Myocardial metastasis from ZEB1- and TWIST-positive spindle cell carcinoma of the esophagus: A case report
CONCLUSION: To the best of our knowledge, there have been no prior reports of cardiac metastasis of esophageal SCC. This case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease, with the autopsy examination showing cardiac metastasis.PMID:38617457 | PMC:PMC11008411 | DOI:10.3748/wjg.v30.i11.1636 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba Source Type: research
Advancements in Barrett's esophagus detection: The role of artificial intelligence and its implications
World J Gastroenterol. 2024 Mar 21;30(11):1494-1496. doi: 10.3748/wjg.v30.i11.1494.ABSTRACTArtificial intelligence (AI) is making significant strides in revolutionizing the detection of Barrett's esophagus (BE), a precursor to esophageal adenocarcinoma. In the research article by Tsai et al, researchers utilized endoscopic images to train an AI model, challenging the traditional distinction between endoscopic and histological BE. This approach yielded remarkable results, with the AI system achieving an accuracy of 94.37%, sensitivity of 94.29%, and specificity of 94.44%. The study's extensive dataset enhances the AI model'...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Sara Massironi Source Type: research
Effects of neoadjuvant chemotherapy < em > vs < /em > chemoradiotherapy in the treatment of esophageal adenocarcinoma: A systematic review and meta-analysis
CONCLUSION: Although nCRT may have a higher pCR rate, it does not translate to greater long-term survival. Moreover, nCRT is associated with higher 30-d mortality, although the specific cause for postoperative complications could not be identified. In the case of nCT, toxic side effects are suspected, which can reduce the quality of life. Given the quality of available studies, further randomized trials are required.PMID:38617451 | PMC:PMC11008422 | DOI:10.3748/wjg.v30.i11.1621 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Armand Csontos Al íz Fazekas Lajos Szak ó Nelli Farkas Csenge Papp Szil árd Ferenczi Szabolcs Bellyei P éter Hegyi Andr ás Papp Source Type: research
Myocardial metastasis from ZEB1- and TWIST-positive spindle cell carcinoma of the esophagus: A case report
CONCLUSION: To the best of our knowledge, there have been no prior reports of cardiac metastasis of esophageal SCC. This case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease, with the autopsy examination showing cardiac metastasis.PMID:38617457 | PMC:PMC11008411 | DOI:10.3748/wjg.v30.i11.1636 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba Source Type: research
MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma
World J Gastroenterol. 2024 Mar 21;30(11):1497-1523. doi: 10.3748/wjg.v30.i11.1497.ABSTRACTEsophageal squamous cell carcinoma (ESCC) is a malignant epithelial tumor, characterized by squamous cell differentiation, it is the sixth leading cause of cancer-related deaths globally. The increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered, coupled with higher risk of metastasis, which is an exceedingly malignant characteristic of cancer, frequently leading to a high mortality rate. Unfortunately, there is currently no specific and effective marker to predict and tre...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Qi-Ying Wei Feng Jin Zhong-Yu Wang Bing-Jie Li Wen-Bo Cao Zhi-Yan Sun Sai-Jun Mo Source Type: research
Advancements in Barrett's esophagus detection: The role of artificial intelligence and its implications
World J Gastroenterol. 2024 Mar 21;30(11):1494-1496. doi: 10.3748/wjg.v30.i11.1494.ABSTRACTArtificial intelligence (AI) is making significant strides in revolutionizing the detection of Barrett's esophagus (BE), a precursor to esophageal adenocarcinoma. In the research article by Tsai et al, researchers utilized endoscopic images to train an AI model, challenging the traditional distinction between endoscopic and histological BE. This approach yielded remarkable results, with the AI system achieving an accuracy of 94.37%, sensitivity of 94.29%, and specificity of 94.44%. The study's extensive dataset enhances the AI model'...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Sara Massironi Source Type: research
Clinical-radiomics nomogram for the risk prediction of esophageal fistula in patients with esophageal squamous cell carcinoma treated with intensity-modulated radiation therapy or volumetric-modulated arc therapy
CONCLUSIONS: The clinical-radiomics nomogram can predict the risk of EF in ESCC patients and is helpful for the individualized treatment of EC.PMID:38617757 | PMC:PMC11009608 | DOI:10.21037/jtd-24-191 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Zhaohui Li Jie Gong Liu Shi Jie Li Zhi Yang Guangjin Chai Bo Lv Geng Xiang Bin Wang Shamus R Carr Alfonso Fiorelli Mei Shi Yilin Zhao Lina Zhao Source Type: research
Comparisons of short-term outcomes between robot-assisted, video-assisted, and open esophagectomy for resectable esophageal cancer after neoadjuvant treatment: a retrospective study
CONCLUSIONS: Compared to VAMIE, no clear benefit exists for RAE in the treatment of resectable EC after neoadjuvant therapy. OE resulted in a longer hospital stay. Although the rate of successful right RLN node removal was higher with RAE, the clinical relevance for this is yet unclear.PMID:38617777 | PMC:PMC11009584 | DOI:10.21037/jtd-24-75 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Ziheng Wu Jiacong Liu Lichen Zhang Muhu Tang Wenbo Shu Berend J van der Wilk Christopher J Anker Zhehao He Luming Wang Wang Lv Linhai Zhu Jian Hu Source Type: research
Robot-assisted minimally invasive esophagectomy versus minimally invasive esophagectomy for thoracic lymph node dissection in patients with squamous cell carcinoma: a retrospective comparative cohort study
CONCLUSIONS: Our study shows that RAMIE may be more effective than MIE in terms of the number thoracic lymph nodes dissected and the extent of dissection. Moreover, RAMIE may be not associated with additional surgical complications.PMID:38617764 | PMC:PMC11009590 | DOI:10.21037/jtd-24-201 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Jingle Lei Yuwen Bai Zhi Qiao Jianqun Ma Source Type: research
Comparison of early postoperative pulmonary complications between two-lung ventilation with artificial pneumothorax and one-lung ventilation with bronchial blockade in patients undergoing minimally invasive esophagectomy: a retrospective propensity score-matched cohort study
CONCLUSIONS: Compared with OLV with bronchial blockade, TLV with CO2 pneumothorax did not reduce the incidence of early PPCs after MIE.PMID:38617773 | PMC:PMC11009580 | DOI:10.21037/jtd-23-1667 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Xiaoxi Li Ling Yu Jiaonan Yang Miao Fu Hongyu Tan Source Type: research
Molecular characteristics and multivariate survival analysis of 43 patients with locally advanced or metastatic esophageal squamous cell carcinoma
CONCLUSIONS: NOTCH1, CBLB and TSC2 alterations were found to be potential indicators of poor prognosis in patients with ESCC. TMB was also positively correlated with the OS of ESCC patients, providing valuable insights for their treatment strategies.PMID:38617776 | PMC:PMC11009591 | DOI:10.21037/jtd-23-1601 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Xia Zhou Wuan Bao Xiang Zhu Di Wang Pengfei Zeng Guojie Xia Minyan Xing Yanyan Zhan Junrong Yan Minchi Yuan Qiang Zhao Source Type: research
The chest X-ray score baseline in predicting continuous oxygen therapy failure in low-risk aged patients after thoracic surgery
CONCLUSIONS: The RALE score predict the risk of COT failure in elderly, low-risk thoracic patients better than the Brixia score. This simple, cheap, and noninvasive method helps evaluate postoperative lung damage, monitor treatment response, and provide early warning for oxygen therapy escalation. Further studies are required to confirm the validity and applicability of this model in different settings and populations.PMID:38617782 | PMC:PMC11009605 | DOI:10.21037/jtd-23-1786 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Tongxin Li Weina Li Fengxi Chen Qianfeng Xu Gaoli Du Yong Fu Lihui Yuan Sha Zhang Wei Wu Ping He Mei Xia Source Type: research
Biofunctional study on chemoresistance in esophageal squamous carcinoma cells induced by missense mutation of < em > NOTCH1 p.E450K < /em >
CONCLUSIONS: The NOTCH1 p.E450K point mutation causes chemotherapy resistance in KYSE140 and KYSE450 ESCC cells. Cell functional experiments showed that the NOTCH1 p.E450K point mutation enhanced the proliferation, migration and invasion abilities of KYSE140 and KYSE450 cells and increased the number of cells in S phase.PMID:38617785 | PMC:PMC11009606 | DOI:10.21037/jtd-23-1880 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Keting Li Wentao Hao Jiwei Wu Xianben Liu Wenqun Xing Yan Zheng Source Type: research
Cancers, Vol. 16, Pages 1504: Clinical and Diagnostic Utility of Genomic Profiling for Digestive Cancers: Real-World Evidence from Japan
Hajime Kuroda
Seigo Yukisawa
Takuya Aoki
Kei Takeshita
Shinichi Ueno
Junichi Nakazawa
Yu Sunakawa
Sachio Nohara
Chihiro Okada
Ko Nishimiya
Shigeki Tanishima
Hiroshi Nishihara
The usefulness of comprehensive genomic profiling (CGP) in the Japanese healthcare insurance system remains underexplored. Therefore, this large-scale study aimed to determine the usefulness of CGP in diagnosing digestive cancers. Patients with various cancer types recruited between March 2020 and October 2022 underwent the FoundationOne&reg; CDx assay at the Keio PleSSision Group (19 hospitals in Japan). A scoring sy...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Marin Ishikawa Kohei Nakamura Ryutaro Kawano Hideyuki Hayashi Tatsuru Ikeda Makoto Saito Yo Niida Jiichiro Sasaki Hiroyuki Okuda Satoshi Ishihara Masatoshi Yamaguchi Hideaki Shimada Takeshi Isobe Yuki Yuza Akinobu Yoshimura Hajime Kuroda Seigo Yukisawa Ta Tags: Article Source Type: research
The prognostic role of pre-treatment neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in esophageal squamous cell carcinoma treated with concurrent chemoradiotherapy
In this study, we retrospectively investigated the prognostic role of pre-treatment neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in esophageal squamous cell carcinoma patients (E... (Source: BMC Cancer)
Source: BMC Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Qirong Man, Peishun Li, Jing Fan, Sen Yang, Chao Xing, Yunling Bai, Miaomiao Hu, Baohu wang and Kaixian Zhang Tags: Research Source Type: research
