Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions.
Plasma Transfer Lowers Epigenetic Age and Mortality in Rats
https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/
Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains m...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Extrachromosomal Circular DNA Implicated in Early Development of Cancer
The abnormal generation of circular DNA as a mechanism of cancer, operating by greatly increasing the expression of genes that favor the growth and development of a particular type of cancer. It is a feature of established tumor tissue, but researchers here note that the early presence of extracellular circular DNA in precancerous tissue is a strong marker for the later development of cancer, in that study participants lacking circular DNA in tissue biopsies near all did not go on to develop cancer. The research is focused on one particular tissue and cancer type, but is likely broadly applicable across many varieties of c...
Source: Fight Aging! - April 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
ISFAR Criticizes New Alcohol Guidance Issued by Canadian Centre on Substance Use and Addiction But Fails to Reveal Its Conflicts of Interest with Big Alcohol
Earlier this year, the Canadian Centre on Substance Use and Addiction released anew guidance on alcohol use. The guidance was notable for concluding that there is a dose-response relationship between the amount of alcohol one consumes and one ' s risk of disease or injury and therefore, greater amounts of alcohol consumption are associated with poorer health outcomes. In particular, the guidance concluded that drinking no alcohol is safer than drinking a low or moderate amount of alcohol.The International Scientific Forum on Alcohol Research (ISFAR) has just published a stingingcritique of the new guidance. The critique es...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - February 23, 2023 Category: Addiction Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Health and Mortality, Do Human Genetic Variants Matter More With Age Or Less With Age?
To what degree do genetic variants drive the observed differences in human life expectancy? The old consensus guesstimate was that environment determines 75% of life expectancy, and genetic variants the other 25%. Further, it is the common wisdom that gene variants become more important to life expectancy in later life, either by providing greater resilience to specific forms of damage and dysfunction, or slowing the pace at which that damage and dysfunction accumulates. A great deal of medical research is based on the insight that gene variants are thought to provide on disease processes.
Views on genetic variants ...
Source: Fight Aging! - October 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How to Relate to People With Low Truth Alignment
The first chapter of my book Personal Development for Smart People is called “Truth” because truth alignment is one of the fundamental principles of personal growth. In order to grow intelligently, we must face and accept reality in as many areas of life as we can. This often involves confronting and dealing with unpleasant truths that we’ve been avoiding for some time.
If we don’t get aligned with truth, we slide into falsehoods and denial, which can slow us down tremendously. Have you seen the lack of truth alignment playing out in the world recently? It’s hard not to notice it these days...
Source: Steve Pavlina's Personal Development Blog - July 30, 2022 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Emotions Relationships Values Source Type: blogs
The rise of targeted therapies: the era of the patient-focused approach
There is an urgent need for innovation in cancer treatments. Although we ’ve seen significant progress in indications for drugs treating particular diseases, cancer research data shows that 10-year survival statistics for cancers such as esophageal and lung cancer, for instance, have shown only a 10 percent increase, while pancreatic cancer has shown no significant im provement sinceRead more …The rise of targeted therapies: the era of the patient-focused approach originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 12, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/m-yair-levy" rel="tag" > M. Yair Levy, MD < /a > < /span > Tags: Meds Oncology/Hematology Source Type: blogs
Gastroenterology Embraces Artificial Intelligence
AI and machine learning have the potential to redefine the management of several GI disorders.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Colonoscopy is one of the true success stories in modern medicine.Studies have demonstrated that colonoscopy screening detects the cancer at a much earlier stage, reducing the risk of invasive tumors and metastatic disease, andreducing mortality. However, while colorectal cancer is highly preventable, it is thethird leading cause of cancer-related deathsin the U.S. A...
Source: Life as a Healthcare CIO - October 13, 2021 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Strength Training and Aerobic Exercise Reduce Cancer Mortality
Researchers here note that undertaking strength training and aerobic exercise acts to reduce mortality due to cancer, to a similar degree as these activities are known to reduce all cause mortality in later life. The mechanisms involved are likely diverse, but it is worth noting that (a) muscle tissue is metabolically active in beneficial ways, such that more muscle is better than less muscle, (b) better immune function is linked to exercise, and immune surveillance is critical to cancer prevention, and (c) exercise helps to reduce chronic inflammation, where chronic inflammation helps to drive the establishment and develo...
Source: Fight Aging! - August 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Benefits of Taking a Break from Alcohol
Alcohol abuse and alcoholism are serious issues across the nation. In fact, there are over 95,000 alcohol-related deaths each and every year. Despite how problematic alcohol can be, it is still the most used substance across the country – many don’t realize the risks and health-related problems associated with alcohol.
Before we look at how taking even a short break can help you in the long-term let’s first look at the major risks associated with excessive alcohol use and binge drinking.
Major Risks of Alcohol Use
When it comes to alcohol abuse, there are many issues that can occur – from long-term physica...
Source: PickTheBrain | Motivation and Self Improvement - May 5, 2021 Category: Consumer Health News Authors: Joe Gilmore Tags: depression featured happiness health and fitness productivity tips self-improvement addiction alcohol self improvement Source Type: blogs
Understanding the link between reflux and cancer can save lives
People who find themselves reaching for antacid several times a month, might consider reaching out to their doctor instead. Gastroesophageal reflux disease (GERD), the same condition that causes heartburn, is also linked to a deadly form of esophageal cancer, adenocarcinoma. Lack of awareness about the link between reflux and cancer has contributed to a 733 […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 30, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/hoag-memorial-hospital-presbyterian" rel="tag" > Hoag Memorial Hospital Presbyterian < /a > < /span > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
3D Printed Shields Protect Guts During Radiotherapy
Researchers at Brigham and Women’s Hospital and MIT have developed 3D printed shields to protect the gastrointestinal tract from the side effects of radiotherapy. Using CT scans, the devices can be custom printed to suit each patient’s anatomy. The materials they’re made of contain high atomic number elements that help to shield tissues from gamma and X-rays.
Radiotherapy can be highly effective at targeting tumors and helping to shrink them. However, it can also have significant consequences for nearby healthy tissues. The side effects can be particularly pronounced in the delicate tissues of the mouth and g...
Source: Medgadget - April 27, 2021 Category: Medical Devices Authors: Conn Hastings Tags: GI Materials Radiation Oncology Radiology Source Type: blogs
Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancer Survivors Exhibit Greater Risk of New Cancers and Higher Mortality Due to those Cancers
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - December 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
