CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
CONCLUSION: The novel protein PDE5A-500aa encoded by circPDE5A can act as an inhibitor of the PI3K/AKT signaling pathway to inhibit the progression of ESCC by promoting USP14-mediated de-ubiquitination of PIK3IP1 and may serve as a potential target for the development of therapeutic agents.PMID:38658954 | DOI:10.1186/s13046-024-03054-3 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Kai Lei Ruihao Liang Jialu Liang Nan Lu Jing Huang Ke Xu Binghua Tan Kexi Wang Yicheng Liang Wenjian Wang Huayue Lin Minghui Wang Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
CONCLUSION: The novel protein PDE5A-500aa encoded by circPDE5A can act as an inhibitor of the PI3K/AKT signaling pathway to inhibit the progression of ESCC by promoting USP14-mediated de-ubiquitination of PIK3IP1 and may serve as a potential target for the development of therapeutic agents.PMID:38658954 | DOI:10.1186/s13046-024-03054-3 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Kai Lei Ruihao Liang Jialu Liang Nan Lu Jing Huang Ke Xu Binghua Tan Kexi Wang Yicheng Liang Wenjian Wang Huayue Lin Minghui Wang Source Type: research
Evaluation of different body temperature measurement methods for patients in the intraoperative period
CONCLUSION: the data from the current study do not recommend using infrared temporal thermometers as a strategy for measuring the body temperature of patients undergoing anesthetic-surgical procedures. Central cutaneous thermometers and esophageal/nasopharyngeal thermometers are equivalent for detecting intraoperative hypothermia.PMID:38655937 | DOI:10.1590/1518-8345.6873.4143 (Source: Revista Latino-Americana de Enfermagem)
Source: Revista Latino-Americana de Enfermagem - April 24, 2024 Category: Nursing Authors: Ariane Souza do Nascimento Cassiane de Santana Lemos Fernanda Baratojo Biachi Fernanda Ribeiro Silva de Lyra Juliana Rizzo Gnatta Vanessa de Brito Poveda Source Type: research
Extensive pulmonary hyalinizing granuloma- an unexpected manifestation during esophageal cancer treatment
Asian J Surg. 2024 Apr 23:S1015-9584(24)00745-0. doi: 10.1016/j.asjsur.2024.04.086. Online ahead of print.NO ABSTRACTPMID:38658278 | DOI:10.1016/j.asjsur.2024.04.086 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 24, 2024 Category: Surgery Authors: Sen-Ei Shai Chen-I Chang Yi-Ling Lai Chi-Wei Hsieh Source Type: research
Identification of Key lncRNAs Associated with Immune Infiltration and Prognosis in Gastric Cancer
In this study, we systematically analyzed lncRNA and miRNA transcriptomic profiles of GC based on bioinformatics methods and experimental validation. An lncRNA-miRNA interaction network related to GC was constructed, and the nine crucial lncRNAs were identified. These 9 lncRNAs were found to be associated with the prognosis of GC patients by Cox proportional hazards regression analysis. Among them, the expression of lncRNA SNHG14 can affect the survival of GC patients as a potential prognostic marker. Moreover, it was shown that SNHG14 was involved in immune-related pathways and significantly correlated with immune cell in...
Source: Biochemical Genetics - April 24, 2024 Category: Genetics & Stem Cells Authors: Wen Jin Jianchao Jia Yangming Si Jianli Liu Hanshuang Li Hao Zhu Zhouying Wu Yongchun Zuo Lan Yu Source Type: research
Annexin A2 combined with TTK accelerates esophageal cancer progression via the Akt/mTOR signaling pathway
Cell Death & Disease, Published online: 24 April 2024; doi:10.1038/s41419-024-06683-wAnnexin A2 combined with TTK accelerates esophageal cancer progression via the Akt/mTOR signaling pathway (Source: Cell death and disease)
Source: Cell death and disease - April 24, 2024 Category: Internal Medicine Authors: Ruiqi Liu Yanwei Lu Jing Li Weiping Yao Jiajun Wu Xiaoyan Chen Luanluan Huang Ding Nan Yitian Zhang Weijun Chen Ying Wang Yongshi Jia Jianming Tang Xiaodong Liang Haibo Zhang Source Type: research
CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal tumor and has become an important global health problem. The PI3K/AKT signaling pathway plays a key role in the development of ESCC. CircR... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 24, 2024 Category: Cancer & Oncology Authors: Kai Lei, Ruihao Liang, Jialu Liang, Nan Lu, Jing Huang, Ke Xu, Binghua Tan, Kexi Wang, Yicheng Liang, Wenjian Wang, Huayue Lin and Minghui Wang Tags: Research Source Type: research
SMARCA4-Deficient Undifferentiated Esophageal Carcinoma: A Clinical Case Series and Literature Review
ConclusionsResearch in SMARCA-deficient UEC is very limited. It is more common in men, age is variable, and associated with Barret ’s esophagus. Further research is necessary to better understand it and to establish treatment guidelines; however, it is clear that SMARCA4-deficient UEC carries a significantly poor prognosis. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 24, 2024 Category: Cancer & Oncology Source Type: research
Fraction dose escalation of hypofractionated radiotherapy with concurrent chemotherapy and subsequent consolidation immunotherapy in locally advanced non-small cell lung cancer: a phase 1 study
CONCLUSIONS: Utilizing the split-course hypo-RT and hypo-boost approach, a fraction dose of 5Gy to a total dose of 60Gy, combined with concurrent chemotherapy and subsequent cICI, was well-tolerated, and yielded promising ORR and survival outcomes.PMID:38652815 | DOI:10.1158/1078-0432.CCR-23-3600 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Rui Zhou FangJie Liu HongMei Zhang DaQuan Wang PengXin Zhang ShiYang Zheng YiMei Liu Li Chen JinYu Guo YingYi Zou Yu-Ming Rong Hui Liu Bo Qiu Source Type: research
Fraction dose escalation of hypofractionated radiotherapy with concurrent chemotherapy and subsequent consolidation immunotherapy in locally advanced non-small cell lung cancer: a phase 1 study
CONCLUSIONS: Utilizing the split-course hypo-RT and hypo-boost approach, a fraction dose of 5Gy to a total dose of 60Gy, combined with concurrent chemotherapy and subsequent cICI, was well-tolerated, and yielded promising ORR and survival outcomes.PMID:38652815 | DOI:10.1158/1078-0432.CCR-23-3600 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Rui Zhou FangJie Liu HongMei Zhang DaQuan Wang PengXin Zhang ShiYang Zheng YiMei Liu Li Chen JinYu Guo YingYi Zou Yu-Ming Rong Hui Liu Bo Qiu Source Type: research
Complete Tumor Response of Esophageal Cancer: How Much Imaging Can Do?
Ann Surg Oncol. 2024 Apr 23. doi: 10.1245/s10434-024-15276-y. Online ahead of print.NO ABSTRACTPMID:38652195 | DOI:10.1245/s10434-024-15276-y (Source: Ann Oncol)
Source: Ann Oncol - April 23, 2024 Category: Cancer & Oncology Authors: Tong Tong Source Type: research
NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway
CONCLUSION: Collectively, our findings show that NUPR1 enhances the progression of ESCC by triggering autophagy and is associated with the MAPK-mTOR signaling pathway.PMID:38653091 | DOI:10.1016/j.prp.2024.155323 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Shiheng Ren Yuxin Chen Qiang Wang Liang Song Zhongwei Xin Mo Shi Xiangyan Liu Source Type: research
Durvalumab impacts progression-free survival while high-dose radiation & gt;66 Gy improves local control without excess toxicity in unresectable NSCLC stage III: Real-world data from the Austrian radio-oncological lung cancer study association registry (ALLSTAR)
CONCLUSION: While Durvalumab impacts PFS, LC can be improved by total radiation doses > 66 Gy without excess toxicity.PMID:38653380 | DOI:10.1016/j.radonc.2024.110294 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2024 Category: Radiology Authors: Franz Zehentmayr Petra Feurstein Elvis Ruznic Brigitte Langer Brane Grambozov Marisa Klebermass Herbert H üpfel Johann Feichtinger Danijela Minasch Martin Heilmann Barbara Breitfelder Claudia Steffal Gisela Gastinger-Grass Karoline Kirchhammer Margit Kaz Source Type: research
An integrated analysis of the anticarcinogenic role of forkhead box protein 1 in oesophageal squamous cell carcinoma
This study investigated the role of FOXP1 in oesophageal squamous cell carcinoma through bioinformatics analysis and experimental verification. We determined through public databases that FOXP1 expresses low in oesophageal squamous cell carcinoma compared with normal tissues, while high expression of FOXP1 indicates a better prognosis. We identified potential target genes regulated by FOXP1, and explored the potential biological processes and signalling pathways involved in FOXP1 in oesophageal squamous cell carcinoma through GO and KEGG enrichment, gene co-expression analysis, and protein interaction network construction....
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Guanzhi Ye Gaojian Pan Xiaolei Zhu Ning Li Hongming Liu Guojun Geng Jie Jiang Source Type: research
