Risk stratification for synchronous/metachronous recurrence after endoscopic submucosal dissection for Barrett ’s esophageal adenocarcinoma using the length of Barrett’s esophagus
ConclusionsRisk stratification of multifocal cancer using length of Barrett ’s esophagus was effective. Further multicenter prospective studies are needed to substantiate our findings. (Source: Esophagus)
Source: Esophagus - April 12, 2024 Category: Gastroenterology Source Type: research
First-line pembrolizumab plus chemotherapy for advanced/metastatic esophageal cancer: 1-year extended follow-up in the Japanese subgroup of the phase 3 KEYNOTE-590 study
ConclusionsWith longer-term follow-up of Japanese patients with advanced/metastatic esophageal cancer, efficacy continued to favor pembrolizumab –chemotherapy compared with placebo–chemotherapy, with no new safety signals observed.Clinical trial registration: ClinicalTrials.gov, NCT03189719. (Source: Esophagus)
Source: Esophagus - April 12, 2024 Category: Gastroenterology Source Type: research
A combined nomogram based on radiomics and hematology to predict the pathological complete response of neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma
To predict pathological complete response (pCR) in patients receiving neoadjuvant immunochemotherapy (nICT) for esophageal squamous cell carcinoma (ESCC), we explored the factors that influence pCR after nICT ... (Source: BMC Cancer)
Source: BMC Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Yu Yang, Yan Yi, Zhongtang Wang, Shanshan Li, Bin Zhang, Zheng Sang, Lili Zhang, Qiang Cao and Baosheng Li Tags: Research Source Type: research
Comment on ''study on the predictive value of pretreatment peripheral blood inflammatory markers regarding immunotherapy in patients with inoperable advanced or locally advanced oesophageal squamous cell carcinoma''
Scand J Gastroenterol. 2024 Apr 11:1-2. doi: 10.1080/00365521.2024.2337840. Online ahead of print.NO ABSTRACTPMID:38602415 | DOI:10.1080/00365521.2024.2337840 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 11, 2024 Category: Gastroenterology Authors: Wenting Pan Li Qin Source Type: research
Pathologic Response is Negatively Impacted by Diabetes for Esophageal Cancer
Ann Thorac Surg. 2024 Apr 9:S0003-4975(24)00258-3. doi: 10.1016/j.athoracsur.2024.03.028. Online ahead of print.NO ABSTRACTPMID:38604392 | DOI:10.1016/j.athoracsur.2024.03.028 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 11, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Christine E Alvarado Stephanie G Worrell Source Type: research
Clinical features and treatment outcomes of PD-1 inhibitor therapy in elderly patients ( ≥ 65 years) with advanced esophageal squamous cell carcinoma: a real-world study
CONCLUSION: The study demonstrated that individuals older than 65 years with locally advanced or metastatic ESCC have a survival benefit from the first-line treatment of PD-1 inhibitors combined therapy, with a manageable safety profile.PMID:38602642 | DOI:10.1007/s12094-024-03453-0 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Yi Yu Tao Wu Wei Gan Can Liu Ran Zhang Jinxiu Zheng Jianping Xiong Jun Chen Junhe Li Source Type: research
Analysis of Molecular Genetic Variants of Lgals4 in Esophageal Cancer: A Preliminary Report
Biochem Genet. 2024 Apr 12. doi: 10.1007/s10528-024-10780-y. Online ahead of print.ABSTRACTEsophageal cancer is the eighth most common cancer worldwide and fourth most common in developing countries. Altered glycosylation pattern of cell membrane molecules along with inflammation is a characteristic attribute of oncogenesis. Galectin-4, a tandem repeat galectin, has shown effect on cancer progression/metastasis in digestive system cancers. This role of galectin-4 can be attributed to variations in LGALS4, gene encoding galectin-4. The present case-control study was designed to analyze four intronic SNPs in LGALS4 with susc...
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Surmeet Kaur Rajiv Devgan Jagdeep Singh Namarta Kalia Jatinder Singh Manpreet Kaur Source Type: research
Oblique conformal anastomosis decreased the risks of cervical anastomotic leakage after totally minimally invasive esophagectomy
CONCLUSION: Oblique conformation anastomosis was stronger and involved a more prominent reduced risk of cervical anastomotic leakage than conventional anastomosis after TMIE.PMID:38604851 | DOI:10.1016/j.asjsur.2024.03.141 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Jinyang Guo Yanzhao Xu Chao Huang Mingbo Wang Fan Zhang Zhao Liu Zhenhua Li Huilai Lv Ziqiang Tian Source Type: research
Analysis of Molecular Genetic Variants of Lgals4 in Esophageal Cancer: A Preliminary Report
Biochem Genet. 2024 Apr 12. doi: 10.1007/s10528-024-10780-y. Online ahead of print.ABSTRACTEsophageal cancer is the eighth most common cancer worldwide and fourth most common in developing countries. Altered glycosylation pattern of cell membrane molecules along with inflammation is a characteristic attribute of oncogenesis. Galectin-4, a tandem repeat galectin, has shown effect on cancer progression/metastasis in digestive system cancers. This role of galectin-4 can be attributed to variations in LGALS4, gene encoding galectin-4. The present case-control study was designed to analyze four intronic SNPs in LGALS4 with susc...
Source: Biochemical Genetics - April 11, 2024 Category: Genetics & Stem Cells Authors: Surmeet Kaur Rajiv Devgan Jagdeep Singh Namarta Kalia Jatinder Singh Manpreet Kaur Source Type: research
Multi-omic analysis of Esophageal Adenocarcinoma uncovers candidate therapeutic targets and cancer-selective post-transcriptional regulation
CONCLUSIONS: By quantitative proteomic analysis we have identified GPA33 as an EAC-selective biomarker. Integrated analysis of proteome, transcriptome, and genome in EAC has revealed several genes with tumor-selective, post-transcriptional regulation of protein expression which may be an exploitable vulnerability.PMID:38604503 | DOI:10.1016/j.mcpro.2024.100764 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - April 11, 2024 Category: Molecular Biology Authors: J Robert O'Neill Marcos Y ébenes Mayordomo Goran Mitulovi ć Sofian Al Shboul Georges Bedran Jakub Faktor Lenka Hernychova Lukas Uhrik Maria Gomez-Herranz Miko łaj Kocikowski Vicki Save Bo řivoj Vojtěšek Mark Arends OCCAMS consortium Ted Hupp Javier Source Type: research
Comment on ''study on the predictive value of pretreatment peripheral blood inflammatory markers regarding immunotherapy in patients with inoperable advanced or locally advanced oesophageal squamous cell carcinoma''
Scand J Gastroenterol. 2024 Apr 11:1-2. doi: 10.1080/00365521.2024.2337840. Online ahead of print.NO ABSTRACTPMID:38602415 | DOI:10.1080/00365521.2024.2337840 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 11, 2024 Category: Gastroenterology Authors: Wenting Pan Li Qin Source Type: research
Pathologic Response is Negatively Impacted by Diabetes for Esophageal Cancer
Ann Thorac Surg. 2024 Apr 9:S0003-4975(24)00258-3. doi: 10.1016/j.athoracsur.2024.03.028. Online ahead of print.NO ABSTRACTPMID:38604392 | DOI:10.1016/j.athoracsur.2024.03.028 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 11, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Christine E Alvarado Stephanie G Worrell Source Type: research
Multi-omic analysis of Esophageal Adenocarcinoma uncovers candidate therapeutic targets and cancer-selective post-transcriptional regulation
CONCLUSIONS: By quantitative proteomic analysis we have identified GPA33 as an EAC-selective biomarker. Integrated analysis of proteome, transcriptome, and genome in EAC has revealed several genes with tumor-selective, post-transcriptional regulation of protein expression which may be an exploitable vulnerability.PMID:38604503 | DOI:10.1016/j.mcpro.2024.100764 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - April 11, 2024 Category: Molecular Biology Authors: J Robert O'Neill Marcos Y ébenes Mayordomo Goran Mitulovi ć Sofian Al Shboul Georges Bedran Jakub Faktor Lenka Hernychova Lukas Uhrik Maria Gomez-Herranz Miko łaj Kocikowski Vicki Save Bo řivoj Vojtěšek Mark Arends OCCAMS consortium Ted Hupp Javier Source Type: research
Comment on ''study on the predictive value of pretreatment peripheral blood inflammatory markers regarding immunotherapy in patients with inoperable advanced or locally advanced oesophageal squamous cell carcinoma''
Scand J Gastroenterol. 2024 Apr 11:1-2. doi: 10.1080/00365521.2024.2337840. Online ahead of print.NO ABSTRACTPMID:38602415 | DOI:10.1080/00365521.2024.2337840 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 11, 2024 Category: Gastroenterology Authors: Wenting Pan Li Qin Source Type: research
Oblique conformal anastomosis decreased the risks of cervical anastomotic leakage after totally minimally invasive esophagectomy
CONCLUSION: Oblique conformation anastomosis was stronger and involved a more prominent reduced risk of cervical anastomotic leakage than conventional anastomosis after TMIE.PMID:38604851 | DOI:10.1016/j.asjsur.2024.03.141 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Jinyang Guo Yanzhao Xu Chao Huang Mingbo Wang Fan Zhang Zhao Liu Zhenhua Li Huilai Lv Ziqiang Tian Source Type: research
