric acid (UA) are essential for many physiological processes in the human body. Abnormal levels of DA and UA can lead to multiple diseases, such as Parkinson&rsquo;s disease and gout. In this work, a three-dimensional reduced graphene oxide&ndash;MXene (3D rGO-Ti3C2) composite el...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Lingjun Shang Ruijiao Li Haojie Li Shuaiqun Yu Xuming Sun Yi Yu Qiongqiong Ren Tags: Article Source Type: research
Giant gout stone with bone destruction in a Chinese man: A case report
Asian J Surg. 2024 Apr 22:S1015-9584(24)00695-X. doi: 10.1016/j.asjsur.2024.04.035. Online ahead of print.NO ABSTRACTPMID:38653704 | DOI:10.1016/j.asjsur.2024.04.035 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 23, 2024 Category: Surgery Authors: Yuxi Liu Rilei Jiang Source Type: research
A potential therapeutic agent for the treatment of hyperuricemia and gout: 3,4-Dihydroxy-5-nitrobenzaldehyde phenylthiosemicarbazide
Eur J Pharm Sci. 2024 Apr 21:106778. doi: 10.1016/j.ejps.2024.106778. Online ahead of print.ABSTRACTUric acid, the metabolic product of purines, relies on xanthine oxidase (XOD) for production. XOD is a target for the development of drugs for hyperuricemia (HUA) and gout. Currently, treatment options remain limited for gout patients. 3, 4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a derivative of the natural product protocatechualdehyde with good biological activity. In this work, we identify a DHNB thiosemicarbazide class of compounds that targets XOD. 3,4-Dihydroxy-5-nitrobenzaldehyde phenylthiosemicarbazone can effectively...
Source: European Journal of Pharmaceutical Sciences - April 23, 2024 Category: Drugs & Pharmacology Authors: Xiongying Yu Shuaiwei Ren Jun Zhou Yongcui Liao Yousheng Huang Dong Huanhuan Source Type: research
Giant gout stone with bone destruction in a Chinese man: A case report
Asian J Surg. 2024 Apr 22:S1015-9584(24)00695-X. doi: 10.1016/j.asjsur.2024.04.035. Online ahead of print.NO ABSTRACTPMID:38653704 | DOI:10.1016/j.asjsur.2024.04.035 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 23, 2024 Category: Surgery Authors: Yuxi Liu Rilei Jiang Source Type: research
