Residual cancer cells after apparent complete pathological response to neoadjuvant therapy in oesophageal adenocarcinoma
Br J Surg. 2024 Apr 3;111(4):znae103. doi: 10.1093/bjs/znae103.NO ABSTRACTPMID:38630793 | PMC:PMC11023542 | DOI:10.1093/bjs/znae103 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - April 17, 2024 Category: Surgery Authors: Robert C Walker Jack Harrington Stella P Breininger Oliver Pickering Samuel L Hill Benjamin P Sharpe Ben Grace Ian Reddin Rushda Rajak Antigoni Manousopoulou Spiros D Garbis Zo ë S Walters Matthew J J Rose-Zerilli Timothy J Underwood Source Type: research
Residual cancer cells after apparent complete pathological response to neoadjuvant therapy in oesophageal adenocarcinoma
Br J Surg. 2024 Apr 3;111(4):znae103. doi: 10.1093/bjs/znae103.NO ABSTRACTPMID:38630793 | PMC:PMC11023542 | DOI:10.1093/bjs/znae103 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - April 17, 2024 Category: Surgery Authors: Robert C Walker Jack Harrington Stella P Breininger Oliver Pickering Samuel L Hill Benjamin P Sharpe Ben Grace Ian Reddin Rushda Rajak Antigoni Manousopoulou Spiros D Garbis Zo ë S Walters Matthew J J Rose-Zerilli Timothy J Underwood Source Type: research
Development of an Interpretable Deep Learning Model for Pathological Tumor Response Assessment After Neoadjuvant Therapy
CONCLUSION: This work illustrates deep learning's potential for assisting pathological response assessment. Spatial heatmaps and patch examples provide intuitive explanations of model predictions, engendering clinical trust and adoption (Code and data will be available at https://github.com/WinnieLaugh/ESCC_Percentage once the paper has been conditionally accepted). Integrating interpretable computational pathology could help enhance the efficiency and consistency of tumor response assessment and empower precise oncology treatment decisions.PMID:38632527 | PMC:PMC11022344 | DOI:10.1186/s12575-024-00234-5 (Source: Biological Procedures Online)
Source: Biological Procedures Online - April 17, 2024 Category: Molecular Biology Authors: Yichen Wang Wenhua Zhang Lijun Chen Jun Xie Xuebin Zheng Yan Jin Qiang Zheng Qianqian Xue Bin Li Chuan He Haiquan Chen Yuan Li Source Type: research
Development of an Interpretable Deep Learning Model for Pathological Tumor Response Assessment After Neoadjuvant Therapy
CONCLUSION: This work illustrates deep learning's potential for assisting pathological response assessment. Spatial heatmaps and patch examples provide intuitive explanations of model predictions, engendering clinical trust and adoption (Code and data will be available at https://github.com/WinnieLaugh/ESCC_Percentage once the paper has been conditionally accepted). Integrating interpretable computational pathology could help enhance the efficiency and consistency of tumor response assessment and empower precise oncology treatment decisions.PMID:38632527 | PMC:PMC11022344 | DOI:10.1186/s12575-024-00234-5 (Source: Biological Procedures Online)
Source: Biological Procedures Online - April 17, 2024 Category: Molecular Biology Authors: Yichen Wang Wenhua Zhang Lijun Chen Jun Xie Xuebin Zheng Yan Jin Qiang Zheng Qianqian Xue Bin Li Chuan He Haiquan Chen Yuan Li Source Type: research
Conditional survival and annual hazard of death in older patients with esophageal cancer receiving definitive chemoradiotherapy
Definitive chemoradiotherapy is one of the primary treatment modalities for older patients with esophageal cancer (EC). However, the evolution of prognosis over time and the factors affected non-EC deaths rema... (Source: BMC Geriatrics)
Source: BMC Geriatrics - April 17, 2024 Category: Geriatrics Authors: Xiao Chang, Wei Deng, Rong Yu and Weihu Wang Tags: Research Source Type: research
Trends in mortality from gastrointestinal, hepatic, and pancreatic cancers in the United States: A comprehensive analysis (1999-2020)
CONCLUSION: While overall gastrointestinal cancer-related mortality declined significantly in the United States from 1999 to 2020, mortality from some cancers increased. Furthermore, differences between sexes and racial groups underscore crucial differences in gastrointestinal cancer mortality, highlighting areas for future research.PMID:38623490 | PMC:PMC11017855 | DOI:10.1002/jgh3.13064 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Hassam Ali Rizwan Ishtiaq Brandon Tedder Joshua Zweigle Romina Nomigolzar Dushyant S Dahiya Vishali Moond Amir Humza Sohail Pratik Patel Debargha Basuli Hans L Tillmann Source Type: research
[Retracted] Downregulation of long non ‑coding RNA GAS5 promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma
Oncol Lett. 2024 Apr 2;27(6):239. doi: 10.3892/ol.2024.14372. eCollection 2024 Jun.ABSTRACT[This retracts the article DOI: 10.3892/ol.2018.8797.].PMID:38623571 | PMC:PMC11017816 | DOI:10.3892/ol.2024.14372 (Source: Oncology Letters)
Source: Oncology Letters - April 16, 2024 Category: Cancer & Oncology Authors: Ke Ke Zhanwen Sun Zhengjun Wang Source Type: research
Reniformin A suppresses non-small cell lung cancer progression by inducing TLR4/NLRP3/caspase-1/GSDMD-dependent pyroptosis
In conclusion, we propose that RA has a significant anticancer effect in NSCLC by inducing TLR4/NLRP3/caspase-1/GSDMD-mediated pyroptosis, which may provide a potential strategy for the treatment of NSCLC.PMID:38626545 | DOI:10.1016/j.intimp.2024.112068 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Huiyu Zhu Yifei Guan Wei Wang Xinhui Liu Sijia Wang Ran Zheng Yihan Li Lei Liu Hua Huang Source Type: research
[Retracted] Downregulation of long non ‑coding RNA GAS5 promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma
Oncol Lett. 2024 Apr 2;27(6):239. doi: 10.3892/ol.2024.14372. eCollection 2024 Jun.ABSTRACT[This retracts the article DOI: 10.3892/ol.2018.8797.].PMID:38623571 | PMC:PMC11017816 | DOI:10.3892/ol.2024.14372 (Source: Oncology Letters)
Source: Oncology Letters - April 16, 2024 Category: Cancer & Oncology Authors: Ke Ke Zhanwen Sun Zhengjun Wang Source Type: research
Systemic inflammation score as a predictor of death within one year after esophagectomy
ConclusionSIS assessment undertaken before beginning esophageal cancer treatment is a useful predictor of death within 1 year of surgery. (Source: Esophagus)
Source: Esophagus - April 16, 2024 Category: Gastroenterology Source Type: research
MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma
World J Gastroenterol. 2024 Mar 21;30(11):1497-1523. doi: 10.3748/wjg.v30.i11.1497.ABSTRACTEsophageal squamous cell carcinoma (ESCC) is a malignant epithelial tumor, characterized by squamous cell differentiation, it is the sixth leading cause of cancer-related deaths globally. The increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered, coupled with higher risk of metastasis, which is an exceedingly malignant characteristic of cancer, frequently leading to a high mortality rate. Unfortunately, there is currently no specific and effective marker to predict and tre...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Qi-Ying Wei Feng Jin Zhong-Yu Wang Bing-Jie Li Wen-Bo Cao Zhi-Yan Sun Sai-Jun Mo Source Type: research
Effects of neoadjuvant chemotherapy < em > vs < /em > chemoradiotherapy in the treatment of esophageal adenocarcinoma: A systematic review and meta-analysis
CONCLUSION: Although nCRT may have a higher pCR rate, it does not translate to greater long-term survival. Moreover, nCRT is associated with higher 30-d mortality, although the specific cause for postoperative complications could not be identified. In the case of nCT, toxic side effects are suspected, which can reduce the quality of life. Given the quality of available studies, further randomized trials are required.PMID:38617451 | PMC:PMC11008422 | DOI:10.3748/wjg.v30.i11.1621 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Armand Csontos Al íz Fazekas Lajos Szak ó Nelli Farkas Csenge Papp Szil árd Ferenczi Szabolcs Bellyei P éter Hegyi Andr ás Papp Source Type: research
Advancements in Barrett's esophagus detection: The role of artificial intelligence and its implications
World J Gastroenterol. 2024 Mar 21;30(11):1494-1496. doi: 10.3748/wjg.v30.i11.1494.ABSTRACTArtificial intelligence (AI) is making significant strides in revolutionizing the detection of Barrett's esophagus (BE), a precursor to esophageal adenocarcinoma. In the research article by Tsai et al, researchers utilized endoscopic images to train an AI model, challenging the traditional distinction between endoscopic and histological BE. This approach yielded remarkable results, with the AI system achieving an accuracy of 94.37%, sensitivity of 94.29%, and specificity of 94.44%. The study's extensive dataset enhances the AI model'...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Sara Massironi Source Type: research
Myocardial metastasis from ZEB1- and TWIST-positive spindle cell carcinoma of the esophagus: A case report
CONCLUSION: To the best of our knowledge, there have been no prior reports of cardiac metastasis of esophageal SCC. This case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease, with the autopsy examination showing cardiac metastasis.PMID:38617457 | PMC:PMC11008411 | DOI:10.3748/wjg.v30.i11.1636 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba Source Type: research
