Cancers, Vol. 16, Pages 1504: Clinical and Diagnostic Utility of Genomic Profiling for Digestive Cancers: Real-World Evidence from Japan

Cancers, Vol. 16, Pages 1504: Clinical and Diagnostic Utility of Genomic Profiling for Digestive Cancers: Real-World Evidence from Japan Cancers doi: 10.3390/cancers16081504 Authors: Marin Ishikawa Kohei Nakamura Ryutaro Kawano Hideyuki Hayashi Tatsuru Ikeda Makoto Saito Yo Niida Jiichiro Sasaki Hiroyuki Okuda Satoshi Ishihara Masatoshi Yamaguchi Hideaki Shimada Takeshi Isobe Yuki Yuza Akinobu Yoshimura Hajime Kuroda Seigo Yukisawa Takuya Aoki Kei Takeshita Shinichi Ueno Junichi Nakazawa Yu Sunakawa Sachio Nohara Chihiro Okada Ko Nishimiya Shigeki Tanishima Hiroshi Nishihara The usefulness of comprehensive genomic profiling (CGP) in the Japanese healthcare insurance system remains underexplored. Therefore, this large-scale study aimed to determine the usefulness of CGP in diagnosing digestive cancers. Patients with various cancer types recruited between March 2020 and October 2022 underwent the FoundationOne® CDx assay at the Keio PleSSision Group (19 hospitals in Japan). A scoring system was developed to identify potentially actionable genomic alterations of biological significance and actionable genomic alterations. The detection rates for potentially actionable genomic alterations, actionable genomic alterations, and alterations equivalent to companion diagnosis (CDx), as well as the signaling pathways associated with these alterations in each digestive cancer, were analyzed. Among the 1587 patients, 5...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research