Fight Aging! Newsletter, August 23rd 2021

In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns. First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk is generally U-shaped, indicating that both high and low levels of IGF-1 may be detrimental. With the exception of a more uniformly positive relationship between IGF-1 and cancer, these effects were remarkably consistent across a wide range of conditions, providing evidence for a unifying pathway that determines risk for most age-associated diseases. These data suggest that IGF-1 signaling could be harmful in older adults, who may actually benefit from the attenuation of biological growth pathways. The Harms Done By Transthyretin Amyloid in the Aging Body https://www.fightaging.org/archives/2021/08/the-harms-done-by-transthyretin-amyloid-in-the-aging-body/ It is becoming clear that transthyretin amyloid accumulation makes a meaningful contribution to cardiovascular disease and a range of other conditions over the course of normal ag...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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AbstractChronic thromboembolic pulmonary hypertension is an underdiagnosed condition. Patients typically present with the symptoms of right heart failure. Diagnosis is usually done by radionuclide ventilation/perfusion (VQ) scan, high-quality multidetector computed tomography (CT) or pulmonary angiography at expert centers. Pulmonary endarterectomy remains the corner stone in management of chronic thromboembolic pulmonary hypertension. Deep hypothermic circulatory arrest is commonly used for the operation at most centers. In-hospital mortality ranges from 1.7 to 14.2%. Pulmonary hemorrhage, reperfusion lung injury, and rig...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
New J. Chem., 2021, Advance Article DOI: 10.1039/D1NJ04453B, PaperIshrat Jahan, Shahid M. Nayeem Among the neurodegenerative diseases, one of the most common dementia is Alzheimer's disease (AD). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Julie Yoo joined the Silicon Valley venture powerhouse after co-founding the health IT startup Kyruus Health.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
ConclusionsWe established the feasibility of initiating and managing patients in a monthly text-based symptom-monitoring program. The provision of smartphones and patient navigation were unique and vital components of this program.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionPatients recovering at home following major cancer surgery regarded electronic symptom-monitoring and feedback as acceptable and beneficial. Patients perceived that the system enhanced information provision and provided a direct link to their care team. Patients felt that the system provided reassurance at a time of uncertainty and isolation, enabling them to feel in control of their symptoms and recovery.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionElectronic patient-reported outcomes are perceived as valuable for variable reasons by Black and White cancer populations, with greater perceived value for communicating with clinicians reported among Blacks. To optimize equitable uptake of ePROs, oncology practices should offer several ePRO options (e.g., web-based, phone-based), as well as paper-based options, and consider the e-health literacy needs of patients during implementation.
Source: Quality of Life Research - Category: Health Management Source Type: research
What started with an unsolicited offer last October turned into major acquisition of Adamas Pharmaceuticals by an East Coast specialty drug maker one year later.
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
What started with an unsolicited offer last October turned into major acquisition of Adamas Pharmaceuticals by an East Coast specialty drug maker one year later.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
The federal government will open the US to international travelers again if they are fully vaccinated and can prove it. For others, exemptions are limited.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Infectious Diseases News Source Type: news
I don’t do Twitter cause social media is cancer so I will post here instead: 1. Social justice - we need more diversity in the specialty and need to stop the white male micro aggressions and unconscious biases. 2. Burnout - this needs to improve. What better way to do this than academic expansion and consolidation? As we all know physicians in academic satellites are deliriously happy, content and have a major say in what their RN/MBA overlords wish to do. 3. Jobs - Potters tweeted... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
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